3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Dr. William Cohn of BiVACOR, Rebecca Richards-Kortum of Rice University, and Michael Suffredini of Axiom Space. Photos courtesy

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a Houston heart innovator, a cancer researcher, and space tech founder.

Dr. William Cohn, chief medical officer at BiVACOR

Why this Houston medical device innovator is pumped up for the first total artificial heart

Dr. William Cohn is the chief medical officer for BiVACOR, a medical device company creating the first total artificial heart. Photo via TMC

It's hard to understate the impact Dr. William Cohn has had on cardiovascular health as a surgeon at the Texas Heart Institute or on health care innovation as the director of the Center for Device Innovation at the Texas Medical Center. However, his role as chief medical officer of BiVACOR might be his most significant contribution to health care yet.

The company's Total Artificial Heart is unlike any cardiovascular device that's existed, Cohn explains on the Houston Innovators Podcast. While most devices are used temporarily for patients awaiting a heart transplant, BiVACOR's TAH has the potential to be a permanent solution for the 200,000 patients who die of heart failure annually. Last year, only around 4,000 patients were able to receive heart transplants.

"Artificial hearts historically have had bladders that ejected and filled 144,000 times a day. They work great for temporary support, but no one is suggesting they are permanent devices," Cohn says on the show. Read more.

Rebecca Richards-Kortum, director of the Rice360 Institute for Global Health Technologies

Rebecca Richards-Kortum, a Rice bioengineering professor and director of the Rice360 Institute for Global Health Technologies, is the lead PI on the project. Photo by Jeff Fitlow/Rice University

The Biden-Harris administration is deploying $150 million as a part of its Cancer Moonshot initiative, and a research team led by Rice University is getting a slice of that pie.

AccessPath is a novel, affordable, slide-free pathology system that helps surgeons determine if they have completely removed tumors during surgery. Rebecca Richards-Kortum, a Rice bioengineering professor and director of the Rice360 Institute for Global Health Technologies, is the lead PI on the project that is receiving up to $18 million over five years from the Advanced Research Projects Agency for Health (ARPA-H).

“Because of its low cost, high speed, and automated analysis, we believe AccessPath can revolutionize real-time surgical guidance, greatly expanding the range of hospitals able to provide accurate intraoperative tumor margin assessment and improving outcomes for all cancer surgery patients,” Richards-Kortum says. Read more.

Michael Suffredini, co-founder of Axiom Space

Axiom Space Co-founder Michael Suffredini is stepping down as CEO. Photo courtesy of Axiom Space

Houston-based space exploration company Axiom Space is searching for a new CEO. Co-founder Mike Suffredini stepped down effective August 9 as CEO. He cites unidentified personal reasons for his transition from CEO to company advisor. Suffredini remains a board member of Axiom Space.

Co-founder Kam Ghaffarian, the company’s executive chairman, is serving as interim CEO until Axiom Space taps Suffredini’s permanent successor. Read more.

Axiom Space Co-founder Michael Suffredini is stepping down as CEO. Photo courtesy of Axiom Space

Axiom Space CEO steps down, search begins for replacement

CEO hunting

Houston-based space exploration company Axiom Space is searching for a new CEO.

Co-founder Mike Suffredini stepped down effective August 9 as CEO. He cites unidentified personal reasons for his transition from CEO to company advisor. Suffredini remains a board member of Axiom Space.

Co-founder Kam Ghaffarian, the company’s executive chairman, is serving as interim CEO until Axiom Space taps Suffredini’s permanent successor.

“We are grateful for Mike’s invaluable contributions to human space exploration and the remarkable growth of Axiom Space,” Ghaffarian says in a news release. “He will continue to offer his unique perspective and expertise as we advance our mission.”

Suffredini — who managed NASA’s International Space Station program from 2005 to 2015 — founded Axiom Space in 2016 with Ghaffarian. The company operates missions to the International Space Station, is building the world’s first commercial space station, and is developing commercial infrastructure for the space economy.

At one point, Suffredini also held the title of president. Axiom Space executive Matt Ondler was promoted to that job in 2023.

