Houston innovator breaks down industry silos with new bp, NASA partnership

houston innovators podcast episode 252

Ken Nguyen, principal technical program manager at bp, joins the Houston Innovators Podcast to discuss the company's new partnership with NASA. Photo courtesy of bp

The recently announced partnership between bp and NASA is a match made in Houston. The energy giant, which as its United States headquarters in Houston, entered into a Space Act Agreement with NASA to combine resources and efforts with innovation in mind.

"Houston has always been known as the Space City, and we're also known as the Energy Capital of the World, but there hasn't always been collaboration," Ken Nguyen, principal technical program manager at bp, says on the Houston Innovators Podcast. "The challenges that NASA is facing is very similar to the challenges that the oil industry faces — we operate in very harsh environments, safety is the most critical aspect of our operation, and now the economic business model for NASA has changed."

Nguyen explains that while both bp and NASA are navigating similar challenges and changes within their industry, they are going about it in different ways. That's where the opportunity to collaborate comes in.

The partnership, which is still new and not fully fleshed out, will look at collaborative innovation into a few focus areas to start out with, including hydrogen storage and development, AI and general intelligence, robotics, and remote operations

"Houston continues to excel — in energy production and in space exploration — but by coming together," Nguyen says, "and for us to be able to tap into (NASA's) knowledge is tremendous. And we, within oil and gas, have a unique set of skills to blend into that with the hopes being that the city becomes this incubator for technology. The potential is there."

Nguyen oversees the implementation of new technologies at bp, and that includes software and hardtech, from cybersecurity to the digitization of the industry, which is an integral part of bp's energy transition plan, Nguyen says on the show.

"For bp, we do feel like as we transition as an international oil and gas company into an integrated energy company and we lean into the energy transition, the adoption of new technology is a critical part of making that viable for the planet and for the company," he says.

According to Nguyen, bp has invested its resources into exploring energy transition technologies like electric vehicle charging — including opening a fast-charging station at its Houston office — and renewable energy, including a solar farm about 10 miles northeast of Corpus Christi.

Another technology bp is keen on is digital twin technology, which can be crucial for enhancing safety for bp personnel and reducing emissions.

Nguyen says digital twin technology "allows us to be able to design and mirror scenarios with real-time variables, such as weather, off-take demands, and volatility."

Activate's application is live from now through October 23, and all founders of early-stage, research-backed hardtech companies in Houston are encouraged to apply. Photo via Getty Images

Hardtech-focused fellowship opens applications for 2025 Houston cohort

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Applications are officially open for a Activate's second Houston cohort.

Activate's application is live from now through October 23, and all founders of early-stage, research-backed hardtech companies in Houston are encouraged to apply. The Berkley, California-based program launched in Houston last year and recently named its inaugural Houston cohort.

“The Activate Fellowship provides an opportunity for approximately 50 scientists and engineers annually to transform into entrepreneurial leaders, derisk their technologies, define first markets, build teams, and secure follow-on funding,” says Activate’s executive managing director, Aimee Rose, in a news release. “With an average 30 percent annual growth in applications since 2015, we know there is high demand for what we do, and we’re excited to see the talent and impactful ideas that come through the pipeline this year.

The program, led locally by Houston Managing Director Jeremy Pitts, has 249 current Activate fellows and alumni that have collectively raised over $2.4 billion in public and private funding since the organization was founded in 2015.

“The success of Activate Fellows is ample evidence that scientists and engineers have the talent and drive to face global challenges head-on,” adds Activate chief fellowship officer, Brenna Teigler. “Our diverse fellows are transforming technical breakthroughs into businesses across the United States in 26 states across a range of sectors spanning carbon management, semiconductors, manufacturing, energy, chemicals, ocean tech, and more.”

The application is available online, and fellows will be selected in April of next year. The 2025 program will begin in June.

Activate is looking for local and regional early-stage founders — who have raised less than $2 million in funding — who are working on high-impact technology. Each cohort consists of 10 fellows that join the program for two years. The fellows receive a living stipend, connections from Activate's robust network of mentors, and access to a curriculum specific to the program.

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This article originally ran on EnergyCapital.

