A Houston biotech company has a new CEO and is ready for growth. Getty Images

With a veteran of the biopharmaceutical industry now aboard as its CEO and an executive at pharmaceutical giant AstraZeneca now serving on its board, Houston-based biopharmaceutical company Pulmotect Inc. is poised for progress.

In September, Dr. Colin Broom joined Pulmotect as CEO. He previously was CEO of Ireland-based Nabriva Therapeutics plc, a biopharmaceutical company that went public in 2015. During Broom's tenure at Nabriva, he helped develop the recently approved drug Xenleta, which treats bacterial pneumonia. Before that, he was chief scientific officer at Pennsylvania-based pharmaceutical company ViroPharma Inc., which Massachusetts-based Shire plc purchased for $4.2 billion in 2014.

Broom's hiring came on the heels of Kumar Srinivasan being named to Pulmotect's board of directors. Srinivasan is vice president of United Kingdom-based AstraZeneca and is its global head of business development and licensing for biopharmaceuticals R&D.

Researchers at MD Anderson Cancer Center and Texas A&M University invented Pulmotect's main product, PUL-042, which holds patents in nine countries. Pulmotect, founded in 2007, emerged from Houston's Fannin Innovation Studio, which nurtures early stage companies in the life sciences sector.

"Attracting such a highly regarded and proven CEO as Colin is a clear signal of the power and potential of Pulmotect's development program," Pulmotect's executive chairman, Leo Linbeck III, founder and chairman of Fannin, says in a release. "Under his leadership, I'm confident that we will advance our technology further into the clinic and closer to the marketplace. His addition is a real game-changer for the company."

Both Broom and Srinivasan are focusing on clinical trials for Pulmotect's PUL-042 product, an inhaled therapy that holds the potential to prevent or treat respiratory infections caused by bacteria, viruses, or fungi. The current Phase 2 trial is evaluating the effectiveness of PUL-042 in treating patients with mild chronic obstructive pulmonary disease (COPD) who've been exposed to a respiratory virus. The current trial is supposed to be followed by additional Phase 2 trials.

COPD, which affects 30 million Americans, is the No. 3 cause of death in the U.S., according to the COPD Foundation. Pulmotect says 40 percent of COPD-related costs could be avoided by preventing complications and hospitalizations, which typically result from COPD problems triggered by a bacterial or viral infection. PUL-042 could substantially decrease those complications, the company says.

Pulmotect seeks to gear PUL-042 toward patients with cancer who are undergoing chemotherapy, as their weakened immunity makes them highly susceptible to pneumonia, Broom says. If the product proves effective with those patients, then people at risk of developing respiratory infections also might benefit from it, including COPD patients and flu patients, he says.

To date, Pulmotect has raised more than $28 million in funding. That includes about $18 million in research grants, including a $7 million grant from the Cancer Prevention and Research Institute of Texas, as well as seven grants from the Small Business Innovation Research program.

Two of Pulmotect's three full-time employees work in Houston, and a team of consultants supports their work, Broom says. A small number of employees might be added during the current Phase 2 trial. Hiring would need to be ramped up if the Phase 2 trial demonstrates that PUL-042 works, he says.

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Houston-based autonomous trucking tech co. raises $20M

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A Houston-based autonomous vehicle technology company has raised early funding.

Bot Auto has announced the completion of its pre-series A funding round which was oversubscribed and raised $20 million. The round was led by investments from Brightway Future Capital, Cherubic Ventures, EnvisionX Capital, First Star Ventures, Linear Capital, M31 Capital, Taihill Venture, Uphonest Capital, and Welight Capital.

“As true believers in autonomous trucking, we're thankful for our investors' shared vision,” Xiaodi Hou, founder and CEO of Bot Auto, says in a news release. “Our strong commitment, combined with recent AI advancements and a sharpened focus on operational efficiency, has created a clear path to commercialization.”

