Houston companies snag spots on regional Inc. 5000 list

by the numbers

Here's what Houston company scored the No. 2 spot among the fastest-growing private companies in the Southwest. Photo via Getty Images

Revenue growth is on fire at Houston-based Simple Solar.

Revenue at Simple Solar, a provider of residential solar installations, soared 8,007 percent from 2019 to 2021, putting it at No. 2 among the fastest-growing private companies in the Southwest. It leads the list of 25 Houston-area companies appearing in the new Inc. 5000 Regional rankings for the Southwest.

Between 2019 and 2021, the 165 private companies on the Southwest list posted an average growth rate of 557 percent. In 2021 alone, they added 16,116 jobs and nearly $5.5 billion to the Southwest’s economy.

“This year’s Inc. 5000 Regional winners represent one of the most exceptional and exciting lists of America’s off-the-charts growth companies,” says Scott Omelianuk, editor-in-chief of Inc. magazine. “They’re disruptors and job creators, and all delivered an outsized impact on the economy. Remember their names and follow their lead. These are the companies you’ll be hearing about for years to come.”

Here are the 25 Houston-area companies that made the Inc. 5000 Regional list for the Southwest, including their regional rankings.

  • No. 2 Simple Solar, Houston-based provider of residential solar installations, 8,007 percent growth
  • No. 6 Medical Edge Recruitment, The Woodlands-based health care recruiting and staffing firm, 2,980 percent growth
  • No. 8 Specialty1 Partners, Houston-based provider of surgical support services for dental practices, 2,921 percent growth
  • No. 15 Magnolia-based online women’s clothing retailer Jess Lea, 1,471 percent growth
  • No. 36 Houston-based accounting and advisory firm EFS Group, 458 percent growth
  • No. 39 Blackbuck Resources, Houston-based designer, builder, and operator of water infrastructure for the oil and gas industry, 432 percent growth
  • No. 48 Leveled Concrete, Houston-based provider of concrete and foundation repair services, 298 percent growth
  • No. 52 iCRYO Brands, Houston-based franchisor of cryotherapy centers, 269 percent growth
  • No. 53 TAXA Outdoors, Houston-based retailer of camping trailers, 268 percent growth
  • No. 58 Proxima Clinical Research, Houston-based contract research organization, 243 percent growth
  • No. 64 Ledge, Katy-based seller of in-pool and backyard furniture and accessories, 234 percent growth
  • No. 66 TekRevol, Houston-based software developer, 226 percent growth
  • No. 79 Finish Line Tax Solutions, Houston-based tax relief firm, 194 percent growth
  • No. 82 Incfile, Houston-based provider of services for small businesses, 192 percent growth
  • No. 99 Flocknote, Magnolia-based provider of technology that helps churches boost attendance and foster connections, 152 percent growth
  • No. 125 Onit, Houston-based developer of workflow and AI software, 104 percent
  • No. 137 InterLinc Mortgage, Houston-based mortgage lender, 85 percent growth
  • No. 140 Classy Art, Houston-based supplier of wall décor, 83 percent growth
  • No. 145 Zulie Venture (Cellpay), Sugar Land-based provider of prepaid wireless services, 78 percent growth
  • No. 149 Total Pump Solutions, Houston-based distributor of fire suppression equipment, 75 percent growth
  • No. 155 Construction Concepts, Houston-based commercial construction firm, 67 percent growth
  • No. 157 Energy Ogre, Houston-based service that helps consumers find electricity plans, 63 percent growth
  • No. 164 Garrison Construction Group, Houston-based commercial construction firm, 60 percent growth
  • No. 165 Technocrats Domain, Houston-based provider of IT services, 60 percent growth
  • No. 166, G&A Partners, Houston-based professional employer organization, 60 percent growth
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Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

Elon Musk's SpaceX site officially becomes the city of Starbase, Texas

Starbase, Texas

The South Texas home of Elon Musk’s SpaceX rocket company is now an official city with a galactic name: Starbase.

A vote Saturday, May 3, to formally organize Starbase as a city was approved by a lopsided margin among the small group of voters who live there and are mostly Musk’s employees at SpaceX. With all the votes in, the tally was 212 in favor to 6 against, according to results published online by the Cameron County Elections Department.

Musk celebrated in a post on his social platform, X, saying it is “now a real city!”

Starbase is the facility and launch site for the SpaceX rocket program that is under contract with the Department of Defense and NASA that hopes to send astronauts back to the moon and someday to Mars.

Musk first floated the idea of Starbase in 2021 and approval of the new city was all but certain. Of the 283 eligible voters in the area, most are believed to be Starbase workers.