Suffredini led the company as it reached numerous milestones, such as:

Earlier this month, Axiom Space named NASA veteran Peggy Whitson, a former student and professor at Houston’s Rice University, as commander of their next global crew heading to the International Space Station aboard a private mission. Whitson and her three fellow crew members arrived in Houston on August 6 to train with Axiom Space, NASA, and SpaceX for Axiom Mission 4. The mission is tentatively scheduled for October.

Axiom Mission 4 will be Peggy Whitson’s second commercial human spaceflight mission with Axiom Space. Photo courtesy of Axiom

Houston space tech unicorn names next mission leader, team

ready for takeoff

NASA veteran Peggy Whitson, a former student and professor at Houston’s Rice University, will command the global crew heading to the International Space Station aboard a private mission directed by Houston-based Axiom Space.

Whitson and her three fellow crew members arrived in Houston on August 6 to train with Axiom Space, NASA, and SpaceX for Axiom Mission 4. The mission is tentatively scheduled for October 2024.

The three astronauts joining Whitson will be:

  • Shubhanshu Shukla, the mission pilot, representing the Indian Space Research Organization
  • Sławosz Uznański, a mission specialist representing the European Space Agency and Poland
  • Tibor Kapu of Hungary, a mission specialist

Axiom Mission 4 will be Whitson’s second commercial human spaceflight mission with Axiom.

“With a culturally diverse crew, we are not only advancing scientific knowledge but also fostering international collaboration. Our previous missions set the stage,” Whitson says in a news release.

Axiom Mission 1 was the first private mission to the space station, Axiom Mission 2 launched the first Saudi woman into space, and

Axiom Mission 3 featured the first Turkish astronaut and first European Space Agency astronaut to fly on a commercial space mission.

With Axiom Mission 4, “we ascend even higher, bringing even more nations to low-Earth orbit and expanding humanity’s reach among the stars,” says Whitton.

From 1981 to 1985, Whitson conducted graduate work in biochemistry at Rice, where she earned a doctoral degree. She was a predoctoral and postdoctoral fellow.

Whitson’s vast experience includes:

  • Adjunct professor in biochemistry and genetics at the University of Texas Medical Branch in Galveston
  • Adjunct assistant professor in biochemistry and genetics at Rice
  • Research biochemist at NASA’s Johnson Space Center
  • Deputy division chief of medical sciences at Johnson Space Center.
  • Chief of station operations at NASA’s Astronaut Office
  • Chief of NASA’s Astronaut Corps
  • Crew member of three NASA space missions

Whitton and the three other astronauts still must gain approval for the Axiom mission from the five organizations that oversee the space station: NASA, the European Space Agency, Roscosmos (the Russian space agency), the Japan Aerospace Exploration Agency, and the Canadian Space Agency.

Axiom 4 “represents Axiom Space’s continued efforts to build opportunity for countries to research, innovate, test, and engage with people around the world while in low-Earth orbit,” says Michael Suffredini, CEO of Axiom Space. “This mission broadens horizons for nations with ambitious goals of advancing scientific, technological, and economic pursuits.”

This mission will emphasize scientific research, tech demonstrations, and space commercialization.

From Florida, the Axiom 4 crew will go to the International Space Station aboard a Falcon 9 rocket and Dragon spacecraft, both made by SpaceX. The crew is expected to spend up to 14 days at the space station.

This week's roundup of Houston innovators includes Samra Nawaz of WellWorth, Michael Suffredini of Axiom Space, and Colin McLelland of Digital Wildcatters. Photos courtesy

3 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries recently making headlines in Houston across energy and space tech.

Samra Nawaz, CEO and co-founder of WellWorth

Samra Nawaz founded WellWorth to tackle the convoluted financial modeling process in upstream oil and gas. Photo courtesy of WellWorth

As much as she loves a good Excel spreadsheet, Samra Nawaz had just about had it with the convoluted — and not always completely accurate — process of building financial models within upstream oil and gas.

"Excel is generally a good tool to automate workflows and build really robust spreadsheets. I live in Excel — I have a spreadsheet for everything," Nawaz says on the Houston Innovators Podcast. "What Excel is not is a database."

Engineering teams work with massive amounts with data that's too big for Excel, she explains, so finance teams then have to work off of aggregated data to build their financial models. She was ranting about why there isn't a better process to her husband, Vinay Acharya, who suggested that they build it themselves. Read more.