Wogbe Ofori, founder and chief strategist of WRX Companies, joins the Houston Innovators Podcast to discuss hardtech and Houston as an innovative city. Photo via LinkedIn

Hardtech startup adviser on mentorship, Houston's past and future as an innovation hub

HOUSTON INNOVATORS PODCAST EPISODE 211

To Wogbe Ofori, the definition of entrepreneurship is simple: "To be more opportunity centric than risk averse." And Houston, as he says, has be entrepreneurial for a very long time — despite it being considered the specialty of a certain coastal region.

"Silicon Valley has hijacked the concept of innovation and entrepreneurship, and this city has been filled with entrepreneurs long before the concept of 'tech entrepreneurs,'" Ofori says on this week's episode of the Houston Innovators Podcast.

Ofori, the founder and chief strategist of WRX Companies, has developed a keen eye for entrepreneurship and innovation activity in Houston and shares his observations on the show. An adviser to Nauticus Robotics and strategist to Intuitive Machines and Jacobs, he's also served as a mentor across the local innovation community.

In fact, on the episode, he explains what makes a good mentor for founders in tech. Ofori says he specializes in helping entrepreneurs see around corners and think things through, make wise decisions, and get things done.

"It starts with an ability to listen," Ofori says of advisers and mentors. "One of the keys to my advisory practice is to not only listen but reframe and ask a lot of questions."

"What differentiates this from therapy — and sometimes the line can be fine," he continues, "is that as a mentor or adviser in the context of commerce, is you're always thinking about it toward a transaction in the marketplace."

As he's spent a lot of time working with hardtech founders, Ofori has observed a momentum within energy transition innovation — specifically Houston's role in it.

"It's difficult for an incumbent to disrupt itself. We’ve been positioning ourselves as moving from the energy capital of the world to the energy transition capital," he says. "Now we are just at the place where we're really going to start to see the difference between those who were caught up in the excitement of the energy transition, and those who really have the faith to see this thing through."

Activate announced Cyrus Wadia as its new CEO and opened its 2024 applications. Photo courtesy of Activate

New-to-Houston hardtech accelerator names new CEO, opens applications

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A national organization that helps accelerate scientists into entrepreneurs has named its new CEO in the same week that applications opened for its 2024 cohort.

This week, Activate announced Cyrus Wadia as CEO of the organization. Based California, Activate recently expanded to Houston. The two-year accelerator provides funding and support for its selected cohorts.

Wadia most recently served as director of worldwide product sustainability at Amazon. He also oversaw sustainable business and innovation at Nike and was appointed assistant director of clean energy and materials R&D at the White House Office of Science and Technology Policy under President Barack Obama.

"I’m thrilled to join this incredible team at such an exciting moment for the organization. Because of Activate, scientists are designing new products, accelerating the creation of new businesses, and becoming leaders who will transform our future," Wadia says in the news release. "I look forward to building on this momentum to expand the role science leadership plays in solving society’s most pressing issues.”

Wadia’s new role takes effect on October 16. Todd Johnson has served as interim CEO for the past year, and he will return to his role on Activate’s board of directors with the transition. The program's led locally by Jeremy Pitts, managing director for Activate Houston, who was named to the role last month.

The announcement came just a few days before Activate opened applications for its 2024 program — which will be the first year to have a Houston cohort. Applications are open until October 17 across Activate's five programs. The two-year, hardtech-focused program was founded in Berkeley, California, in 2015 and expanded to Boston and New York before launching its virtual program, Activate Anywhere.

“Activate’s recruitment process is crucial, as it centers around finding scientists directly interested in solving urgent problems,” Pitts says. “Activate fellows are turning their technical breakthroughs into businesses that can help industries like manufacturing, energy, chemicals, computing, and agriculture, to meet their decarbonization and resiliency goals.”

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A version of this article originally ran on EnergyCapitalHTX.

Square Robot's Houston office has the ability to showcase the technology to its potential customers. Photo courtesy of Square Robot

Boston-based tech company grows Houston team to deliver robotics to energy industry

do the robot

The robots are coming. Although the rise of Chat GPT has frightened plenty of professionals, we’re not on the precipice of the singularity just yet. And some of Houston’s coolest robots are contained in above-ground tanks, simply doing jobs that are too expensive and difficult for humans. The mechanical helpers in question come courtesy of Square Robot.

