Houston expert: Balancing flexibility, accountability, and performance in a hybrid world

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Accountability in the remote work environment goes both ways, and leaders must model the behaviors they expect from employees. Photo via Getty Images

Amazon, Salesforce, and Nike are just a few companies making headlines in 2024 for requiring employees to return to the office.

At the same time, technology is evolving, automation and efficiency gains are taking center stage, and employees continue to seek greater flexibility. This has fueled the debate around the future of where work gets done in 2025 and beyond.

Proponents of a remote or hybrid work model believe it leads to increased employee productivity, higher job satisfaction, and access to a larger talent pool. Detractors have a different viewpoint – suggesting employee isolation is greater, cyber security concerns are more complex to manage, and it’s hard to accurately evaluate employee performance.

So, what’s the answer?

The future of work lies in harnessing the power of the employer/employee relationship. This involves establishing clear guidelines for what working “looks like” inside and outside the company, measuring performance tied to company goals, and holding leaders and employees accountable for how these interactions occur.

A remote work policy helps establish clear guidelines. For example, should business cameras be on for all meetings? What is considered an acceptable business casual dress code? Can pets be on screen? Addressing the issues around a remote workspace, how to interact during a meeting, and what to wear helps to define company expectations and how you would like your business to be represented.

Formal performance management tools and processes have been in place for decades. While an annual event is important, encouraging managers and employees to have regular and structured performance conversations and share transparent feedback (regardless of where they work) helps you celebrate what’s exceptionally good, acknowledge what’s on track, and quickly course correct when needed.

Accountability in the remote work environment goes both ways, and leaders must model the behaviors they expect from employees. When the rule is cameras on, that means everyone, regardless of their title. When you’ve established working hours, be available to take the call or respond to the Teams chat within a reasonable timeframe. And when you need to be away from work, set expectations for when and how to reach you.

So, where is the best place to start when updating or establishing guidelines? First, review your key business objectives and work out what’s required to support the successful achievement of those goals. Design your remote and/or hybrid model around those objectives and place employees at the forefront of that design.

If you think about it, it’s no different than being in the office. You expect your employees and managers to show up, be fully present, and hold themselves accountable. That should be the expectation no matter where you “sit.”

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Michelle Mikesell is the chief people officer at Houston-based G&A Partners.

Evolving workplace will challenge businesses to adapt in 2023, says this expert. Photo via Getty Images

Expert shares 5 workplace trends for Houston businesses in 2023

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Today’s workplace is undergoing rapid change in the post-pandemic world. For businesses, modifying their core infrastructure to adapt will be a challenge heading into 2023, and human resources professionals will be at the center of helping employers successfully navigate the transformation.

The top trends our HR experts expect to unfold in 2023 range from managing data protection, maintaining compliance with complex regulations, boosting employee engagement, and creating a sustainable model to support workplace flexibility.

Protecting privacy in HR systems

New privacy laws and requirements will take effect in five states in 2023, and several other states and the federal government are considering privacy-related bills. Businesses will be watching California closely as the California Privacy Rights Act that goes into effect Jan. 1, 2023, becomes the first to grant privacy rights to employees.

The act grants employees and job applicants who work in California certain rights regarding the personal information companies collect from them. Employers must also provide privacy notices when that information is being collected.

The CPRA will force companies to evaluate whether their systems are configured for data mapping – the process of knowing what data you’re collecting and how it’s being processed – so they can effectively and efficiently respond to employees’ requests under CPRA. Privacy management tools or plug-ins may also be necessary to help businesses fulfill rights requests.

While Texas’ current privacy laws aren’t as stringent as the CPRA, HR professionals will be watching how CPRA impacts companies. Similar legislation could pass in the coming years, and businesses and HR teams can prepare by investing in agile and flexible systems, allowing for adaptability when new requirements are introduced.

Maintaining compliance with complex regulations

The pandemic and underlying labor concerns that have been lingering for years have driven significant workplace change, such as rights and protections related to paid leave, minimum wage, and salary.

Staying up-to-date on laws and regulations governing employment practices, how employees are treated, and working conditions requires significant time and attention for businesses. Yet, for companies that aren’t compliant, the consequences can result in fines, lawsuits, and claims.

For small and mid-sized businesses, partnering with an employment lawyer or HR outsourcing provider can help you understand what requirements impact your business so you can ensure you’re compliant. HR professionals can then develop and enforce policies that help protect your workplace.