Michael Suffredini, CEO of Axiom Space

Axiom Space CEO Michael Suffredini has opened the company's new HQ in the Houston Spacepory. Photo courtesy of Axiom Space

Axiom Space, co-founded by CEO Michael Suffredini, has opened its new Assembly Integration and Test Building, which will be the new headquarters for the Houston-based aerospace company at a new 22-acre campus at the Houston Spaceport at Ellington Airport in Southeast Houston. The building will include employee offices, facilities for astronaut training and mission control, testing labs and a high bay production facility to house Axiom Space Station modules currently under construction.

Axiom Space partnered with Jacobs, Turner Construction Company, Savills, and Griffin Partners to expand the company’s headquarters with the Houston spaceport building, which is the tenth spaceport in the nation.

For the first time in Houston’s history, the Space City is now home to the development of human-rated spacecraft with the Axiom Stations modules. Houston Spaceport has laboratory office space like technology incubator space and large-scale hardware production facilities, and is the world’s first urban commercial spaceport. Read more.

Collin McLelland, co-founder and CEO of Digital Wildcatters

Collin McLelland, co-founder and CEO of Digital WildcattersThis Houston-based media company launched a networking platform to help solve the energy crisis. Photo courtesy

Digital Wildcatters, a Houston company that's providing a community for the next generation of energy professionals, has closed its seed plus funding round at $2.5 million. The round by energy industry veteran Chuck Yates, who also hosts his podcast "Chuck Yates Needs a Job" on the Digital Wildcatters' podcast network.

"Our mission is to empower the next generation of energy professionals to advance their careers and collaboratively address the global energy crisis," Collin McLelland, co-founder and CEO of Digital Wildcatters, says in the release. "We are incredibly grateful to have an investor base that not only believes in our vision but also supports our endeavor to craft innovative products that will redefine the future of the energy industry." Read more.

Here's what Houston tech and startup news trended this year on InnovationMap in space tech. Image via Getty Images

Top Space City news of 2023: New Houston unicorn, an IPO, spaceport development, and more

year in review

Editor's note: As the year comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. In the Space City, there were dozens of space tech stories, from a space tech company reaching unicorn status to another completing its IPO. Here are five Houston space tech-focused articles that stood out to readers this year — be sure to click through to read the full story.


Local university gets green light to launch new building at Houston Spaceport

City of Houston has entered into an agreement with Texas Southern University to develop an aviation program at the Houston Spaceport. Photo via fly2houston.com

With a financial boost from the City of Houston, the aviation program at Texas Southern University will operate an aeronautical training hub on a two-acre site at Ellington Airport.

The Houston Airport System — which runs Ellington Airport, George Bush Intercontinental Airport, Hobby Airport, and Houston Spaceport — is chipping in as much as $5 billion to build the facility, which will train aeronautical professionals.

On May 3, the Houston City Council authorized a five-year agreement between the airport system and TSU to set up and operate the facility. Continue reading the full story from May.

Houston space tech startup closes deal to IPO

Intuitive Machines will be listed on Nasdaq beginning February 14. Photo via intuitivemachines.com

It's official. This Houston company is live in the public market.

Intuitive Machines, a space tech company based in Southeast Houston, announced that it has completed the transaction to merge with Inflection Point Acquisition Corp., a special purpose acquisition company traded on Nasdaq.

“We are excited to begin this new chapter as a publicly traded company,” says Steve Altemus, co-founder, president, and CEO of Intuitive Machines, in a news release. “Intuitive Machines is in a leading position to replace footprints with a foothold in the development of lunar space. With our launch into the public sphere through Inflection Point, we have reached new heights financially and opened the doors for even greater exploration and innovation for the progress of humanity.”

The transaction, which was originally announced in September, was approved by Inflection Point’s shareholders in a general meeting on February 8. As a result of the deal, the company will receive around $55 million of committed capital from an affiliate of its sponsor and company founders, the release states. Continue reading the full story from February.

Houston to host 6 Italian aerospace companies with new program

Six Italian companies are coming to the Space City to accelerate their businesses thanks to a new program. Photo via nasa.gov

It's an Italian invasion in Houston — and it's happening in the name of accelerating innovation within aerospace.

