The Houston SBA has joined forces with various organizations across a 32-county footprint to align with SBA’s goal of supporting small businesses. Photo via Unsplash

In alliance with their mission of supporting Houston small businesses the Small Business Administration Houston District Office has expanded its partnerships.

The Houston SBA has joined forces with various organizations across a 32-county footprint.

“Small businesses represent an important and valuable resource in our community and our robust SBE program shows just how much small businesses can contribute when given the chance, and what it can mean in terms of overall economic benefits to the economy," Sabeeta Bidasie-Singh, director of business equity for Port Houston, says in a news release. “Collaborating with partners like the SBA is a key part of our success in supporting the small business ecosystem.”

Organizations signed a Strategic Alliance Memoranda to collaborate to further the interests of small businesses. In 2023, strategic partnerships included Greater Houston Partnership, Indo-American Chamber of Commerce, Houston Hispanic Chamber of Commerce, Fort Bend County Economic Opportunity & Development, Port Houston, Harris County Department of Economic Equity and Opportunity, Harris County Department of Education, Ion, Impact HUB, and Vision Galveston.

“Every small business deserves the chance to prosper,” Tim Jeffcoat, district director for Houston SBA, says in a news release. “SBA Houston strategically chose to partner with these important organizations so that small businesses of all kinds, everywhere in the 32-county Houston district, will benefit.”

SBA works with small business owners to assist with resources and support business growth and development. SBA also assists with businesses that need recovery from a declared disaster. SBA field offices and partnerships with public and private organizations like Ion help the city’s entrepreneurs.

“As a premiere destination for entrepreneurs to make their ideas a reality, we’re delighted to collaborate with the Small Business Administration to help Houstonians start, maintain and grow businesses,” Deanea LeFlore, senior director of Strategic Alliances at Ion, says in a news release. “We're excited to expand our relationships with the SBA to empower Houston’s small business community to scale their businesses, contributing to greater economic growth in the city.”

This week's innovators to know roundup includes Patrick Jankowski of the Greater Houston Partnership, Deanea LeFlore of The Ion, and Dr. Mehdi Razavi of the Texas Heart Institute. Photos courtesy

3 Houston innovators to know this week

who's who

Editor's note: In this week's Monday roundup of Houston innovators, I'm introducing you to three innovators across the city — from the Greater Houston Partnership, The Ion, and Texas Heart Institute.

Patrick Jankowski, senior vice president of research

The Greater Houston Partnership hosted its annual economic outlook event online this week. Photo courtesy of the GHP

At the GHP's annual economic outlook, Patrick Jankowski, senior vice president of research, predicts that 2021 will be a "bipolar year." The first and second halves of the year are going to look different, Jankowski says, it's just a matter of how different at this point. In addition to the vaccine and COVID case numbers, the things the GHP as well as Houston businesses are watching is the new Biden Administration.

"We won't see any significant growth in the economy until we get to the second half of the year," he says. Read more.

Deanea LeFlore, director of partnerships at The Ion

Deanea LeFlore, director of partnerships at The Ion, joins this week's episode of the Houston Innovators Podcast. Photo courtesy of Station Houston

Houston is just a few months away from being able to walk into The Ion, and the organization's director of partnerships, Deanea LeFlore, hopes that when that happens, they are entering a innovation hub reflective of the city.

"I think that when people walk into The Ion, what's personally important to me, is that it looks like Houston so that you see yourself reflected in the people in the building as well as the programming," LeFlore says. "That's my biggest hope and aspiration, and I believe we are well on track to be able to deliver on exactly that."

LeFlore shares more on what she's been working on — from online programming to growing partnerships at The Ion. Listen to the podcast and read more.

Dr. Mehdi Razavi, director of Electrophysiology Clinical Research & Innovations at the Texas Heart Institute

A medical device coming out of the Texas Heart Institute has been recognized for its innovation. Photo via THI

A new technology out of Houston's Texas Heart Institute's was named the top future medical product design worldwide last month as part of the annual Create the Future Design contest. The med device, which allows for pain-free defibrillation, is being developed by THI's Electrophysiology Clinical Research & Innovations team in conjunction with scientists at Rice University and UCLA, the technology allows doctors to place up to 12 tiny nodes around the heart to pace and defibrillate the heart without using a shock.

The technology will be most useful for atrial fibrillation and ventricular fibrillation, which can lead to sudden death, stroke, and congestive heart failure, according to Dr. Mehdi Razavi, the head investigator on this project and leader of the THI team.

