This week's Houston innovators to know are hoping to make an impact. Courtesy photos

Starting off a new — hopefully drier — week in Houston, these three Houston innovators to know are looking to make an impact. From using tech for good to creating a women's movement in Texas business, these three Houstonians are on a roll.

Cristen Reat, co-founder and program director at BridgingApps

BridgingApps, a program backed by Easter Seals of Greater Houston, uses technology like iPads to help provide services for children and adults with disabilities — as well as for veterans — and their families. Courtesy of BridgingApps

At the cusp of the tablet generation, Cristen Reat saw her child, who had down syndrome, and this convenient emerging technology and connected the dots. She helped start a support group in a therapy clinic where many parents were interested about why mobile devices and apps were so engaging to their children.

"We were just amazed about how our children with different types of disabilities were engaged with the devices, were able to communicate with the devices, and were making big strides in their therapy," says Reat.

BridgingApps was founded by Reat and Sami Rahman in 2010, both seeking to help their children grow. The program became a part of Easter Seals of Greater Houston in 2011. The website currently boasts over 3,000 apps which users can sort through by category, age, price, skill, grade level, mobile device, and more. The apps are also able to benefit and treat veterans and their families. Read more about Reat and the BridgingApps program here.

Charley Donaldson, co-founder and COO of CaringBand

CaringBand is using a simple technology to better connect family and friends to the ones they love. Courtesy of CaringBand

When Charley Donaldson's mother-in-law was diagnosed with cancer, he and his wife knew they were in for a tough time. What they didn't realize was how important communication was going to be with each other. The ability to check in with loved ones frequently is tough — whether it's a good day or a bad day, people are busy and picking up the phone can be time consuming.

"It's like, you want to show people that you care about them, but you don't want to interrupt their day, or you don't want to be a burden to them if they aren't up to company," Donaldson says.

CaringBand is a light-up bracelet that's Bluetooth enabled, and connects to a mobile app. A person gives the bracelet to a loved one, who then pairs it with his or her smartphone. App users can send and receive pre-set messages of encouragement to and from other app users. Those wearing a CaringBand bracelet get alerted by a blinking light or vibration that lets them know someone is thinking about them. The wearer then reads these encouraging messages on the CaringBand app when convenient and with no need to respond. Read more about the Houston company connecting loved ones.

Ludmila Golovine, president and CEO of MasterWord Services Inc. and a founding member of Women in Localization's Texas Chapter

Ludmila Golovine, president and CEO of MasterWord Services Inc. and a founding member of newly formed Women in Localization's Texas Chapter, writes on the importance of localization. Courtesy of Golovine

Your business message is only as good as the receiver's ability to understand it. Localization is extremely important for business growth, and Ludmila Golovine, president and CEO of MasterWord Services Inc., wrote a guest article for InnovationMap about this importance as it pertains to the digital age.

"Opening a website or an app that wasn't intended for you can feel a lot like being lost in another country: you cannot understand the street signs, everything is different, and you don't even know how to ask a question of where to go," she writes.

Golovine is a founding member of newly formed Women in Localization's Texas Chapter. The organization is hosting its first Houston panel and networking event on Tuesday, September 24, from 6 to 8 p.m. at Station Houston. Read Golovine's guest article here.

BridgingApps, a program backed by Easter Seals of Greater Houston, uses technology like iPads to help provide services for children and adults with disabilities — as well as for veterans — and their families. Courtesy of BridgingApps

Houston nonprofit optimizes technology for special needs treatment and diagnoses

Using tech for good

When the first iPad was released in April of 2010, tech accessibility changed in more ways than mobile checkouts or on-the-go streaming.

The interface of the device is built around the multi-touch screen, which became a game changing component in special needs therapy and sparked the founding of BridgingApps, a program part of Easter Seals Greater Houston.

The program provides access to educational and therapeutic tools to parents, teachers, and therapists to use these mobile devices and apps to target and improve cognitive and physical development in children and adults with disabilities.

"I am the parent of a child with multiple disabilities; my son was born with Down syndrome," says Cristen Reat, co-founder and program director at BridgingApps.

Reat tells InnovationMap that she helped start a support group in a therapy clinic where many parents were interested about why mobile devices and apps were so engaging to their children.

"We were just amazed about how our children with different types of disabilities were engaged with the devices, were able to communicate with the devices, and were making big strides in their therapy," says Reat.

BridgingApps was founded by Reat and Sami Rahman in 2010, both seeking to help their children grow. The program became a part of Easter Seals of Greater Houston in 2011. The website currently boasts over 3,000 apps which users can sort through by category, age, price, skill, grade level, mobile device, and more. The apps are also able to benefit and treat veterans and their families.

"I was amazed at how quickly my son was able to do things independently with these touch screens that he was not able to do with traditional computers," Reat tells InnovationMap.

The Easter Seals Greater Houston organization was recently awarded a $15,000 grant from the Comcast Foundation as part of the Comcast NBCUniversal Assistive Technology Grant Fund, expand the available equipment used in the community technology labs with new equipment such as the TobiiDynavox EyeMobile Mini Classic Eye Gaze system that includes new software called Look To Learn and SnapCore First, and the AbleNet Latitude Mounting Arm that holds an iPad, Kindle, or other tablet and mounts to beds, wheelchairs, and tabletops.

The nonprofit offers three assistive technology services labs across the Houston area, in Bellaire, the Woodlands, and Stafford. According to the website, each lab has open lab days that the public can access without an appointment to explore a variety of assistive technology, including adapted toys and switches, specialized software and computer equipment, communication devices, and mobile devices and apps. Workshops and trainings are also available.

