10 can't-miss events at Houston Energy and Climate Week 2026

HECW lineup

Houston Energy and Climate Week returns Sept. 12-18. Photo via rice.edu

Editor's note: Houston Energy and Climate Week returns for its third year, Sept. 12–18, with panels, happy hours, pitch days and tours focused on the energy transition.

The Ion District will host many of the week's events. Here are details on some can't-miss, signature events and how to register. Find the full schedule here. Please note: this article may be updated to add more events.

Sept. 13 — The & Awards

Kick off the week by celebrating Houston honorees leading the future of energy at the & Awards. The & Awards will honor Zay Zeidman, chairman of Houston First and managing partner of Altitude Ventures; The University of Houston's Renu Khator and Ramanan Krishnamoorti; Maryanne Maldonado, CEO of the World Affairs Council; and Fervo Energy co-founders Tim Latimer (CEO) and Jack Norbeck (CTO). The inaugural posthumous Lifetime Ambassador Award will honor former Houston Mayor Sylvester Turner, and this year’s Allies in Energy grant recipients will also be recognized. The evening will include a fireside chat, an immersive gallery, live music, passed hors d'oeuvres, Champagne and plenty of networking opportunities.

This event is Sunday, Sept. 13, from 6-9 p.m. at ARTECHOUSE Houston. Register here.

Sept. 14 — Brews on the Bayou

Head to Saint Arnold Brewery for a more laid-back kickoff event. Grab a beer and take in a live conversation with Paul Hobby, managing director of Genesis Park, and Katie Mehnert, CEO of The Bee Suite and co-founder of HECW. Rice University's Aaron Pomerantz will moderate the discussion. Then hear a live performance from AY Young.

This event is Monday, Sept. 14, from 6-9 p.m. at Saint Arnold Brewery. Register here.

Sept. 14–18 — Sip For Sustainability

Enjoy a signature cocktail at five H Town Restaurant Group spots each night of Houston Energy and Climate Week. A portion of every purchase will go toward Allies in Energy, which supports education, collaboration, and community programs that drive a more sustainable future. Participating eateries include Hugo's, Xochi, Uber, Zaranda and Caracol.

These events begin Monday, Sept. 14, from 3-5 p.m. Find more information on each day's happy hour here.

Sept. 15 — HTX Tech Tours

HECW will present two Tech Tours this year, offering attendees a closer look at the region's climatech scene. The Metro Innovation Tour & Market will visit Sugar Land Town Square, Shell Technology Center Houston, SLB West Houston Campus, University of Houston at Sugar Land, Ambrosia Space, NanoTech Materials and Syzygy Plasmonics. The Bay City South Innovation Tour will visit Sugar Land Town Square and Erthos Project Bravo in Matagorda County. Both tours will head to Astros Night at Daikin Park to wrap up the day.

These events are Tuesday, Sept. 15. Find more information here.

Sept. 15 — Meet the Activate Houston Cohort 2026 Fellows

Meet Activate's latest cohort, which was named this summer, and learn more about their hardtech and climate-focused solutions. Also meet founders from the organization’s 2025 cohort during Houston Energy and Climate Startup Week.

This event is Tuesday, Sept. 15, from 5-7 p.m. at the Ion. Register here.

Sept. 15 – Cypher Pilotathon and Startup Showcase

Grab coffee and take in keynotes and panels featuring leaders from Amperon, Aramco Ventures, New Climate Ventures, Syzygy Plasmonics and many others during this signature event, this year under the theme “The NEW Energy Industrial Revolution.” After lunch, hear pitches from 31 ventures during the Pilotathon. This year's event will also feature a startup showcase with interactive booths where attendees can meet founders and see demonstrations, plus an industry hub where corporates and investors can engage with emerging technologies and identify the pilots they want to move forward with.

This event is Tuesday, Sept. 15, from 9 a.m.-5 p.m. at POST Houston. Get tickets here.

Sept. 15 — Houston Astros Energy Night

Catch a game and chat with fellow clean energy enthusiasts during Houston Astros Energy Night. The 'Stros take on the Kansas City Royals. A bonus? Dollar Hot Dog Night at Daikin Park.