The funds raised will be focused on developing the technology and will opt to avoid unnecessary hiring ahead of operational maturity, scaling the operational footprint prior to product readiness, over expansion and partnership debt. The company aims for a more sustainable and efficient future, and is hoping its engineers and AV executives help Bot Auto become an autonomous trucking game changer.

The Investment is expected to help expand Bot Auto's tech development in autonomous trucking that will focus on safety and operation efficiency.

“Our prospects for success have never been more promising,” Hou adds. “ We march forward, committed to bringing this transformative technology to humanity for a brighter future.”

Bot Auto’s vision aligns with the pioneering spirit of Houston’s legacy in space exploration, striving to achieve remarkable feats in technology and transportation. The company is dedicated to leveraging this investment to make significant strides in the US autonomous trucking industry, ultimately contributing to a more sustainable and efficient future.

Profile: Houston founder helps create a new way of making clean electricity

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When Cindy Taff was a vice president at the giant oil and gas company Shell in Houston, her middle schooler Brianna would sometimes look over her shoulder as she worked from home.

“Why are you still working in oil and gas?” her daughter asked more than once. “Is there a future in it? Why aren’t you moving into something clean?”

The words weighed on Taff.

“As a parent you want to give direction, and was I giving her the right direction?” she recalled.

At Shell, Taff was in charge of drilling wells and bringing them into production. She worked on oil and natural gas that's called unconventional in the industry, because the oil or natural gas is difficult to get out of the ground — it doesn't naturally gush out like in movies. It's a term often used for oily shale rock. Taff was somewhat unconventional for the industry, too. Her coworkers used to tease her for driving an efficient hybrid.

“You’re not helping oil and gas prices by driving a Prius," they'd say.

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EDITOR’S NOTE: This is part of an occasional series of personal stories from the energy transition — the change away from a fossil-fuel based world that largely causes climate change.

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Taff wanted Shell to pursue the energy that comes from the Earth's natural heat — geothermal. Her team looked into it, but Shell never greenlit any of those projects, saying it would take too much time to recoup the investment.

When Brianna went to college, she was passionate about energy too, but she wanted to work on renewables. After her sophomore year, in the summer of 2020, she got an internship at a geothermal company — one that in fact had just been launched by Taff's former colleagues at Shell — Sage Geosystems in Houston.

Now it was Taff looking over her daughter's shoulder and asking question as she worked from home during the pandemic.

And Sage executives were talking to Brianna, too. “We could use your mom here," they said. "Can you get her to come work for us?” Brianna recalled recently.

That's how Cindy Taff left her 36-year career at Shell to become chief operating officer at Sage.

“I didn't understand why Shell wasn't pursuing it,” she said about applying the company's drilling expertise to heat energy. "Then I got this great opportunity to pivot from oil and gas and work with these guys that I have the utmost respect for. And also, I wanted to make my daughter proud, quite frankly.”

Brianna Byrd, now 24, is the operations engineer and spokesperson at the company. She's glad her mother, now CEO, left oil and gas.

“Of course I’m biased, she’s my mom, but I don’t think Sage would be where it is without her,” she said.

The United States is a world leader in electricity made from geothermal energy, but this kind of electricity still accounts for less than half a percent of the nation’s total large-scale generation, according to the U.S. Energy Information Administration. In 2023, most geothermal electricity came from California, Nevada, Utah, Hawaii, Oregon, Idaho and New Mexico, where there are reservoirs of steam, or very hot water, close to the surface.

The Energy Department estimates this next generation of geothermal projects, like what Sage is doing, could provide some 90 gigawatts by 2050 — enough to power 65 million homes or more. That hinges on private investment, and on companies like Sage introducing this form of energy to regions where, until now, it’s been thought to be impossible.

How it works

Sage has two main technologies: The first makes electricity out of heat. The company drills wells and fractures hot, dry rock. Then electric pumps push water into those fractures, heating it up, and the hot water gets jettisoned to the surface where it spins a turbine.

