With fresh funding, Houston cancer-fighting cell therapy gears up for continued clinical trials

Houston innovators podcast episode 259

Sarah Hein, co-founder and CEO of March Biosciences, joins the Houston Innovators Podcast to discuss how the company will use its series A funding. Photo via march.bio

When cancer originates in a patient, their body fights as hard as it can against the disease, but sometimes, the cancer wins the battle. However, one Houston cell therapy startup is working on an artillery of therapeutics to help arm patients' bodies to win the war.

Founded in 2022, March Biosciences is a cell therapy company born in part out of the Texas Medical Center's Accelerator for Cancer Therapeutics, where Sarah Hein served as inaugural entrepreneur in residence. In that role, she met her co-founders Max Mamonkin and Malcolm Brenner.

Now, leading the startup as CEO, Hein tells the Houston Innovators Podcast that with March's lead product, MB-105, an autologous CD5 CAR T cell therapy, the name of the game is to zero in on advancing this particular treatment to its phase II trial next year.

"Targeted therapies are targeted. Our target is expressed on these T-cell cancers, and there are a couple other cancers, like Mantle Cell Lymphoma or Chronic Lymphocytic Leukemia," Hein says on the show. "Unfortunately, I don't think there's ever going to be a magic bullet that is going to hit a huge swath of these cancers. We're going to continue to chip away at these cancers by creating really elegantly engineered therapies against these different kinds of tumors.

"March, in general, is committed to this idea that we're going to continue to work on difficult tumors and different targets with our uniquely engineered targeting strategy against these diseases. As we expand into the next year, you'll see us speak on this a little more on how we're going to continue to work on new diseases that havent been addressed previously," she continues.

Hein explains how March Biosciences — named in part as a nod to one of Houston's best months weather wise — has benefitted from the support of the local life science community. Last year, March announced its partnership with CTMC (Cell Therapy Manufacturing Center), a joint venture between MD Anderson Cancer Center and National Resilience. Hein says over the past year, they've moved into CTMC and that's allowed them to accelerate their progress as a company.

"Houston has a unique sophistication in cell therapy. Where we've had biotech spinout, cell therapy has been one of our more successful verticals," she says. "We've had resources and knowledge here that were uniquely available for our drug category."

Earlier this month, March Biosciences announced an oversubscribed $28.4 million series A led by Mission BioCapital and 4BIO Capital and bringing the company's total funding secured to more than $51 million, including its prestigious CPRIT grant. Hein says this funding will go toward further developing March's therapeutics and team as it gears up for its phase II trial next year.

Ultimately, Hein explains on the show how passionate she is and her team is on continuing to develop treatments to fight cancer with their targeted approach.

"I never have to explain to people why we would go out and fight cancer. I think it's a self-evident hypothesis," she says. "But what I personally find is exciting in cancer therapies in general are these immune therapies, where you using the body's own immune system to seek out and destroy the cancer cells.

"What's really exciting about that is these are the same immune cells that fight cancer or pre-cancers for most of your life and usually what happens is the cancers figure out a way to mass themselves. With modern approaches, we can boost the immune system."

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The Texas Medical Center's ACT program is making sure the most-promising cancer research makes it to its life-saving commercialization stage. Photo via tmc.edu

Houston program buoys promising cancer research with live-saving innovation

act-ing now

How do you bring promising cancer research to the masses? TMC Innovation's Accelerator for Cancer Therapeutics was established with that question in mind.

Funded by a $5 million grant from CPRIT, or the Cancer Prevention and Research Institute of Texas, in 2019 and in collaboration with the Gulf Coast Consortia and the University of Texas Medical Branch, the first cohort began their intensive work in 2021. The deadline to join the next cohort is October 13.

Since its inception, ACT has seen the forming of 19 companies — two of which have been awarded CPRIT seed grants, along with four in contention for one this year — as well as $92 million in dilutive funding and $10 million in non-dilutive funding.

“We’ve recruited investigators and companies from the breadth and width of the state of Texas, so all the way from Lubbock to Galveston from Dallas to the Rio Grande Valley,” Ahmed AlRawi, program manager, tells InnovationMap. “We've had an amazing set of investigators who have gone through the program — 56 teams to be precise.”

AlRawi says that the first pillar of the program is education. To that end, the cohort works with entrepreneurs in residence like Michael Torres. Best known as the co-founder of ReCode Therapeutics, Torres says that one of his greatest passions lies in translating science into medicines. ReCode is a genetic medicines company that is currently clinical-stage. It’s raised more than $300 million in the last two years, certainly something to which scientist-entrepreneurs earlier in their careers would aspire.

