5 most popular innovation stories in Houston this week

What's trending

From Houston getting a new biotech accelerator to events you can't miss this month, here's what news trended this week. Photo by PeopleImages

Editor's note: Houston began October with a flurry of innovation news stories, from a new accelerator being launched in town and three innovators to know to events not to miss and a name change for a Houston company. Here are this week's top stories.

3 Houston innovators to know this week

This week's Houston innovators are bringing new exciting things to town. Courtesy photos

New and exciting things are coming to town — from a data-focused conference two two startup development organizations announcing a Houston presence. Here are three Houston innovators making it happen in town. Click here to continue reading.

10+ can't-miss Houston business and innovation events for October

Check out these conferences, pitch competitions, networking, and more. Getty Images

October is another busy one for Houston innovation. Data-focused conferences, a rescheduled grand opening for The Cannon, and so much more. Click here to continue reading. 

Exclusive: Houston sports tech company rebrands to attract a wider range of clients

FanReact is now Truss, and the company will be able to reach a greater audience. Photo courtesy of Truss

A Houston company that's specialized in digital sports fan engagement is reinventing itself to grow its client base.

FanReact, which earlier this year spun off its esports business into a new company called Mainline, is now known as Truss. The transition opens doors for the company to reach new clients that aren't in the sports industry — but that maybe want to take a page out of the fan experience's book. Click here to continue reading. 

Houston millionaire starts biotech accelerator for companies focusing on regenerative medicine

The new biotech accelerator has already worked with two companies, which have relocated their operations to Houston. Getty Images

A new Houston-based startup accelerator is planning to advance companies focusing on regenerative medicine and stem cell treatment.

Houston Healthspan Innovation Group was created by founder and CEO Ed Bosarge, a local entrepreneur who's made millions of developing health care and finance technology. Click here to continue reading. 

Health insurance tech startup taps Texas for its launch due to its large uninsured population

California-based Sidecar Health has rolled out its health insurance tech services in Texas. Images via sidecarhealth.com

The health insurance situation in Texas is anemic.

Last year, 17.7 percent of Texans lacked health insurance, according to newly released data from the U.S. Census Bureau. That's the highest rate of uninsured residents among all of the states.

The problem is even more acute in the Houston metro area. In 2018, nearly 1 in 5 residents of the region (18.6 percent) had no health insurance, the Census Bureau says. That's the highest rate of uninsured residents among the country's 25 most populous metro areas.

If you do the math, that translates into more than 5 million residents of Texas, including more than 1.3 million in the Houston area, who have no health-insurance safety net. A startup called Sidecar Health is setting out to reduce those numbers. Click here to continue reading.

FanReact is now Truss, and the company will be able to reach a greater audience. Photo by PeopleImages

Exclusive: Houston sports tech company rebrands to attract a wider range of clients

Name change

A Houston company that's specialized in digital sports fan engagement is reinventing itself to grow its client base.

FanReact, which earlier this year spun off its esports business into a new company called Mainline, is now known as Truss. The transition opens doors for the company to reach new clients that aren't in the sports industry — but that maybe want to take a page out of the fan experience's book.

"Our team has done an incredible job creating great digital experiences for our customers in the sports and athletics space," says Patrick Schneidau, CEO of Truss, in a news release. "At the same time, we have heard from organizations outside of sports that they want to create a similar 'fan experience'' for their customers, employees, partners and volunteers by providing content and connections the same way that athletic teams do."

According to Schneidau, there's also some market dissatisfaction that has left Truss with this opportunity for growth.

"Those organizations and their audiences – while not wanting to sacrifice great user experience and engagement – don't trust current options that host their communities at the expense of a loss of privacy," he adds. "All of these organizations focus on the need for a privacy-focused community platform."

The rebranding ties into some technological expansions Truss now has to offer, including branded digital web and mobile experiences, verified user profiles, community-defined moderation standards, and person-to-person and group chats.

"With our new mission to serve people who share a passion for any organization, our customers can now create the same level of engagement already available with your favorite sports team," says Schneidau. "Whether your organization supports critically ill patients, service men and women, university students or people of faith, Truss can create the communication, collaboration and connections that so many organizations desire for their community."

TMC Innovation, Station Houston, and FanReact all made executive hires last week. Courtesy photos

3 Houston innovators to know who are starting new roles

Who's who

It's been a busy week for Houston innovators. TMC Innovation Institute hired its new director, and Station Houston created a new director position — and filled it too. Plus, FanReact decided to divide and conquer its esports business, which meant a new executive hire.

Tom Luby, director of the TMC Innovation Institute

Tom Luby will run the Texas Medical Center's Innovation Institute. Courtesy of TMC

The Texas Medical Center has been searching for its new director over the past few months, but turns out, their pick was right next door at JLABS @ TMC serving as the site head. Tom Luby took the position, and has big plans to continue the institutes growth ahead of TMC3.

