Overheard: Houston's innovation leaders weigh in on the city's developing ecosystem at SXSW

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The city's top power players within Houston's energy innovation ecosystem joined virtual SXSW to discuss Houston's life science innovation scene and developing an inclusive ecosystem. Photos courtesy

Another day of SXSW 2021 has concluded, and just like the first day, Houston innovators logged on to discuss technology and innovation that's taking off in town.

The second of the two days of programming focused on the development of the Houston innovation ecosystem — including how the city is factoring in diversity and inclusion into development — with interviews hosted by me, Natalie Harms, editor of InnovationMap. Missed out on the fun? Catch up with a few overheard moments from Houston House or stream the full interviews below.

"“We have to be true to ourselves of what works for Houston. Making sure the DEI is interwoven and in our DNA of our ecosystem so that we don’t make the same mistakes as other cities." — Ashley DeWalt, managing director of DivInc Houston

Video courtesy of the Greater Houston Partnership

Houston has an advantage in developing its innovation ecosystem because it can do so by learning from established ecosystems on the coasts. Locally, that means making diversity and inclusion a top priority. At a virtual SXSW Houston House panel, Ashley DeWalt, managing director of DivInc Houston, and Jan Odegard, interim executive director of The Ion, discuss the importance of prioritizing inclusion in developing Houston's innovation ecosystem. Click here to watch the full interview.

“This pandemic has really highlighted a lot of the health care disparities that are present within our systems. … Houston is in a unique position to address that.” — Fiona Mack, head of JLABS @ TMC

Video courtesy of the Greater Houston Partnership

The Texas Medical Center is the largest medical center in the world with over 10 million patients coming in annually — and JLABS @ TMC is right in the middle of that. With this access to patients and clinical trials, Houston has a lot of potential to attract new innovative companies solving the world's biggest health care problems. At a virtual SXSW Houston House HOU Talk, Fiona Mack, head of JLABS @TMC, discusses the momentum behind health tech innovation in Houston. Click here to watch the full interview.

“Whatever the training is, you have to actually create bias disruptors and points of friction and processes that change behavior. If we don’t have a way to implement what we learn, it doesn’t really change culture.” — LaTanya Flix, senior vice president at the GHP

Video courtesy of the Greater Houston Partnership

In light of the Black Lives Matter movement, corporations of all shapes and sizes were inspired to look inward to address inequity within their workforce — from training to shifts in workplace culture. At a virtual SXSW Houston House HOU Talk, LaTanya Flix, senior vice president of Diversity, Equity and Inclusion (DEI) at the Greater Houston Partnership, shares how she's on a mission to spread mindful DEI initiatives across all of the GHP's member organizations. Click here to watch the full interview.

“I see a world where I’m sitting in a boardroom, and I’m not the only woman anymore.” — Samantha Lewis, principal at Mercury Fund

Video courtesy of the Greater Houston Partnership

Women in venture capital are used to being the only women in the room and are fighting for that not to be the case for future generations. At a virtual SXSW Houston House panel, Sandy Guitar, managing director of the HX Venture Fund moderates a discussion with fellow women in VC, Paige Pitcher, director of innovation at Hines, and Samantha Lewis, principal at Mercury Fund. Click here to watch the full interview.

“There’s an incredible number of innovations that have popped up in Houston, but a lot of them have been centered around solving engineering-type problems at industrial scale — and that still exists, but doesn’t get as much coverage as consumer-facing technologies.” — Josh Pherigo, director of research and data analytics at GHP

Video courtesy of the Greater Houston Partnership

When tracking any sort of progress or growth, business look to their numbers and data. Houston's innovation system is no different. At a virtual SXSW Houston House HOU Talk, Josh Pherigo, director of research and data analytics at the Greater Houston Partnership, dives in deep with the facts and figures of Houston's burgeoning innovation ecosystem by following the venture dollars coming into local startups. Click here to watch the full interview.

“If you look at the density in Houston, being the energy capital of the United States, there are probably few places in the world where you can walk 15 minutes in either direction and talk to about 100 companies that would potentially be customers.” — Matthew Costello, CEO and co-founder of Voyager Portal

Video courtesy of the Greater Houston Partnership

A good startup idea comes from necessity and a way to apply technology to solve problems and shorten business delivery times, and the maritime shipping industry has a lot of opportunities for these types of innovations. At a virtual SXSW Houston House HOU Talk, Matthew Costello, CEO and co-founder of Voyager Portal, sets sail on a conversation about the maritime shipping industry — and how it was ripe with disruption. Click here to watch the full interview.

“You have institutions of exception in Houston where innovation flows from. The question isn’t that it’s not there, it’s how have we been tapping it.” — David Schubert, president of Magnolia Tejas Corp.

Video courtesy of the Greater Houston Partnership

Houston has a burgeoning life science innovation scene — but what's that next step for its development? At a virtual SXSW Houston House HOU Talk, David Schubert, president of Magnolia Tejas Corp. discusses the potential of Houston's world-class oncologists and biotech innovators have to make the city a hub for cancer innovation. Click here to watch the full interview.