A longtime resident of Dallas, Torres moved his family to Houston last year, calling it “the place to be for cancer startups in Texas.”

Initially, says Torres, Houston wasn’t on his radar. But thanks to a call from ACT external advisor Dan Hargrove, Torres realized that the city might be a fit for him and his goals.

“I wanted to find a project that I could help support, sort of take my experience as a cofounder and help guide the next great startup within the ecosystem,” he says.

Torres and AlRawi agree that the biggest successes to come out of ACT so far include March Biosciences, a company from the first cohort, which is focused on developing CAR-T cell strategies to help combat hematological cancers; CPRIT fundee, OmniNano Pharmaceuticals, which uses patented nanotechnology to co-deliver a pair of therapeutical agents to solid tumors; and the latest, CrossBridge Bio.

Part of the most recent cohort, Torres has joined Drs. Kyoji Tsuchikama and Zhiqiang An as the last company’s CEO. To that end, he’s partnered with the world-class researchers out of UT Health Houston to build a next-generation antibody drug conjugate company that he believes will produce “better and safer and more effective drugs than what's currently on the market today.”

All the more reason that Torres he’s glad to have moved to Houston at what he calls “a really exciting time.” He’s thankful for the Texas Medical Center and the relationships it fosters. “We're all sort of aligning on creating a sustainable biotech ecosystem,” he says. And the next big cancer fighting company may well emerge from ACT.

7 Hills Pharma, an innovative immunotherapy company, was awarded a $13.5 million grant from the Cancer Prevention and Research Institute of Texas. Photo via Getty Images

Houston immunotherapy company to use $13.5M grant to further develop cancer treatments

future of pharma

Between Bangalore and Chennai in the Indian state of Andhra Pradesh, you’ll find the town of Tirupati. It’s home to seven peaks that host a Hindu temple complex devoted to a form of Vishnu, Venkateshvara. It is also the region from which Upendra Marathi originally hails. It’s where his father, and many other family members, attended medical school.

“My father’s first job was to take care of the pilgrims,” recalls Marathi.

It's only natural that his groundbreaking Houston company would be named 7 Hills Pharma.

“That sort of selflessness and giving back, I wanted to embody it in the name of the company,” Marathi says.

Now, 7 Hills Pharma is announcing that last month, it was awarded a $13.5 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT). That’s on top of more than $13 million in NIH grants, making the company the second largest recipient of SBIR/STTR grants in Texas.

Launched in 2016, 7 Hills Pharma is working to develop drugs that can overcome the all-too-common problem of immunotherapy resistance. Thanks to the Nobel Prize-winning work of Jim Allison in the realm of immuno-oncology, the field was “very hot” at the time, says Marathi, particularly in Houston.

So what has 7 Hills developed? Oral small molecules that activate integrins — the receptors that allow cells to bind to one another — allowing for the cell-to-cell interactions that create a successful immune response to immune checkpoint inhibitors such as Yervoy. In other words, they have created capsules that increase the effectiveness of drugs that allow the body’s own immune response to fight cancers.

But that’s not all. Tests have shown that the same discovery, called alintegimod, can also augment the effectiveness of vaccines. The pill, which co-founder and co-inventor Peter Vanderslice calls “a beautiful way to amplify the vaccines,” can potentially be applied to anything from influenza to coronavirus.

Their greatest challenge, says Vanderslice, is the very fact that the technology is so novel.

“Most large pharmas are very risk averse,” he explains. “They only want to do ‘me-too’ kinds of drugs.”

7 Hills Pharma is the third company Marathi, both a PhD and an MBA, has helped to found based on technology he co-invented. Vanderslice is director of the molecular cardiology research laboratories at The Texas Heart Institute.

“It’s very much a homegrown company,” Marathi says.

And a small one, at least for now. Working out of JLabs@TMC, the full-time team is currently just Marathi and Siddhartha De, the senior director of development. Marathi convinced De to transplant himself and his family from India for the purpose of assisting 7 Hills with preparing its drugs for clinical readiness.

The CPRIT funds will allow 7 Hills Pharma to hire several long-time team members full-time and with benefits.

“The bringing of talent and bringing of technology to TMC and what was born at Texas Heart Institute is rather remarkable,” says Rob Bent, the company’s director of operations.