This event is Tuesday, Sept. 15, starting at 7:10 p.m. at Daikin Park. Get tickets here.

Sept. 16 — Greentown Labs Climatech Summit

Entrepreneurs, investors, corporate leaders, policymakers and philanthropists will head to Houston this month for the annual Greentown Climatetech Summit. Hear from Greentown CEO Georgina Campbell Flatter and keynote speaker Tim Latimer, CEO and co-founder of Houston geothermal unicorn Fervo Energy, plus numerous other engaging panels at the Ion. Then head to Greentown Labs for an open house and startup showcase, where attendees can meet some of the climatech incubators' members, before taking in the startup pitch competition followed by happy hour over at the Continental Club.

This event is Wednesday, Sept. 16, from 8 a.m.–9 p.m. at multiple locations. Register here.

Sept. 17 — Rice Alliance Energy Tech Venture Forum

Hear from clean energy startups from around the world at the 23rd annual Energy Tech Venture Forum. In addition to the pitches, this event will also host keynotes from Sean Maher, chief economist at Phillips 66, and Ira Ehrenpreis, founder and managing partner of DBL Partner. Panels will focus on technologies, infrastructure and commercialization strategies needed to deploy breakthrough innovations at scale. Following the event, the Rice Alliance will also name its annual “Most Promising” startup.

This event is Thursday, Sept. 17, from 7:30 a.m.-5 p.m. at Rice University’s Jones Graduate School of Business. Register here.

Sept. 18 — Halliburton Labs Finalists Pitch Day

Hear from Halliburton Labs' latest cohort of entrepreneurs. The incubator aims to advance the companies’ commercialization with support from Halliburton's network, facilities and financing opportunities. Its latest cohort includes one company from Texas.

This event is Friday, Sept. 18, from 8 a.m.-noon at The Ion. Register here.

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This article originally appeared on our sister site, EnergyCapitalHTX.com.

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A mix of public and private investors have funded Greentown Labs and its latest raise. Photo via GreentownLabs.com

Investors from Houston, Boston fuel Greentown with $4M commitment

seeing green

Greentown Labs, a climatetech incubator with locations in the Houston and Boston areas, has announced it has received funding from a mix of investors.

The $4 million in funding came from both of the Houston and Massachusetts locations. Houston investors included Bobby Tudor, CEO of Artemis Energy Partners and chairman of the Houston Energy Transition Initiative; David Baldwin, co-founder of OpenMinds and TEX-E and partner at SCF Partners; and Rice University. Other investors included MassDevelopment and the City of Somerville.

“The challenges of the energy transition are immense, and the role played by technology incubators like Greentown Labs is essential,” Tudor says in a news release. “We believe this role, which is a partnership between academia, industry, philanthropists, entrepreneurs, and governments, is the best way to get to effective, scalable solutions in a time frame that the urgency of the challenge requires. We need all hands on deck, and this partnership between Massachusetts and Texas can be a role model for others.”

According to Greentown, the funding will support its financial position and contribute to preparing the incubator for its next chapter of supporting its its leadership team prepare for Greentown’s next chapter supporting and growing its 575 startups.

“Greentown’s mission aligns closely with the Houston Energy Transition Initiative’s goal of accelerating global solutions to address the dual challenge of meeting growing energy demand globally while also significantly reducing CO2 emissions,” adds Steve Kean, president and CEO of the Greater Houston Partnership.

With the announcement of the funding, Greentown named its board members, including Tudor, who will serve as Greentown Labs Board Chair. The other Houston-based board members are:

  • David Baldwin, co-founder of OpenMinds and TEX-E; partner atSCF Partners
  • Bob Harvey, former president and CEO of GHP; board member of TEX-E
  • Jane Stricker, senior vice president of energy transition and executive director of HETI

“With this new funding, Greentown is poised to expand its impact across its existing ecosystems and support even more climatetech startups,” adds Kevin Dutt, interim CEO of Greentown Labs. “We believe in the essential role entrepreneurship will play in the energy transition and we’re grateful for the support of our partners who share in that belief and our collective commitment to commercializing these technologies as quickly and efficiently as possible.”

