Corporations can do more than just throw money at innovation efforts. Photo via Getty Images

I vividly remember, it was a typical Tuesday at Houston Exponential, and I’m sipping maybe my third coffee of the morning when the phone rings.

On the line is yet another hopeful voice from a newly minted innovation group at a "big company." They lay out their vision: “We’ve got this new innovation group! It’s me — a tech enthusiast who’s been yelling into the corporate void about needing to shake things up for the last two decades — plus a data scientist who loves numbers more than people, and a procurement guy who… well, procures stuff. And here’s the kicker: they’ve handed us $60 million to put to work. But here’s the catch — this treasure needs to be turned into a groundbreaking innovation that will dazzle the C-Suite, in about six months.”

I chuckle then sigh, because I’ve heard this story not once or twice, but about a dozen times over. And unfortunately, each of those grand plans crashed faster than a shooting star burning out over the Texas night sky — brilliant, swift, and leaving us wondering what might have been. Why? Well, let’s dig into some observations from my time working with institutional innovators from around the world and uncover just why throwing money at innovation like confetti at a wedding isn’t the quick fix big companies hope it will be.

The big miss here is a deep understanding of and ability to articulate the challenges. Innovation isn’t a highway where you can just press the gas and speed straight to Mt. Scale. It’s more like a winding country road with breathtaking views, unexpected potholes, and the occasional bewildered chicken crossing your path. For institutional innovators — the brave souls charting the course through this ever-changing landscape — the journey is filled with excitement, challenges, and the promise of discovery.

In my first hand experience mentoring over 500 startups and corporations, I’ve seen that the magic of innovation doesn’t come from a deep-pocketed budget but from a deep understanding of the problems we aim to solve. If you can view challenges through a kaleidoscope of perspectives, not just through the monochrome lens of one industry, you find the alternate routes that, while not exactly shortcuts, do keep you from turning down dark alleys and dead ends. A key observation here is that solutions to hard problems often lie in adjacent industries.

For example, consider how biomimicry has led to inventions like Velcro, inspired by burrs' ability to stick to animal fur, or how bullet trains in Japan were designed to mimic the kingfisher's beak for better aerodynamics. These are just a few examples of how solutions to complex problems often reside right in front of us or in the industry next door. Right here in Houston, Pumps & Pipes is a glowing example of how experts from Energy, Life Science and Space converge on similar problem sets with wildly different perspectives and applications.

Imagine if the engineers at NASA sat down for tacos with teachers from the local high school, or if doctors brainstormed with video game designers over a game of pickleball. Sounds fun, right? But it’s also where the magic happens. When we step out of our industry bubbles, we find that the solutions to our biggest problems often come from the most unexpected places.

So how do we begin to find these solutions? It all starts with a clear and clearly articulated challenge statement.

A crucial factor in encouraging organizations to look beyond traditional industry boundaries is to foster a deep understanding of problem-solution fit (you can read more about Problem - Solution fit in my last article here) and that means a deep understanding of the Problem. By guiding problem holders to dig deep into the nuances of the problems they aim to address, we expand their perspective. Once a comprehensive grasp of the problems are established, new pathways for solutions organically emerge. To do this you must broaden the collective thinking to the point where solutions from other industries become not just viable but often the most effective approach. My favorite quote on this subject is that “people don’t need a ¼ inch drill bit, they need a ¼ inch hole, and really they don’t need a ¼ hole, they need to hang a picture and when framed in that context, a command strip is more effective at solving the problem.”

So how do we do this? It’s easy, just continuously ask "why" or “why does this matter to your customer” to peel back the layers of the initial problem statements to reveal underlying causes or first principles. Ok this is actually much harder than it sounds but when organizations are guided through exercises to distill their challenges into first principles and more universal problem statements, a transformation occurs, resulting in several benefits:

  1. Expanding Solution Horizons: By elevating the problem discussion beyond industry-specific issues, the range of potential solutions widens remarkably.
  2. Universal Problem Statements: Restating the issues into more universal terms unlocks innovative approaches and solutions previously unseen.
  3. Enhanced Solution Fit and Success Probability: This reframing leads to solutions that are not only more fitting but also stand a higher chance of successfully being adopted and integrated and thus resolving the underlying issues.
  4. Increased Buy-In: These solutions are and are perceived as more novel and thus receive increased buy-in across the organization when moving towards adoption.

The critical lesson here is the power of abstracting the problem. By pulling back from the immediate and specific issues and reinterpreting them into broader, more universally applicable challenges, we can tap into a richer vein of solutions. This approach not only broadens the scope of potential innovations but also increases the alignment and effectiveness of the solutions we pursue.

The art of crafting challenge statements that are both broad enough to inspire innovative thinking and specific enough to be actionable is crucial. These statements serve as beacons, guiding both internal and external innovation efforts towards solutions that are not bound by conventional industry norms. By framing challenges in a way that invites diverse perspectives, organizations unlock innovative solutions that transcend traditional boundaries, fostering a more expansive and inclusive approach to problem-solving.