The next step for 7 Hills Pharma is a Phase Ib/IIa clinical trial in patients with treatment-resistant solid tumors. And the team just finalized the deck that will help raise another $10 million to $250 million in the company’s series A. And hopefully sooner rather than later, a new set of medical pilgrims will be thanking 7 Hill Pharma for its care.

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Port Houston reports emissions progress as cargo volumes climb

Greener growth

Port Houston’s initiatives to reduce emissions have shown some positive results, according to new data from the Port of Houston Authority.

Pulling from the Goods Movement Emissions Inventory (GMEI) report, which tracks port-related air emissions, Port Houston cited several improvements compared to the most recent report from 2019.

The port has seen total tonnage and container volumes increase by 16 percent and 28 percent, respectively, since 2019. However, greenhouse gas emissions have increased at a slower rate, growing only by 10 percent during the same time period, according to the data.

Additionally, emissions of nitrogen oxide fell by 7 percent, and emissions of particulate matter fell by 4 percent, despite adding 280 more pieces of cargo handling equipment.

“These results show that our emission-reduction efforts are working, and we are moving in the right direction,” Chairman Ric Campo said in a news release.

The Port Commission also recently approved items related to the $3 million U.S. Environmental Protection Agency Clean Ports Program (CPP) grant, which it received last year. The items will allow the port to work towards five new sustainability initiatives.

They include:

  1. An inventory of the port’s Scopes 1, 2, and 3 for greenhouse gas emissions
  2. A Port Area Climate Action Plan for the area and surrounding communities
  3. A CPP Truck Route Analysis
  4. Creation of the CPP Trucking Industry Collaborative
  5. Design of a customized website for Port of Houston Partners in Maritime Education, which is a non-profit leading maritime workforce development effort in local schools

Port Houston aims to be carbon neutral by 2050.

Houston leader on building inclusive communities through innovation

Guest Column

Innovation is often celebrated for speed or curiosity, but genuine progress is about inclusion and expanding the populations that benefit from new technologies.

For example, at Yale University, nursing students are now utilizing a hyper-realistic patient mannequin with Down syndrome, which not only mimics appearance but also fosters both empathy and competence in medical professionals who will treat people of all abilities. Tools like this remind us that innovation is not only about what is new, but also about how we include everyone in progress.

Inclusive Technology: What It Means

Inclusive technology design begins with diverse users in mind, including people living with disabilities such as blindness, hearing loss, or limb loss. Additionally, neurodiverse learners and those with varied learning styles benefit from inclusive technology. The purpose is to create tools that serve everyone in their homes, classrooms, workplaces, and public spaces. Inclusive technology is not only about empathy, but also equity. Innovation bridges gaps and extends access to all people.

National and Local Innovations Advancing Inclusion

Across the country, inclusive technology is transforming access for individuals with varying abilities. Robotics adapted for visually impaired students, audio-virtual reality labs for immersive learning, and AI-based platforms that personalize lessons for students are helping students engage in ways traditional tools cannot. These innovations are not just technical; instead, they are also deeply human, designed to expand access and opportunity for every learner.

Locally, Houston-based organizations demonstrate how inclusive tech can be paired with supportive programs to amplify impact:

  • BridgingApps, a program of Easter Seals of Greater Houston, provides assistive-tech labs and mobile devices for children and adults with disabilities, helping students communicate, learn, and connect in ways they may not have thought possible before.
  • MADE Houston creates adaptive classroom environments for twice-exceptional learners (gifted students with learning differences), ensuring that both their strengths and challenges are incorporated in the curriculum and class experiences.

Both programs partner with Camp For All to provide barrier-free camp experiences to their students.

Innovative technology has the power to change student outcomes and improve the quality of life. Reports such as Inclusive Technology in a 21st Century Learning System show that students with disabilities who have access to these tools are two to three times more likely to graduate from high school than those without.

Complementing these technology-driven advances are experiential programs that create community and empowering experiences.

Camp For All, for example, offers medically safe and adaptive camp experiences for children and adults with challenging illnesses, disabilities, or special needs. Camp For All demonstrates how barrier-free environments, combined with opportunities to explore and try new activities, foster confidence and resilience in campers, such as those who benefit from Easter Seals of Greater Houston and MADE Houston camps.

Why This Matters

When tools and technologies are designed to include everyone, the impact has the potential to impact all people. Individuals with physical, sensory, or learning differences gain confidence and access to opportunities, which leads to more diverse workforces and stronger communities.