According to Greentown, the incubator plans to announce its new CEO in the coming months.

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This article originally ran on EnergyCapital.

Here's what student-founded startups are leaving CERAWeek with fresh funding. Photo courtesy of HETI

Houston clean tech startup pitch competition names winners at annual CERAWeek event

pitch perfect

For the third year, the Greater Houston Partnership's Houston Energy Transition Institute hosted its startup pitch competition at CERAWeek by S&P Global. A dozen startups walked away with recognition — and three some with cash prizes.

HETI joined partners Rice Alliance for Technology and Entrepreneurship and TEX-E for the 2024 Energy Venture Day and Pitch Competition at CERAWeek on Wednesday, March 20. Forty-two companies, which have collectively raised over $265 million in investment funding already, pitched to judges. Nine startups won awards across three tracks.

TEX-E, a Texas nonprofit that supports student-founded upstarts, had five of its companies pitch and three winners walked away with monetary prizes. Teams that competed in the TEX-E Prize track, many of which come from Houston universities, include:

  • AirMax, University of Texas at Austin
  • BeadBlocker, University of Houston
  • Carvis Energy Solutions, Texas A&M University
  • Coflux Purification, Rice University
  • Solidec, Rice University

Solidec, which is working on a platform to produce chemicals from captured carbon, won first place and $25,000. The company also recently scored a $100,000 grant from Rice's One Small Step Grant program, as well as a voucher from the DOE. Coflux Purification, which has a technology that destroys PFAS in filtration, won second place and$15,000. The company also secured a One Small Step Grant to the tune of $80,000. AirMax, which focuses on optimizing sustainability for air conditioning equipment, won third place and $10,000.

Last year, Houston-based Helix Earth Technologies took home the top TEX-E price and $25,000 cash awards. The venture, founded by Rawand Rasheed and Brad Husick from Rice University, developed high-speed, high-efficiency filter systems derived from technology originating at NASA.

The rest of the companies that pitched competed for non-monetary awards. Here's what companies won:

  • Group A (CCUS, oilfield solutions, analytics and minerals):
    • First place: Ardent
    • Second place: Vaulted Deep
    • Third place: Mitico
  • Group B (batteries, renewables, water, and grid technology):
    • First place: SungreenH2
    • Second place: FeX Energy
    • Third place: Mercurius Biorefining
  • Group C (Mobility, Materials, and hydrogen solutions)
    • First place: Thiozen
    • Second place: Power2Hydrogen
    • Third place: Arolytics
HETI, Rice Alliance, and TEX-E celebrated the winners at a private reception on Wednesday evening.
Here's what news trended on InnovationMap this week. Photo via Getty Images

5 most popular innovation stories in Houston this week

what's trending

Editor's note: Another week has come and gone, and it's time to round up the top headlines from the past few days. Trending Houston tech and startup news on InnovationMap included Houston being named a semifinalist by a NSF program, a tech company naming new execs, and more.


Houston named semifinalist for major energy transition funding opportunity

Houston is in the running to receive millions from a program from the National Science Foundation. Photo via Getty Images

The National Science Foundation announced 34 semifinalists for a regional innovation program that will deploy up to $160 million in federal funding over the next 10 years. Among the list of potential regions to receive this influx of capital is Houston.

The Greater Houston Partnership and the Houston Energy Transition Initiative developed the application for the NSF Regional Innovation Engine competition in collaboration with economic, civic, and educational leaders from across the city and five regional universities, including the University of Houston, The University of Texas at Austin, Texas Southern University, Rice University, and Texas A&M University.

The proposed project for Houston — called the Accelerating Carbon-Neutral Technologies and Policies for Energy Transition, or ACT, Engine — emphasizes developing sustainable and equitable opportunities for innovators and entrepreneurs while also pursuing sustainable and equitable energy access for all.

