Houston innovation hub adds Oxy, United, and Woodside as partners

onboarding

The Ion named three corporate partners ahead of its annual innovation-focused festival. Photo courtesy of the Ion

Houston’s Ion innovation hub has recruited three heavyweight corporate partners, the hub announced earlier this week.

The new partners are:

  • Houston-based energy company Occidental (known as Oxy).
  • United Airlines Ventures, the sustainability-focused VC arm of Chicago-based United Airlines. United operates a major hub in Houston.
  • Australia-based Woodside Energy, which maintains an office in Houston.

Oxy, United Airlines Ventures, and Woodside will share their expertise in support of Ion’s mission to transform Houston into a global innovation ecosystem, according to an Ion news release. In addition, they will participate in Ion programming and network with Ion affiliates. Executives from all three of the new partners will serve on the Ion Leadership Advisory Roundtable.

“Welcoming our newest partners into Ion’s ecosystem is a further testament to our momentum in the aerospace and energy transition,” says Jan Odegard, who became executive director of the Ion in 2021 after a year of holding the interim position. “Each organization brings their own culture of innovation that aligns with what we are doing at the Ion.”

Michael Leskinen, president of United Airlines Ventures, says the VC firm believes “the Ion will be the epicenter for Houston’s rapidly growing innovation community — a one-stop shop to share ideas, foster startups, and to develop relationships with Houston’s brightest companies and academia.”

Oxy, United Airlines Ventures, and Woodside join Ion corporate partners such as:

  • Aramco Americas
  • Baker Botts
  • BP
  • Chevron
  • ExxonMobil
  • Global Custom Commerce
  • Intel
  • Microsoft
  • Transocean

The Ion announced the new corporate partners in advance of the second annual Ion Activation Festival, set for May 17-19. The Ion and Rice Management Co. host the festival, which shines a spotlight on entrepreneurship and innovation in Houston.

Activities will take place primarily at the Ion’s 16-acre campus. To register for the festival, visit the Ion’s website.

The inaugural festival, held in 2022, drew more than 2,500 attendees.

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The Ion has announced its latest startup-focused program. MediaTech Venture's Houston startup incubator is launching next month. Photo courtesy of the Ion

New Houston incubator launches to support media tech innovation

ready to grow

Houston has a new incoming incubator program for innovators within the media technology space.

The Ion announced a new partnership with MediaTech Ventures, an Austin-based global media industry venture development company, that will bring the MediaTech incubator program to Houston. Applications are open now, and the first cohort will kick off the program in January.

“Modern media has to continually evolve and adapt to new market channels, and with each platform comes the opportunity for innovation to leverage what is possible. It’s why Houston continues to build its market and resources for media technology entrepreneurs and startups looking to make an impact in this constantly evolving space,” says Jan E. Odegard, executive director of the Ion, in a news release.

“We’re thrilled to partner with MediaTech Ventures to further bolster the startups that are an integral part of our innovation community," he continues.

The 12-week program will help early-stage companies tackle marketing, development, and production with education and mentorship with MediaTech Ventures' startup curriculum and platform. The Ion will house the initiative and startups will have access to the hub for programming and networking.

“Ion is the perfect home for our incubator program,” says Josh Sutton, Houston Program Manager at MediaTech Ventures, in the release. “Our goal is to not only tap into the Ion’s valuable innovation ecosystem both within its four walls and beyond it, but to catalyze the development of media technologies and offer more resources for entrepreneurs looking to advance modern media.”

Founded in 2016 to advance the media technology economy, MediaTech Ventures focuses on "unifying innovation with capital, and validating and scaling technology-enabled media startups," per the news release. The program's startups have raised over $10 million following the completion of the curriculum.

An info session is taking place on December 5 at Second Draught in the Ion, and interested applicants can meet, ask questions, and learn more about the program.

The Ion will house a new innovation hub focused on the future of medicine. Image courtesy of The Ion

Houston Methodist to open health innovation center in the Ion

coming soon

The Houston Methodist healthcare system has teamed up with the Ion innovation hub to open a health care innovation center.

The 1,200-square-foot tech hub is expected to open later this year. It initially will be geared toward activities like entrepreneurial programming, networking, mentoring, and pitching.

The space will be modeled after Houston Methodist’s Center for Innovation Technology Hub, which opened in 2020. In fact, the new hub will be a smaller “twin” of the existing hub, according to a news release.

