Houston biotech startup selected to pitch at SXSW

austin bound

PHIOGEN, based at Texas Medical Center Innovation, is headed to Austin next month. Photo courtesy of TMC

Houston biotech startup PHIOGEN is among 45 finalists that will present at this year’s SXSW Pitch showcase in Austin.

PHIOGEN is one of five food, nutrition, and health startups that will participate in the pitch competition, set for March 9 and 10. A panel of judges will listen to the pitches and then pick the winners. Since 2009, SXSW Pitch finalists have raised more than $23.2 billion in funding.

PHIOGEN has developed the world’s first biogenetics technology platform to harness the power of bacteriophages in the fight against serious drug-resistant infections. Bacteriophages — viruses that are found in bacterial cells — “are ubiquitous in the environment and are recognized as the most abundant biological agent on earth,” according to an article published in 2022 by StatPearls.

Founded in 2023, PHIOGEN is a spinoff of the Baylor College of Medicine’s TAILOR Labs. The startup, based at the Texas Medical Center’s Innovation Hub, has attracted more than $5 million in funding.

“Nothing about our treatments is fabricated; it boils down to creating natural environments that mimic real-life infections, driving biological changes to create ‘super phages’ against the superbugs,” Amanda Burkardt, CEO of PHIOGEN, said in 2023. “As a result, we receive high-performing phage fighters that are trained and ready to deliver safe and effective treatments for clinical applications.”

Professional services firm KPMG is the main sponsor of SXSW Pitch.

Six of this year’s SXSW Pitch judges are from Houston:

Heath Butler of Mercury Fund
Jesse Martinez of LSA Global
Trevor Purvis of the Houston Astros
Anu Puvvada of KPMG
Irene Tang of StartOut
Nate Thompson of HTX Sports Tech

“2024 is an exciting year for startups, and we are looking forward to showcasing these inspiring companies that are making waves in their respective industries and the world as a whole, as well as help connect them with the resources needed to continue advancing,” says Chris Valentine, producer of SXSW Pitch.

Three Houston innovators discussed the strides the city is making in terms of equitable funding opportunities. Photos courtesy

SXSW panel: What Houston needs to do to develop as an equitable tech ecosystem

houston house

Houston has consistently been recognized as one of the most diverse cities in the country — but is that translating into equitable funding opportunities for diverse founders? A panel at SXSW this year discussed whether or not Houston's playing field is level for people of color within the innovation ecosystem.

"People do business with who they know — and who they like," says Felix Chevalier, co-founder of Urban Capital Network, when the panel was asked where the disconnect is with funding diverse founders. "I think it boils down to a lack of exposure and a lack of relationships."

Chevalier was joined by Jesse Martinez of Resolved Ventures and VamosVentures and Denise Hamilton of WatchHerWork, who moderated the discussion, which was hosted in the Greater Houston Partnership's Houston House on Sunday, March 13, at SXSW in Austin.

"We have to look at the pipeline — what the existing ecosystem looks like," says Martinez, who leads the LatinX Alliance, an organization that's relocating its operations to Houston. "We have new funds, new diverse GPs, and we have more investors — and we're building talent. ... We are making great strides, but we still need more of us to be funding our diverse founders."

The key to the equation, the panelists agreed, is education and programming — both for potential investors, like UCN does with its hands-on support for its diverse investor base, and for founders of color who might be more hesitant to plunge by starting a company.

"The way you start to dissolve that fear for folks, for example, who may be in a corporate space but may want to spread their entrepreneur wings, is to just get involved with the ecosystem," Chevalier says. "What ends up happening is you bump into someone you know or someone who is from the same talent you are originally — all you have to do is immerse yourself in the environment."

"The opportunities are out there, but it is incumbent upon in those who want it to put themselves in a position to meet people who are in the environments that are going to help facilitate whatever your objectives are," he continues.

Hamilton explained her experience raising money as a Black woman — investors didn't want to bet on her. It's a chicken and an egg situation, she says, and support for diverse founders in terms of programming and investors focused specifically on underserved communities are going to help break the cycle. It's not about charity, but equitable opportunities.

"I don't want any charity – I don't want an overabundance of kindness. Scaffold me like you scaffolded Mark Zuckerberg," Hamilton says, giving Facebook as an example of a company that was supported in a way she never had. "If you are going to be in a nascent ecosystem, you need to have structures that explain why your pitch deck has to be efficient, why you need a team. We've got to not focus just on the money piece, but on this whole psychosocial aspect."

With Hamilton's call to Houston's development as an equitable tech ecosystem, the conversation turned to discuss whether or not Houston is ready to provide this support to startups and rise to being the global innovation hub the city wants to be.

"We've got to find our tribe. We have all the pieces," Martinez says. "It's going to take time, and we have to be very intentional. ... It's really about thinking of Houston as a startup itself. How do we act as a team, and bring in partners and investors to make it a thriving ecosystem over time."