“The ACT Engine will leverage our diverse energy innovation ecosystem and talent, creating a true competitive advantage for existing and new energy companies across our region," says Jane Stricker, senior vice president of energy transition and executive director for HETI, in a statement. "Texas is leading the way in nearly every energy and energy transition solution, and this Engine can catalyze our region’s continued growth in low-carbon technology development and deployment." Read more.

4 Houston startups selected for preeminent medtech accelerator

A handful of Houston startups were selected for a national accelerator program. Photo via Getty Images

Four Houston startups have been selected for the 2023 cohort of the MedTech Innovator’s four-month accelerator program.

Los Angeles-based MedTech Innovator, which bills itself as the world’s largest medtech accelerator, will award $800,000 in funding to winners of its competitions throughout the 2023 program. The grand prize is $350,000.

Almost 1,200 startups applied to participate in this year’s accelerator. From that group, MedTech Innovator, its corporate partners, and more than 400 judges picked nearly 200 candidates for in-person pitching and partnering events. Sixty-one startups ultimately were chosen for the 2023 cohort, which kicks off June 14 and 15. Read more.

Houston startup addresses mother-daughter dynamic with first app of its kind

A Houston-founded company is targeting mothers and daughters with their teletherapy app. Photo courtesy of Passport Journeys

When Lacey Tezino’s mother died of cancer she vowed to help other mothers and daughters find their own ways to bond in beautiful, nurturing ways.

Tezino turned that vow into a mission that is now available for others to embark on with an online therapy app tailored specifically for the mother-daughter dynamic Passport Journeys.

The Houston-based company is billed as the first mother-daughter teletherapy application that stands out in a crowded market place on online therapy like Better Help. Tezino, the founder and CEO, partnered with seven Houston-based licensed behavioral health clinics to make the dream a reality. Read more.

Houston company crowned No. 1 large employer in Texas by Fortune Magazine, joining 21 local firms on list

These Houston employers reign supreme when it comes to the best workplaces. Photo by Scott Halleran/Getty Images

Houstonians looking for their next employment opportunity might want to consider these 22 Houston-based companies that were just named the best workplaces in Texas by Fortune Magazine and Great Place to Work.

David Weekley Homes was named the No. 1 large employer in Texas, with workers celebrating that their company goes "above and beyond in almost every way possible" and values trust more than anything else.

"They trust you to get your work done and you never feel guilty about having to leave early for a medical appointment, or to pick your kid up from school," the report says. "They trust you to get your work done while maintaining a normal personal life." Read more.

Houston tech company adds 3 members to its C-suite

Softeq has named three members to its executive team. Photos courtesy of Softeq

A tech development company has expanded its executive suite with three new additions to its team.

Softeq Development Corp. has hired Craig Ceccanti as COO, Albert Esser as chief delivery officer, and Edwin Lemus as chief people officer. The new hires' roles were effective as of June 1. The Houston company, founded in 1997, creates hardware and software solutions for its clients. Softeq also runs a venture fund and studio for startups from around the world.

“With the significant growth of our engineering services business plus the addition of our Venture Studio and $40 million Venture Fund, we saw an opportunity to welcome new leaders with global experience and fresh thinking to continue evolving our business and scaling for the future,” says Christopher A. Howard, founder and CEO of Softeq, in a news release. “This is a huge investment in our team, and with the addition of these three leaders to our C-suite we will centralize our global leadership team in Houston while providing support and expertise to our team across 22 countries and clients worldwide.” Read more.

Houston is in the running to receive millions from a program from the National Science Foundation. Photo via Getty Images

Houston named semifinalist for major energy transition funding opportunity

making moves

The National Science Foundation announced 34 semifinalists for a regional innovation program that will deploy up to $160 million in federal funding over the next 10 years. Among the list of potential regions to receive this influx of capital is Houston.

The Greater Houston Partnership and the Houston Energy Transition Initiative developed the application for the NSF Regional Innovation Engine competition in collaboration with economic, civic, and educational leaders from across the city and five regional universities, including the University of Houston, The University of Texas at Austin, Texas Southern University, Rice University, and Texas A&M University.

The proposed project for Houston — called the Accelerating Carbon-Neutral Technologies and Policies for Energy Transition, or ACT, Engine — emphasizes developing sustainable and equitable opportunities for innovators and entrepreneurs while also pursuing sustainable and equitable energy access for all.