Technology, educational tools, and thoughtfully designed programs can reduce barriers, improve academic outcomes, and help prepare individuals for future employment and independent living. Conversely, failing to design inclusively can further entrench inequities related to race, income, and abilities.

For context, while the national graduation rate for students with disabilities has risen to 74%, it still lags behind the 88% rate for peers without disabilities. Technology and inclusive programs help bridge this gap, ensuring that not only more students graduate, but that individuals with disabilities also are better prepared to access higher education, participate fully in the workforce, and engage in social and civic life.

Inclusive tools, such as accessible transportation services, audible pedestrian signals, braille ballots for voting, and short-term device loan programs like TTAP, expand opportunities and promote equitable participation across all aspects of society.

Additionally, research shows that early exposure and inclusion of those living with disabilities, such as in classrooms, community spaces, and club activities, fosters a greater acceptance of differences and proclivity toward inclusive attitudes as children mature. When we begin focusing on acceptance and innovative solutions for all people from the very beginning, our communities are stronger and we increase access to participation for all.

Challenges, Opportunities, and Ripple Effects

Despite progress, obstacles to scaling inclusive technology remain. Many families and schools cannot afford high-end assistive devices, and tools are often developed without input from the users who will rely on them the most.

Although grants and pilot programs exist, systemic funding and support are still limited. Educators, healthcare providers, and city planners also require training and guidance to effectively implement these tools. Overcoming these challenges requires coordinated efforts among technology companies, educators, nonprofits, policymakers, and the communities they serve.

Houston’s rich mix of innovation, research institutions, and nonprofit networks makes it an ideal testing ground for inclusive technology, and we are seeing more advancements daily. Schools and early learning centers are piloting innovative tools, including adaptive learning software, interactive robotics, music therapy, and word prediction programs.

At the same time, medical and therapy programs use simulation labs and telehealth tools to improve treatment for children and adults with disabilities. Civic and public spaces are also becoming more accessible through smart city initiatives such as wayfinding apps, inclusive playgrounds, and sensory-friendly public areas. These examples demonstrate that inclusive technology is about creating meaningful opportunities for everyone, regardless of ability, background, or resources.

When inclusion is prioritized, the benefits extend far beyond individual users. Educational outcomes improve as more students meet learning goals and graduate successfully. Workforce readiness increases as a broader range of skills and abilities enters the labor market. Community equity grows as individuals from underserved communities gain access to tools and experiences that were previously inaccessible.

Increasing participation for students and individuals translates into stronger local and state economies. At its core, inclusive technology creates equity and resilience at both the individual and community level.

Moving Forward

Designing with empathy, investing in equitable access, and acting with urgency are essential to building communities where everyone has the opportunity to contribute. Houston, with its combination of medical research institutions, ed-tech startups, aerospace leadership, nonprofit networks, and pilot programs, is uniquely positioned to lead the nation in inclusive innovation.

By prioritizing technology and programs that serve all learners, the city can demonstrate that meaningful progress is measured not by speed or novelty, but by the number of people who benefit from it. When cities, organizations, and communities commit to inclusive design, they build stronger and more equitable places where everyone benefits and thrives.

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Pat Prior Sorrells is president and CEO of Camp For All, a Texas-based nonprofit organization. Located in Burton, Texas, the 206-acre Camp For All site was designed with no barriers for children and adults with special needs to experience the joy of camping and nature. Camp For All collaborates with more than 65 nonprofit organizations across the Greater Houston area and beyond to enable thousands of campers and their families to discover life each year. She speaks regularly on the need for inclusive design in public spaces.

7 innovative startups that are leading the energy transition in Houston

meet the finalists

Houston has long been touted as the energy capital of the world, and it's now it's also a leading player in the energy transition — home to numerous startups and innovators working toward a cleaner future.

As part of the 2025 Houston Innovation Awards, our Energy Transition Business category honors innovative startups that are providing solution within renewables, climatetech, clean energy, alternative materials, circular economy, and more.

Seven energy transition companies have been named finalists for the 2025 award. They range from a spinoff stimulating subsurface hydrogen from end-of-life oil fields to a company converting prickly pear cactus biogas into energy.

Read more about these climatetech businesses, their founders, and their green initiatives below. Then join us at the Houston Innovation Awards on Nov. 13 at Greentown Labs, when the winner will be unveiled at our live awards ceremony.

Tickets are now on sale for this exclusive event celebrating all things Houston Innovation.

Anning Corporation

Clean energy company Anning Corporation is working to develop geologic hydrogen, a natural carbon-free fuel, using its proprietary stimulation approaches and advanced exploration modeling. The company said that geologic hydrogen has the potential to be the lowest-cost source of reliable baseload electricity in the U.S.