Boosting employee engagement

Nearly 100 million American workers quit their jobs during the “Great Resignation.” Now employers are facing a new challenge: low levels of employee engagement, also known as “Quiet Quitting.” A lack of employee engagement and dissatisfaction with pay are likely two key components driving this trend.

To reverse the trend, businesses and HR professionals should ask employees what they want through surveys or stay interviews, then analyze strategies that have not worked in recent years. Consider incentives outside of pay, such as retention bonuses or additional paid time-off. Then ensure your managers are equipped to lead, coach, and mentor their team members.

Refocusing recruiting, onboarding, and retention efforts can also help boost engagement. Turnover is costly, so invest time and resources in retaining employees you have. But when it’s time to hire, HR professionals should implement a comprehensive onboarding program that gives new employees resources and support to succeed early in their role.

Integrating flexibility with organizational structure

In a recent survey by Ogletree Deakins, 72 percent of company leaders reported that, since the pandemic, their employees’ desire for remote work is stronger. That’s prompted many companies to consider making remote work a permanent option.

Businesses should determine whether an in-office, hybrid, or fully remote workforce is best long term, then HR departments should develop and implement policies, procedures, and support that employees need to thrive in that environment.

For companies hesitant to commit to a hybrid workplace, discuss with company leaders what the impact on company culture will be and determine if a tailored approach could work. If an in-office strategy is best, be transparent in communicating the reasons with your employees.

HR’s role in helping companies grow and thrive

HR professionals will shoulder much of the responsibility in this workplace transformation. From developing policies and procedures to facilitating change to overseeing compliance and safety efforts, HR teams will be critical to how well businesses navigate the evolving workplace.

For small and mid-sized businesses, HR outsourcing services can fill the gap with expertise and competitive benefits that help attract and retain talent or by managing day-to-day tasks such as payroll, allowing your HR team to devote its time to more strategic initiatives.

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Arielle Carver is an HR adviser with G&A Partners.

From startups to global corporations — here's what you need to know about paying remote workers. Photo via Getty Images

Houston expert: Weighing the pros and cons of how to pay remote workers

Guest column

In the years leading up to the COVID-19 pandemic, the U.S. job market saw a steady increase in hybrid and remote work opportunities. The mass adoption, however, of a more “flexible workplace” — and the teleconferencing technologies necessary to make it a widespread option — was not yet commonplace. And in many industries, the idea of offering employees the ability to work from home several days a week — or more — brought up concerns over loss of productivity and loss of control.

Although the tech industry was more open to the idea of hybrid and remote work (and offered the option to a growing number of employees) — it wasn’t until pandemic lockdowns sent millions of workers home in early 2020, that the landscape of the American workplace, as a whole, changed forever.

For those workers whose positions allowed them to work from home, there were challenges related to balancing remote work with remote learning and overcoming Wi-Fi and teleconferencing glitches.

To minimize the time necessary to adapt to a whole new way of doing business, tech companies stepped in — utilizing their innovation to power hybrid work spaces and provide applications and other means to facilitate virtual collaboration and solve network connectivity and security concerns.

As employees — in tech and other industries — adapted to the “new normal,” a few things became clear:

  • Productivity — in many cases — increased
  • Hybrid and remote work option are viable for the long term
  • Employees value flexibility (in many cases, they value it over a higher salary)
  • Remote work offered up a whole new world of opportunities — no matter where you live or where your business is located

For employees and employers alike, hybrid/remote work broke down geographic barriers — allowing tech companies to hire qualified talent anywhere in the world and providing employees with the ability to relocate to hometowns that offer lower living expenses, a better quality of life, or the opportunity to be closer to family in other cities or states.

This new geographic freedom also brought up a very important question — especially for tech companies based in regions with a high cost of living:

As we open job opportunities up to remote workers across the country, do we pay employees based on their location (cost of living) or the job description?

According to an April 2022 article in Fast Company, “Several large tech companies, including Meta and Google, announced that employees moving to cities with a lower cost of living would be taking a pay cut. For instance, Google employees moving to cheaper cities or outside of the office hub could see a cut—as high as 25 percent —in their compensation.”

While Reuters’ “Pay cut: Google employees who work from home could lose money,” by Danielle Kaye noted that “…smaller companies including Reddit and Zillow have shifted to location-agnostic pay models, citing advantages when it comes to hiring, retention and diversity.”

