Three Houston women "are redefining what it means to build and run a business amid the new normal.” Photos courtesy

A spotlight is shining on three future Elon Musks from the Houston area.

Forbes magazine recently unveiled its final installment of 250 entrepreneurs on the Forbes Next 1000, a list of inspiring entrepreneurs and small-business leaders “who are redefining what it means to build and run a business amid the new normal.” Among the 250 are three entrepreneurs from the Houston area.

“As we enter another pandemic year, entrepreneurs and small-business owners are finding new ways to thrive amidst ever-uncertain circumstances,” Maneet Ahuja, senior editor of Forbes, says in a news release. “The fourth and final class of Next 1000 entrepreneurial heroes is writing the playbook for not only achieving financial recovery but speeding past it. These sole proprietors, self-funded shops, and pre-revenue startups are proving that — through resolve, hard work, and solid planning — anything is possible.”

Here are the three Houston-area entrepreneurs who made the final installment of the Next 1000 list for 2021, per Forbes:

Vernee Hines, 28, co-founder, UpBrainery Technologies (Houston)
UpBrainery Technologies is a technology ecosystem that's aimed at disrupting educational and classroom norms through the use of its proprietary technology. Its marketplace provides an AI-driven software platform and research-based, results-driven curriculum to students, parents, teachers and organizations. Cofounded in 2020 by Hines and Ghazal Qureshi, UpBrainery has helped more than 5,000 students. Clients include Whataburger, Nasdaq, The Houston Rockets, The Girl Scouts of America, and Girls Inc.

Carolyn Rodz, 42, co-founder, Hello Alice (Houston)
A former investment banker with JP Morgan, Rodz channeled her funding experience into creating Hello Alice, an online platform that serves as a one-stop-shop for aspiring entrepreneurs, connecting them with funders, services and professional networks. She originally cofounded the Houston-based company with Elizabeth Gore in 2017 to serve as an accelerator for women-owned businesses. It's since grown to work with all clients, and has raised $8.5 million.

JoAnn Ajayi-Scott, 60, founder, Essence of a Lady (Missouri City)

Essence of a Lady started as a social club in 1989' Scott later reorganized it into a non-profit organization to match girls with mentors in the hope that those relationships would give them the help and support they need to graduate high school. To date, they have impacted the lives of more than 1,000 girls through the more than 400 women who have mentored them as chaperones, workshop presenters, sponsors and donors.

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This article originally ran on CultureMap.

Forbes has identified 1,000 entrepreneurs as rising stars in the business world. And three of them call Houston home. Photos via Forbes

3 Houston innovators make Forbes list of up-and-coming entrepreneurs

next big things

Three Houston entrepreneurs are basking in the national spotlight.

The trio — Vernee Hines, Carolyn Rodz, and Siddhartha Sachdeva — were just named to Forbes' Next 1000 list of the country's up-and-coming entrepreneurs. They're among the 250 standouts who make up the second installment of this year's Next 1000 class.

Forbes says the year-round Next 1000 initiative "showcases the ambitious sole proprietors, self-funded shops, and pre-revenue startups in every region of the country — all with under $10 million in revenue or funding and infinite drive and hustle."

Forbes accepts nominees for Next 1000, and then "top business minds and entrepreneurial superstars" pick those who make the final cut. Among those minds are LinkedIn co-founder Reid Hoffman; baseball legend Alex Rodriguez; Sheryl Sandberg, chief operating officer of Facebook; and Carla Harris, managing director of Morgan Stanley.

"Americans are launching new companies at a historic rate, aided by the accelerated shift in the way we live and work and an influx of technological tools that made it easier for anyone to start their own business from anywhere," Maneet Ahuja, senior editor of Forbes, says in a news release. "The latest class of Next 1000 entrepreneurial heroes offer hope for the future as we emerge from the pandemic on the path towards economic recovery."

Hines, Rodz, and Sachdeva are the initiative's three Houston representatives in the summer 2021 group.

Hines co-founded UpBrainery Technologies with Ghazal Qureshi in 2020. UpBrainery operates a tech ecosystem aimed at disrupting educational and classroom norms through the use of proprietary technology, according to Forbes.

UpBrainery's marketplace provides an AI-driven software platform and research-based, results-driven curriculum to students, parents, teachers, and organizations. So far, UpBrainery has helped more than 5,000 students. Clients include Whataburger, Nasdaq, the Houston Rockets, the Girl Scouts of America, and Girls Inc.

"Because I deeply understand curriculum and the theory of education, I understand the biases marginalized students face every day, and I co-founded UpBrainery with the goal of eliminating historical education biases, leveling the playing field for underrepresented students, and providing a technology solution that reaches even the most disconnected student," Hines says on her company's website.

Rodz co-founded Hello Alice with Elizabeth Gore in 2017 as an accelerator for women-owned businesses. Today, the Hello Alice online platform serves as a one-stop shop for all aspiring entrepreneurs, connecting them with funders, services, and professional networks, Forbes explains. To date, it has raised $8.5 million in funding.