It takes commitment, Hamilton says, and that's happening in the Bayou City.

"Everything is not figured out right now — but there's a commitment to figuring it out," she says. "It's not going to be Silicon Valley overnight — it will never be Silicon Valley. Because this is Houston."

This week's roundup of Houston innovators includes Aaron Knape of sEATz, Ivery Boston III of Houston Exponential, and Jesse Martinez of the LatinX Startup Alliance. Courtesy photos

3 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from sportstech to startup-focused nonprofit work — recently making headlines in Houston innovation.

Aaron Knape, CEO and co-founder of sEATz

Aaron Knape joins the Houston Innovators Podcast to share how he's taking the sEATz platform into a new vertical. Photo courtesy of sEATz

Although sEATz was founded in 2018, Aaron Knape, CEO and co-founder, says it's only now that the company is really coming into its own as a startup ready to scale in a big way.

"I tell the team that we're kind of coming out of stealth mode — I know we're not in a true stealth mode, but we haven't spent a lot of money on sales and marketing," Knape says on this week's episode of the Houston Innovators Podcast. "Now it's time to start putting that emphasis on who we are, that we're here, and we're ready to take over."

Knape joins the show to discuss sEATz's expansion into health care and what's next for the growing company. Click here to read more and stream the podcast.

Ivery Boston III, director of inclusive innovation at Houston Exponential

Ivery Boston III joins HX to lead inclusive efforts. Photo via LinkedIn

Houston Exponential made a new hire to reflect on the city's diversity. Ivery Boston III is one week into his role as HX's director of inclusive innovation. He will be tasked with leading prototyping and testing new inclusive ideas and ways of operating, according to a news release from HX. He will also be responsible for creating opportunities for underrepresented founders to succeed in Houston.

Boston joins HX from Miami, where he led research, strategy, recruitment of high-growth startups, and impact reporting for the Miami Downtown Development Authority.

"I am excited to serve the Houston community as the director of inclusive innovation at Houston Exponential," says Boston in the release. "I'm a massive fan of HX's work advocating for, connecting, and raising the profile of the Houston innovation ecosystem while linking local founders to funding. It is a privilege to join this exemplary team and provide additional attention to underrepresented and under-encouraged founders within the city." Click here to read more.

Jesse Martinez, founder of the LatinX Startup Alliance

Jesse Martinez, founder of the LatinX Startup Alliance, joins InnovationMap for a Q&A on why he's relocating his nonprofit to Houston. Photo courtesy of LSA

Wheen Jesse Martinez was looking for startup support as a Latino founder, he couldn't find it. So, he took the initiative to make it himself and launched the LatinX Startup Alliance. The Houston native announced his plans to relocate his Silicon Valley nonprofit to The Ion next year.

He tells InnovationMap why he thinks Houston is the right market for LSA.

"We're on the ground floor. We're helping to build that foundation. It's not an afterthought. It's not something that now we're trying to go back and think of diversity," Martinez tells InnovationMap. "I think that's the beautiful thing about Houston and everyone that I've met is that it's been so diverse and inclusive. That spirit is already there. So, how do we just maximize that?" Click here to read the full Q&A.

Jesse Martinez, founder of the LatinX Startup Alliance, joins InnovationMap for a Q&A on why he's relocating his nonprofit to Houston. Photo courtesy of LSA

Houston native brings LatinX startup support to the Ion with HQ move

Q&A

Jesse Martinez was working in Silicon Valley before it was Silicon Valley. He took his years of experience within that tech ecosystem and launched the LatinX Startup Alliance to support his fellow Hispanic entrepreneurs — and now he's bringing that support to his hometown.

The LatinX Startup Alliance will move its headquarters into The Ion in 2022, Martinez tells InnovationMap. He's excited to finally make his professional return to Houston and to help support the diverse ecosystem — one that has been created with diversity at the forefront, unlike Silicon Valley and other coastal tech hubs.

Martinez joined InnovationMap for a Q&A about the new HQ announcement and what he's excited about in terms of DEI in Houston's tech scene.

InnovationMap: Tell me a little bit about your own tech and entrepreneurship journey.

Jesse Martinez: In 1996, one weekend I was at Barnes and Noble reading the newspaper, and, for whatever reason, I went through the classified ads and this one ad caught my eye. It said, "internet sales for internet company." So I faxed in my resume and I got a call back, did my phone screens, and they flew me out to San Jose. I interviewed with the founders in Sunnyville where the startup was based. The name of the startup was Internet Systems Inc., funded by Sequoia Capital and I ended up joining as employee number 27.

