3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Amanda Ducach of SocialMama, Sam Newman of Little Red Box Grocery, and Gina Luna of GP Capital Partners. Courtesy photos

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from investment to femtech — recently making headlines in Houston innovation.


Amanda Ducach, founder and CEO of SocialMama

Amanda Ducach, founder of SocialMama, is gearing up for a total rebrand and new product launch. Photo courtesy of SocialMama

For years, Amanda Ducach has been collecting data from the users of her social networking app, SocialMama. Now that data is fueling the AI of the new platform and a whole new phase of the company.

"When you have a compatibility-friendship-based product, you have crazy amounts of data. We could have went and sold that — like an unethical company and like a lot of companies we've unfortunately seen do recently. Instead, we used the data to improve our product to create positive health outcomes for our users," Ducach says.

Ducach share more of what she's working on ahead of the launch of the new platform and what it's been like starting and running a consumer-focused app in Houston on the Houston Innovators Podcast. Click here to read more and stream the episode.

Sam Newman, founder of Little Red Box Grocery

Equitable access to services is integral to the vitality of all communities. Photo courtesy

In a recent guest column for InnovationMap, Sam Newman, founder of Little Red Box Grocery, writes of how around 40 million Americans, including five million Texans, live in food deserts. Startups have an opportunity for impact.

"Equitable access to services is integral to the vitality of all communities. Good food, secure housing – it doesn’t just nourish bodies and minds, it can spur new investment into our neighborhoods and prove once and for all that manmade deserts of any kind do not have to exist if we let imagination and innovation prevail. If there was ever a time to prioritize access – and action – it is now," he writes. Click here to read more.

Gina Luna, partner at GP Capital Partners

GP Capital Partners is a part of a new initiative to provide training and job placement for future cybersecurity professionals. Photo courtesy

Houston-based private credit and equity investment firm GP Capital Partners has teamed up with LP First Capital, a private equity firm with offices in Austin and New York, to form National Cyber Group. The new entity, headquartered in Washington, D.C., will provide foundational IT certification training, job placement resources, and more, according to a news release.

Gina Luna, managing partner of GP Capital Partners, says this is a huge opportunity for Houston, as the city's tech jobs continue to grow, and the city continues to be a major hub for tech talent.

"There are many Houston companies that need well-trained, qualified cybersecurity analysts and many hard-working Houstonians that would find a career in cybersecurity an attractive path to better opportunity for themselves and their families. National Cyber Group can provide both, which is certainly good for Houston," she says. Click here to read more.

Equitable access to services is integral to the vitality of all communities. Photo by Erik Scheel/Pexels

Founder: Inflation is creating a barrier to healthy food access, affordable housing for Houstonians

guest column

Approximately 40 million Americans, including five million Texans, live in food deserts. These are communities with low access to fresh and healthy foods and high access to unhealthy alternatives, where a trip to the grocery store is oftentimes a tradeoff between convenience, cost, and choice. Everyone deserves (indeed, needs) good food access, yet current market offerings are not designed to satisfy demand.

And food is but one part of a tapestry of disparity – which includes among other things health and wellness services, digital connectivity, debt and access to credit, and housing insecurity – that disproportionately impacts historically marginalized communities and leaves residents vulnerable to greater risks. These issues, long-standing though they are, have become more acute with inflation, as the cost of everything goes up and wages lag.

According to the U.S. Department of Labor, the price of food that people eat at home rose 10 percent in the last year. At the same time, the cost of rent in Houston also increased 10 percent last year - Houston now ranks in the top 50 most expensive cities in America for renters. Across Texas, rents are up 30 percent in Austin, 11 percent in San Antonio, and 17 percent in Dallas-Fort Worth last year. When tenants face a rent increase it hampers their ability to move, because even if they are working, it can be a challenge to pay the lump sum of a new first month’s rent plus a security deposit. This is a huge barrier for our neighbors living paycheck to paycheck.

Whether it’s rent or the price of eggs, families are being squeezed, and in order to bridge this widening chasm – the Market Gap and Equity Gap – we need to embrace fresh solutions for all who live in service deserts. Fortunately, new organizations are coming to the fore in a targeted and meaningful way:

Tech start-ups such as Providers and Forage are empowering low-income households with greater access and insight on how and where to use food stamps.

At the community level, New York-based Wellfare is leveraging density and community knowledge to run a direct-to-door food subscription model for low-income households. And here in Houston, my organization, Little Red Box Grocery, will soon be launching a reimagined community store, designed to bring the benefits of good food access + health to Houston’s Food Deserts.

Yet when it comes to the wellspring of uncertainty, so much flows downstream from unstable housing it is hard to overstate its importance on family stability. If a landlord increases the rent, some renters can certainly move, but others have no choice but to pay up as they cannot afford the upfront costs required to find alternative housing. And the more one spends on housing, the less there is for life’s other many necessities… including food.

Fresh food access and housing insecurity are intertwined challenges that we must meet head on. Fortunately, companies like Rhino are helping solve one of renters’ biggest financial hurdles – the up-front cash required for a security deposit – with security deposit insurance. This gives renters a low-rate policy as affordable as $5 per month for an apartment renting for $1,000 per month. Some property owners in Texas are already accepting it as an alternative way to secure an apartment.

The benefits of this kind of arrangement are easy to see. People can put money that would otherwise be locked away in a security deposit into savings, pay down debt, buy groceries for their family in a manner that improves home and community health and well-being. One could even start a business, or pursue a degree. The point is that it frees up home economics to be used in a manner most efficient for that family.

And services such as this should help level the playing field. In a recently released survey of renters, renters of color were more likely to pay a security deposit than white renters and they paid $150 more on average in the security deposit than white renters. Renters of color also submitted more applications and paid higher application fees than white renters.

Equitable access to services is integral to the vitality of all communities. Good food, secure housing – it doesn’t just nourish bodies and minds, it can spur new investment into our neighborhoods and prove once and for all that manmade deserts of any kind do not have to exist if we let imagination and innovation prevail. If there was ever a time to prioritize access – and action – it is now.

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Sam Newman is the founder of Houston-based Little Red Box Grocery bringing the benefits of good food access to Houston’s Second Ward.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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