“The ACT Engine will leverage our diverse energy innovation ecosystem and talent, creating a true competitive advantage for existing and new energy companies across our region," says Jane Stricker, senior vice president of energy transition and executive director for HETI, in a statement. "Texas is leading the way in nearly every energy and energy transition solution, and this Engine can catalyze our region’s continued growth in low-carbon technology development and deployment."

If Houston's proposal is selected as a finalist, it could receive up to $160 million over 10 years. The final list of NSF Engines awards is expected this fall, and, according to a release, each awardee will initially receiving about $15 million for the first two years.

"Each of these NSF Engines semifinalists represents an emerging hub of innovation and lends their talents and resources to form the fabric of NSF's vision to create opportunities everywhere and enable innovation anywhere," NSF Director Sethuraman Panchanathan says in a news release. "These teams will spring ideas, talent, pathways and resources to create vibrant innovation ecosystems all across our nation."

The NSF selected its 34 semifinalists from 188 original applicants, and the next step for Houston is a virtual site visit that will assess competitive advantages, budget and resource plans for R&D and workforce development, and the proposed leadership’s ability to mobilize plans into action over the first two years.

"Houston is poised, like no other city, to lead the energy transition. The ACT Engine presents a remarkable opportunity to not only leverage the region's unparalleled energy resources and expertise but also harness our can-do spirit. Houston has a proven track record of embracing challenges and finding innovative solutions,” says Renu Khator, president of the University of Houston, in the statement. “Through the collaborative efforts facilitated by the ACT Engine, I am confident that we can make significant strides towards creating a sustainable future that harmonizes economic growth, environmental protection and social equity."

NSF Engines will announce awards this fall after a round of in-person interviews of finalists named in July. With Houston's track record for building thriving industry hubs in energy, health care, aerospace, and the culinary arts, the region is eager to establish the next generation of leaders and dreamers responding to some of the greatest economic and societal challenges ever seen in America.

“Our energy innovation ecosystem is inclusive, dynamic, and fast growing," says Barbara Burger, energy transition adviser and former Chevron executive, in the release. "The ACT Engine has the potential to increase the amount of innovation coming into the ecosystem and the capabilities available to scale technologies needed in the energy transition. I am confident that the members of the ecosystem — incubators, accelerators, investors, universities, and corporates — are ready for the challenge that the ACT Engine will provide."

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This article originally ran on EnergyCapital.

EnergyCapitalHTX is now live and reporting on Houston's role in the energy transition. Photo via Getty Images

Gow Media's media platform launches to report on Houston energy transition news

it's go time

Houston's newest media platform has officially gone live.

EnergyCapitalHTX.com, originally announced in March, is now up and running. Houston-based Gow Media, a multi-platform media company and the parent company of InnovationMap, CultureMap, SportsMap, and ESPN Radio 97.5FM and 92.5FM, launched the site tonight at an event at Gow Media's office.

“We are excited to roll out our new outlet, EnergyCapitalHTX.com. We have been very impressed by Houston’s efforts to lead the global transition of energy and to address the 'dual challenge' of meeting the world’s growing demand for energy while at the same time reducing carbon emissions,” says David Gow, CEO of Gow Media.

“On our new site, we plan to provide informative, unbiased coverage of the Houston-based initiatives, spanning big corporations and startups," he continues. "We hope that a site dedicated to the transition will bring visibility to the city’s substantive progress and to the path forward.”

The site will cover Houston's energy transition ecosystem — the people, companies, capital sources, and numerous initiatives in Houston. Lindsey Ferrell serves as the inaugural editor of the site.

The site’s inaugural sponsor is HETI, which launched in 2021. Led by Executive Director Jane Stricker, HETI was founded to drive economic growth in the Houston area within the energy transition toward a lower carbon future.

“We are excited to support Gow Media with the launch EnergyCapitalHTX.com,” Stricker says in an earlier news release. "There is so much innovative and exciting activity in our ecosystem. Houston is the Energy Capital of the World, and this platform will amplify the energy leadership that is already happening here.”

