This week's roundup of Houston innovators includes Aaron Knape of sEATz, Ivery Boston III of Houston Exponential, and Jesse Martinez of the LatinX Startup Alliance. Courtesy photos

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from sportstech to startup-focused nonprofit work — recently making headlines in Houston innovation.

Aaron Knape, CEO and co-founder of sEATz

Aaron Knape joins the Houston Innovators Podcast to share how he's taking the sEATz platform into a new vertical. Photo courtesy of sEATz

Although sEATz was founded in 2018, Aaron Knape, CEO and co-founder, says it's only now that the company is really coming into its own as a startup ready to scale in a big way.

"I tell the team that we're kind of coming out of stealth mode — I know we're not in a true stealth mode, but we haven't spent a lot of money on sales and marketing," Knape says on this week's episode of the Houston Innovators Podcast. "Now it's time to start putting that emphasis on who we are, that we're here, and we're ready to take over."

Knape joins the show to discuss sEATz's expansion into health care and what's next for the growing company. Click here to read more and stream the podcast.

Ivery Boston III, director of inclusive innovation at Houston Exponential

Ivery Boston III joins HX to lead inclusive efforts. Photo via LinkedIn

Houston Exponential made a new hire to reflect on the city's diversity. Ivery Boston III is one week into his role as HX's director of inclusive innovation. He will be tasked with leading prototyping and testing new inclusive ideas and ways of operating, according to a news release from HX. He will also be responsible for creating opportunities for underrepresented founders to succeed in Houston.

Boston joins HX from Miami, where he led research, strategy, recruitment of high-growth startups, and impact reporting for the Miami Downtown Development Authority.

"I am excited to serve the Houston community as the director of inclusive innovation at Houston Exponential," says Boston in the release. "I'm a massive fan of HX's work advocating for, connecting, and raising the profile of the Houston innovation ecosystem while linking local founders to funding. It is a privilege to join this exemplary team and provide additional attention to underrepresented and under-encouraged founders within the city." Click here to read more.

Jesse Martinez, founder of the LatinX Startup Alliance

Jesse Martinez, founder of the LatinX Startup Alliance, joins InnovationMap for a Q&A on why he's relocating his nonprofit to Houston. Photo courtesy of LSA

Wheen Jesse Martinez was looking for startup support as a Latino founder, he couldn't find it. So, he took the initiative to make it himself and launched the LatinX Startup Alliance. The Houston native announced his plans to relocate his Silicon Valley nonprofit to The Ion next year.

He tells InnovationMap why he thinks Houston is the right market for LSA.

"We're on the ground floor. We're helping to build that foundation. It's not an afterthought. It's not something that now we're trying to go back and think of diversity," Martinez tells InnovationMap. "I think that's the beautiful thing about Houston and everyone that I've met is that it's been so diverse and inclusive. That spirit is already there. So, how do we just maximize that?" Click here to read the full Q&A.

Ivery Boston III joins HX to lead inclusive efforts. Photo via LinkedIn

Houston Exponential hires new exec to promote inclusive innovation

new to hou

Houston's considered one of the most diverse cities in the country, and Houston Exponential is focused on building an innovation ecosystem that's reflective of that.

The nonprofit organization announced a new hire that will lead this initiative. Ivery Boston III started this week as HX's director of inclusive innovation. He will be tasked with leading prototyping and testing new inclusive ideas and ways of operating, according to a news release from HX. He will also be responsible for creating opportunities for underrepresented founders to succeed in Houston.

"Other cities, in their dogged pursuit of being the next 'Silicon Valley,' followed the coastal playbook and weren't deliberate to support underserved entrepreneurs," says Serafina Lalany, executive director of Houston Exponential, in the release. "There is still much work to be done to address subtle and persistent forms of bias in the ways underrepresented founders access the resources, capital, and talent needed to thrive here in Houston. This move, for Houston Exponential and for the City of Houston, is part of an intentional strategy to foster a more inclusive, accessible ecosystem."

Boston joins HX from Miami, where he led research, strategy, recruitment of high-growth startups, and impact reporting for the Miami Downtown Development Authority.

"I am excited to serve the Houston community as the director of inclusive innovation at Houston Exponential," says Boston in the release. "I'm a massive fan of HX's work advocating for, connecting, and raising the profile of the Houston innovation ecosystem while linking local founders to funding. It is a privilege to join this exemplary team and provide additional attention to underrepresented and under-encouraged founders within the city."

Boston has also worked with Indeed.com, Zipcar, Sodexo, and other companies within market reporting. He attended Temple University.

"I look forward to rolling up my sleeves and ensuring that all Houstonians can see a viable path to entrepreneurship," he continues. "It's time to leverage Houston's diversity to bring in additional funding sources, create jobs, and use the profound local awareness of the world to launch businesses, services, and products that serve the global market."

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.