Square Robot co-founder and chief technology officer Jerome Vaganay started the company in 2016 in Boston. The company opened its Houston office in August of 2019.

“A lot of our partners and client base is out of here,” says director of operations, Matt Crist.

Karishma Prasad, director of technical operations, who joined the team in Houston earlier this year, adds “It’s a great centralized place for us. Houston is a great hub both nationally and internationally. There is so much energy transition innovation happening here.”

Square Robot is indeed a robotics company, but it trades in a very specific type of robot. The SR-1 is an innovative tank inspector.

“Since the ‘60s there’s been a traditional way of going into a tank. People would go inside and clean it with a variety of products," Crist explains. "Once it was clean, they would come in and inspect it repair it and that could take months.”

In fact, it could often cause a 15 or 16-week outage, he says.

Square Robot’s brainstorm was to take the human element out of the process. In other words, robots can do the job more safely, efficiently and quickly than a human ever could by collecting 18,000 data points per square foot, while allowing the product — most often diesel — to stay in the tank.

Square Robot saves those vast weeks of time, but perhaps even more importantly, says Prasad, “We’re avoiding emissions being released into the atmosphere.”

With its key location in Houston, Square Robot has worked with most of the major names in the energy world, including ExxonMobil, Chevron, BP, and Crist’s former employer, Phillips 66.

The latest robot is the SR-3, which is currently being tested in Houston. Curious webwatchers can see its progress on Square Robot’s website. Unlike the flagship SR-1, the new robot boasts a side launcher that allows it to be completely immersed in a tank before being launched.

But perhaps the most exciting thing about Square Robot’s 15-human Houston office is its test tank. There, potential partners can see exactly what the company’s ingenious creation can do. Square Robot will participate in ILTA, the International Operating Conference & Trade Show, which takes place from May 21-24. On the 24th, the company will host an open house from noon to 3 p.m. to allow potential users to see the SR-3 in action in the 42-foot-long test tank.

Square Robot will complete its hundredth tank inspection in May. It is also growing beyond the oil and gas world to include work with the power industry and was recently selected as a finalist in the Incubatenergy Lab Start Up program. This is one robot that we will happily allow to take over formerly all-too-human responsibilities.

Square Robot has a team of 15 in Houston. Photo courtesy of Square Robot

Houston-based Nauticus Robotics founder, Nicolaus Radford, shares the latest from his company and why we're primed for a hardtech movement. Image via LinkedIn

Houston innovator shares difficult journey to IPO, the challenges of hardtech innovation, and more

Q&A

It's been a busy past year or so for Nicolaus Radford, founder and CEO of Nauticus Robotics. He's taken his company public at a difficult time for the market, launched new partnerships with the United States Marine Corps, and even welcomed a new family member.

Originally founded in 2014 as Houston Mechatronics, Nauticus Robotics has designed a fleet of underwater robots and a software platform for autonomous operations. Radford caught up with InnovationMap about these recent milestones for him and the company in an interview.

InnovationMap: Tell me about life after IPO. What’s been surprising for you leading your company through the transition and now on the other side of IPO?

Nicolaus Radford: I'll tell you what, it’s the hardest thing I ever did in my professional career by a factor of 10. Everybody finds their red line once or twice in their career. You know, when you're working 100 hours a week, you're going to bed at 2 am, you're waking up at 6:30 am, you're sleeping three hours a night, right? Everybody's found that moment once in a while and you're like, “okay, I've touched my red line and I would never want to do that again.” This was I knew where my red line was, and I went so far beyond it, I couldn't even see where I thought my red line was. It was a very exceptionally challenging period of time. It took a long to complete the transaction, and the market was just changing under our feet. Rules were and regulations were changing — were we grandfathered in or were we not?

I'm part of some business organizations and, and some of those confidential relationships have turned into friendships. And a couple of them call me and they're like, “we're really worried. We think this is going to be we don't know if you're going to get it done. And we just want you to be aware that you're not you may not get it done.” It is a little scary because once you engage in it, you're running quite a tab with bankers and law firms and all sorts of things. And if you don't complete the deal, it just might kill the company. But we did it. We were one of a few people last year to actually get a deal over the line. I'm very proud of that. I think it speaks to the quality of the deal that we had. The macro economic environment was exceptionally difficult. It remains to be very difficult today. But we had strong backing from our strategic investors and our partners that were already on the cap table. They put a tremendous amount of money into the deal.