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Houston college joins inaugural workforce accelerator supported by Google

hands-on training

Houston City College (HCC) is one of 15 community colleges from around the country to be selected for the first-ever Workforce Futures Accelerator.

The three-year effort is supported by Google.org, the tech company’s philanthropic arm, and led by the Association of Community College Trustees (ACCT), a non-profit educational organization that represents over 500 community, junior, and technical colleges. The accelerator focuses on helping colleges embed virtual, employer-sponsored training opportunities into short-term workforce training programs, giving participants access to opportunities that they might otherwise receive through internships or other "work-based learning" stints.

"The Workforce Futures Accelerator reflects the Houston City College mission of offering a high-quality, affordable education for workforce training and career development," Pretta VanDible Stallworth, HCC trustee and chair-elect of the ACCT board of directors, said in a news release. "Advancing student success and creating pathways to opportunities ensures that our students are well equipped to succeed and build a secure future in today's economy.”

Through the accelerator, HCC is tasked with fusing online project-based learning opportunities with its workforce education programs. The idea is to give students hands-on experiences working on projects sponsored by employers, allowing them to gain real-world knowledge in the process.

HCC will select two workforce programs that meet the accelerator’s criteria and insert into them into coursework. In the second and third year of the accelerator, the selected colleges are expected to scale the programs by adding instructors and programs to develop a network of to support their continued implementation.

“Participation by HCC will strengthen how we provide students with career-connected learning experiences that complement their classroom education and align with the needs of employers,” HCC Chancellor Margaret Ford Fisher added in the news release. “We are focused on ‘future forward’ strategies to meet the present and future needs of our region’s businesses.”

Two other Texas colleges were chosen to participate in the accelerator: Lamar Institute of Technology in Beaumont and Grayson College in Denison.

The remaining cohort includes:

  • Bergen Community College in Paramus, New Jersey
  • Central Louisiana Community College in Alexandria, Louisiana
  • Clark State College in Springfield, Ohio
  • Great Basin College in Elko, Nevada
  • Heartland Community College in Normal, Illinois
  • Hudson County Community College in Jersey City, New Jersey
  • Manchester Community College in Manchester, New Hampshire
  • Mesa Community College in Mesa, Arizona
  • Mohave College in Kingman, Arizona
  • San Joaquin Delta Community College in Stockton, California
  • San Juan College in Farmington, New Mexico
  • West Virginia University Parkersburg in Parkersburg, West Virginia

New report ranks Texas among top 10 states where AI could disrupt jobs

AI Workforce

A new nationwide report examining where AI could "reshape" the most jobs has ranked Texas No. 9 among the most at-risk states for AI job disruption.

The new SmartAsset report compared all 50 states and the District of Columbia to calculate the estimated percent of the workforce employed in the 26 occupations with the highest AI exposure, as determined by June 2026 research by the Virginia Economic Information and Analytics Division.

The findings revealed that 500,000 Texas workers, or 3.55 percent of the total workforce, are employed in occupations with "high exposure to potential AI disruption."

This also places the Lone Star State as the 9th most at-risk state in the U.S. where AI exposure can lead to "declining hiring demand, wage pressure, task automation, and other forms of disruption."

"States with larger concentrations of highly exposed occupations could experience more pronounced labor-market changes, particularly in roles where core tasks are more vulnerable to AI-driven restructuring," the report's author wrote.

Texas' biggest cities, like Houston and Austin, are known for their thriving tech and business industries, and the study noted that many of the occupations within those sectors are the most at risk. The Virginia Economic Information and Analytics Division said the top five most AI-exposed occupations in the U.S. are: mathematicians, proofreaders, correspondence clerks, court reporters, and media and communication workers. Additionally, computer programmers, database administrators, web developers, telephone operators, and communications equipment operators round out the top 10 most at-risk positions.