We have clients on both sides of this equation, but it is important to note that asking an employee to take a pay cut might be risky in a competitive labor market. Making a decision on location-based pay versus job-based pay should consider all factors involved to help determine what's best for your workforce and your business.

We outlined a few pros and cons for each pay model. As you make decisions for your own organization, it’s a good idea to consider the following:

Pros and cons of location-based pay

  • PRO: Workers are paid wages commensurate with where they live and can expect to cover state and local taxes, housing, and other expenses associated with that location.
  • PRO: A company can save on wage costs, mainly if remote workers live in more affordable markets.
  • CON: Employees who live in less expensive housing markets make less for the same work done by co-workers in locations with a higher cost of living.
  • CON: Companies may experience higher turnover rates if they impose a pay cut policy that penalizes employees who move to smaller, more rural locations.

Pros and cons of job-based pay

  • PRO: Employees who live in a lower-cost area can opt for a larger home and more expensive "extras" and save more than if they choose to live in a city with a higher cost-of-living.
  • PRO: A job-based compensation structure can be more straightforward to administer because it focuses on allocating pay systematically and not on where employees live, which may shift over time.
  • CON: Employees with specialized skills and expertise who live in more expensive geographic markets may not be compensated as generously as those who work for competitors with location-based pay policies. This can diminish a company's recruiting competitive edge.
  • CON: Employees who move to locations with increased legislative and regulatory requirements can create increased operational costs for employers as they comply with new laws in the new location.
  • CON: Job-based pay structures can increase a company's wage (operating) costs.

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Lisa Bauer is director of compliance services at G&A Partners.

Employers across industries need to step up their game when it comes to retention and recruitment. Photo via Getty Images

Houston expert: How to thrive as an employer amid The Great Resignation

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With Baby Boomers and older generations exiting the workforce in droves and COVID-19 variants still straining hospitals and doctors’ offices, the health-care industry is experiencing its own “Great Resignation” at a time when health-care occupations are projected to add more jobs than any other occupational group.

The U.S. Bureau of Labor Statistics’ Occupational Outlook Handbook reports that “Employment in health-care occupations is projected to grow 16 percent from 2020 to 2030, much faster than the average for all occupations, adding about 2.6 million new jobs … mainly due to an aging population, leading to greater demand for health-care services.”

This greater demand might run into a supply issue if employers don’t act swiftly to find creative ways to retain and recruit their staffs. Today’s workforce knows its value and is no longer so easily enticed or satisfied with basic benefits packages. It’s an employee market and employers across all industries are having to step up and bring their A-game when it comes to retention and recruitment.

What you can do to up your ‘A-game’ in 2022

COVID has taught employers that they must change to survive. Spend the time now to develop a strategic plan that will allow you to adapt and improve throughout the year. Be sure to give yourself a cushion in your budget that will allow you to meet new employee demands as they arise and to be generous with relocation and sign-on incentives when you compete for top talent. You can later list these incentives in your job advertisements and highlight any other benefits that might capture interest and bring talent into your organization.

Start your recruitment and retention efforts with a survey of your staff. Find out what they really need and want from you, then try to find ways to meet their demands. Some simple ways for you to take care of your employees right now include:

Bring employees meals to their floor.

Hospitals are becoming filled up once again with sick patients and most are understaffed as employees are contracting COVID from patients. Treat your staff to healthy food—not cookies and cakes—allow them to really stop and take 15 minutes to breathe and fuel their body. This can be done twice or three times a week for each shift. Talk to them about food options or restrictions so that everyone feels like they can participate.

Bring in a counselor on a monthly basis that employees may access during their shift.

Providing this accessible, valuable resource will give your staff the opportunity to address their mental health and wellness and can help you reduce burnout among your ranks.

Allow at least one meeting a week to be focused solely on your employees.

Often the shift start-up meetings are rushed due to the day’s demands. Spend at least one of these meetings a week asking your team things like, “Where do you feel you impacted someone this week?” or ask everyone to share a personal achievement that has helped them personally keep going. This will help you build unity with your team and develop a more positive, empathetic relationship.

Provide bonus incentives to take on extra shifts.

There’s a lot of work to be done and often too few people to do it, so make it worth their while by offering a bonus for taking on more work than normal. You can also provide an option for them to earn overtime on a rotation so they can plan accordingly and still have opportunities for rest and a life balance.

Help relieve the stress of being in a high-risk environment by offering additional paid sick leave for a COVID-related absence.