For the first time, Italy has announced an international aerospace-focused program in the United States. The Italian Trade Agency and Italian Space Agency will partner with Space Foundation to launch Space It Up, an initiative that will accelerate six companies in Houston.

“The launch of Space It Up marks a pivotal moment in our ongoing commitment to nurturing innovation and facilitating global partnerships," Fabrizio Giustarini, Italian Trade Commissioner of Houston, says in a news release. "This program serves as a testament to the collaborative spirit that defines the aerospace industry. It represents the convergence of Italian ingenuity and Houston's esteemed legacy in space exploration, setting the stage for unprecedented advancements." Continue reading the full story from August.

Houston space tech startup raises $350M series C, clinches unicorn status

Axiom Space CEO Michael Suffredini (right) has announced the company's series C round with support from Aljazira Capital, led by CEO Naif AlMesned. Photo courtesy of Axiom Space

Houston has another unicorn — a company valued at $1 billion or more — thanks to a recent round of funding.

Axiom Space released the news this week that it's closed its series C round of funding to the tune of $350 million. While the company didn't release its valuation, it confirmed to Bloomberg that it's over the $1 billion threshold. Axiom reports that, according to available data, it's now raised the second-most funding of any private space company in 2023 behind SpaceX.

Saudi Arabia-based Aljazira Capital and South Korea-based Boryung Co. led the round. To date, Axiom has raised over $505 million with $2.2 billion in customer contracts, according to the company.

“We are honored to team with investors like Aljazira Capital, Boryung and others, who are committed to realizing the Axiom Space vision,” Axiom Space CEO and president Michael Suffredini says in a news release. “Together, we are working to serve innovators in medicine, materials science, and on-orbit infrastructure who represent billions of dollars in demand over the coming decade. Continue reading the full story from August.

Texas university to build $200M space institute in Houston

Texas A&M University will build a new facility near NASA's Johnson Space Center. Photo courtesy of JSC

Texas A&M University's board of regents voted to approve the construction of a new institute in Houston that hopes to contribute to maintaining the state's leadership within the aerospace sector.

This week, the Texas A&M Space Institute got the greenlight for its $200 million plan. The announcement follows a $350 million investment from the Texas Legislature. The institute is planned to be constructed next to NASA’s Johnson Space Center in Houston.

“The Texas A&M Space Institute will make sure the state expands its role as a leader in the new space economy,” John Sharp, chancellor of the Texas A&M System, says in a news release. “No university is better equipped for aeronautics and space projects than Texas A&M.” Continue reading the full story from August.

Prada is collaborating with Houston-based aerospace company Axiom Space on the design of spacesuits for NASA’s Artemis III mission to the moon. Photo via axiomspace.com

Houston company collaborates with major fashion designer for spacesuit project

astronaut couture

Courtesy of the Prada luxury brand, NASA astronauts are getting an infusion of fashion.

Prada is collaborating with Houston-based aerospace company Axiom Space on the design of spacesuits for NASA’s Artemis III mission to the moon. Astronauts haven’t yet been chosen for the mission, which is set for 2025.

“Prada’s technical expertise with raw materials, manufacturing techniques, and innovative design concepts will bring advanced technologies instrumental in ensuring not only the comfort of astronauts on the lunar surface, but also the much-needed human factors considerations absent from legacy spacesuits,” says Michael Suffredini, co-founder, president, and CEO of Axiom Space.

The spacesuit, called the Axiom Extravehicular Mobility Unit (AxEMU), is geared toward improving astronauts’ flexibility, boosting protection against harsh conditions, and supplying tools for exploration and scientific activities.

“Our decades of experimentation, cutting-edge technology, and design know-how – which started back in the ’90s with Luna Rossa challenging for the America’s Cup – will now be applied to the design of a spacesuit for the Artemis era. It is a true celebration of the power of human creativity and innovation to advance civilization,” says Lorenzo Bertelli, marketing director of the Prada brand.

NASA has enlisted Axiom and Charlotte, North Carolina-based Collins Aerospace to outfit astronauts with next-generation spacesuits. Axiom’s partners on this project are KBR and Sophic Synergistics, both based in Houston, along with Air-Lock, A-P-T Research, Arrow Science and Technology, David Clark Co., and Paragon Space Development.