"It's extremely painful. It's like someone takes a two by four and just pounds you from the inside in the chest, or a horse kicking you in the chest," Razavi says. He went on to add: "I have actually one patient who was a Vietnam veteran. He said nothing that he faced in battle was as disconcerting—not just because of the pain, but the fact that you don't know when the pain is when the shock is about to happen. That anxiety is just overwhelming." Read more.

Deanea LeFlore, director of partnerships at The Ion, joins this week's episode of the Houston Innovators Podcast. Photo courtesy of Station Houston

​Innovation hub exec wants to ensure Houston's diversity is well represented

Houston innovators podcast episode 61

The Ion is in its home stretch. Expected to open in early 2021, the rising innovation hub is inches away from its exciting entrance into the Houston market. Yet despite the physical location's ongoing construction, Deanea LeFlore and her team have been hard at work for months establishing partners and programming for The Ion's goal of serving Houston.

"The primary objective of The Ion is economic resilience," LeFlore, who is director of partnerships at The Ion says on this week's episode of the Houston Innovators Podcast. "We want Houstonians to be better off economically as a result of this project and as a result of them participating in the tech and innovation economy."

Meeting this goal is LeFlore's job priority and bringing economic support can mean upskilling, creating more new business, access to capital, resources for growing businesses, and diversifying the workforce — something she's personally committed to.

Recently, The Ion received a grant to create the Minority Business Enterprise Aerospace Innovation Hub focused on supporting minority innovators within the space and adjacent industries with an accelerator program and business programming. The program is providing informative sessions on how to get involved, and the next one is on Dec. 16.

"We're hoping that at the end of this, as startups get coaching and tips from NASA and partners, that they'll learn what it takes to expand in the aerospace industry," LeFlore says. "That's a really exciting development and a new opportunity for minority businesses in Houston."

Personally, LeFlore, who worked for the city's international relations for about 17 years, is excited to have a hub focused on innovation that is representative of the city.

"I think that when people walk into The Ion, what's personally important to me, is that it looks like Houston so that you see yourself reflected in the people in the building as well as the programming," LeFlore says. "That's my biggest hope and aspiration, and I believe we are well on track to be able to deliver on exactly that."

LeFlore shares more on what she's been working on — from online programming to growing partnerships at The Ion. Listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


The Ion has tapped DivInc. as a partner. Courtesy of Rice University

The Ion announces partnership with nonprofit to serve Houston's diverse entrepreneurs

diving into diversity

Houston is ranked the No. 1 diverse city in the nation, and a local organization has forged a new partnership to make sure that diversity is represented within the city's innovation ecosystem.

The Ion, an innovation hub currently rising in Midtown Sears Building, and DivInc, a Texas nonprofit, have agreed to partner to advance diversity among Houston entrepreneurs. It's Austin-based DivInc's first Houston initiative, according to a news release.

"Our experience equipping diverse entrepreneurs with strategies to create exceptional companies, coupled with the Ion's enthusiasm and thoughtful approach to building an inclusive space where entrepreneurs from all walks of life can thrive is a winning combination," says Preston L. James, founder and CEO of DivInc, in the release.

"No matter where they are in their entrepreneur journey, we want all Houstonians to know DivInc is here to help you achieve your biggest dreams."

Since its founding in 2016, DivInc has worked to provide over 60 founders and more than 50 tech companies with resources and support for growth. Locally, DivInc is already working on programming to extend its reach to Houston entrepreneurs, including a kick-off event at The Ion on Tuesday, March 3, at 5:30 pm.

"As The Ion looked for a partner to provide best practices and resources to our local business communities and leaders that have historically been overlooked, we knew our partner needed to be ambitious, thoughtful and encouraging, but also have a record of success and experience working shoulder-to-shoulder with entrepreneurs," says Deanea LeFlore, senior director of The Ion, in the release.

"Our efforts and relationship with DivInc will do just that. We can't wait to help our stakeholders take their businesses to new heights and further demonstrate Houston is the best city in America for diverse entrepreneurs to thrive."

Houston-based BrainCheck has expanded into its own office space, innovators to know, and The Ion names new leadership — here are this week's top stories. Photo courtesy of BrainCheck

5 most popular innovation stories in Houston this week

what's trending

Editor's note: This week's top stories include new office space for a growing Houston health tech company, an energy software-as-a-service startup raises more money than it expected, and more trending innovation news.

3 Houston innovators to know this week

This week's innovators to know are focused on bringing startup programming and venture capital to Houston. Courtesy photos

This past week has been full of exciting innovation news in Houston — from big fundraising round closings to a new unicorn coming out of the Bayou City.

Houston innovators to know this week include a new program director for Houston's newest startup accelerator, a venture capital fund leader, and more. Continue reading.

