Marc Nathan, Meredith Wheeler, and Maggie Segrich are this week's Houston innovators to know. Courtesy photos

Passion is usually the motivator for starting a business, and this week's innovators to know have an undeniable passion for what they are doing.

Marc Nathan is passionate about Texas startups — it's why he started and still maintains a comprehensive newsletter of Texas innovation news. Meanwhile, Maggie Segrich and Meredith Wheeler are passionate about bringing together a community of women with Sesh Coworking.

Here's more of what you need to learn about this week's innovators to know.

Marc Nathan, vice president of client strategy at Egan Nelson and publisher of Texas Squared

Marc Nathan shares how he's seen the city of Houston's innovation world change dramatically over the past few decades. Photo courtesy of Marc Nathan

While he technically lives in Austin now, Marc Nathan is extremely proud of his Houston heritage. A third generation Houstonian, Nathan worked as an entrepreneur before getting involved with the Houston Technology Center. The University of Texas alum's current role at Egan Nelson — an Austin-based, startup-focused law firm, that brought him back to Austin a few years ago.

As much of a Houstonian at heart he is, Nathan is a major player in the entire Lone Star State's innovation world. He publishes a weekly newsletter, called Texas Squared, that he hopes can connect the dots between Texas's four innovation ecosystems — Dallas, Austin, San Antonio, and Houston, or DASH, as he likes to call them.

"I can tell you 10 years ago being an innovation person in Houston, I couldn't have told you anything about what was going on in Dallas or Austin," Nathan says on the most recent episode of the Houston Innovators Podcast. "Now, we're seeing a lot more collaboration among cities, and I think it's very important and useful."

Read more and stream the episode here.

Meredith Wheeler and Maggie Segrich, co-founders of Sesh Coworking

sesh coworking

Meredith Wheeler and Maggie Segrich founded Sesh Coworking after years of working from home and feeling the need for a community. Photo courtesy of Sesh

Working from home can be extremely isolating, but Meredith Wheeler found the "bro culture" of coworking off putting. For years she craved a female-focused community, and now with her business partner, Maggie Segrich, she's created exactly that with Sesh Coworking.

"We come at the creation of this space and the running of this community from the female experience," Wheeler tells InnovationMap. "Most coworking spaces, when they are run only by men, it's natural that they are coming from their perspective and experience."

The coworking space in Montrose officially opened for business on Feb. 3. Sesh has memberships and day passes available for anyone who wants to cowork, but the space is designed from the female perspective.

"For me, starting Sesh is kind of like giving women that space and opportunity to let their guard down, and feel like they can be their actual selves," Segrich says.

Read more and check out photos of the Sesh space here.

Marc Nathan shares how he's seen the city of Houston's innovation world change dramatically over the past few decades. Photo courtesy of Marc Nathan

Lifelong Houstonian weighs in on growth within the city's innovation ecosystem over the past 20 years

HOUSTON INNOVATORS PODCAST EPISODE 17

Houston's innovation ecosystem might not have a bigger advocate based in Austin than Marc Nathan. The third generation Houstonian is one of the few people to see the city go through its highs and lows as a developing innovation ecosystem over the past few decades.

While his full-time job is working in marketing for Egan Nelson, an Austin-based, startup-focused law firm, Nathan's greatest contribution to the Texas startup scene is his weekly newsletter, Texas Squared, that gathers up the Lone Star State's innovation and startup news.

Nathan also used to work at the Houston Technology Center years before it converted into Houston Exponential and focused specifically on helping startups raise money.

"Finding money was relatively difficult, and it's not any easier now," Nathan says on this week's episode of the Houston Innovators Podcast. He notes that organizations like the Houston Angel Network and local venture capital firms like Mercury Fund have made a huge difference.

A lot has changed within Houston, Nathan says. There's more startups, money, and press around Houston innovation. He's also seeing more collaboration between the Texas cities he calls DASH —Dallas, Austin, San Antonio, and Houston.

"I can tell you 10 years ago being an innovation person in Houston, I couldn't have told you anything about what was going on in Dallas or Austin," Nathan says on the podcast. "Now, we're seeing a lot more collaboration among cities, and I think it's very important and useful."