You know, I look back on it and it's, you know, ringing the Nasdaq bell when we listed, and giving that speech at the podium — it was a surreal moment. I remember when I was standing there looking at the Nauticus logo on the seven-story Nasdaq tower, having as many people in the company as we could bring, and just sharing that moment with all of them, especially my wife, who, I will be very clear about this, I could not have gotten through this moment without her. She is the rock that keeps our family together and my head straight. A little known fact — we had a newborn during this time as well, so that was also very difficult. And and she just handled so much that there's just not another person like her.

I was excited but cautious at the same time. I mean, the life of a CEO of a public company at large, it's all about the process following a process, the regulations, the administration of the public company, the filings, the reportings — it can feel daunting. I have to rise to the occasion to tackle that in this the next stage of the company.

IM: You’re working with the military on a project that adapts Nauticus’s tech for Marine Corps use. What’s it been like working with the military on this project?

NR: We've probably worked with military interests for the last six years, but all of the things that we have been doing have been extremely confidential and hush. Now we've been able to work with customers that have a stronger public facing persona, and the Defense Innovation Unit is one of those. Their charter is it's quite literally looking for commercial technology and adapting that towards military applications, and so it's been nice to be able to show the utility and the application of of a lot of our technology and what we've been working on for so long as it's applied on a broader scale to the big services, whether it's the Navy or the Marine Corps. Both of the programs we’re working on are all about mine countermeasures, and mines are really, really difficult, especially underwater mines. We've been we've been applying all of Nauticus’s broad technology portfolio to being able to search autonomously and being able to identify and neutralize threats in the water. I love that mission because anytime we can remove our service men and women from these situations, that's just the right thing to do. There are those three universal truths — all babies are cute, all puppies are huggable, and all Canadians are nice. But there's a fourth one — nobody wants to defuse an underwater bomb. And so I'm really happy to be working on robotics technologies where that's the case.

IM: The Ion recently announced Nauticus as a new tenant. What’s the strategy behind creating a footprint there?

NR: We've signed the definitive documents with the Ion about our presence there. We’ve been designing it for a while, and now we're starting to build it out. They're giving us temporary space, so we're going to be immediately there. Nauticus was really born from this connection to spaceflight. We started up Nauticus around NASA, and there's an incredible amount of talent here. And people tend to change jobs sometimes, so we were attracting a lot of talent from NASA. Now that NASA has solidified their mission and what they're doing and gained a little traction, we wanted to have more draw from the universities being up in town. Clear Lake, even though we have water access and it's much closer to Galveston where we test a lot, we wanted to be up in town. So, we're creating a bit of an innovation center. There's a lot more collisions downtown with customers and talent, it just made sense that we had to be there. And because we support the city of Houston so much and what they're doing for the startup community and early stage companies like ourselves that, we want to support that.

IM: How would you describe the state of the hardtech sector?

NR: We still need improvement by far. Hardtech companies are still viewed as a bad investment. We're always going out to investor events, and I remember this one investor came up to me and asked me to tell him a little bit about my company. The second he got into the essence of what we do and sussed out that obviously we are not just a software company, he just goes full stop. “Hey, listen, you know, our investment thesis is we only invest in software companies.” I had just kind of had it and I sort of shot back at him and I just said, “that's a rather that's a rather dumb value proposition and pretty shortsighted.” And we parted ways. It just irritates me that that's this is most of everybody's comeback. Like, they're a special class because they only invest in software companies.

I'm sure you've heard of ChatGPT and how that's going to alter the world forever. Now is probably a really shitty time to be a software developer, and I think it's going to place an extra emphasis and value on hard tech companies because I haven't seen ChatGPT run a run a milling machine yet break a piece of metal on a machine or assemble a circuit board. I love that now the position of companies like ours that are in the robotics space where you take this multidisciplinary blend of hardware, software, and electronics toward an application, because I think that is going to start becoming a premium value.

