Historic downtown Houston building plans to expand inclusive coworking for entrepreneurs

moving on up

Esperson Flex plans on expanding within the historic Niels Esperson Building in the next five years. Photo via espersonflex.com

A nearly 100-year-old building in downtown Houston is welcoming in entrepreneurs, small business owners, and enterprise firms with a new opportunity to innovate outside of traditional office spaces.

Esperson Flex — a coworking concept managed by Cameron Management in The Niels Esperson Building, which has stood out in Houston's skyline since its inception in 1927 — offers various membership tiers in its facility featuring private offices, desk space, conference room, and access to the overall area for freelancers. As an add-on option to the membership, members will have the opportunity to connect with other entrepreneurs through offering reciprocal daily use passes to Cannon members and allow them to book the conference rooms.

“Coworking allows small entrepreneurs to have a community and startup ecosystem that is very cheap and very flexible," Cameron Management CEO Dougal Cameron tells InnovationMap. “They can invest money in their enterprise instead of signing expensive long leases.”

Photo via espersonflex.com

Esperson coworkers have access to The Cannon's digital platform, Cannon Connect, which provides a digital platform for connections, resources, and services to investors, entrepreneurs, startups, and small businesses.

Currently, the offering of the venue is 12,300 square feet and 62 percent of it is leased.The company hopes to expand the coworking facilities to 62,000 square feet in the next five years, according to Cameron.

There are seven groups who are growing their own coworking business under the Esperson and Cameron Management umbrella, and some include working with groups that are specifically targeting often overlooked demographics, including Hispanic, Black, and female entrepreneurs. The Us Space, for instance, is a women of color-focused collective providing support and coworking for its community.

“We believe that entrepreneurship is the answer to many important problems in our world,” Cameron Management CEO Dougal Cameron tells InnovationMap.

In addition, the facility works with the Prison Entrepreneurship Program, which is a comprehensive re-entry program to help empower those trying to change their lives.

Photo via espersonflex.com

Located downtown, Esperson Flex is the latest in flexible work spaces by Cannon, which also include locations in the Energy Corridor, Houston Galleria, Galveston, The Woodlands, and, as of this week, Memorial.

Spaces like Esperson Flex have become increasingly popular for remote workers, and in some cases, have shown increases in overall productivity. In a survey conducted by Airtasker, remote employees worked 1.4 more days every month, than office workers, which equals 16.8 more days every year. In a similar survey by the Gartner 2021 Digital Worker Experience Survey, 43 percent said that flexible working hours helped them achieve more productivity.

The Cannon, too, has seen coworking and community-building opportunities from all corners of Houston, as the company's CEO, Jon Lambert, shared on the Houston Innovators Podcast.

The Cannon Galveston @ the MarMo has opened as a convening space for Galveston entrepreneurship. Photo via TheCannon.com

Houston coworking company opens new Galveston hub amid profound growth and expansion

seaside innovation

The Cannon Houston has expanded its footprint throughout 2021, and one of the coworking company's newest hubs has opened its doors seaside.

The Cannon Galveston @ the MarMo is a new coworking space with membership options starting at $180 a month for entrepreneurs. The building is a former credit union space that Galveston real estate entrepreneur, Jimmy McClure, bought and renovated. McClure is also one of The Cannon's board members as of a couple months ago.

"We've always felt there was this opportunity to create this coastal innovation community," says Alex Gras, chief commercial officer at the Cannon. "And we found a great partner in Jimmy McClure."

In the aftermath of the pandemic, Gras says people are going to be more intentional about where they spend their time, and this location offers its member companies something different.

The new space has membership options starting at $180 a month. Image via TheCannon.com

"Not only does Galveston have the allure of a coastal town with a more relaxed atmosphere, but it has some amazing support organizations," he says.

Gras is referring to the numerous innovative institutions on the island that have been operating in silos over the years — including University of Texas Medical Branch at Galveston, Texas A&M Galveston, Galveston College, Galveston ISD, Vision Galveston, and more. Gras says the feedback for The Cannon providing this neutral convening space for entrepreneurship has been so positive.

"Galveston really has the raw ingredients to become an amazing innovation ecosystem," Gras tells InnovationMap.

From a programming perspective, entrepreneurs can expect exactly what The Cannon has brought to its other locations. The team recently held a hacakathon in collaboration with The Ion, Vision Galveston, and UTMB — which was a major success, according to Gras — and plans to host a pitch competition on March 10.