Nathan discusses his experience in both Houston and Austin's startup scene, and where he sees this collaboration going. Plus, he weighs in on The Ion, the merge between Capital Factory and Station Houston, funding and accelerator trends, how to make the most out of SXSW and more.

Listen to the full episode below — or wherever you get your podcasts — and subscribe for weekly episodes.


From friends and family rounds to how to navigate a seed round, here's what you need to know about raising money in Texas. Getty Images

Here's what you need to know if you're raising a seed round in Texas

Guest column

In the vast majority of startups we've worked with across Texas, their "seed round" is not the first money in the door. That money is often called a "Friends & Family Round" and it's usually from people so close to the entrepreneurs that they are willing to take a gamble before there is really even much "there" to invest in. It also might include bootstrap funds put in by the entrepreneurs themselves.

After an F&F Round, Texas startups will pursue a "seed round," which generally includes some angel investors in the local and broader ecosystem. A problem we occasionally run into is that Texas entrepreneurs, including those in Houston, will get bad advice on what the right structures are for this kind of deal; either because they are reading a blog post from Silicon Valley (where things work VERY differently) or they're talking to someone marketing themselves as an "adviser" when their advice doesn't have much substantive deal experience backing it.

If your seed round is under $1 million, you will most likely structure it as a convertible note with a valuation cap and a 2 to 3 year maturity. Convertible notes are extremely slimmed down investment instruments that angel investors across Texas will be very familiar with. Usually, the "deal" in a convertible note round is that investors will get minimal up-front rights, in order to streamline early decision-making and keep legal costs down for negotiation, but they will get back-end protections like debt treatment if the company goes south. They will also almost always get a valuation cap and/or a discount on the price that future VCs pay, as recognition for the extra risk the seed investors are taking relative to later investors.

Once seed rounds get above $1 million, a more robust equity (stock) based investment structure starts to make more sense. There are two types of equity rounds, broadly speaking: seed equity and full VC-style equity. The latter involves a large set of heavily negotiated documents with robust investor protections, and is the structure most often utilized for a Series A (after seed). The former (seed equity) is a slimmed down version of full VC docs designed to give investors some rights, but keep negotiation costs (including legal fees) within a range that's reasonable for the smaller amount of money being raised. Investors vary as to whether they will accept simpler seed equity docs, or require you to give them full VC-style protections.

Given the diversity of investor expectations and contexts you're likely to run into in structuring a seed round, and the very high-stakes (and permanent) implications of the contracts you're going to sign, it's extremely important that advisers you work with have specialized experience in these kinds of deals.

In the case of lawyers specifically, it's also extremely important that they not have conflicts of interest with the investors you are raising money from. We too often see clever investors nudge entrepreneurs toward utilizing the investor's preferred law firm. Anyone with an ounce of honesty and experience can see why that's a problem.

Make sure you understand the high-level concepts and structures that are within the norms of your startup ecosystem, and then work with experienced, trustworthy advisors to translate everything into a deal that makes sense for your company's unique context.

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Jose Ancer is an emerging companies partner at Egan Nelson LLP. He also writes for Silicon Hills Lawyer, an internationally recognized startup/vc law blog focused on entrepreneurs located outside of Silicon Valley, including Texas.

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Houston cleantech, space startups named to World Economic Forum cohort

top honor

Two Houston-based startups have been selected to join the World Economic Forum's Technology Pioneers community.

The two-year program aims to help mission-driven, early-stage start-ups scale their innovations through multi-stakeholder initiatives, co-creating partnerships and other gatherings for community members. One-hundred startups are selected each year from around the globe, this year hailing from 23 countries and working in AI, energy, space, biotech markets and more.

Cleantech startup Vaulted Deep was one of 11 energy and climate companies to be named to the cohort. Julia Reichelstein and Omar Abou-Sayed founded the company in 2023. Its technology injects excess organic waste underground to remove carbon dioxide from the atmosphere.

Last year, Vaulted Deep inked a 12-year deal with Microsoft to remove up to 4.9 million metric tons of carbon dioxide from the environment.

The startup has earned several accolades in recent years, including a No. 3 spot on Fast Company’s list of the World’s Most Innovative Companies of 2026. It was also recently named to market intelligence and advisory firm Cleantech Group's annual Global Cleantech 100 list for a second year in a row.