Software companies tend to attract more equity investment because people have this idea that the scaling costs and the startup costs are lower. Anyone with a keyboard can get online, create a website, and have an e-commerce business. Turns out, that because that’s true, there’s a million out there. What I love about a hardtech company that if you get it right, the cost of trying to compete with that company that figured it out is so high that the negative now begins the benefit. A fast follower is almost impossible.

The VC community sprung up in a post World War II world to help fund the commercialization of the computer and silicon — that's kind of what it originated from. I mean, there was not an investment vehicle that companies that were developing technology in this space could go to and get a loan, couldn't go to the bank. The venture capital world developed to help spawn hard tech investments. And, I hate to break it to you, but one of the most valuable companies in the world was a hard tech company: Tesla. This is a physical world. And I believe the last 50 years were absolutely characterized by the ubiquitous manipulation of the virtual world, but the next 50 years are going to be characterized by the ubiquitous manipulation of the physical world. And that's where we're at.

IM: What’s next for Nauticus?

NR: What’s next is tough to talk about, because I can only talk about what’s already been published. I see Nauticus being the preeminent ocean robotics company. I want Nauticus to be an empire. It starts small but it grows — and it grows in many different ways, and we’re exploring all of those different ways to grow. We’re leading a technology renaissance in the marine space — and that happens only a few times in an industry.

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This conversation has been edited for brevity and clarity.

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Houston researchers develop dissolvable implant for targeted cancer drug delivery

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Researchers at Houston Methodist have developed a biodegradable implant that can be used to safely and consistently deliver drug treatments to tumors and then dissolve without the need for further surgery.

The implant is only the size of a grain of rice, but its potential is staggering. The biodegradable nanofibrous drug-eluting seed (b-NDES) works as a reservoir parked inside a soft tumor, where it can slowly release immune-stimulating drugs over time. This overcomes a consistent problem with drugs such as immune checkpoint inhibitors. Normal systemic administration sees comparatively little of the drug making its way to the tumor, with most of it circulating throughout the body. The b-NDES is like deploying a small guerrilla fighting force embedded in enemy territory, doing maximum damage to the entrenched tumor.

"To improve cancer treatment, we're trying to start a fire inside the tumor itself," Corrine Chua, associate professor in the Center for BioNanoengineering at Houston Methodist Research Institute, said in a news release. "By activating immune cells directly within the tumor microenvironment, those cells can then travel throughout the body and seek out cancer wherever it exists. The b-NDES platform was developed to help keep therapeutic drugs concentrated inside tumors while minimizing exposure to healthy tissues.”

Chua co-led the study with Alessandro Grattoni, chair and director of the Center for BioNanoengineering at Houston Methodist Research Institute.

The study included support from the Nancy Owens Breast Cancer Foundation and the National Institutes of Health/National Cancer Institute.

Chau and Grattoni used preclinical models of triple-negative breast cancer, an aggressive form of cancer that is estrogen receptor-negative, progesterone receptor-negative and HER2-negative. Because of the receptor negativity, some popular treatments like tamoxifen and trastuzumab are ineffective. Chemotherapy has been shown to be the best course of action.

The b-NDES implant is deployed alongside radiation drugs. It keeps the drugs focused on the tumor, reducing the amount of harmful side effects typically seen when drugs are circulated more widely in the body. In 60 percent of the models, tumors were eliminated and did not cause side effects beyond the tumor site. Once the drugs have been deployed, the implant breaks down naturally.

While promising, more research will have to be done to expand use to other tumor types.

"Although the study focused on triple-negative breast cancer models, the approach could have broader applications for solid tumors," Grattoni added in the release. "It could potentially be used in cancers where there is a tumor lesion accessible for placement, including pancreatic or lung cancers."

New Houston platform Same Day Reels launches for on-demand content creation

In The Moment

If an event doesn't happen on Instagram, did it even really happen? In today's social media-driven age of branding and audience engagement, the answer increasingly is no.

Houston entrepreneur Karen De Amat is looking to fill the online content creation needs of companies with her new venture, Same Day Reels, which launched in early August. It will serve as a platform to connect companies and brands with talent that can help turn an event into a viral moment as it is happening.