The MarMo is a former credit union building renovated by Jimmy McClure. Image via TheCannon.com

"At the end of the day, entrepreneurs are looking for peers that they can do this with and not feel like they are so alone, as well as advisers, mentors, and coaches who help them think differently and investors who can provide some economic capital to help prop up their ideas," Gras explains. "Any programming we do in the future will have elements of social, networking, and education — but all in the confines of making sure we're providing all these different human, economic, and social capital to the entrepreneurs of Galveston."

It's not just toward the Gulf of Mexico where The Cannon has expanded profoundly this year. The company's sportstech hub opened in the Galleria area in collaboration with Braun Enterprises and Gow Media (InnovationMap's parent company).

"The thing that's exciting about this profound growth is it's reflective of the two driving initiatives of the Cannon — one being establishing a network of programmatically connected innovation hubs throughout the entire expanse of the city of Houston," says Lawson Gow, founder of The Cannon. "The other is looking for opportunities where Houston can go deep into an industry and be the best at that."

Sportstech is one of those avenues of opportunity, according to Gow, but the team is always looking for other verticals that might be a similar fit.

Additionally, The Cannon opened a new space in the Esperson building in downtown Houston. This space is small, says Lawson Gow, founder of The Cannon, but has room to grow.

"We want to create network of hubs — some in the community want highly-programed environments," Gow explains, adding that the Esperson Coworking likely won't feature the same level of programming as seen at some of the other locations.

Gow explains that he expects to grow the team at The Cannon to sport these expansions, crediting Gras for building and cultivating the team. Gras joined The Cannon in February.

Alex Gras joined The Cannon as managing director in February, and recently transitioned into chief commercial officer. Photo via LinkedIn

"It wouldn't surprise us if we more than double our team within the next year," Gow says.

This profound growth comes after 18 months of uncertainty — which allowed Gow and his team to rethink some of their plans.

"Pre-covid had our eyes on expansion outside of the city, and we've dialed it back — it's been a healthy exercise", Gow says, "to reset our focus on the whole sprawl of Houston in setting up eight to 10 locations across the city so that we're truly democratizing access to all the tools entrepreneurs need to grow."

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CPRIT CEO: Houston’s $2B in funding is transforming cancer research and prevention

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With its plethora of prestigious health care organizations like the University of Texas MD Anderson Cancer Center, UTHealth Houston, and the Baylor College of Medicine, Houston sits at the heart of cancer research and prevention in Texas.

Of course, it takes piles of cash to support Houston’s status as the state’s hub for cancer research and prevention. Much of that money comes from the Cancer Prevention and Research Institute of Texas (CPRIT).

Data supplied by CPRIT shows organizations in Harris County gained $2.3 billion in institute funding from 2009 through 2025, or nearly $145 million per year. That represents almost 60 percent of the roughly $4 billion that CPRIT has granted to Texas institutions over a 16-year period.

“The life sciences ecosystem that has developed and changed in Houston is phenomenal,” Kristen Doyle, who became the agency’s CEO in July 2024, tells InnovationMap. “In the next decade, we will look back and see a great transformation.”

That ecosystem includes more than 1,100 life sciences and biotech companies, according to the Greater Houston Partnership.

Houston plays critical role in clinical trials

Texas voters approved the creation of CPRIT in 2007. Twelve years later, voters agreed to earmark an extra $3 billion for CPRIT, bringing the state agency’s total investment in cancer research and prevention to $6 billion.

To date, CPRIT money has gone toward recruiting 344 cancer researchers to Texas (mainly to Houston) and has supported cancer prevention services for millions of Texans in the state’s 254 counties. CPRIT funding has also helped establish, expand, or relocate 25 cancer-focused companies. In Houston, MD Anderson ranks as the No. 1 recipient of CPRIT funding.

Regarding cancer research, Doyle says Houston plays a critical role in clinical trials.

“[Clinical trials are] something that CPRIT has focused on more and more. Brilliant discoveries are crucial to this whole equation of solving the cancer problem,” Doyle says. “But if those brilliant ideas stay in the labs, then we’ve all failed.”

Researchers conduct more clinical trials in Houston than anywhere else in the U.S., the Greater Houston Partnership says.

Doyle, a 20-year survivor of leukemia, notes that a minority of eligible patients participate in clinical trials for cancer treatments, “and that’s one of the reasons that it takes so long to get a promising drug to market.”

An estimated 7 percent of cancer patients sign up for clinical trials, according to a study published in 2024 in the Journal of Clinical Oncology.

MD Anderson takes on cancer prevention

Doyle also notes that Houston is leading the charge in cancer prevention.