"The whole idea of BridgingApps is a shortcut, so that you don't have to Google search every day," says Reat. "It's basically the Yelp of special needs apps where you can type in a diagnosis, a skill, something you're looking for, and you'll come up with a video, instructions, and summary that helps people figure out what can help them today."

The organization was also awarded a $75,000 grant by Blue Cross and Blue Shield of Texas, which, according to a news release, will help the nonprofit serve 50 individuals that are veterans and or current military as well as their family members through services such as digital trainings through app reviews and videos, face-to-face counseling and counseling via tele-health, especially for those without transportation or living in rural areas.

BridgingApps currently has a team of two full-time and seven part-time employees. The nonprofit hosts an annual fundraiser each Spring called Walk With Me. The next walk is scheduled for April 25 at the Houston Zoo.
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Houston researchers report promising first in-human trial for implantable cancer therapy

cancer breakthrough

When it comes to cancer remedies, the treatment can be as challenging for the body as its cause. But what if immunotherapy could be localized? That’s precisely what a Houston team may soon make a reality.

Rice University researchers, in partnership with MD Anderson Cancer Center, recently published their findings from the first in-human trial of an implantable cancer-fighting treatment in the journal Clinical Cancer Research. The paper details testing of AVB-001, encapsulated cells engineered to release interleukin-2 (IL-2)—a naturally occurring signaling protein that boosts immunity—in the peritoneal cavities of 14 patients. The goal is to avoid the toxicity usually experienced with less targeted treatments, as well as find a solution to IL-2s’ abbreviated half-lives.

“Traditional IL-2 therapy has shown potent antitumor activity, but its clinical use has been limited by severe side effects and delivery challenges,” Omid Veiseh, director of the Rice Biotech Launch Pad, professor of bioengineering at Rice and a senior author on the study, said in a press release. “This platform allows us to localize and sustain cytokine exposure directly where tumors reside while minimizing systemic toxicity.”

Serous ovarian carcinoma is especially well-suited to the use of AVB-001 because it tends to spread throughout the abdomen. After a minimally invasive laparoscopic procedure, patients implanted with the cells were noted to tolerate the treatment well. Half of the enrolled patients’ cancer was stabilized, with several among them reporting extended signs of benefit. No maximum tolerated dose was reached and there were no life-threatening events tied to the study.

If that sounds like less-than-earth-shaking results, this is only the beginning. The capsules were implanted for about one week because IL-2 activity drops off after that. The researchers now know that further testing should include either higher levels, repeated doses, or a combination thereof, in order to create stronger advances.

The team has already made early headway on this next step. Preclinical studies in nonhuman primates were not only tolerated well, but without added toxicity, the apes had consistent pharmacological effects.

“This is a foundational step,” Veiseh explained. “We now have evidence that the platform is safe, biologically active and potentially scalable. The next phase is optimizing dosing and exploring combination therapies to unlock its full clinical potential.”

The combination would also include a checkpoint inhibitor, which might improve AVB-001’s tumor-fighting power. “What is exciting is that we are not just delivering a drug, we are programming a microenvironment,” added Dr. Amir Jazaeri, professor of gynecologic oncology at MD Anderson, member of the Rice Biotech Launch Pad’s clinical advisory board and a senior author on the study. “This opens the door to combination strategies that could amplify immune responses in ways that have not been feasible before.”

Houston startup raises $6M to scale home-based healthcare platform

fresh funding

As healthcare systems race to expand care beyond hospitals and into the home, investors are placing bigger bets on the infrastructure needed to make that shift possible.

This month, Rosarium Health announced it has raised $6 million in seed funding led by Kalos Ventures, with participation from ResilienceVC, Rock Health Capital, Symphonic Capital, Black Tech Nations Ventures and others.

The investment will help the Houston-based startup continue to build its platform, which features a national network of 800-plus clinicians and 3,000-plus contractors to coordinate home accessibility upgrades and modifications for seniors and people living with disabilities.

For founder and CEO Cameron Carter, the company’s mission grew out of firsthand caregiving experiences.

“From my own personal caregiving experiences, I realized that the benefits exist on paper, but not in reality,” Carter said in a news release. “Families are being left to figure out the paperwork and installations all on their own, which shouldn’t be how this works.”

While Medicare Advantage and Medicaid plans have expanded coverage for home-based services and accessibility modifications, the logistics behind delivering those services often remain fragmented.

Rosarium’s platform coordinates the entire process, from clinical assessments and referrals to contractor management, documentation, reimbursement and installation.

“A clinician can document that a home isn’t safe and a plan can approve a benefit, but there’s no one that’s responsible for making sure the work actually gets done,” Carter says. “We built the missing piece.”

The company was founded in 2021 as Rose Health and was a 2023 participant in the Texas Medical Center’s Accelerator for HealthTech program. It has scaled quickly, building a network of more than 800 clinicians and 3,000 contractors across 34 states.

Rosarium is currently in-network for 1.2 million Medicare and Medicaid lives, with projected coverage expected to reach nearly 4 million by the end of the year, according to the release.

“We’re excited to back Cameron because he and the team at Rosarium are building the infrastructure healthcare needs right now to make the home a safe and comfortable place of care,” Kate Ballinger, investor at Kalos Ventures, added in the release.

As part of the recent investment, Ballinger will join Rosarium’s board of directors.

With eyes on the future, Rosarium plans to grow its partnerships with Medicaid and Medicare Advantage plans, including CalViva and Community Health Plan of Imperial Valley, strengthening its presence in California while expanding access to underserved communities.

Additionally, Carter predicts that home-based healthcare will be part of a broader transformation happening across the industry.

“There’s a growing recognition that health outcomes are shaped by what happens in the home,” he said in the release. “The future of healthcare isn’t just treating people after something goes wrong. It’s creating environments that help prevent those problems in the first place.”