"Events move quickly, and social media moves even faster,” said De Amat. “Same Day Reels was built to help brands capture the moment while it still matters. We are creating a more efficient way for businesses and creators to work together. Brands need content faster, and creators need more opportunities to turn their talent into real work. Same Day Reels brings those needs together.”

The company is focused on adding livestreams and concurrent short video content to "activations, launches, fundraisers, grand openings, conferences, hospitality experiences, and private celebrations." Such content can significantly increase the visibility of a product or brand according to digital marketing brands like Wyzowl, whose data found 63 percent of people in 2026 prefer to learn about new products via short video.

Packages offered by Same Day Reels will include filming, editing, and publishing content within hours of the targeted event.

De Amat says that her content creation platform will be a way to preserve the excitement of events and launches by enshrining them with immediate social media-driven memories.

“Event content is no longer just something you post after the fact,” De Amat said. “It is part of how people experience, remember and share the moment.”

Previously, De Amat is also the founder and CEO of Social Behavior, an influencer marketing company she launched from her home in 2014. It quickly garnered an array of clients and thrust De Amat into the spotlight, including numerous appearances on Fox 26's The Isiah Factor. Influencer Marketing Hub named her one of the top CEOs of influencer marketing companies in Houston in 2025.

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This article originally appeared on CultureMap.com.

Bristol Myers Squibb to build $2.3B Houston pharma manufacturing campus

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New Jersey-based pharmaceutical giant Bristol Myers Squibb Co. has officially named Houston as the home of its new state-of-the-art manufacturing site.

The 60,000-square-foot facility represents a $2.3 billion investment, according to a news release. It is expected to create 500 skilled jobs and will be located in Houston's Generation Park.

BMS first announced that it was considering Houston among 16 other cities for the facility in May. The new hub will manufacture small molecule, biologic and antibody-drug conjugates and is part of a $40 billion commitment to invest in the United States over five years. Construction is slated to begin next year, with the facility coming online in 2030.

"We're building the domestic manufacturing capabilities needed to deliver the next generation of medicines and support future scientific breakthroughs. Houston and the state of Texas offer the talent, infrastructure, and partnership needed to help bring that vision to life," Christopher Boerner, CEO and board chair of BMS, said in the release.

The new facility will feature a modular, multi-modal design, which will allow the company to reconfigure and add to its manufacturing capabilities over time. BMS says it expects the facility to "(grow) in scale and capability well beyond its opening configuration."

"Our decision to build this state-of-the-art manufacturing campus in Houston, Texas, reflects our confidence in the region’s ability to support a world-class, digitally advanced supply operation,” Karin Shanahan, EVP and chief supply chain and operations officer of BMS, added in the release. “This facility is designed to deliver the speed, quality, and reliability that patients depend on, combining flexible, modular manufacturing with advanced digital capabilities to ensure consistent supply across multiple modalities. It strengthens our ability to operate with resilience and positions us to reliably deliver medicines to patients today while adapting future demands.”

Texas Gov. Greg Abbott shared that the state has granted BMS a $4.89 million Texas Enterprise Fund (TEF) grant for the project. TEF grants, administered by the Texas Economic Development & Tourism Office, support business relocation or expansion projects that create "new, good-paying jobs in the community and attract significant new capital investment to the state." The development is also a qualified project under the Texas Jobs, Energy, Technology, and Innovation (JETI) program.

“Texas is a global hub for life sciences, where today’s innovations shape the future of healthcare,” Abbott said in a news release. “This $2.3 billion investment by Bristol Myers Squibb in the dynamic biotech ecosystem in Houston is a testament to the depth of our skilled workforce and the pipeline of talent coming through our nation-leading technical colleges and research universities. With lower operating costs and easy access to markets across the U.S. and the world, Texas drives affordability for consumers.”

"Bristol Myers Squibb’s announcement is a tremendous win for Texas and the Houston region, further reinforcing our position as a premier destination for life sciences and advanced manufacturing,” added Greater Houston Partnership President and CEO Steve Kean.

Last fall, Eli Lilly and Co. selected Generation Park, a 4,300-acre, master-planned commercial district near Lake Houston, for its $6.5 billion manufacturing plant. More than 300 locations in the U.S. competed for the factory. Read more here.

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