Collins maintains a sizable presence at the Houston Spaceport.

In July, Axiom secured a NASA task order potentially worth $147 million to modify the Artemis III spacesuit for astronauts heading to the International Space Station. This follows a $228 million NASA task order awarded to Axiom in 2022 for development of the Artemis III spacesuit.

The task orders are part of Axiom’s $1.26 billion spacesuit contract with NASA. All told, NASA has earmarked as much as $3.5 billion for new spacesuits.

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Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”

Axiom Space wins NASA contract for fifth private mission, lands $350M in financing

ready for takeoff

Editor's note: This story has been updated to include information about Axiom's recent funding.

Axiom Space, a Houston-based space infrastructure company that’s developing the first commercial space station, has forged a deal with NASA to carry out the fifth civilian-staffed mission to the International Space Station.

Axiom Mission 5 is scheduled to launch in January 2027, at the earliest, from NASA’s Kennedy Space Center in Florida. The crew of non-government astronauts is expected to spend up to 14 days docked at the International Space Station (ISS). Various science and research activities will take place during the mission.

The crew for the upcoming mission hasn’t been announced. Previous Axiom missions were commanded by retired NASA astronauts Michael López-Alegría, the company’s chief astronaut, and Peggy Whitson, the company’s vice president of human spaceflight.

“All four previous [Axiom] missions have expanded the global community of space explorers, diversifying scientific investigations in microgravity, and providing significant insight that is benefiting the development of our next-generation space station, Axiom Station,” Jonathan Cirtain, president and CEO of Axiom, said in a news release.

As part of Axiom’s new contract with NASA, Voyager Technologies will provide payload services for Axiom’s fifth mission. Voyager, a defense, national security, and space technology company, recently announced a four-year, $24.5 million contract with NASA’s Johnson Space Center in Houston to provide mission management services for the ISS.

Axiom also announced today, Feb. 12, that it has secured $350 million in a financing round led by Type One Ventures and Qatar Investment Authority.

The company shared in a news release that the funding will support the continued development of its commercial space station, known as Axiom Station, and the production of its Axiom Extravehicular Mobility Unit (AxEMU) under its NASA spacesuit contract.

NASA awarded Axiom a contract in January 2020 to create Axiom Station. The project is currently underway.

"Axiom Space isn’t just building hardware, it’s building the backbone of humanity’s next era in orbit," Tarek Waked, Founding General Partner at Type One Ventures, said in a news release. "Their rare combination of execution, government trust, and global partnerships positions them as the clear successor-architect for life after the ISS. This is how the United States continues to lead in space.”

Houston edtech company closes oversubscribed $3M seed round

fresh funding

Houston-based edtech company TrueLeap Inc. closed an oversubscribed seed round last month.

The $3.3 million round was led by Joe Swinbank Family Limited Partnership, a venture capital firm based in Houston. Gamper Ventures, another Houston firm, also participated with additional strategic partners.

TrueLeap reports that the funding will support the large-scale rollout of its "edge AI, integrated learning systems and last-mile broadband across underserved communities."

“The last mile is where most digital transformation efforts break down,” Sandip Bordoloi, CEO and president of TrueLeap, said in a news release. “TrueLeap was built to operate where bandwidth is limited, power is unreliable, and institutions need real systems—not pilots. This round allows us to scale infrastructure that actually works on the ground.”

True Leap works to address the digital divide in education through its AI-powered education, workforce systems and digital services that are designed for underserved and low-connectivity communities.

The company has created infrastructure in Africa, India and rural America. Just this week, it announced an agreement with the City of Kinshasa in the Democratic Republic of Congo to deploy a digital twin platform for its public education system that will allow provincial leaders to manage enrollment, staffing, infrastructure and performance with live data.

“What sets TrueLeap apart is their infrastructure mindset,” Joe Swinbank, General Partner at Joe Swinbank Family Limited Partnership, added in the news release. “They are building the physical and digital rails that allow entire ecosystems to function. The convergence of edge compute, connectivity, and services makes this a compelling global infrastructure opportunity.”

TrueLeap was founded by Bordoloi and Sunny Zhang and developed out of Born Global Ventures, a Houston venture studio focused on advancing immigrant-founded technology. It closed an oversubscribed pre-seed in 2024.

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