Turning lofty ambitions into tangible results begins with understanding that innovation isn’t just about flashy gadgets or the latest buzzwords. It’s about solving real problems for real people. This means rolling up our sleeves, listening intently, and sometimes realizing that the solution isn’t a high-tech wonder but perhaps something as simple and elegant as a command strip instead of a hole in the wall.

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Jon Nordby is managing partner at Anthropy Partners, a Houston-based investment firm, and professor of entrepreneurship at the University of Houston.

Spaces plans to open a new location in Houston this month, Chevron Technology Ventures invests in autonomous vehicle tech, and more Houston innovation news. Courtesy of Spaces

New coworking space to open, Houston to host Accenture's health tech awards, and more innovation news

Short stories

A lot is happening in the Houston innovation ecosystem — so much that you may have missed a few key news items. Let's hit the highlights, shall we?

Applications are open for major health tech awards program that is coming to town, a Houston corporate venture fund doles out cash to self-driving cars, new coworking space to deliver, a diversity-focused partnership launches, and more Houston innovation news.

Chevron Technology Ventures invests in self-driving cars

Voyage is growing its fleet of self-driving vehicles with the help of a Houston corporate VC fund. Photo via voyage.auto

Silicon Valley's Voyage, a self-driving car technology company, closed its series B round at $31 million. Houston-based Chevron Technology Ventures contributed to the round.

The round's funds will go toward expanding the company's fleet of G2 autonomous vehicles in California and Florida, as well as introduce Voyage's G3 self-driving car, Oliver Cameron, co-founder and CEO at Voyage, writes in a release.

"Chevron has been supporting the public's transportation needs for over 100 years. As our customers' mobility needs and preferences change, we want to continue to be part of their journeys. Our investment in Voyage affirms this commitment," says Barbara Burger, CTV president, in a release. "We established the Future Energy Fund in 2018 with an initial commitment of $100 million to invest in breakthrough technologies that enable the ongoing energy transition. The fund looks for technologies that lower emissions and support low carbon value chains. Our investment in Voyage fits well within the objectives of the Future Energy Fund while also informing our perspective on the changing energy landscape."

Accenture to close out health tech challenge in Houston

accenture

The national challenge will conclude in Houston. Courtesy of Accenture

Applications are open for the fourth annual Accenture HealthTech Innovation Challenge and close on September 22. Finalists will present to judges from global health companies at one of two regional events — in Boston on Nov. 7 or in San Francisco on Dec. 5. The final judging event will take place in Houston on February 6, 2020.

"We look forward to this year's submissions as we continue to identify bold ideas from startups that deliver new solutions for health organizations to improve the lives of consumers, clinicians and employees," says Brian Kalis, managing director of digital health and innovation at Accenture, in a release. "Since its inception, the Accenture HealthTech Innovation Challenge has brought healthcare organizations and startups together to tackle the world's biggest health issues where we have received more than 2,200 applications, invited more than 90 startups to compete and who have benefitted from the guidance of nearly 1,000 executive judges from the healthcare industry."

The submission form, including additional details about the challenge's criteria, eligibility, and requirements, is available at: Accenture HealthTech Innovation Challenge-Health.

GotSpot wins pitch competition

Reda Hicks claimed the win at a military spouse pitch event. Trish Alegre-Smith/Military.com

Reda Hicks, who founded Houston-based GotSpot Inc., won a $15,000 check from the StreetShares Foundation and Samuel Adams' Brewing the American Dream at the Great American Military Entrepreneur at the Military Influencer Conference in Washington, D.C.

GotSpot is a website that allows for people with commercial space — a commercial kitchen, conference room, spare desks, etc. — to list it. Then, space seekers — entrepreneurs, nonprofits, freelancers, etc. — can rent it.

"This award is a game-changer for me," Hicks says to Military.com. "This will allow me to hire more incredible military spouses and help GotSpot on its path to go global."

Rice University launches new sports business course

Rice University

Rice University has a new sports business program. Photo courtesy of Rice University

Rice University, along with the Houston Texans, is introducing a new program for the university's sport management students. Pro Sports: Management is a course designed to teach the business side of the sports world.

"We are thrilled to partner with Rice University on a curriculum that will provide their best and brightest students with insight into the real-world opportunities and challenges facing today's sports teams," says Houston Texans President Jamey Rootes in a release from Rice. "This program is rather unique because our leading executives will work alongside Rice professors to teach current best practices in franchise management across every discipline. We believe that this type of practical industry exposure is the best way to prepare the next generation of leaders in the field of sports management and a valuable contribution to the level of professionalism within our industry."

The classes will be held weekly in the executive offices of the Texans. The course will cover ticketing, public relations, event management, human resources and more.

Spaces plans to open second coworking location in Houston

Spaces, an Amsterdam-based coworking space company that entered the Houston market with a lease in Kirby Grove announced in 2017, plans to open its newest location this month. Courtesy of Spaces

The new Spaces CityCentre One location is planned to open on Monday, September 30. It's the Amsterdam-based company's second coworking space in Houston, with a third already in the works. The first location was in Kirby Grove in 2017, and Spaces Galleria at Post Oak will be opening in the second quarter of 2020.