Jan Odegard, executive director of the Ion, says the collaboration with Houston Methodist “will advance the Ion’s ability to support entrepreneurs and innovators that are already at the Ion as we embark on a new focus in health care innovation.”

Amid the rise of artificial intelligence and other tech advancements, along with the health care sector’s continuing drive to cut costs, one forecast indicates the value of the global market for digital health care will jump from $216.4 billion in 2022 to $441 billion by 2026. That would represent an increase of 104 percent.

Houston Methodist is the Ion’s first health care partner. The Ion already has partnerships in the aerospace and energy sectors.

“We are advancing the evolution of the hospital’s role in health care through digital transformation,” said Michelle Stansbury, vice president of innovation and IT applications at Houston Methodist. “Having a footprint at the Ion will not only provide the Ion’s network and Houston community with a window into what we are doing for patients, consumers and providers, but also gives The Ion community and rising innovators an opportunity to bring its own ingenuity and ideas to life with ours.”

Houston Methodist operates eight hospitals in the Houston area.

The 266,000-square-foot Ion anchors a 16-acre innovation district in Midtown. Rice Management Co. developed the district on behalf of Rice University.

“By enhancing opportunities for our network of academics, businesses, entrepreneurs, and innovators to collaborate across the Ion District and globally, we’re creating a more resilient future economy for our region,” says Bryson Grover, investment manager of real estate at Rice Management.

The space will be modeled after Houston Methodist’s Center for Innovation Technology Hub, which opened in 2020. Natalie Harms/InnovationMap

The Ion, NASA, and Rice University have teamed up to create new programming and collaboration within space innovation in Houston. Photo courtesy of The Ion

New strategic partnership sets out to bolster Houston's space economy

rocket fueled collaboration

The Ion innovation district and NASA’s Johnson Space Center are setting up a pipeline for Houston-area entrepreneurs to share ideas and intellectual property with the space agency.

The Ion and NASA are collaborating with Rice University on the new project, which is aimed at creating events, programming, and initiatives to promote the aerospace sector and the use of NASA technologies in the broader economy.

Vanessa Wyche, director of Johnson Space Center, says in a news release that the alliance will “help NASA solve challenges, develop spinoff technologies, grow minority entrepreneurs, and accelerate innovative and tech-forward solutions in Houston.”

Innovations developed through the new project will propel commercialization of space, Wyche says.

Much of the focus of the new alliance will be on minority-owned businesses, as well as aerospace and tech entrepreneurs. The Ion’s Aerospace Innovation Accelerator for Minority Business Enterprises will play a part in this strategy.

As part of the new collaboration, NASA and the Ion will open an application process for interested startups and entrepreneurs in the fall of 2022. The selected applicants will participate in programming through mid-2023.

“NASA’s Johnson Space Center has led the U.S. and the world on an ongoing journey of human exploration, and the Ion is here to accelerate tomorrow’s space endeavors. … Together we will safeguard Houston’s title as ‘Space City’ and advance the global space industry for future missions,” says Jan Odegard, executive director of the Ion.

Houston stands to grab a sizable share of the continuously growing space economy.

A Space Foundation report shows the value of the global space economy rose to $447 billion in 2020, up 4.4 percent from $428 billion in 2019. Morgan Stanley estimates the global space economy could generate revenue of $1 trillion or more by 2040, with satellite broadband representing nearly 40 percent of the sector.

Meanwhile, a report from the U.S. Bureau of Economic Analysis indicates the U.S. space economy accounted for $125.9 billion of price-adjusted GDP in 2019.

In Texas, the annual GDP of the space economy is estimated at $11.7 billion. The Perryman Group, a Waco-based economic analysis firm, forecasts this figure could soar to more than $27.3 billion in 2030 and nearly $57.6 billion in 2040.

The Perryman Group says the Texas space economy is expected to expand about 120 percent faster than the U.S. space economy, with the state’s portion of this economy potentially approaching 15 percent by 2040.

“Texas already plays an important role in space exploration and related industries,” the firm says in a report. “With a major public-sector presence, large and growing private-sector initiatives, and aggressive development efforts, the state is likely to significantly increase its share of the [space economy].”

The Ion Prototyping Lab is now open and will be powered by TXRX. Photo by Natalie Harms/InnovationMap

Ion Houston opens unique prototyping lab, names TXRX as partner

new to hou

Midtown Houston's innovation hub has unveiled its latest building feature and named its operation partner for the space.