I was new to this whole world. We were one of two pioneers in the web hosting services space — pre-Rackspace, pre-AWS, et cetera. In less than a year, we went from startup to public company trading at $35 a share via two acquisitions. So that was my whole intro into the world of tech startups, Silicon Valley, and stock options.

Because of that work, I caught the startup bug and did my first startup with my brother in 2000. We had two acquisition offers. We turned one down, and we were entertaining the second one, which was between $8 and $10 million. And then the market crashed in March of 2000. Those offers went away, and we tried to raise more money, but just couldn't do it. And then we ended up shutting down December of 2000.

IM: How did you come to start the LatinX Alliance?

JM: In 2010, I was looking to do my second startup. And it was early days of community-based organizations providing services for their founders — Black founders, Jewish founders, and others. And I did a set of Google searches to try to find something for myself. I'm like, "I'm Latino, I'm a tech and founder what's available for us?" And there was nothing. That left me scratching my head. Like how can this be? This is the global mecca of tech. That became the beginning of Latino Startup Alliance. We launched in 2011 in the Mission District of San Francisco with six people with their mission to empower Latino tech founders. Fast forward to today, we're over a thousand members globally. Our mission is still the same. And last year, we changed our name from Latino to LatinX to be more supportive and inclusive.

IM: You’re from Houston originally, but when did you have the idea of bringing the alliance to Texas?

JM: I was super excited to meet Bob Harvey (from the Greater Houston Partnership) and team, when they did a delegation to Silicon Valley. I met them at the Salesforce Tower, and we started talking about tech and Aggies and all the above. And they're like, "by the way, do you know that we're know committing to tech? We're finally making that commitment from the city on down, you should be there." And I'm like, "well, I've been waiting for this all my life." Houston was so engaged in oil, gas and energy. And so it was finally refreshing to hear that Houston had made that commitment. It felt right and it made sense to move our headquarters to Houston, and we'll officially launch in 2022.

IM: The new headquarters of the LatinX Startup Alliance is in The Ion. How will you work with them collaboratively and what can people expect from your organization?

JM: One of the things that we did early on as an organization is do a series of events — weekly events as well as a yearly summits. We were actually going to host our first summit in October of this year, because of the pandemic and the uncertainty, we decided to postpone it just because we wanted to be respectful for everyone's health and safety. We pushed it to next year, targeting the same month — October of 2022. And that'll be two days of programming focused on tech and also tech careers. So, there'll be a Friday and a Saturday. One of the things we want to ensure is that by hosting something on Saturday on tech careers, is that more people will be able to attend. And then Friday we'll focus on tech, founders, and startups.

Through our monthly events, we'll have office hours, we'll have meetups, and what we call LSA founder dinners. We just hosted one last week in Oakland, and we used to do these all the time. We're going back to that now that we can, and especially as we launch in Houston is ensuring that we have that consistency as we start building that community. It's like starting over, which is great. The biggest part is being able to support and champion the LatinX tech community here in Houston and also the state of Texas.

IM: How do you envision growing the LatinX Startup Alliance internationally?

JM: We've always been global from day one. We've had founders come from other cities and countries to Silicon Valley because it was such a hub for many, many years. It'll be interesting to see what happens moving forward. A lot of people have moved away to their hometowns or new cities. So now we have a more distributed network of founders and startups and also investors. So when you talk about access and access to opportunities, it's certainly a big win for those founders and startups across the west.

IM: What should people know about LSA?

JM: We operate under three pillars, which are awareness, access, and acceleration. Through the awareness piece, it's creating awareness around LatinX tech, startups and founders, both of those that are in the ecosystem and those that want to learn more. Access is being able to include people in tech programming, again for founders or for the public to participate in whatever it is we post, you know, from a founder perspective, it could be an invitation to attend Techcrunch or SaaStr Annual— either virtually or in person in San Francisco. We've had a partnership with both of them. So, we have diversity scholarships for our members.

IM: How have you seen things change in terms of connecting LatinX founders with funding?

JM: There is more access, and we help facilitate some of the awareness. You might not be aware of all the investors angel investors. And so that's where we try to be the bridge and be able to make those warm introductions between investors and also the startup founders. There are a lot more diverse funds. There's a lot more diverse general partners, which is awesome. And I think there's access to more. Does that mean that everyone's getting funded? No. It's not easier to get money, but there's just more money to go around. But you still have to go through the same steps and follow the process.

IM: Ahead of the launch of the LatinX Startup Alliance in Houston, who are you looking to connect with?

JM: Everyone, because you never know who that one person's going to be —corporates, companies, startups, founders, investors, other nonprofits. One of things that I've been doing as I've been going back to Houston is just meeting people from the ecosystem.One of the things that we're working on right now is setting up a group of key stakeholders for LatinX Houston Alliance. Who are those key players that we can bring together on a monthly basis? I'm thinking like a town hall of 40 or so people talk about what we need to do to better support and champion the ecosystem.

