3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Jason Bock of CTMC, Barbara Burger, and Mario Amaro of Ease. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from cell therapy to energy transition — recently making headlines in Houston innovation.

Jason Bock, founder and CEO of CTMC

Jason Bock, founder and CEO of the Cell Therapy Manufacturing Center, joins the Houston Innovators Podcast to explain the complicated — yet necessary — process of scaling cell therapies. Photo courtesy

Last year, a project out of MD Anderson spun out to create a new joint venture, CTMC — Cell Therapy Manufacturing Center, with National Resilience, a company that was founded to help advance life-saving therapeutics. The JV is based in the Texas Medical Center and led by CEO Jason Bock, who says the entity's location is critical.

"Houston has a chance to play a role in all aspects of cell therapy," he says, from discovery to the clinical side. "Some really interesting cell therapies that are in development were discovered here in Houston."

Bock shares more on how the impact CTMC is making on cell therapy advancement on the podcast. Read more.

Barbara J. Burger, startup adviser and mentor

Energy innovation expert, Barbara Burger, shares how she sees the future of energy playing out as a dance between mice — the startups — and elephants — the incumbent corporations. Photo courtesy

The way Barbara Burger sees it, the energy transition depends on a dance between startups, or the mice, and corporates, aka the elephants. In a guest column for InnovationMap, she explains what questions each side needs to address.

"There are lots of questions here and the why is often an iterative journey for both sides," she explains. "It is as much mindset, influence, strategy, champions, and risk tolerance at individual levels as it about technology and economics." Read more.

Mario Amaro, CEO and founder of Ease

Mario Amaro, founder of Ease, was selected for one of Amazon's accelerator programs. Photo courtesy of Amazon

Amazon's AWS Impact Accelerator Latino Founders Cohort named the 20 startups joining its accelerator that will connect Latinx founders to its network of mentors, provide programming, and even dole out funding.

A Houston company has joined a new Amazon program focused on Latin American founders. Photo courtesy of Amazon

Houston startup named to Amazon's Latinx-focused cohort

ready to grow

Amazon named the 20 startups joining its accelerator that will connect Latinx founders to its network of mentors, provide programming, and even dole out funding.

The AWS Impact Accelerator Latino Founders Cohort is a part of Amazon's $30 million commitment to supporting underrepresented startup founders. The eight-week program started this week in Amazon's Seattle headquarters.

“This cohort of the AWS Impact Accelerator aims to highlight the viability and ingenuity of Latino-led startups, so the VC community can increase support to these founders,” says Howard Wright, vice president and global head of startups at AWS, in the news release. “We’re looking forward to playing an active role in helping these companies turbocharge their growth through access to capital, experts, and all of the innovations that the AWS tech stack has to offer.”

Houston-based Ease, founded by Mario Amaro in 2018, the health care fintech platform allows for medical professionals to start, grow, and manage their private practices with bookkeeping tools and other software infrastructure. So far, the company has worked with more than 300 practices. Per Cruncbase data, the company has raised $2.8 million in pre-seed and grant funding. According to Amazon, the company's investors include Slauson & Co. and Precursor Ventures.

Mario Amaro, founder of Ease, was selected for one of Amazon's accelerator programs. Photo courtesy of Amazon

Last year, Ease was named among the 50 companies in the inaugural cohort of the Google for Startups Latino Founders Fund. In that program, each company received an equity-free $100,000 investment, as well as programming and support from Google, mentorship from technical and business experts, access to free mental health therapy, and more.

Ease stood out among the nearly 1,100 submissions to the program, according to the release, and joins 19 other companies from across the country and even Argentina, Brazil, Colombia, Mexico, Venezuela, and Puerto Rico. Each of the cohort companies will receive up to $225,000 in cash and AWS Activate credits, alongside a training curriculum, networking opportunities with Amazon staff and potential investors, and ongoing advisory support.

The other startups in the program include:

Alvva, a, immigrant-focused fintech platform from California
Cogniflow, a personal AI platform founded in Colombia with a New York US HQ
Deskfy, a marketing portal from Brazil with its US HQ in Delaware
DivySci Software, an edtech organization founded in New York
EducUp, an edtech company from Florida
Fielder, a Mexico-founded enterprise software-as-a-service with US-based operations in Delaware
GamerSafer, a security tech company within gaming from California
Kigüi, a Mexican money-saving grocery app
Kuentro, a Venezuelan affordable hiring platform that caters to middle- and working-class job seekers
Lazo Fintech Inc, a Florida-based fintech and legal platform
Leantime, a developer tool from North Carolina
Monadd, a Florida-founded personal finance platform
PilotoMail, a remote work platform founded in Puerto Rico
Sign-Speak, a New York startup with an American Sign Language device
STIGMA, a mental health mobile app from Illinois
Outtrip, a Argentina-founded tourism platform with US operations in Delaware
Panda Salud, a Mexico-based platform connecting health care small businesses with diagnostic test providers
Tienditapp, a Mexico-based app with a last-mile delivery model
TuCuota, a payment collections tool from Argentina

DocSpace was founded by Chief Product Officer Miles Montes (left) and CEO Mario Amaro, a physician and U.S. Navy Veteran. Photo courtesy of DocSpace

Houston digital health platform raises $1.2M seed round

money moves

A Houston-based software company providing clinicians a turn-key platform for their practice has announced the close of its seed funding round.

