The new $1 million gift will target top recruits. Photo courtesy of University of Houston

One of the most prestigious foundations in Texas has made a generous gift to a local university's fledgling medical department. The M.D. Anderson Foundation has pledged $1 million to the University of Houston College of Medicine, UH announced.

The sizable gift is meant to establish the M.D. Anderson Foundation Endowed Professorship in Medicine, specifically to recruit a leader in health care to join the College of Medicine faculty, according to a press release.

The gift, matched one-to-one by an anonymous donor to create a $2 million endowment, aims to support the new medical school's mission to improve health and health care in underserved communities in Houston and across Texas.

This isn't the first time the M.D. Anderson Foundation has supported UH. The foundation has gifted more than $6 million to UH Libraries, UH Law Center, Hobby School of Public Affairs, and the College of Medicine.

"Innovation in health care requires a fresh approach and a willingness to break down traditional silos to collaborate with experts in other health disciplines such as pharmacy, engineering, law and even data sciences, said Dr. Stephen Spann, founding dean of the UH College of Medicine," in a statement.

"By harnessing the power of data analytics, we can fundamentally change the way we deliver higher quality and cost-effective care to more people. Thanks to the M.D. Anderson Foundation's generosity and vision, we will be able to recruit a new faculty member who can help us greatly to accomplish these goals."

As previously reported, UH received a $50 million gift from an anonymous donor in 2019 to establish the "$100 Million Challenge," meant to recruit top nationally recognized and awarded research faculty for chairs and professorships, designed to inspire another $50 million in investments from additional donors.

Now, the school hopes to utilize these funds to address what the school describes as a "critical primary care physician shortage, especially in low-income and minority communities lacking access to a regular source of care and have gaps in preventative care, which leads to higher rates of sickness, hospitalization, and death."

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This article originally ran on CultureMap.

Lisa and Nicky Holdeman are ensuring a bright future of UH med students. Photo courtesy of University of Houston

University of Houston power couple prescribes major gift for college of medicine

funding future doctors

University of Houston medical students and staff will receive a gift that's just what the doctor ordered.

A prestigious and longtime UH power couple has bequeathed two major gifts a major gift to the school's burgeoning College of Medicine. Dr. Nicky and Lisa Holdeman — who together boast more than 45 years at the university — have established an endowed and chair/professorship and a scholarship for medical students, the school announced.

In their will/trust the Holdemans have established, per UH:

  • The Nicky R. and Lisa K. Holdeman Endowed Professorship/Chair, which will support a clinical teaching faculty member responsible for the oversight and strategic direction of the College of Medicine's clinics, as well as enhancing the student and patient experience.
  • The Nicky R. and Lisa K. Holdeman Endowed Scholarship, which will support students in the College of Medicine, which was founded in 2020 on a social mission to improve health and health care in underserved communities in Houston and across Texas.

The Holdemans say that they were inspired by the UH College of Medicine's mission to address a significant statewide primary care physician shortage and how social determinants of health, such as income, housing, food supply and transportation, contribute to health outcomes.

"I have a true admiration for the comprehensive physician, someone comfortable addressing multiple health issues," Nicky Holdeman relays in a statement. "The physicians being trained at the University of Houston will be well prepared to manage most of the patients, with most conditions, most of the time. That's really what primary care medicine is all about."

As previously reported, UH's medical school will welcome its second class of 30 students this summer and will have 480 students at full enrollment, within the decade.

More on the duo, who have been married for 38 years: A UH biography notes that Nicky, physician and professor emeritus at the UH College of Optometry, served as associate dean for clinical education and executive director of the University Eye Institute during his 30 years at the college. He retired in 2019.

Meanwhile, Lisa joined UH in 2006 and serves as vice chancellor for the UH System and vice president for UH marketing and communications. She works directly with UH System Chancellor and UH President Renu Khator and school leadership.

"This gift is especially gratifying because it comes from two dedicated UH leaders whose professional careers have already contributed so much to our University's success," said Renu Khator. "That kind of enlightened commitment on their part sets an admirable example. I know I speak for many when I express our deep appreciation for their generous support of the College of Medicine and the important work it is undertaking in our community."

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This article originally ran on CultureMap.

The University of Houston broke ground on its new medical school building and named the College of Medicine's inaugural class. Photo via UH.edu

Houston medical school presents inaugural class as construction begins on new building

doctors in training

This month, the University of Houston has taken a couple huge steps toward establishing a prestigious medical school program — the first new medical school to be established in Houston in almost 50 years.

UH has broken ground on its $80 million medical school building that is expected to be completed in 2022, and the program has named its inaugural class.

The new cohort of future doctors is a group diverse in ethnic background and life experience. The school plans to tackle a key issue in public health: the shortage of primary care doctors. These future doctors are charged by the university with eliminating health disparities in underserved urban and rural areas, which often have poorer health outcomes.

The UH College of Medicine received 1,728 applications for its first class of students; 164 applicants were interviewed for the 30 available spots, according to UH. An 18-member admissions committee screened those most likely to pursue primary care.

Here is a breakdown of UH's inaugural medical school class:

  • 30 students
  • 73 percent underrepresented minorities in medicine
  • 63 percent female
  • 57 percent first generation in college
  • 40 percent low socioeconomic status
  • 100 percent Texas resident
  • Five graduates of the University of Texas at Austin; two graduates each from the University of Houston, Baylor, Texas A&M, Houston Baptist, Prairie View A&M, and Rice University

According to the school, the goal is for 50 percent of graduates of the UH College of Medicine to choose primary care specialties including family medicine, general internal medicine, and general pediatrics. For some perspective, nationally, only about 20 percent of medical students choose primary care.

"We were very deliberate in our pursuit of medical students who fit the mission. This is much different than most other medical schools because we need different solutions for the current health care problems facing our city and state," said Dr. Stephen Spann, founding dean of the College of Medicine, in a statement.

Each student will receive a $100,000 four-year scholarship through philanthropy to cover tuition and fees. At full enrollment, the College of Medicine will have 480 students, per the school. The Health 2 Building in the UH Medical District will be the college's temporary home for the first two years until a new $80 million medical school building is completed in 2022. Construction crews broke ground on the new building on June 15, according to the university.

Being part of UH's inaugural medical school is deeply personal for students such as Cenk Cengiz. At 14, Cengiz's family emigrated from Turkey to Houston, but could not afford health insurance. Cengiz attended high school and college without ever seeing a doctor, which attracted him to the field of medicine and peaked his interest in the medical school's unique mission to help underserved communities.

"I came a long way from washing dishes at age 14 at a pizza store," Cengiz said in a statement. "My parents are super proud of me."

Dr. Stephen Spann is the founding dean of the College of Medicine. Photo via uh.edu

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This article originally ran on CultureMap.

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”