Jason Ethier, who's seen Greentown Labs from its early days to it's impressive impact today, joins the Houston Innovators Podcast. Photo courtesy

Like many successful operations, Greentown Labs, a climatetech incubator based in Somerville, Massachusetts, outside of Boston, had its humble beginnings.

"Greentown is one of those things where a business seems obvious in retrospect," says Jason Ethier, a serial energy entrepreneur, on this week's episode of the Houston Innovators Podcast.

He says he and a few other founders were working on their various ventures in a building that ended up getting slated for demolition, forcing them to find a new place to set up shop.

"We were all building stuff within energy and technology," Ethier remembers. "We had to find a new building, and the landlord looked at us and said, 'I don't want to deal with a bunch of small companies. I want one company, one check, and one lease."

The group of entrepreneurs formed Greentown as a way to make the rent work, but they started attracting interest from other founders who wanted in. The organization evolved to what it is today — a dual-located energy incubator that's supported over 500 companies that have raised over $4 billion in funding.

Ethier, whose startup at the time brought him to Houston frequently, recognized the same scrappy founder mentality and need for incubation support in the Bayou City and was a key player in expanding Greentown to Houston in 2021.

"Every city is proud of who they are, but I think Houston especially is a city that likes to solve problems and build things locally," Ethier says. "When presented the opportunity to help build and ecosystem here, members of the ecosystem raised their hands and said, 'how can I help.'"

Juliana Garaizar, who was hired as launch director for Houston and now is head of Greentown Houston, tapped Ethier to support the expansion into town. Now, as senior director of membership at Greentown Labs, he works hands on with startups at Greentown.

He's taken his knowledge as a serial entrepreneur and incubation leader to launch the EnergyTech Startups podcast with co-host Lara Cottingham, the vice president of strategy, policy, and climate impact at Greentown Labs.

"As an entrepreneur, sometimes you feel a gap in the market in your bones and you just have to do something about it," Ethier says, explaining that he observed that when meeting people, he realized Houston got a bad rap. "Houston isn't viewed as a cool place to build a company if you don't know how good it is to be here."

The other thing Ethier says he realized was that Houston founders were understated in what they accomplished. So, he set out to start a podcast that would shine the spotlight on a Houston energy entrepreneur on a regular basis. The show, launched last fall, das now introduced listeners to over 20 energy founders and is continuing to do so on a biweekly basis.

Ethier shares more on his views of the future of Houston as an energy transition leader on the show. Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.