These Houston businesses punch in among Texas' best employers, report says

workin' it

The Houston area boasts some top-tier employers. Photo by Getty Images

A slew of Houston-area companies may soon see a surge of inquiries and resumes, thanks to a new ranking.

Great Place to Work, which helps employers improve their workplace culture, and Fortune magazine teamed up to select the Best Companies to Work For in 2022 in two categories: small and midsize employers, and large employers.

In the new report, powerhouse Houston-based builder/developer David Weekley Homes tops the list of the top 20 large employers in Texas — a big jump from its No. 20 spot last year.

“We are incredibly honored to be recognized as the top company on the Best Workplaces in Texas list,” said Robert Hefner, vice president of Human Resources for David Weekley Homes, in a statement. “We’re very proud to offer an amazing workplace culture as well as competitive benefits and perks for our team, which inspires them to delight our customers.”

Powerhouse business IT firm Hewlett Packard Enterprise follows on the large employer list at No. 2, followed by apartment owner and operator Camden Property Trust at No. 3. Mortgage lender Cornerstone Home Lending, commercial real estate company Transwestern, and community college system Lone Star College also land on the prestigious list.

Meanwhile, four of Texas’ top 20 small and midsize employers to work for are right here in the Houston area. They are: mortgage provider Republic State Mortgage, online education hub Continued, oil and gas consulting firm E.A.G. Services, and AI-based e-commerce firm PROS.

Here’s the list of the top 20 small and midsize employers on the list of the Best Companies to Work For:

  1. Credera, Addison
  2. Bestow, life insurance company, Dallas
  3. Publishing Concepts, collector of oral histories, Dallas
  4. Pariveda Solutions, business and technology consulting firm, Dallas
  5. 49 Financial, financial planning provider, Austin
  6. Highland Homes, homebuilder, Plano
  7. AIM, provider of special education services, San Antonio
  8. Republic State Mortgage, mortgage provider, Houston
  9. Continued, provider of online continuing education, Houston
  10. Freese and Nichols, engineering, planning, and consulting firm, Fort Worth
  11. OJO Labs, home search platform, Austin
  12. Dialexa, digital product consulting firm, Dallas
  13. Granite Properties, commercial real estate developer, investor, and manager, Plano
  14. E.A.G. Services, oil and gas consulting firm, Houston
  15. Ontic Technologies, producer of “protective intelligence” software, Austin
  16. PROS, provider of AI-based software for e-commerce, Houston
  17. Scribe Media, book publisher, Austin
  18. Embark, business advisory firm, Dallas
  19. ProPath, operator of pathology practices, Dallas
  20. CerpassRX, pharmacy benefits manager, The Colony

Here’s the list of the top 20 large employers in Texas, according to Great Place to Work and Fortune:

  1. David Weekley Homes, homebuilder, Houston
  2. Hewlett Packard Enterprise, provider of business IT, Spring
  3. Camden Property Trust, apartment owner and operator, Houston
  4. Texas Health Resources, healthcare system, Arlington
  5. Vizient, healthcare consulting firm, Irving
  6. Ryan LLC, tax services and consulting firm, Dallas
  7. Hilcorp Energy, energy exploration and production company, Houston
  8. PrimeLending, a Plains Capital Company, mortgage lender, Dallas
  9. Cornerstone Home Lending, mortgage lender, Houston
  10. Transwestern, commercial real estate company, Houston
  11. Dell Technologies, seller of personal computers, network servers, data storage services, and software, Round Rock
  12. NuStar Energy, pipeline and terminal operator, San Antonio
  13. Mr. Cooper (Nationstar Mortgage), mortgage lender, Coppell
  14. Lone Star College, community college system, Houston
  15. USAA, financial services provider, San Antonio
  16. Sailpoint, provider of identity security software, Austin
  17. Enhabit Home Health & Hospice, home health and hospice provider, Dallas
  18. Epicor Software, provider of software for business process management, Austin
  19. Hilti, provider of tools and technology for construction companies, Plano
  20. Alcon Laboratories, producer of eye care products, Fort Worth

Great Place to Work selected the Best Companies to Work For in 2022 based on feedback from employee surveys and data from Great Place to Work-certified employers.