The company was founded by CEO Sophie Broun in 2024 and is a member of Greentown Labs. Last month, it also announced that it was chosen to participate in Breakthrough Energy’s prestigious Fellows Program. Anning raised a pre-seed round this year and is currently raising a $6 million seed round.

Capwell Services

Houston-based methane capture company Capwell Services works to eliminate vented oil and gas emissions economically for operators. According to the company, methane emissions are vented from most oil and gas facilities due to safety protocols, and operators are not able to capture the gas cost-effectively, leading operators to emit more than 14 million metric tons of methane per year in the U.S. and Canada. Founded in 2022, Capwell specializes in low and intermittent flow vents for methane capture.

The company began as a University of Pennsylvania senior design project led by current CEO Andrew Lane. It has since participated in programs with Greentown Labs and Rice Clean Energy Accelerator. The company moved to Houston in 2023 and raised a pre-seed round. It has also received federal funding from the DOE. Capwell is currently piloting its commercial unit with oil and gas operators.

Deep Anchor Solutions

Offshore energy consulting and design company Deep Anchor Solutions aims to help expedite the adoption of floating offshore energy infrastructure with its deeply embedded ring anchor (DERA) technology. According to the company, its patented DERA system can be installed quietly without heavy-lift vessels, reducing anchor-related costs by up to 75 percent and lifecycle CO2 emissions by up to 80 percent.

The company was founded in 2023 by current CEO Junho Lee and CTO Charles Aubeny. Lee earned his Ph.D. in geotechnical engineering from Texas A&M University, where Aubeny is a professor of civil and environmental engineering. The company has participated in numerous accelerators and incubators, including Greentown Labs, MassChallenge, EnergyTech Nexus LiftOff, and others. Lee is an Activate 2025 fellow.

Eclipse Energy

Previously known as Gold H2, Eclipse Energy converts end-of-life oil fields into low-cost, sustainable hydrogen sources. It completed its first field trial this summer, which demonstrated subsurface bio-stimulated hydrogen production. According to the company, its technology could yield up to 250 billion kilograms of low-carbon hydrogen, which is estimated to provide enough clean power to Los Angeles for over 50 years and avoid roughly 1 billion metric tons of CO2 equivalent.

Eclipse is a spinoff of Houston biotech company Cemvita. It was founded in 2022 by Moji Karimi (CEO and chairman of Cemvita), Prabhdeep Sekhon (CEO of Eclipse), Tara Karimi, and Rayyan Islam. The company closed an $8 million series A this year and has plans to raise another round in 2026.

Loop Bioproducts

Agricultural chemical manufacturing company Loop Bioproducts leverages the physiology of prickly pear cactus grown in Texas to produce bioenergy, food, and remediate industrial wastewater streams. The company uses its remote sensing technology, proprietary image-based machine learning model, and R&D innovation to capture raw biogas from the cactuses and is focused on scaling cactuses as an industrial crop on land.

Rhiannon Parker founded Loop Bioproducts in 2023.

Mars Materials

Clean chemical manufacturing business Mars Materials is working to convert captured carbon into resources, such as carbon fiber and wastewater treatment chemicals. The company develops and produces its drop-in chemical products in Houston and uses an in-licensed process for the National Renewable Energy Lab to produce acrylonitrile, which is used to produce plastics, synthetic fibers, and rubbers. The company reports that it plans to open its first commercial plant in the next 18 months.

Founded in 2019 by CEO Aaron Fitzgerald, CTO Kristian Gubsch, and lead engineer Trey Sheridan, the company has raised just under $1 million in capital and is backed by Bill Gates’ Breakthrough Energy, Shell, Black & Veatch, and other organizations.

Solidec

Chemical manufacturing company Solidec has developed autonomous generators that extract molecules from water and air and converts them into pure chemicals and fuels that are free of carbon emissions onsite, eliminating the need for transport, storage, and permitting. The company was founded around innovations developed by Rice University associate professor Haotian Wang.

The company was selected for the Chevron Technology Ventures’ catalyst program, Greentown Labs, NSF I-Corps and was part of the first cohort of the Activate Houston program. It won first place at the 2024 startup pitch competition at CERAWeek. Solidec was founded in 2023 by Wang, who serves as chief scientist, CEO Ryan DuChanois, and CTO Yang Xia. It closed a $2.5 million seed round earlier this year.

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