This week's Houston innovators to know roundup includes Josh Pherigo of the Greater Houston Partnership, Brittany Barreto of FemTech Focus, and Ted Gutierrez of SecurityGate.io. Photos courtesy

3 Houston innovators to know this week

Who's who

Editor's note: Another Monday, another round of innovators to know in Houston as you start your week. This week's edition features a researcher who has crunched the numbers on Houston's tech specialties, a founder who's shining a spotlight on femtech, and an entrepreneur who's snagged a deal with Chevron.

Josh Pherigo, research director of data analytics at the Greater Houston Partnership

Josh Pherigo at GHP used data to look into what tech specialties are thriving in Houston — and what niches have shown promising growth. Photo via LinkedIn

When Josh Pherigo decided to look where venture capital money was going in Houston, he did so to investigate what potential industries had growth opportunities. He found that Houston has an opportunity to be a leader in clean tech — but it has some in-state competition.

Pherigo's study for the Greater Houston Partnership found that there was a cleantech war emerging between Austin and Houston. While Houston's ecosystem has a greater presence of cleantech startups, Austin cleantech is still bringing in more VC investments. However, in Houston, between new corporate incubators and Greentown Labs entering Houston, the city is creating a lot of infrastructure for this industry.

"It's going to be interesting over the next few years to see how Houston can position itself as the leader in Texas for this, because they are going to have a lot of competition from Austin," Pherigo says. Read more.

Brittany Barreto, founder of FemTech Focus

Brittany Barreto launched FemTech Focus to help call attention to women's health and wellness, as well as to help accelerate companies with tech solutions within the field. Photo courtesy of FemTech Focus

Brittany Barreto has conducted dozens of interviews with femtech entrepreneurs, and it's become abundantly clear that general accelerators aren't giving femtech companies the full picture.

"Femtech startups actually need a little bit of different advice — that's why I'm very bullish on creating a femtech accelerator," Barreto says. "In femtech, we have some unique barriers. If you just go to a general accelerator, they might not cover these issues, and you'll be blindsighted."

Barreto is now working on specified program with The Guild that's launching this month. Then, in 2021, she hopes to go live with a full program under her company, FemTech Focus. Read more.

Ted Gutierrez, founder and CEO of SecurityGate.io

Chevron has tapped SecurityGate.io's risk management cybersecurity platform. Photo courtesy of Security Gate

Last week, Ted Gutierrez announced that his company, SecurityGate.io scored a partnership with Chevron. The deal means that the energy giant will adopt SecurityGate's risk management platform for scaling operational technology cybersecurity.

"We're very excited to be working with Chevron as they replace manual, spreadsheet cybersecurity practices with scalable, digitized processes," says Ted Gutierrez, CEO at SecurityGate.io, in a press release. "Their risk management team has done amazing work and it's exciting to see where they're headed." Read more.

Josh Pherigo at GHP used data to look into what tech specialties are thriving in Houston — and what niches have shown promising growth. Photo via LinkedIn

Greater Houston Partnership researcher identifies the city's top tech specialties

HOUSTON INNOVATORS PODCAST EPISODE 48

When you look at Houston's venture capital investment patterns, what do they tell you? To Josh Pherigo, research director of data analytics at the Greater Houston Partnership, it paints a picture of what tech and startup niches are thriving.

Based on PitchBook data, Pherigo put together an analysis of what industries within Houston are attracting the most investments. The study came out of the fact that Houston's hold on oil and gas is going to shift as the industry goes through the energy transition. Since O&G is such a crucial part of Houston's economy, the city will have to see a rise in new industries to remain competitive with its economy.

"The idea was to look at the innovation ecosystem and see what the technologies are that are doing well here at at attracting VC funding," Pherigo says on the Houston Innovators Podcast. "And by seeing how well certain technologies are doing, we'll be able to see if these are some areas that have some natural competitive advantages in Houston's economy that we can then use to spur growth in the next few decades — and even just out of the recession we're in right now."

The report found that life science and oil and gas currently attract the most VC investments in Houston, but Pherigo found potential in a few other industries like B2B payments technology — Houston-based fintech startup, HighRadius recently raised $125 million.

The study, which also compared Houston to Austin and Dallas, found that there was a cleantech war emerging between Austin and Houston. While Houston's ecosystem has a greater presence of cleantech startups, Austin cleantech is still bringing in more VC investments. However, in Houston, between new corporate incubators and Greentown Labs entering Houston, the city is creating a lot of infrastructure for this industry.

"It's going to be interesting over the next few years to see how Houston can position itself as the leader in Texas for this, because they are going to have a lot of competition from Austin," Pherigo says.

Pherigo goes into more detail about what he found interesting in the report, and even dives into what the data shows for the future of Houston's tech specialties in the episode of the podcast. You can listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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