DocSpace raised $1.2 million in seed funding led by Slauson & Co. with participation by Precursor Ventures, Acrew Capital's Scout Fund, and SputnikATX Ventures. The company's angel investors Nathan and Sonia Baschez, Nikhil Krishnan, and Eliana Murillo. The company was founded by CEO Mario Amaro, a physician and U.S. Navy Veteran, and Chief Product Officer Miles Montes, an expert in platform product management previously at ADP and ShopLatinx.

"Existing practice management software requires clinicians to manually self-navigate the expensive and complicated business formation process before they're able to utilize any of their product services," says Amaro in a news release. "When you require clinicians to do all the hard work of starting a new business then force them to purchase expensive software, it's no surprise that fewer clinicians have the opportunity to build new businesses in their communities."

Since its launch in March 2020, DocSpace has helped hundreds of clinicians, therapists, dentists, physicians, and optometrists build their practices with its end-to-end software that provides, according to the release, HIPAA-compliant tools like "digital health storefronts with custom themes to back office management tools like scheduling, video conferencing, banking, payroll, and bookkeeping."

"Making it easier for clinicians to start new businesses is critical to decreasing clinician burnout, giving more choices to patients, and reducing the amount of administrative and overhead bloat in delivering health services. We should treat clinicians like entrepreneurs and reduce the barriers to them striking out on their own," says Nikhil Krishnan, the founder of Out-Of-Pocket and adviser and investor to DocSpace.

The seed funding go toward building out DocSpace Pay, a payment system tool for patients and clinicians.

"This is why we were inspired by Shopify's business model and the infrastructure they created to empower retail merchants to be small business owners," says Amaro. "We are building the first clinical practice operating system that provides clinician entrepreneurs the opportunity to seek practice independence, helping them get to market faster, while leveling the playing field so they can compete against large hospital systems and other VC-backed healthcare startups."

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5 must-read Houston innovation headlines: AI for seniors, major Meta news

Trending News

Editor's note: The first half of June brought big innovation headlines for Houston, from AI exploration to major Meta investments and the 2026 Fortune 500 list. Below are the five most-read InnovationMap stories published June 1-14, 2026:

1. Houston lab explores how AI bots can help the elderly

The University of Houston’s Empathetic Lifespan AI & Robotics for Aging (ELARA) Lab is currently conducting research into how AI bots may be able to help the elderly live more social and independent lives through several ongoing initiatives. The lab officially launched last month as part of the Gerald D. Hines College of Architecture & Design under the leadership of Assistant Professor Chorong Park. Part of the lab’s mission is tackling ongoing problems with aging, such as dealing with disabilities and social isolation. Researchers’ current work is focused on designing a new AI companion bot specifically tailored to the needs of older people. Continue reading.

2. New UH survey reveals concerns over AI data center growth in Houston

A new report out of the University of Houston shows that area residents remain wary of the long-term effects of operating data centers. The recent survey from the University of Houston’s latest SPACE City Panel, conducted by the Center for Public Policy at the Hobby School of Public Affairs, shows that while 85 percent of Houston-area residents use AI, nearly 63 percent oppose the construction of AI data centers within 1 mile of their homes. Continue reading.

3. Meta to bring $115 million AI data center training initiative to Houston

Meta and Associated Builders and Contractors have entered into a partnership to invest $115 million in training programs for the construction of AI data centers, with a portion of the project launching in Houston. The companies announced June 8 that they would open America’s Workforce Academies at ABC chapter training centers in Houston; Indianapolis; Baton Rouge, Louisiana; and Columbus, Ohio. Continue reading.

4. 27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston is a giant among U.S. hubs for corporate headquarters. The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 23 Fortune 500 headquarters. Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3. Continue reading.

5. 7 Houston neighbors named to U.S. News' best places to live in 2026

Several Houston suburbs have been crowned the best places to live in the U.S. for 2026, according to U.S. News & World Report. Sugar Land is the highest-ranked city in the Houston metro, and it ranks as the 10th best place to live in the country. Continue reading.

Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

No. 9 ExxonMobil
No. 21 Chevron
No. 29 Phillips 66
No.55 Sysco
No. 75 ConocoPhillips
No. 89 Enterprise Products Partners
No. 103 Plains GP Holdings
No. 133 Hewlett Packard Enterprise
No. 149 NRG Energy
No. 157 Quanta Services
No. 164 Baker Hughes
No. 173 Occidental Petroleum
No. 179 Waste Management
No. 201 EOG Resources
No. 204 Group 1 Automotive
No. 207 Halliburton
No. 223 Cheniere Energy
No. 236 Corebridge Financial
No. 262 Targa Resources
No. 266 Kinder Morgan
No. 388 Westlake
No. 435 CenterPoint Energy
No. 438 APA
No. 440 Comfort Systems USA
No. 455 NOV
No. 488 KBR
No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.

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