“We get some national recognition for programs that have been developed in Houston that then can be replicated in other parts of the country,” she says.

Much of the work in Houston focusing on cancer prevention takes place at MD Anderson. The hospital reports that it has received more than $725 million from the CPRIT since 2007, representing approximately 18 percent of CPRIT’s total awards.

“These efforts can have profound impact on the lives of patients and their families, and this funding ensures our exemplary clinicians and scientists can continue working together to drive breakthroughs that advance our mission to end cancer,” Dr. Giulio Draetta, chief scientific officer at MD Anderson, said in a November news release, following the most recent CPRIT award for the hospital totalling more than $29 million.

CPRIT funding for Houston institutions supplements the more than $4.5 billion in federal funding for health and life sciences research and innovations that the Houston area received from 2020 to 2024, according to the Greater Houston Partnership.

“We are curing cancer every single day,” Doyle says of CPRIT. “Every step that we are taking — whether that’s funding great ideas or funding the clinical trials that are bringing promising drugs to Texas and to the world — we are making a difference.”

Houston energy tech co. breaks ground on low-cost hydrogen pilot plant

Coming Soon

Houston’s Lummus Technology and Advanced Ionics have broken ground on their hydrogen pilot plant at Lummus’ R&D facility in Pasadena, Texas.

The plant will support Advanced Ionics’ cutting-edge electrolyzer technology, which aims to deliver high-efficiency hydrogen production with reduced energy requirements.

“By demonstrating Advanced Ionics’ technology at our state-of-the-art R&D facility, we are leveraging the expertise of our scientists and R&D team, plus our proven track record of developing breakthrough technologies,” Leon de Bruyn, president and CEO of Lummus, said in a news release. “This will help us accelerate commercialization of the technology and deliver scalable, cost-effective and sustainable green hydrogen solutions to our customers.”

Advanced Ionics is a Milwaukee-based low-cost green hydrogen technology provider. Its electrolyzer converts process and waste heat into green hydrogen for less than a dollar per kilogram, according to the company. The platform's users include industrial hydrogen producers looking to optimize sustainability at an affordable cost.

Lummus, a global energy technology company, will operate the Advanced Ionics electrolyzer and manage the balance of plant systems.

In 2024, Lummus and Advanced Ionics established their partnership to help advance the production of cost-effective and sustainable hydrogen technology. Lummus Venture Capital also invested an undisclosed amount into Advanced Ionics at the time.

“Our collaboration with Lummus demonstrates the power of partnerships in driving the energy transition forward,” Ignacio Bincaz, CEO of Advanced Ionics, added in the news release. “Lummus serves as a launchpad for technologies like ours, enabling us to validate performance and integration under real-world conditions. This milestone proves that green hydrogen can be practical and economically viable, and it marks another key step toward commercial deployment.”

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This article originally appeared on EnergyCapitalHTX.com.

TMC launches new biotech partnership with Republic of Korea

international collaboration

Houston's Texas Medical Center has launched its new TMC Republic of Korea BioBridge.

The new partnership brings together the TMC with the Osong Medical Innovation Foundation, or KBIOHealth. The Biobridge aims to support the commercialization of Korean biotech and life science startups in the U.S., foster clinical research, and boost collaboration in the public, private and academic sectors.

Through the partnership, TMC will also develop a Global Innovators Launch Pad to foster U.S. market entry for international health care companies. Founders will be selected to participate in the 10-week program at the TMC Innovation Factory in Houston.

“Gene and cell therapies are driving biotech innovation, opening possibilities for treating diseases once thought untreatable," William McKeon, president and CEO of the Texas Medical Center, said in a news release. "Expanding biomanufacturing capacity is essential to delivering the next wave of these therapies, and partnerships with leading innovators will strengthen our efforts in Houston and internationally.”

McKeon officially signed the TMC Korea BioBridge Memorandum of Understanding with Myoung Su Lee, chairman of KBIOHealth, in South Korea in October.

"This collaboration marks a significant milestone for Korea’s biohealth ecosystem, creating a powerful bridge between Osong and Houston," Lee added in the release. "By combining KBIOHealth’s strength in research infrastructure and Korea’s biotech talent with TMC’s global network and accelerator platform, we aim to accelerate innovation and bring transformative solutions to patients worldwide.”

This is the seventh international strategic partnership for the TMC. It launched its first BioBridge with the Health Informatics Society of Australia in 2016. It launched its TMC Japan BioBridge, focused on advancing cancer treatments, last year. It also has BioBridge partnerships with the Netherlands, Ireland, Denmark and the United Kingdom.

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