"What I hope to be helpful with is providing an overall strategic vision around TMC Innovation that allows us to scale from what's already been done here," Luby says in an InnovationMap interview.

Before moving to Houston, Luby worked in Boston's booming life sciences ecosystem. While it's not fair to compare Houston and Boston — a city that has had decades of growth in the space — he does note some similarities.

"If you roll the Boston tape back lets say 20 years where Boston was focused on generating a place where life science startups could have a chance to develop and be successful, that's where Houston is," Luby says. "We've gotten to a point where we're starting to see a really good density." Read more from the Tom Luby interview here.

Deanea LeFlore, director of community engagement, partnerships, and education at Station Houston

Deanea LeFlore is Station Houston's new director of community engagement, partnerships, and education. Courtesy of Station Houston

Station Houston hired Deanea LeFlore as director of community engagement, partnerships, and education. Previously, LeFlore served as chief of protocol for the city of Houston and a vice president of the Greater Houston Convention and Visitors Bureau.

"My passion is promoting Houston as a world-class place to invest, work and live, and I am thrilled to join an organization that embodies this same spirit," says LeFlore in a release. "Station's dedication to accelerating Houston's tech growth through collaboration and innovation compliments my professional experience and I look forward to opening our doors to new partners, expanding programming with our long-time supporters, and introducing Station to a new network of leaders." Read more about Station's new hire here. 

Patrick Schneidau, CEO of RanReact

Chris Buckner (left), who has served as FanReact's CEO since its founding in 2014, will be the CEO of Mainline, and Patrick Schneidau has been hired to serve as CEO of FanReact. Photos courtesy

Houston-based FanReact has spun off its esports business as its own company, Mainline. Former FanReact CEO Chris Buckner will take the reins of the new business as CEO, and Patrick Schneidau has been hired as FanReact CEO.

Schneidau has has a long career in Houston's tech scene. He spent 12 years at Houston software company PROS and was on the leadership team when the company went public in 2007. Since he left his position as CMO at PROS, he served as the chair of the Talent Committee for Houston Exponential and serves on the board for InnovationMap.

"The Mainline business has been so successful in recent history, that it just made sense for us to dedicate resources toward building that market," Schneidau says. "The momentum in that market as a whole — and in Mainline specifically — is just too large to ignore and not put 100 percent of Chris' time in." Read more about the spinoff company here.

Chris Buckner (left), who has served as FanReact's CEO since its founding in 2014, will be the CEO of Mainline, and Patrick Schneidau has been hired to serve as CEO of FanReact. Photos courtesy

Houston startup spins off services to focus on esports and hires new CEO

CEO subs in

Houston-based FanReact LLC has decided to divide and conquer. The sports marketing and digital solutions platform announced it will spin off its Mainline business as its own company so that it can better focus on the esports market.

Chris Buckner, who has served as FanReact's CEO since its founding in 2014, will be the CEO of Mainline, and Patrick Schneidau has been hired to serve as CEO of FanReact. Both companies are evaluating which assets and employees go where, but both entities plan to hire.

"We see a tremendous opportunity for Mainline in the esports market," says Buckner in a release. "The acceleration in growth in our media and collegiate partnerships gave us the opportunity to focus exclusively on that market. At this point it makes sense to separate our Mainline business from FanReact to give each organization dedicated resources to serve our customers and partners."

Schneidau has has a long career in Houston's tech scene. He spent 12 years at Houston software company PROS and was on the leadership team when the company went public in 2007. Since he left his position as CMO at PROS, he served as the chair of the Talent Committee for Houston Exponential and serves on the board for InnovationMap.

Together, Schneidau and Buckner see the potential for Houston to rise as an epicenter for esports.

"Houston has the second highest viewership of any city in the United States behind Los Angeles," Buckner tells InnovationMap. "I think that's a product of Houston's diversity."

The spinoff allows for Buckner to focus on Mainline, which has become necessary as the business grew over time.

"The Mainline business has been so successful in recent history, that it just made sense for us to dedicate resources toward building that market," Schneidau says. "The momentum in that market as a whole — and in Mainline specifically — is just too large to ignore and not put 100 percent of Chris' time in."

Houston makes sense for an esports market, and the city is on board. ESPN's inaugural collegiate esports championship will be hosted in Houston from May 10 to 12 at the George R Brown Convention Center during the Comicpalooza weekend — and local organizations are on board with the rise of esports in Houston.

"I have been personally in contact with every major university in the city and they all are taking esports seriously," Buckner says. It's actually a really exciting time for esports in Houston."

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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