Houston health tech startup moves into new office amid major growth

BrainCheck has moved to a new office as it grows its team and expands its product. Natalie Harms/InnovationMap

Following a series A round of fundraising, a Houston digital health startup is on a bit of a hiring spree, leading to new office space the company has room to grow into.

BrainCheck, which was founded in 2015 by neuroscientist David Eagleman, is a cognitive assessment startup that has developed a software tool for primary care doctors to use to assess their patients' cognitive health so that they can more quickly diagnose and treat them for maladies like dementia.

The 19-person company headquartered in Houston — with a secondary office in Austin focused on product development — has relocated its operations from coworking space in the Texas Medical Center to an office in the Rice Village area. The move was made possible by an $8 million series A financing round that closed in October. Continue reading.

TMCx company receives investment from Houston VC, UH program recognized, and more innovation news

TMCx

A TMCx company has raised money in Houston, UH's online program named best in the nation, and more Houston innovation news. Courtesy of TMCx

Houston's innovation ecosystem has seen a busy January so far — the city has claimed a unicorn in High Radius, The Ion has named a series of new execs, and so much more.

Given this influx of news, you might've missed some other Houston innovation headlines, like UH being recognized for its online master's program, recent fundings, and Texas being named a state for female entrepreneurs. Here's a few short stories to catch you up. Continue reading.

The Ion Houston names 3 new execs to its team

Jan E. Odegard, Deanea LeFlore, and Chris Valka have been named senior directors at The Ion. Photos courtesy of The Ion

The Ion, an entrepreneurship center being developed in the old Sears building in Midtown by the Rice Management Company, has named three new senior directors to its team.

Deanea LeFlore, Jan E. Odegard, and Chris Valka are the three newly named leaders of the organization, effective immediately. They join — and will report to — Gabriella Rowe, who was named executive director in October.

"To grow the Houston innovation system and spearhead our mission for the Ion we've hired three new leaders with fresh perspectives, ideas, and approaches," says Allison K. Thacker, president and chief investment officer of the Rice Management Company, in a news release. "Each individual has a unique connection to Houston and the Ion, and we're thrilled to have them join our effort to build on the culture of innovation across our city, and within the community we're cultivating at the Ion." Continue reading.

Houston-based oil and gas software company raises $1.6 million

XXXL pumpjack silhouettes

Houston-based M1neral has raised $1.6 million in an oversubscribed pre-seed round. Getty Images

A Houston energy tech startup that's digitally optimizing the minerals rights buying and selling process has closed an oversubscribed pre-seed financing round to the tune of $1.6 million.

M1neral's round was co-led by Amnis Ventures and Pheasant Energy, among a few other select investors and strategic partners. The company was co-founded by Jacob Avery, Kyle Chapman, and Shawn Cutter.

"Amnis Ventures is delighted to co-lead the current round of funding in M1neral. The founders come with deep knowledge of oil and gas, coupled with proven, delivered technology implementations in the energy space," says Manuel Silva III, president of Amnis Ventures Inc., in a press release. "The M1neral platform will bring age-old upstream oil and gas processes into the technology revolution of the 21st century that we have come to expect in other sectors." Continue reading.

Jan E. Odegard, Deanea LeFlore, and Chris Valka have been named senior directors at The Ion. Photos courtesy of The Ion

The Ion Houston names 3 new execs to its team

new hires

The Ion, an entrepreneurship center being developed in the old Sears building in Midtown by the Rice Management Company, has named three new senior directors to its team.

Deanea LeFlore, Jan E. Odegard, and Chris Valka are the three newly named leaders of the organization, effective immediately. They join — and will report to — Gabriella Rowe, who was named executive director in October.

"To grow the Houston innovation system and spearhead our mission for the Ion we've hired three new leaders with fresh perspectives, ideas, and approaches," says Allison K. Thacker, president and chief investment officer of the Rice Management Company, in a news release. "Each individual has a unique connection to Houston and the Ion, and we're thrilled to have them join our effort to build on the culture of innovation across our city, and within the community we're cultivating at the Ion."

To focus on the Ion's Academic Partner Network, Jan E. Odegard has been appointed senior director of industry and academic partners. Odegard's background includes research and leadership at Rice University in computing. Odegard will also oversee The Ion's labs, which include human/robotics interaction lab, an immersive reality lab and an industrial prototyping lab.

Deanea LeFlore has been named senior director of community and corporate engagement. Like Rowe, LeFlore had a similar role at Station Houston before this new position. Before that, she spent most of her career working for the city of Houston and served under four Mayors over 17 years.

Lastly, Chris Valka, has been hired as senior director of operations, overseeing finance, accounting, human resources, operations, and facilities management. Prior to this position, Valka served in the president's cabinet overseeing a similar spectrum of responsibilities at the University of St. Thomas.