The paid leave should be for the employee to quarantine at home and convalesce or care for an immediate family member who has the disease, and it should not take away from their accrued unused time off. Consult your HR advisor or attorney to find out whether paid sick leave is legally required in your jurisdiction.

Say “thank you.”

It may sound overly simple but just having the executive leadership go in and say thank you, shake hands, or even show up to a shift meeting can show the staff that their leadership cares about their hard work and recognizes the excellent care they are providing to their clients and patients. People in health care or associated service industries just want to know that they are making a difference, so share positive feedback from patients when you can. It matters.

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Denise Macik is the manager of strategic HR advisory services for G&A Partners, a leading professional employer organization that has been helping entrepreneurs grow their businesses for more than 25 years.

Maintaining employee engagement can be tough this time of year even pre-pandemic. Here are some tips and considerations from a local expert. Photo via Getty Images

Houston expert: How to keep your employees engaged during the holidays

Guest Column

When you combine standard holiday distractions with a year of prolonged and intensified stress, it can result in an exhausted team and real employee engagement (and productivity) problems for your business.

So, what can you do to minimize the impact of this year's holiday slump? It starts with understanding why employees tend to disengage during the holidays.

Reasons your employees are less engaged around the holidays

While employee engagement is something to be focused on throughout the year, the holiday season can be a particularly challenging time. Pre-pandemic, common distractions included holiday parties, upcoming travel plans, and the pressure to find the perfect gift.

This year, travel and large holiday gatherings will likely take a back seat to burnout, pressure to keep family safe, and a different kind of shopping stress (like factoring in delivery times), which could pull employees away from work commitments.

Plus, the business gets busier. While not every business is seasonal, the end of the year tends to be a busier time for many companies, especially for those whose fiscal year matches the calendar. For these companies, the arrival of the holiday season can be an abrupt reminder that they only have a few days left to accomplish the year's goals, meet their annual quotas, or close out requests they've been meaning to get to throughout the year.

We also have the arrival of flu season. When you combine cold and flu season with a very contagious coronavirus, you can be looking at sidelining even the most dedicated employee for days or even weeks. And, unlike vacations, employers have a much harder time planning for illness.

There's also the end of the school session. Working parents are looking forward to spending quality time with their family, and prior to time off from work, they may still need to make childcare arrangements during the workday, the cost of which can be burdensome at the holidays.

Ideas for boosting employee engagement around the holidays

Even though the holidays can compound workplace stress, there are effective strategies you can put in place to minimize the impact of any holiday-related slumps:

Plan ahead. The single most important thing employers can do to prepare for the holiday season is to plan ahead. If you haven't already, make sure you have all PTO requests in. Forecasting for a lighter staff or arranging additional coverage and adjusting timelines for projects during the holidays can help you meet year-end objectives without intensifying the strain on your already stressed team.

Be flexible and understanding. It's important to try to be as accommodating as you can (within reason). Between potential illnesses, family responsibilities, and added financial burdens, employees will appreciate a little more flexibility and understanding during the holidays. Allowing employees to adjust their schedules or even work overtime to complete projects can build morale and have a positive impact on your bottom line. If you can't accommodate employees' requests, communicate early, and keep an open dialogue to help them understand why. Loyal employees want the company to succeed as much as you do.

Encourage employees to stay healthy. We've all come to understand that more than ever this year. Keeping any wellness programs in place (online or otherwise) can make a big difference. To help keep your staff healthy, happy, and productive during the holidays, you can:

  • Host a flu-shot clinic or encourage employees to get one from their healthcare provider
  • Provide general tips and education about the importance of getting enough rest
  • Make sure common areas are cleaned thoroughly for those present in workplace facilities

Embrace the holiday spirit. While it may not be appropriate for every employer to focus on a specific holiday tradition, ignoring the holiday season isn't going to improve engagement. In fact, a little holiday cheer is exactly what most of us need this year. Even if your team is fully remote you can host intentional, inclusive activities to help employees decompress and encourage camaraderie and collaboration.

Show appreciation for your employees. A little extra employee appreciation or recognition is always needed and welcomed. Your team has worked through some very difficult times in 2020. Celebrate their successes with (if possible) an end-of-year bonus, a complimentary meal, a meaningful gift, or simply a kind email or handwritten note. The holiday season is a great opportunity to show your appreciation for all of your team's hard work. It can be a much-needed reset for what we all hope is a much-improved 2021.

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Susan Crowder, senior HR adviser at Houston-based G&A Partners.