The CityCentre One location will have over 60,000 square-feet of workspace with perks, including a business club, dedicated desk space, private offices, and seven fully-equipped meeting rooms. Plus, the building is just steps away from CityCentre, a mixed-use development with restaurants, entertainment, housing, and more. Membership pricing starts at $111 a month at the new location.

Cemvita Factory receives more backing from oil and gas industry

Cemvita FactoryCemvita Factory

Houston-based Cemvita Factory, a biotech company that can mimick photosynthesis and convert CO2 into glucose and other substances, has received equity investment from BHP. The amount of the investment was not disclosed.

The investment will help Cemvita Factory continue to develop its biomimicry technology for oil and gas applications to reduce the volume of greenhouse gas emissions.

"This strategic investment fits well with BHP's vision of the future: reducing operational greenhouse gas emissions, reducing environmental impact and the development of low-emissions technology, including increased application of carbon capture, utilization and storage technology," says BHP's chief geoscientist, Laura Tyler, in a release.

Last month, Occidental Petroleum's low carbon subsidiary, Oxy Low Carbon Ventures LLC, announced it invested an undisclosed amount of funds into Cemvita Factory.

Two organizations join forces to promote diversity in the Houston Startup Scene

Impact Hub Houston and The Cannon have teamed up to grow programming and events surrounding diversity. Photo courtesy of The Cannon

In an effort to promote diversity and inclusion within the Houston innovation ecosystem, The Cannon and Impact Hub Houston have teamed up. The collaboration will drive programming and events geared at growing the conversation and resources for startups and entrepreneurs.

"One of Houston's best differentiating qualities is that we are truly a melting pot," says Lawson Gow, founder and CEO of The Cannon, in a news release. "We want our community to reflect the amazing diversity across our city, so we have to move beyond simply discussing diversity and work to create an environment where innovation can thrive and real change can happen. We are confident Impact Hub will be the perfect partner to bring those aspects to our community."

Gow, who is the son of InnovationMap's parent company's CEO, opened the doors to its new 120,000-square-foot facility in July. Impact Hub Houston will have a presence in the space.

"Over the past few years, Lawson and I have brainstormed how we could work together to connect and grow our region's innovation ecosystem and demonstrate how organizations can evolve from competition to true collaboration," says Grace Rodriguez, CEO and Executive Director of Impact Hub Houston, in the release. "I'm so excited that those talks have developed into this partnership: Through The Cannon and Impact Hub Houston, we'll be able to effectively 'meet people where they are' geographically, socially, and culturally, helping diverse entrepreneurs and startups at the myriad intersections of place, purpose, demographics, psychographics, and business growth stages."

Houston innovator nominated for prestigious Silicon Valley award

Alley Lyles is up for an award for her work in digital transformation.

Alley Lyles, digital transformation manager at Direct Energy and Houston startup mentor, was nominated for a Women in IT - Silicon Valley award as Transformation Leader of the Year. The awards event is on October 9.

She is up against Emily Dunn at Anaplan, Windy Garrett at Atos, Manju Abraham at Delphix, Aashima Gupta at Google, Patricia Grant at ServiceNow, and Nataliya Anon at Svitla Systems.

"I am proud to represent Houston in Silicon Valley. The Houston hustle is real. I see it amongst my colleagues who got me here. The hustle isn't always glamorous, so I appreciate the moment when a kid from the East End can shine."

Chevron Technology Venture will have an office in the new, 120,000-square-foot coworking space The Cannon is expecting to open this spring. Courtesy of The Cannon

Chevron venture arm enters partnership with West Houston coworking space

2 for 1

As corporate venture grows as a presence in oil and gas, more and more startups have access to funding from large corporations. Aware of the corporate venturing trend, The Cannon, a West Houston coworking space, has formed a partnership with Chevron Technology Ventures, Chevron's venture arm that's currently based in Downtown Houston.

CTV will have an office and regular office hours in The Cannon's new, 30-acre campus that is expected to open this spring. (A previous version of this story included other details of the CTV office at The Cannon.)

"We are always trying to surround our members with as much support and as many resources as possible to help them succeed. Chevron's engagement with our community will help further these efforts in a really exciting way," says Lawson Gow, founder and CEO of The Cannon, in a release. Gow is the son of David Gow, owner of InnovationMap's parent company Gow Media.

Established in 1999, CTV aims to champion "the innovation, commercialization and integration of emerging technologies into Chevron," reads the Chevron website. The team seeks to identify and invest in technologies or processes that could enhance and optimize core aspects of Chevron's operations. The technologies of interest to CTV are, according to the website: Water management, production enhancement, emerging materials, power systems, information technology, and subsurface and base business.

The Cannon's commitment to helping startups find access to venture has been an ongoing goal since May of last year when The Cannon launched Cannon Ventures — a venture studio and investor network. Cannon Ventures then teamed up with a few other venture funds in December to create the Houston Investment Network Alliance.

Peek inside what the new Cannon space will look like

Courtesy of The Cannon

Houston-based Abel Design Group and Burton Construction are responsible for the designs and execution of the building.

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.