"As we prepare for The Ion's opening in early 2021, we are excited to welcome Deanea LeFlore, Dr. Jan E. Odegard, and Chris Valka, to our growing team," says Rowe in the release. "I am excited to see what this diverse group of experts will bring to our efforts to build an inclusive innovation hub in a tech-forward environment that promotes all that is great about Houston."

The 270,000-square-foot Ion building broke ground in July of last year and is slated to open in 2021. Recently, the organization announced its first programming partner — Rice University's Glasscock School of Continuing Studies, and select courses have already begun.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 23 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.

Elon Musk's SpaceX is about to make its debut on Wall Street

Money Moves

Elon Musk's rocket company SpaceX will make its debut on Wall Street Friday, June 12, and both institutional and retail investors are expected to gobble up the 555.6 million shares going up for sale at $135 apiece. Musk, already the world's richest man, could become its first trillionaire.

SpaceX is likely to become the biggest IPO ever, with proceeds of around $75 billion. SpaceX hopes to become the first company to send people to Mars. In fact, part of Musk’s future compensation depends on SpaceX eventually establishing a colony of at least 1 million people on the red planet.

Why SpaceX is going public now

In a video conference on Musk's social media platform X, he told JPMorgan CEO Jamie Dimon that people have suggested for the last 10 years that he take SpaceX public. He's doing it now because the company plans to put 100,000 next-generation Starlink satellites into orbit. Deploying AI data centers in space is a “massive new growth base and you need capital for that,” he said.

Going public provides access to the capital that SpaceX needs. But it also exposes it to more scrutiny from shareholders and more regulatory oversight. That includes filing quarterly financial reports, which critics say incentivizes short-term thinking over longer-term planning and creates unnecessary costs for a company. Securities regulators are currently soliciting public comment on a proposal to require public companies to file the financial reports only twice every year.

How the IPO impacts the company

Musk will hold the majority of a special class of shares, giving him control over decisions related to company strategy, finances and personnel. On the latter, because of his ownership of most of these Class B shares, the only person who can fire Musk as CEO is Musk.

The company credits Musk with being the “driving force” behind its growth, innovation and success. But what happens if Musk is no longer in the picture? SpaceX warns that the loss of Musk could disrupt its ability to execute its strategy as well as hurt its “reputation and relationships with customers, partners and other stakeholders.”

The company also warns that finding a replacement with the same skills and experience as Musk would be time-consuming, if not nearly impossible. As Wedbush Securities analyst Dan Ives wrote Wednesday, “At the end of the day Musk is SpaceX and SpaceX is Musk.”

What could make or break SpaceX

Currently in the test phase, the gigantic reusable Starship rocket is key to SpaceX realizing Musk's ambitions. Much of the commercial space business hinges on SpaceX developing Starship’s capability to be fully reusable and hearty enough for a quick turnaround between flights. If that doesn't happen, SpaceX warns that putting data centers and satellites in space will take longer and cost more money, meaning it risks customers bailing on the company.

Analysts say that by pioneering reusable rockets, SpaceX has established a clear lead on competitors such as Blue Origin, led by Amazon founder Jeff Bezos. The Starlink satellite business competes with, among others, AST SpaceMobile – which is relying on a SpaceX rocket to send its latest generation of satellites into orbit next week.

The prospectus filed last week says SpaceX’s biggest potential market is the sale of business-oriented artificial intelligence products designed to transform how people get work done. It’s an opportunity SpaceX predicts would be worth $22.7 trillion if it could somehow dominate rivals like Anthropic, OpenAI and Microsoft in a highly competitive industry. But the prospectus shows no clear path to profitability for the xAI business, which merged with SpaceX earlier this year.

Why Wall Street is paying attention

If the SpaceX IPO is as successful, the stock could quickly join the Nasdaq 100, a widely followed index that tracks the 100 largest non-financial companies in the composite. That's important because some popular funds, such as the $460 billion QQQ exchange-traded fund, mimic the index and will automatically buy whatever is listed in the index.

Nasdaq recently changed its rules to allow select companies to enter the Nasdaq 100 after just 15 trading days.

S&P Dow Jones Indices, on the other hand, is sticking to established and more traditional thresholds that will not allow SpaceX or other companies with gargantuan IPOs faster entry into its S&P 500 index. That means even high-profile companies will still need to wait for their stocks to trade a full 12 months before they can enter the index.

Companies want to be in the S&P 500 in particular because it's arguably the most important index on Wall Street, with trillions of dollars either mimicking it exactly or benchmarked against it. Vanguard's VOO fund that tracks the S&P 500 has roughly $950 billion invested in it, for example.