“As workers struggle with the Great Resignation, burnout, and COVID disruptions, these exceptional companies offer workplace experiences as strong as prior to the pandemic,” says company CEO Michael Bush.

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This article originally ran on CultureMap.

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Houston researchers report promising first in-human trial for implantable cancer therapy

cancer breakthrough

When it comes to cancer remedies, the treatment can be as challenging for the body as its cause. But what if immunotherapy could be localized? That’s precisely what a Houston team may soon make a reality.

Rice University researchers, in partnership with MD Anderson Cancer Center, recently published their findings from the first in-human trial of an implantable cancer-fighting treatment in the journal Clinical Cancer Research. The paper details testing of AVB-001, encapsulated cells engineered to release interleukin-2 (IL-2)—a naturally occurring signaling protein that boosts immunity—in the peritoneal cavities of 14 patients. The goal is to avoid the toxicity usually experienced with less targeted treatments, as well as find a solution to IL-2s’ abbreviated half-lives.

“Traditional IL-2 therapy has shown potent antitumor activity, but its clinical use has been limited by severe side effects and delivery challenges,” Omid Veiseh, director of the Rice Biotech Launch Pad, professor of bioengineering at Rice and a senior author on the study, said in a press release. “This platform allows us to localize and sustain cytokine exposure directly where tumors reside while minimizing systemic toxicity.”

Serous ovarian carcinoma is especially well-suited to the use of AVB-001 because it tends to spread throughout the abdomen. After a minimally invasive laparoscopic procedure, patients implanted with the cells were noted to tolerate the treatment well. Half of the enrolled patients’ cancer was stabilized, with several among them reporting extended signs of benefit. No maximum tolerated dose was reached and there were no life-threatening events tied to the study.

If that sounds like less-than-earth-shaking results, this is only the beginning. The capsules were implanted for about one week because IL-2 activity drops off after that. The researchers now know that further testing should include either higher levels, repeated doses, or a combination thereof, in order to create stronger advances.

The team has already made early headway on this next step. Preclinical studies in nonhuman primates were not only tolerated well, but without added toxicity, the apes had consistent pharmacological effects.

“This is a foundational step,” Veiseh explained. “We now have evidence that the platform is safe, biologically active and potentially scalable. The next phase is optimizing dosing and exploring combination therapies to unlock its full clinical potential.”

The combination would also include a checkpoint inhibitor, which might improve AVB-001’s tumor-fighting power. “What is exciting is that we are not just delivering a drug, we are programming a microenvironment,” added Dr. Amir Jazaeri, professor of gynecologic oncology at MD Anderson, member of the Rice Biotech Launch Pad’s clinical advisory board and a senior author on the study. “This opens the door to combination strategies that could amplify immune responses in ways that have not been feasible before.”

5 must-read innovation headlines: Pharma giant considers Houston hub + more

Trending news

Editor's note: With May coming to a close, it's time to look back at the biggest innovation headlines for the second half of the month. Major moves were made in May, with NuScale Power entering the market, Persona AI inking a deal with Under Armour, and a pharma giant considering Houston for its next manufacturing hub. Here are the most-read InnovationMap stories published May 15-29, 2026:

1. Pharma giant considers Houston for $1 billion manufacturing campus

Another pharmaceutical giant is considering Houston’s Generation Park for a manufacturing hub. According to a recent filing with the Texas Jobs, Energy, Technology and Innovation (JETI) program, Bristol Myers Squibb Co. is considering the northeast Houston management district for a new $1 billion multi-modal pharmaceutical manufacturing campus.