"Waste management is one of the world's great invisible infrastructure systems ... The need for new infrastructure is growing as disposal challenges become more complex and regulations evolve. Vaulted is building the first new disposal pathway for organic waste in decades by putting it deep underground, permanently," the company shared in a LinkedIn post. "This year, we're joining the World Economic Forum's 2026 Tech Pioneers alongside innovators working on the many interconnected challenges shaping our future."

Houston-based Venus Aerospace was also selected to join the cohort, along with six other spacetech companies. The company was founded in 2020 by Sassie and Andrew Duggleby.

The startup specializes in next-generation rocket engine propulsion as a cleaner alternative to traditional combustion engines. The company's rotating detonation rocket engine (RDRE) burns fuel more efficiently and completed a successful high-thrust test flight last year. Venus says it’s the only company in the world that makes a flight-proven, high-thrust RDRE with a “clear path to scaled production.”

"Frontier technologies matter most when they expand what people, industries, and nations can do," Sassie Duggleby, co-founder and CEO of Venus, said in a news release. "For Venus, RDRE does not just represent a more efficient engine. It is a foundation for faster movement, more capable space systems, and new forms of connectivity across the planet. Being named a Technology Pioneer validates the potential of this technology to help shape a future where distance is less limiting."

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This article originally appeared on our sister site, EnergyCapitalHTX.com.

Houston Methodist receives record $110M gift, names future tower

historic gift

Houston Methodist has received the largest gift in the health system's history to establish new funds for neurological, neuroscience, and women’s health research and treatment.

The $110 million gift comes from Houston-based The Brockman Medical Research Foundation, which supports education and research in the science, medicine and healthcare fields. In response, Houston Methodist announced that it will name its forthcoming 26-story hospital facility the Brockman Centennial Tower.

The tower’s entrance will be named the Anna Margaret Bellows Centennial Hall to honor Anna Margaret Bellows, a young camper who died during the Camp Mystic flooding last summer.

“This extraordinary gift accelerates discovery and transforms how care is delivered,” Dr. Marc Boom, president and CEO of Houston Methodist, said in a news release. “We are grateful to The Brockman Medical Research Foundation for its incredible generosity and vision that will help change the lives of generations of patients. Naming Centennial Tower in recognition of this gift reflects the scale of this commitment and its impact on the future of neuroscience, neurological care and women’s health.”

The gift will be divided into two parts:

  • $100 million will go toward creating an innovation fund within the Houston Methodist Academic Institute and the Houston Methodist Neurological Institute
  • $10 million will be devoted to Houston Methodist's Department of Obstetrics and Gynecology

“This tremendous gift will accelerate translational research that broadens our understanding of neurological and other diseases,” Dr. Jenny Chang, president and CEO of the Houston Methodist Academic Institute, added in the release. “It will allow us to leverage state-of-the-art platforms to detect, diagnose and deliver therapeutics, keeping patient care at the center of our mission.”

The Brockman Centennial Tower is expected to open next year in the Texas Medical Center. Spanning more than 1 million square feet, it will house 400 patient beds, an expanded emergency department, new operating rooms and a rooftop garden. It will be connected to Houston Methodist's flagship Paula and Joseph C. “Rusty” Walter III Tower, which opened in 2018. The Centennial Tower was estimated to cost $1.4 billion when announced in 2022.

In addition to the news of the Brockman gift, Houston Methodist also announced this month that it has launched the Houston Methodist Center for Cell and Gene Therapy and tapped an internationally recognized scientist as its leader.

The new center is focused on discovering and developing innovative and cost-effective therapies for a variety of congenital and acquired diseases, including cancer, HIV and cardiovascular disease.

Dr. Malcolm Brenner has been named as the center's inaugural leader and will assume the role starting in October. He will work alongside scientists and support staff from Baylor College of Medicine and Texas Children's Hospital.

Brenner is a professor of pediatrics, medicine, molecular and human genetics and translational biology at Baylor College of Medicine. He is known for making early advances in using bone marrow transplantation as a form of cell therapy and in engineered immune-cell treatments for cancer and infections, according to a release from Houston Methodist.

“Malcolm Brenner is a pioneer in the field of cell and gene therapy and is uniquely qualified to lead Houston Methodist’s research efforts in this field,” Chang added. “His vision and leadership will play a pivotal role in advancing our work in this space.”