The Ion opened its The Ion Prototyping Lab with the announcement that Houston nonprofit TXRX Labs will be the operator of the lab. The IPL’s 6,500 square-foot space will include access to tools — such as laser cutters, CNC mills and lathes, electronics assembly equipment, and 3D printers — as well as programming, training, and support.

“The Houston community’s growing need for these services has led to our growth from a small community organization to a partnership with Houston’s leading center for innovation, The Ion,” says Roland von Kurnatowski, president of TXRX Labs, in a news release. “With our presence at The Ion and in its Prototyping Lab, we are able to join together innovative ideas and technology to create a social and collaborative space to support tomorrow’s entrepreneurs' needs and challenges.”

Founded in 2008 and based in the East End Maker Hub, TXRX Labs provides community-focused engineering and fabrication services and job training programs. The nonprofit's goal is to make Houston a major 21st-century manufacturing hub.

The new space within the 266,000 square-foot innovation hub was designed by Gensler and is "the largest open corporate and startup-aligned prototyping space in Houston," according to the release.

“As part of Gensler’s contributions to the development of The Ion, we strategically designed the Prototyping Lab to function as a dedicated space for innovators and entrepreneurs to collaborate,” says Vincent Flickinger, senior associate and design director of Gensler Houston. “The Ion Prototyping Lab is equipped with tools for prototyping robotics and other energy focused innovations and cultivates an entirely new way of doing business in a reimagined, historic building and with one of Houston’s fastest-growing innovators, TXRX. We look forward to introducing the IPL’s offerings to the public.”

The IPL is the latest opening for The Ion. Last summer, the hub, which is opened and managed by Rice Management Company, opened its coworking space. The next openings to expect are an investor studio and several restaurant concepts, including Late August, The Lymbar, and more. Common Bond On-The-Go, located on the main floor of the Ion, opened this week too.

“With its close proximity to Houston’s Central Business District and The Texas Medical Center, The Ion is thrilled to provide the Houston tech community the Prototyping Lab operated by TXRX as an essential resource for businesses,” says Jan E. Odegard, executive director of The Ion, in the release. “The Ion serves as a driver and convener of activity, while TXRX's successful model of hands-on training and technological innovation is being leveraged to jumpstart the activity of entrepreneurs, corporations, and researchers. You think it, we make it.”

Members will have daily access to the IPL from 9 am to 5 pm. The cost of the membership has not been announced, but IPL will offer grant opportunities, per the release. All members must first complete a safety and skills training course.

The Ion has officially opened its coworking space on the second floor of the Midtown building. Rendering courtesy of Common Desk

The Ion Houston announces opening of its coworking space

calling all coworkers

The Ion Houston's coworking space — roughly four times the size of a typical Walgreens drugstore — opened this week ready to welcome its pre-leased tenants and potential coworkers alike.

The coworking space, Common Desk, occupies 58,400 square feet on the second floor of The Ion. That represents about one-fifth of the 266,000-square-foot Ion complex.

Amenities at Common Desk include craft coffee from local purveyors, unlimited conference room bookings, access to all shared areas on the second floor, private chat booths, full kitchens, and break areas.

Other tenants at The Ion include Chevron Technology Ventures and Microsoft. The Ion opened earlier this year, occupying the former Sears store in Midtown following a $100 million conversion. It's part of the 16-acre Innovation District, being developed by Rice University and the City of Houston.

"We can't wait for our new Common Desk tenants and members across their network to experience the magic that's being made here," Jan Odegard, executive director of The Ion, says in a news release. "Just as The Ion, alongside developer Rice Management Company, set out to build an innovation community and hub different from anything the nation has ever seen, Common Desk set out to build its biggest and most innovative space yet."

Dallas-based Common Desk specializes in flexible office space. Its location at The Ion is the company's largest flex office space to date.

"Common Desk has joined the ranks of some of the nation's top companies to cultivate an authentic, game-changing community destined to transform Houston's innovation ecoscape," says Dawson Williams, head of growth and partnerships at Common Desk.

Members of the Common Desk location at The Ion also can use the company's three other coworking spaces in Houston, as well as it locations in Austin, Dallas-Fort Worth, and North Carolina.

Common Desk's coworking space has several options for leasing. Photos courtesy of Common Desk

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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