2. Modular nuclear reactor co. NuScale Power moves into Houston market

The nuclear energy renaissance continues in Texas with an announcement by NuScale Power. The Oregon-based provider of proprietary and innovative advanced small modular reactor (SMR) nuclear technology announced in April it would be opening office space in Houston’s CityCentre.

3. Persona AI teams with Under Armour to protect next-gen robots

Houston-based Persona AI has cemented a partnership with sportswear manufacturer Under Armour to provide materials to protect future robots operating in dangerous conditions. Through the partnership, Persona AI and Under Armour will launch a research initiative to explore whether advanced performance textiles can improve the durability and resilience of humanoid robots operating in harsh industrial environments.

4. Houston quantum energy chip startup emerges from stealth with $12M round

Houston-based Casimir has emerged from stealth with a $12 million seed round to commercialize its quantum energy chip. The round was led by Austin-based Scout Ventures. Lavrock Ventures, Cottonwood Technology, Capital Factory, American Deep Tech, and Tim Draper of Draper Associates also participated in the round. The oversubscribed round exceeded the company’s original $8 million target.

5. Global summit spotlights Houston's growing role in brain health, innovation

The Center for Houston’s Future and UTMB are bringing the Texas Brain Economy Summit back to Houston this summer to continue to position the region as a global leader in brain health. The summit, held June 9-10 at the Texas Medical Center's Helix Park, will bring together more than 500 executives, researchers, policymakers and innovators from around the world to discuss the global brain economy.

Houston startup raises $6M to scale home-based healthcare platform

fresh funding

As healthcare systems race to expand care beyond hospitals and into the home, investors are placing bigger bets on the infrastructure needed to make that shift possible.

This month, Rosarium Health announced it has raised $6 million in seed funding led by Kalos Ventures, with participation from ResilienceVC, Rock Health Capital, Symphonic Capital, Black Tech Nations Ventures and others.

The investment will help the Houston-based startup continue to build its platform, which features a national network of 800-plus clinicians and 3,000-plus contractors to coordinate home accessibility upgrades and modifications for seniors and people living with disabilities.

For founder and CEO Cameron Carter, the company’s mission grew out of firsthand caregiving experiences.

“From my own personal caregiving experiences, I realized that the benefits exist on paper, but not in reality,” Carter said in a news release. “Families are being left to figure out the paperwork and installations all on their own, which shouldn’t be how this works.”

While Medicare Advantage and Medicaid plans have expanded coverage for home-based services and accessibility modifications, the logistics behind delivering those services often remain fragmented.

Rosarium’s platform coordinates the entire process, from clinical assessments and referrals to contractor management, documentation, reimbursement and installation.

“A clinician can document that a home isn’t safe and a plan can approve a benefit, but there’s no one that’s responsible for making sure the work actually gets done,” Carter says. “We built the missing piece.”

The company was founded in 2021 as Rose Health and was a 2023 participant in the Texas Medical Center’s Accelerator for HealthTech program. It has scaled quickly, building a network of more than 800 clinicians and 3,000 contractors across 34 states.

Rosarium is currently in-network for 1.2 million Medicare and Medicaid lives, with projected coverage expected to reach nearly 4 million by the end of the year, according to the release.

“We’re excited to back Cameron because he and the team at Rosarium are building the infrastructure healthcare needs right now to make the home a safe and comfortable place of care,” Kate Ballinger, investor at Kalos Ventures, added in the release.

As part of the recent investment, Ballinger will join Rosarium’s board of directors.

With eyes on the future, Rosarium plans to grow its partnerships with Medicaid and Medicare Advantage plans, including CalViva and Community Health Plan of Imperial Valley, strengthening its presence in California while expanding access to underserved communities.

Additionally, Carter predicts that home-based healthcare will be part of a broader transformation happening across the industry.

“There’s a growing recognition that health outcomes are shaped by what happens in the home,” he said in the release. “The future of healthcare isn’t just treating people after something goes wrong. It’s creating environments that help prevent those problems in the first place.”

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