These are the 16 remaining occupations most exposed to AI disruption, in order:

  • Data Entry Keyers
  • Statistical Assistants
  • Office Support Workers
  • Interpreters and Translators
  • Database Architects
  • Software Quality Assurance Analysts
  • Medical Transcriptionists
  • Software Developers
  • Writers and Authors
  • Payroll Clerks
  • Web Designers
  • Miscellaneous Computer Occupations
  • Insurance Claims Processors
  • Telemarketers
  • Computer Numerically Controlled Tool Programmers
  • Bookkeeping and Accounting Clerks

A separate SmartAsset report from April 2026 found about 20.5 percent of Texas workers use AI to do their jobs in some capacity. That trend will continue to shift further as employers and employees choose to adopt — or reject — AI implementation.

Across the U.S., Washington topped the list as the state with the highest concentration of AI-exposed jobs, with nearly 5.7 percent of the state's workforce employed in the 26 most at-risk positions. SmartAsset said Washington's high prevalence of technology companies is a significant factor that skyrocketed the state to the top of the list.

"Home to major technology companies including Microsoft, Amazon, T-Mobile and Expedia, the state has large numbers of computer programmers and software developers, two occupations with high exposure," the report said.

Meanwhile, Mississippi ranked No. 51 with the lowest concentration of AI-exposed jobs in the nation. About 22,500 workers in Mississippi, or 1.93 percent of its workforce, are at risk for AI disruption.

The top 10 states where AI could reshape the most jobs are:

  • No. 1 – Washington
  • No. 2 – Virginia
  • No. 3 – District of Columbia
  • No. 4 – California
  • No. 5 – Utah
  • No. 6 – Maryland
  • No. 7 – Colorado
  • No. 8 – New Hampshire
  • No. 9 – Texas
  • No. 10 – North Carolina
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This article originally appeared on CultureMap.com.

UH lands $1.2M NIH grant to fight superbugs using AI, quantum sensing

drug defense

The fight against antibiotic-resistant bacteria like MRSA is getting science fiction-like upgrades at the University of Houston thanks to a new four-year, $1.26 million grant from the National Institutes of Health.

The university says the recent funding brings total federal support up to $3.5 million for 11 years for the project, which uses AI and quantum-sensing technology to better understand how bacterial proteins develop resistance to drugs.

Any medical professional will tell you that one of the worst things that can happen is almost killing an infection. Bacteria that survive attacks from conventional antibiotic treatments emerge tougher, more resistant and more aggressive than before–making them much harder to treat. A good example is the superbug methicillin-resistant Staphylococcus aureus (MRSA).

UH chemistry professors Yuhong Wang and Shoujun Xu are working on this issue. They know full well that fighting superbugs requires new technology and new approaches, which is what they aim to pioneer with their new grant.

“Drug-resistant bacterial infections such as MRSA are becoming harder to treat, creating an urgent need for faster ways to understand how antibiotics and other small molecules interact with bacterial proteins,” Wang said in a news release.

Wang and Xu’s work centers around GTP, a cellular fuel that can cause tiny changes to a cell's structure when it mutates. Sometimes, those shape changes make it easier for drugs to breach the wall and attack the cells.

The UH scientists are employing AlphaFold, an AI-powered tool that can scan large molecular libraries in seconds. From these models, they can see promising drug combinations for future testing.

Once identified, the team uses their invention, super-resolution force spectroscopy, to monitor the cells. Tiny magnetic beads are attached to genetic material, then magnified to see how strong that material is when pulled. They can measure this incredible microscopic process through an atomic magnetometer, typically used in quantum physics. Combined, all these tools allow a high-definition look at how each molecule might respond to new chemical approaches.

“We're the only chemists in the world that use an atomic magnetometer for biological research,” Xu said. “It's a technique developed by physicists, and there is usually a gap between techniques developed by physicists and biological applications. Yuhong and I have been bridging that gap together for the past 10 years.”

Eventually, Wang and Xu hope to develop powerful software that can be used by drug manufacturers to model cellular responses. With enough predictive data, the software could even get ahead of superbugs’ own mutation, allowing drugs to be developed before new strains arrive.

"We want an algorithm where you input a protein sequence, score the mutation hotspots, and develop new inhibitors before a drug-resistant species even emerges," Wang added.

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