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This conversation has been edited for brevity and clarity.

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Houston chemist lands $2M NIH grant for cancer treatment research

future of cellular health

A Rice University chemist has landed a $2 million grant from the National Institute of Health for his work that aims to reprogram the genetic code and explore the role certain cells play in causing diseases like cancer and neurological disorders.

The funds were awarded to Han Xiao, the Norman Hackerman-Welch Young Investigator, associate professor of chemistry, from the NIH's Maximizing Investigators’ Research Award (MIRA) program, which supports medically focused laboratories.

Xiao will use the five-year grant to develop noncanonical amino acids (ncAAs) with diverse properties to help build proteins, according to a statement from Rice. He and his team will then use the ncAAs to explore the vivo sensors for enzymes involved in posttranslational modifications (PTMs), which play a role in the development of cancers and neurological disorders. Additionally, the team will look to develop a way to detect these enzymes in living organisms in real-time rather than in a lab.

“This innovative approach could revolutionize how we understand and control cellular functions,” Xiao said in the statement.

According to Rice, these developments could have major implications for the way diseases are treated, specifically for epigenetic inhibitors that are used to treat cancer.

Xiao helped lead the charge to launch Rice's new Synthesis X Center this spring. The center, which was born out of informal meetings between Xio's lab and others from the Baylor College of Medicine’s Dan L Duncan Comprehensive Cancer Center at the Baylor College of Medicine, aims to improve cancer outcomes by turning fundamental research into clinical applications.

They will build upon annual retreats, in which investigators can share unpublished findings, and also plan to host a national conference, the first slated for this fall titled "Synthetic Innovations Towards a Cure for Cancer.”

Houston neighbor ranks as one of America's most livable small cities

mo city

Some Houston suburbs stick out from the rest thanks to their affluent residents, and now Missouri City is getting time in the spotlight, thanks to its new ranking as the No. 77 most livable small city in the country.

The tiny but mighty Houston neighbor, located less than 20 miles southwest of Houston, was among six Texas cities that earned a top-100 ranking in SmartAsset's 2024 " Most Livable Small Cities" report. It compared 281 U.S. cities with populations between 65,000 and 100,000 residents across eight metrics, such as a resident's housing costs as a percentage of household income, the city's average commute times, and the proportions of entertainment, food service, and healthcare establishments.

According to the U.S. Census Bureau, Missouri City has an estimated population of over 76,000 residents, whose median household income comes out to $97,211. SmartAsset calculated that a Missouri City household's annual housing costs only take up 19.4 percent of that household's income. Additionally, the study found only six percent of the town's population live below the poverty level.

Here's how Missouri City performed in two other metrics in the study:

1.4 percent – The proportion of arts, entertainment, and recreation businesses as a percentage of all businesses
29.9 minutes – Worker's average commute time

But income and housing aren't the only things that make Missouri City one of the most livable small cities in Texas. Residents benefit from its proximity from central Houston, but the town mainly prides itself on its spacious park system, playgrounds, and other recreational activities.

Missouri City, Texas

Missouri City residents have plenty of parkland to enjoy. www.missouricitytx.gov

The Missouri City Parks and Recreation Departmen meticulously maintains 21 parks spanning just over 515 acres of land, an additional 500 acres of undeveloped parkland, and 14.4 miles of trails throughout the town, according to the city's website."Small cities may offer cost benefits for residents looking to stretch their income while enjoying a comfortable – and more spacious – lifestyle," the report's author wrote. "While livability is a subjective concept that may take on different definitions for different people, some elements of a community can come close to being universally beneficial."

Missouri City is also home to Fort Bend Town Square, a massive mixed-use development at the intersection of TX 6 and the Fort Bend Parkway. It offers apartments, shopping, and restaurants, including a rumored location of Trill Burgers.

Other Houston-area cities that earned a spot in the report include

Spring (No. 227) and Baytown (No. 254).The five remaining Texas cities that were among the top 100 most livable small cities in the U.S. include Flower Mound (No. 29), Leander (No. 60), Mansfield (No. 69), Pflugerville (No. 78), and Cedar Park (No. 85).

The top 10 most livable small cities in the U.S. are:

No. 1 – Troy, Michigan
No. 2 – Rochester Hills, Michigan
No. 3 – Eau Claire, Wisconsin
No. 4 – Franklin, Tennessee
No. 5 – Redmond, Washington
No. 6 – Appleton, Wisconsin
No. 7 – Apex, North Carolina
No. 8 – Plymouth, Minnesota
No. 9 – Livonia, Michigan
No. 10 – Oshkosh, Wisconsin

The report examined data from the U.S. Census Bureau's 2022 1-year American Community Survey and the 2021 County Business Patterns Survey to determine its rankings.The report and its methodology can be found on

smartasset.com