"Hello Alice is what I wish I had when I started my first business 15 years ago," Rodz told the Golden Seeds website in 2020. "After a career in investment banking, I made a long, hard, expensive transition into entrepreneurship. It wasn't until I sold that company that I realized how much I learned."

"When I started a second business, I discovered networks and opportunities I didn't know about the first time, and doors opened up," she added. "With Hello Alice, our goal was to put all entrepreneurs on an equal footing, giving them the knowledge, opportunities, and connections they need to thrive from day one."

Sachdeva founded Innowatts in 2014. The company offers an AI-powered SaaS platform that helps electricity providers operate more efficiently and transition toward sustainable energy, Forbes says. Innowatts has raised nearly $27 million in funding.

"The COVID-19 crisis has brought challenges for the energy sector, but there will always be a need for accurate forecasting and real-time intelligence," Sachdeva says in a recent news release. "Innowatts has flourished by using its groundbreaking AI technologies to help customers build resilience and cope with the unprecedented shifts in power consumption caused by the pandemic."

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Austin company to bring AI-powered school to The Woodlands

AI education

Austin-based Alpha School, which operates AI-powered private schools, is opening its first Houston-area location in The Woodlands.

The 8,000-square-foot school, scheduled to be ready for the 2026-27 academic year, initially will serve students in kindergarten through eighth grade. Alpha says the school will offer “open workshop spaces and innovative classrooms that support personalized instruction, core academics, leadership development, and real-world life skills.”

Alpha sets aside two hours each school day for the AI-driven, self-paced study of core subjects like math, reading and science. The rest of each school day consists of life-skills workshops focusing on topics such as leadership and financial literacy.

Alpha’s school in The Woodlands has begun accepting applications for the 2026-27 school year. Annual tuition costs $40,000.

“The Woodlands is one of the most dynamic, forward-thinking communities in Texas, and Alpha is proud to bring

an innovative educational model that complements its strong academic foundation,” says Rachel Goodlad, head

of expansion for Alpha.

Founded in 2014, Alpha School combines adaptive technology-driven instruction with immersive life-skills workshops. Its model emphasizes mastery-based learning in core subjects alongside development of communication, critical thinking, financial literacy and leadership skills. It operates more than 15 schools across the country.

Elsewhere in Texas, Alpha operates schools in Austin, Brownsville, Fort Worth and Plano. Alpha also operates 12 Texas Sports Academy campuses in Texas, including locations in Houston, Pearland and Richmond, along with a NextGen Academy esports school in Austin, a school for gifted students in Georgetown, and lower-cost Nova Academy campuses in Austin and Bastrop.

Alpha has fans and critics. While supporters tout students’ high achievement rates, detractors complain about the high tuition and the AI-influenced depersonalization of education.

“Students and our country need to be in relationship with other human beings,” Randi Weingarten, president of the American Federation of Teachers, a teachers union, tells The New York Times. “When you have a school that is strictly AI, it is violating that core precept of the human endeavor and of education.”

Alpha co-founder MacKenzie Price, a podcaster and social media influencer, doesn’t share Weingarten’s views.

“Parents and teachers: We need to embrace this change,” Price wrote after President Trump signed an executive order promoting AI in schools.

The Times notes that Alpha doesn’t employ AI as a tutor or a supplement. Rather, the newspaper says, AI is “the school’s primary educational driver to move students through academic content.”

Houston researcher secures $1.7M to develop drug for aggressive form of breast cancer

cancer research

A University of Houston researcher has joined a $3.2 million effort to develop a new drug designed to attack a cancer-driving protein commonly found in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most difficult-to-treat forms of cancer and accounts for 10 percent to 15 percent of all breast cancer cases. The disease gets its name because tumors associated with it test negative for estrogen receptors, progesterone receptors and excess HER2 protein, making it difficult to target. Due to this, TNBC is often treated with general chemotherapy, which can come with negative side effects and drug resistance, according to UH.

UH College of Pharmacy research associate professor Wei Wang is developing a drug that can target the disease more specifically. The drug will target MDM2, a protein often overproduced in TNBC that also contributes to faster tumor growth.

Wang is working on a team led by Wei Li, director of the University of Tennessee Health Science Center College of Pharmacy’s Drug Discovery Center. She has received $1.7 million to support the research.

Wang and UH professor of pharmacology and toxicology Ruiwen Zhang have discovered a compound that can break down MDM2. In early laboratory models, the compound has shown the ability to shrink tumors.

Wang and Zhang will focus on understanding how the treatment works and monitoring its effectiveness in models that closely mirror human disease.

“We will study how the drug targets MDM2 and evaluate the most promising drug candidates to determine effective dosing, understand how the drug behaves in the body, compare it with existing treatments and assess early safety,” Wang said in a news release.

Li’s team at the University of Tennessee will be working on the chemistry and drug design end of the project.

“This work could lead to an entirely new class of therapies for triple-negative breast cancer,” Li added in the release. “We’re hopeful that by directly removing the MDM2 protein from cancer cells, we can help more patients respond to treatment regardless of their tumor type.”