Photos: Downtown Houston innovation hub in renovated office building opens to the public

ready to launchpad

Downtown Houston has a new innovation space in Amegy on Main. Photo courtesy of Amegy Bank

Last week, a group of innovators, commercial real estate professionals, and Amegy Bank employees celebrated yet another feat in the Houston innovation ecosystem: another innovative and collaborative space's grand opening.

The Downtown Launchpad is officially open across a few floors in Amegy on Main, a renovated office building on the Southwest side of downtown Houston at 1801 Main St. The grand opening reception was held outside in the building's first floor courtyard adjacent to its upgraded parking garage. The event on May 18 coincided with Houston Tech Rodeo.

"The major renovations to Amegy on Main support our strong Amegy Bank culture and reinforce our commitment to supporting the Houston business, technology and entrepreneur community," says Kelly Foreman, senior vice president and manager of corporate real estate and facilities for Amegy, in a news release. "This space serves as a hub for start-ups and innovation, and the resulting job creation through these incubator programs will continue to be meaningful and impactful for our city."

The renovated space includes:

  • Coworking space managed by The Cannon
  • Accelerator and event space for the Launchpad
  • Main Line Café, a chef-driven restaurant concept open to the public
  • New courtyard
  • First-floor gaming lounge
  • New shared spaces and design elements for the building, such as expanded windows for improved daylight, new furniture, enhanced coffee bars
  • Expanded conference space

Originally announced in October 2019, the Downtown Launchpad opened parts of its upgraded space last fall. Now, the full renovation project is completed, offering a new opportunity for collaboration.

"Amegy on Main has become unlike any other space in Houston," Foreman continues. "We are thrilled to offer this new space, its amenities and business development support to our employees and the expanding innovation community."

Click through some photos of the complete spaces below.

Indoor/outdoor dining areas

Photo courtesy of Amegy Bank

The Cannon Houston's third location is planned to open on December 9. Photo courtesy of The Cannon

Photos: The Cannon Houston's downtown space expects to open its doors early next month

ready for liftoff

A Houston entrepreneurial hub plans to open its third coworking space location only a few weeks after its main campus debuted in West Houston.

The Cannon Houston's newest location will be a 17,000-square-foot space on the top floor of The Cannon Tower at Amegy on Main in Downtown Houston. The opening date for the new space is Monday, December 9.

The announcement follows the grand opening of The Cannon's 120,000-square-foot flagship space, which is now close to being completely leased by startups and small businesses, and represents another step in the company's ambitious expansion plan.

"We've long known that we will need multiple locations across Houston in order to serve our mission of supporting Houston's entrepreneurs, and we are thrilled to work with an incredibly forward-thinking organization like Amegy to continue to fulfill this mission," says Cannon founder and president, Lawson Gow, in a news release. "The Cannon Tower at Amegy on Main will be unlike any other space in the city, in which we will be developing a 'vertical village' of innovation, programs, and resources, transforming Amegy on Main into a hub for Downtown Houston's entrepreneurs."

Gow — who is the son of David Gow, owner of InnovationMap's parent company, Gow Media — recently transitioned into his position as The Cannon named Jon Lambert as CEO earlier this month.

The Cannon's space is just one part of the equation that is the Downtown Launch Pad — a joint project between Central Houston, Downtown Redevelopment Authority, The Cannon, and Amegy Bank. The Amegy building will also house MassChallenge and gener8or, as well as event and common space for programming on the 11th floor.

"Amegy Bank is thrilled to be a part of the expansion of the innovation community by offering space, amenities, and business development support," says Kelly Foreman, Amegy Bank's senior vice president and manager of corporate real estate and facilities, in a news release. "We have a long track record of helping businesses grow, and creating this space for a hub of start-ups and accelerators is yet another way to do just that."

Moving forward, The Cannon will play a role in expanding workspace, resources, and programming in the building. The space is now open for leasing, and the first 100 members to join the new space will receive free parking for the course of their membership.

Plans for growth

Photo courtesy of The Cannon

The Cannon Houston will be a major player as the Downtown Launch Pad expands throughout the building.

The Downtown Launch Pad will house accelerator programs MassChallenge and gener8tor and coworking space from The Cannon. Photo courtesy of Downtown Launch Pa

New innovation ‘vertical village’ announced for downtown Houston

Coming soon

The Cannon Houston, a startup incubator and coworking space, and Houston-based Amegy Bank announced a partnership to create a 17,000-square-foot innovation space in downtown.

The Downtown Launch Pad is expected to open on a few floors of the Amegy Bank building at 1801 Main St. in the spring. Along with coworking space, the new hub will house MassChallenge Texas, which had its inaugural cohort earlier this year, and gener8tor, an early acceleration program announced in last month.

Mayor Sylvester Turner announced the project at Central Houston Inc.'s annual meeting on October 24. Both the accelerators that will be in the new hub received a combined combined $4 million in economic development grants from the Downtown Redevelopment Authority to be distributed over the next five years.

"Central Houston and the Downtown Redevelopment Authority are committed to establishing Downtown Houston as a nexus for innovation and a leader in urban entrepreneurship," says Bob Eury, president of both entities, in a news release. "We've found strong, strategic partners in Amegy Bank and The Cannon, both of which are committed to fostering and sustaining a vibrant innovation culture in Houston, from startup to production."

Amegy Bank has tapped Gensler for the redesign. The 13th floor of the building will house the coworking space powered by The Cannon. This space is expected to open before the end of the year.

"We originally created The Cannon to be the missing piece in Houston's startup ecosystem," says Lawson Gow, founder and CEO of The Cannon and Cannon Ventures. Gow is the son of David Gow, owner of InnovationMap's parent company, Gow Media. "Through the Cannon Tower and The Downtown Launch Pad, we are excited to join up with Central Houston, the Downtown Redevelopment Authority and Amegy Bank to create an entire 'vertical village' of innovation—a system of floors at Amegy on Main that will provide Houston's entrepreneurs with all the programs and resources they need to thrive."

The building's 10th and 11th floors will also be a part of the Downtown Launch Pad. The 10th floor will house the two accelerators, and the 11th floor will be a dedicated event space. The lobby of the building will be a common space for all members of the Cannon Tower and will have meeting rooms, a game room, work stations, a coffee bar, and a deli.

"Amegy Bank has a long history of reinvesting in the local community and supporting Texas families and businesses," says Kelly Foreman, senior vice president and corporate real estate and facilities manager for Amegy. "Now, through our partnerships with The Cannon and The Launch Pad, we are taking our commitment to small businesses to the next level by converting a part of Amegy on Main into a hub for emerging technology and start-up companies that aligns all the players across the entrepreneurial spectrum—corporations, mentors, investors, service providers and the startups themselves. This combination of offerings and capabilities will unlock significant value for Downtown, helping to attract and retain companies from not only Houston, but from around the country."

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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