Nauticus Robotics's multimillion-dollar project with the U.S. Defense Innovation Unit is moving forward. Photo via nauticusrobotics.com

A Houston company that announced a partnership with the United States Defense Innovation Unit has revealed its moving on to the next milestone.

Nauticus Robotics Inc., which went public last September and trades under NASDAQ ticket KITT, announced today that it has completed the first phase of its Amphibious Autonomous Response Vehicle, called the Terranaut, with the DIU. The Houston-based company has developed a fleet of autonomous robots using artificial intelligence for underwater data collection.

“The Defense Innovation Unit has been a fantastic partner," says Nicolaus Radford, founder and CEO of Nauticus, in a news release. "They leverage our mature catalog of technologies we’ve developed from our outside investments and apply those to pressing problems facing the Services."

The multi-million dollar contract with the Marine Corps Systems Command and the Office of the Deputy DoD CTO for Mission Capabilities, which originally awarded last October, tasked Nauticus with adapting its technology to become "a new autonomous mine countermeasure robot for use in surf zones and beach areas," according to the company. The robot's plans include the ability to both swim and walk onto the beach.

The tech also includes Nauticus's ToolKITT software, plus more advanced tools like "machine vision, autonomous mission planning, and acoustic data networking," per the release.

“We believe this partnership will be instrumental in not only furthering the U.S. Marine Corps’ integration of cutting-edge robotics capabilities, but ultimately helping to keep servicemembers out of harm’s way,” Radford continues.

Nauticus, which was originally founded in 2014 as Houston Mechatronics Inc., recently announced its European expansion earlier this year,

Nauticus Robotics has been awarded another multimillion-dollar contract from the U.S. Defense Innovation Unit. Photo via nauticusrobotics.com

Houston robotics company secures multi-million-dollar government contract

more collaboration

Webster-based Nauticus Robotics Inc., a newly minted public company, continues to make waves with government contracts.

Nauticus says it has been awarded a second multimillion-dollar contract from the U.S. Defense Innovation Unit, part of the U.S. Defense Department, for development of a self-piloted amphibious robot system powered by the company’s ToolKITT command-and-control software.

In February, Nauticus said it had been given a ToolKITT contract by the Defense Innovation Unit. Under that contract, ToolKITT is being used aboard a remotely controlled undersea vehicle operated by the Navy.

Similar contracts with the Defense Innovation Unit could be on the horizon, Nauticus says.

Nauticus develops oceangoing robots under the brand names Aquanaut and Hydronaut, along with the ToolKITT autonomy software and related services. It’s forecasting 2023 revenue of $90 million.

Driven by machine learning, ToolKITT helps identify, categorize, and perform activities that can “remove, detect, identify, inspect, and neutralize hazards underwater,” according to a Nauticus news release.

ToolKITT is used for various self-piloted robotics products, including Nauticus’ Aquanaut.

“We are humbled and honored to be doing our part to advance the usage of robotics and autonomous systems to remove servicemembers from harm’s way,” says Ed Tovar, director of business development for defense systems at Nauticus.

Nauticus’ stock began trading September 13 on the Nasdaq market. The milestone came four days after Nauticus merged with publicly traded CleanTech Acquisition Corp., a “blank check” shell company formed to acquire or merge with a business. At one point, the merger was valued at $560 million.

The new combo, operating under the Nauticus name, is led by Nauticus founder and CEO Nicolaus Radford.

“The closing of this business combination represents a pivotal milestone in our company’s history as we take public our pursuit of transforming the ocean robotics industry with autonomous systems,” Radford says in a news release. “Not only is the ocean a tremendous economic engine, but it is also the epicenter for building a sustainable future.”

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.