But a funny thing happened during testing in Starr County, Texas. In late 2021, the team realized much of their technology could also be used to store energy.

If that works, it could be a big deal. Currently, to store energy at large scale, the United States is adding batteries, mostly lithium-ion type, to solar and wind projects, so they can charge up and send electricity back to the electric grid when the sun is not shining or the wind is not blowing. These batteries typically supply four hours maximum power.

Sage envisions some of its technology placed at solar and wind farms, too. When electricity demand is low, they'll use extra energy from a solar or wind farm to run electric pumps, pumping water into the underground fractures, leaving it there until demand for electricity increases — storing the energy beneath the Earth's surface for hours, days or even weeks.

It's a novel way to use the technology, said Silviu Livescu, lead author on a report looking at the future of geothermal in Texas. Livescu knows Taff and has followed the company's progress.

“It’s the right moment for companies like Sage with a purpose, with a mission and with the technology to show that geothermal indeed is the energy source we need to address climate change,” said Livescu, who co-founded a different geothermal startup in Austin, Texas.

These days, Taff is often out in front, talking with politicians and policymakers about the potential of geothermal. She attended the United Nations COP28 climate talks last year to share her vision for this kind of energy.

Sage has raised $30 million so far and is growing.

It's building a small (3-megawatt), geothermal energy storage system at San Miguel Electric Cooperative, Inc., south of San Antonio this year. It's working with U.S. military facilities in Texas that see geothermal as a way to power their bases securely. Sage recently announced partnerships for heating communities in Bucharest, Romania; clean electricity from geothermal for Meta's data centers, and energy storage and geothermal projects in California.

The company is final-testing a proprietary turbine to more efficiently convert heat to electricity.

Because of her oil and gas background, Taff said she knows geothermal will only be adopted widely if the cost comes down. The mantra at Sage is: It's going to be clean and it's going to be cheap. She's excited to be working in a field she feels is on the cusp of playing a big role in cleaning and stabilizing the electrical grid.

“I’ve never looked back,” she said. “I love what I’m doing and I think it’s going to be transformative.”

Houston bio-based materials founder rebrands, evolves future-focused sustainability startup

HOUSTON INNOVATORS PODCAST EPISODE 255

At first, Zimri T. Hinshaw just wanted to design a sustainable, vegan jacket inspired by bikers he saw in Tokyo. Now, he's running a bio-based materials company with two product lines and is ready to disrupt the fashion and automotive industries.

Hinshaw founded Rheom Materials (née Bucha Bio) in 2020, but a lot has changed since then. He moved the company from New York to Houston, built out a facility in Houston's East End Maker Hub, and rebranded to reflect the company's newest phase and extended product lines, deriving from dozens of different ingredients, including algae, seaweed, corn, other fruits and vegetables, and more.

"As a company, we pivoted our technology from growing kombucha sheets to grinding up bacteria nanocellulose from kombucha into our products and then we moved away from that entirely," Hinshaw says on the Houston Innovators Podcast. "Today, we're designing different materials that are more sustainable, and the inputs are varied."

Now, in addition to Rheom's leather-like alternative, Shorai, the company has a plastic-like material, Benree, that's 100 percent bio based.

"The scope of what we were doing — both on what raw materials we were using and what we were creating just kept expanding and growing," Hinshaw says.

With that major evolution past just kombucha-based textiles, it was time for a new name, ideated by the company's technical team. "Rheom" is the combination of "rheology" — the study of how polymers flow — and "form."

Rheom has also built a state-of-the-art chemicals testing lab at its new facility after moving into it early last year.

"We've got a ton of capabilities now — and we've been growing those since the beginning," Hinshaw says. "Now we have all this testing equipment — things that pull materials apart, things that test the flexibility of materials."

Next up, Rheom, which is backed by Houston-based New Climate Ventures, among other VCs, will raise a series A funding round to continue supporting its growth.