What are the best companies to work for in Houston? Inc. magazine has released its list. Getty Images

Inc. named the​ best workplaces in U.S. — and 6 Houston companies landed on the list

workers loving work

These days, finding work is a full-time job for thousands of struggling Houstonians. Some of those people might want to check out six employers from Greater Houston that were just named among the country's best workplaces.

On May 5, Inc. magazine revealed the 395 employers in the U.S. that made its 2020 list of the best workplaces. In all, 30 employers in Texas ranked among the country's top workplaces.

To develop the ranking, Omaha, Nebraska-based Quantum Workplace surveyed employees from more than 3,000 companies in the U.S. on topics such as trust, management effectiveness, perks, and confidence in the future. Quantum based the final list on a composite score of survey results.

Houston employers that appear on the 2020 list are:

  • Alliantgroup, a tax consulting firm
  • AMB Architects, an architecture firm that specializes in designing medical and corporate offices, stores, and building renovations.
  • Eagle Pipe, a distributor of pipes for industrial and municipal projects
  • G&A Partners, an HR outsourcing company
  • Rekruiters, a staffing firm
  • The Black Sheep Agency, a marketing, branding, and design firm

Here's a rundown of the other Texas companies that earned spots on Inc.'s list of the country's best workplaces.

Dallas

  • Dialexa, a provider of technology R&D and development
  • Embark, a financial consulting firm
  • January Digital, a digital marketing and consulting firm
  • Munck Wilson Mandala, a tech-focused law firm
  • OneDay, a provider of a video storytelling platform for senior living centers
  • OutMatch, a provider of a platform that helps employers hire, retain, and develop employees
  • Worldwide Express, a shipping company

Addison

  • Lone Star Analysis, a provider of analytics software

Fort Worth

  • Blue Jean Networks, an IT support and services company

Irving

  • 5, an energy advisory firm
  • JB Warranties, an insurance firm

Plano

  • LiquidAgents Healthcare, a staffing agency for nurses
  • The Vested Group, a consulting firm for users of NetSuite software
  • TRUth, an advertising and marketing agency

Austin

  • 9Gauge Partners, a business management consulting firm
  • Abilitie, a provider of simulation-based learning tools
  • AlertMedia, a provider of emergency notification software
  • AllPro Hospitality Staffing, a staffing service for hotels and caterers
  • OJO Labs, a maker of AI-powered software for homebuyers and home sellers
  • Personiv, an outsourcing company
  • Pushnami, a provider of digital marketing software
  • SourceDay, a maker of supply chain management software
  • The Zebra, an insurance comparison website

Round Rock-based Jacaruso Enterprises also showed up in the ranking. It offers sales training, technology, and consulting for hotels.

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This article originally ran on CultureMap.

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Greentown Labs names Lawson Gow as its new Houston leader

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Greentown Labs has named Lawson Gow as its Head of Houston.

Gow is the founder of The Cannon, a coworking space with seven locations in the Houston area, with additional partner spaces. He also recently served as managing partner at Houston-based investment and advisory firm Helium Capital. Gow is the son of David Gow, founder of Energy Capital's parent company, Gow Media.

According to Greentown, Gow will "enhance the founder experience, cultivate strategic partnerships, and accelerate climatetech solutions" in his new role.

“I couldn’t be more excited to join Greentown at this critical moment for the energy transition,” Gow said in a news release. “Greentown has a fantastic track record of supporting entrepreneurs in Houston, Boston, and beyond, and I am eager to keep advancing our mission in the energy transition capital of the world.”

Gow has also held analyst, strategy and advising roles since graduating from Rice University.

“We are thrilled to welcome Lawson to our leadership team,” Georgina Campbell Flatter, CEO of Greentown Labs, added in the release. “Lawson has spent his career building community and championing entrepreneurs, and we look forward to him deepening Greentown’s support of climate and energy startups as our Head of Houston.”

Gow is the latest addition to a series of new hires at Greentown Labs following a leadership shakeup.

Flatter was named as the organization's new CEO in February, replacing Kevin Dutt, Greentown’s interim CEO, who replaced Kevin Knobloch after he announced that he would step down in July 2024 after less than a year in the role.

Greentown also named Naheed Malik its new CFO in January.

Timmeko Moore Love was named the first Houston general manager and senior vice president of Greentown Labs. According to LinkedIn, she left the role in January.

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This article originally appeared on our sister site, EnergyCapitalHTX.com.

Houston foundation grants $27M to support Texas chemistry research

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Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

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Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

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