The election victory was personal for Musk. The billionaire’s popularity has diminished since he became the chain-saw-wielding public face of President Donald Trump’s federal job and spending cuts, and profits at his Tesla car company have plummeted.

SpaceX has generally drawn widespread support from local officials for its jobs and investment in the area.

But the creation of an official company town has also drawn critics who worry it will expand Musk’s personal control over the area, with potential authority to close a popular beach and state park for launches.

Companion efforts to the city vote include bills in the state Legislature to shift that authority from the county to the new town’s mayor and city council.

All these measures come as SpaceX is asking federal authorities for permission to increase the number of South Texas launches from five to 25 a year.

The city at the southern tip of Texas near the Mexico border is only about 1.5 square miles (3.9 square kilometers), crisscrossed by a few roads and dappled with airstream trailers and modest midcentury homes.

SpaceX officials have said little about exactly why they want a company town and did not respond to emailed requests for comment.

“We need the ability to grow Starbase as a community,” Starbase General Manager Kathryn Lueders wrote to local officials in 2024 with the request to get the city issue on the ballot.

The letter said the company already manages roads and utilities, as well as “the provisions of schooling and medical care” for those living on the property.

SpaceX officials have told lawmakers that granting the city authority to close the beach would streamline launch operations. SpaceX rocket launches and engine tests, and even just moving certain equipment around the launch base, requires the closure of a local highway and access to Boca Chica State Park and Boca Chica Beach.

Critics say beach closure authority should stay with the county government, which represents a broader population that uses the beach and park. Cameron County Judge Eddie Trevino, Jr. has said the county has worked well with SpaceX and there is no need for change.

Another proposed bill would make it a Class B misdemeanor with up to 180 days in jail if someone doesn’t comply with an order to evacuate the beach.

The South Texas Environmental Justice Network, which has organized protests against the city vote and the beach access issue, held another demonstration Saturday that attracted dozens of people.

Josette Hinojosa, whose young daughter was building a sandcastle nearby, said she was taking part to try to ensure continued access to a beach her family has enjoyed for generations.

With SpaceX, Hinojosa said, “Some days it’s closed, and some days you get turned away."

Organizer Christopher Basaldú, a member of the Carrizo/Comecrudo Nation of Texas tribe, said his ancestors have long been in the area, where the Rio Grande meets the Gulf.

“It’s not just important,” he said, “it’s sacred.”

Texas-based 'DoorDash for laundry' startup tumbles into Houston market

No Scrubs

Laundry may seem like an endless task that piles up, but a new service offers a solution to overwhelmed Houston families.

NoScrubs, an Austin-based home laundry pickup service has just expanded to Houston. Described by the company as "DoorDash — but for laundry," they wash customer's clothes at local laundromats and return them the same day, folded and ready to be put away.

The service took off like gangbusters in Austin, making an expansion to the state's largest city an obvious choice. It's not universal coverage just yet.

For now, only the following ZIP codes have NoScrubs service available: 77002, 77004, 77005, 77006, 77007, 77008, 77009, 77010, 77018, 77019, 77024, 77025, 77027, 77046, 77056, 77057, 77081, 77098, 77401, 77030, 77003.

A single pickup starts at $40 for 20 pounds of laundry, while the basic monthly subscription is $60 for two pickups. All services use hypoallergenic detergents.

The average American family spends about 240 hours a year on laundry, making it a very time-consuming chore. For people with disabilities, difficult work schedules, and other circumstances, it can be a real help, says co-founder Matt O'Connor.

"Some of our favorite customer stories simply revolve around saving people time when they have something challenging going on," he writes in an email. "For example, one customer reviewed NoScrubs saying 'So happy I could cry! (Partially because I'm pregnant and my emotions are heightened!)...1000% recommend if you have time restrictions or physical restrictions! ' So, whether it’s saving time, the affordability, or the pleasantly surprising turnaround time, NoScrubs has a variety of benefits for any customer."

NoScrubs is also a new opportunity for Houston's gig workers. Because there are no passengers, it can be a safer alternative to driving ride share for women and other people apprehensive about having strangers in their cars. As NoScrubs partners with local laundromats, drivers are also going to centralized locations rather than all over the map, leading to less wear and tear on their cars. The laundromats benefit as well, since NoScrubs loads are ones that would otherwise be done at home.

"Our model makes driving a tiny fraction of the time, so folks who don’t want to wear down their vehicles and spend a ton on gas love working at NoScrubs," added O'Connor.

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