Four Rice University lab-stage innovations are receiving fresh funding to get them closer to commercialization. Photo courtesy of Rice University

Four Houston research projects are splitting hundreds of thousands of dollars in grant funding from Rice University.

After announcing the One Small Step Grant program in September to support Rice-developed, lab-stage innovations, the university has named its inaugural recipients. After receiving nearly 30 applicants, four research projects were selected to share $360,000 in grant funding.

“Being able to fund near-commercial projects represents a leap forward in our mission of supporting the cutting-edge work of our faculty and students and helping bring those to market,” Adrian Trömel, assistant vice president for strategy and investments, says in a news release. “Feedback from industry and investors show that they’re excited on how the One Small Step grants help derisk these technologies, getting them ready to launch. Watch this space for the next generation of leading deeptech companies.”

The selected projects include:

  • PerisBio, developed by Samira Aglhara Fotovat and Samantha Fleury from Rice Professor Omid Veiseh's Lab, focuses on novel, hydrogel-encapsulated engineered "cell factories" for the minimally invasive treatment of endometriosis. The project received a $100,000 award.
  • Solidec, founded by Ryan Duchanois and Yang Xia from Rice Professor Haotian Wang's Lab, is a room temperature, solid-state direct air capture technology. The project received a $100,000 award.
  • HornetX, led by Rice Professor Aditya Mohite's Lab, aims to produce highly stable green hydrogen using a perovskite-based photoelectrochemical cell with leading efficiency. The project received a $80,000 award.
  • Coflux, developed by Jeremy Daum and Alec Ajnsztajn from the labs of Rice Professors Rafael Verduzco and Pulickel Ajayan, focuses on covalent organic framework-based photocatalysts for instream remediation of PFAS (per- and polyfluoroalkyl substances) from water. The project received a $80,000 award.

The Office of Innovation created an investment advisory committee — made up of entrepreneurs, investors and corporate executives across industries — to select these recipients. The grant program was funded by the Office of Innovation, with support from Breakthrough Energy Fellows for climate and energy projects

“The inaugural winners of the One Small Step Grant represent the innovative spirit and dedication to excellence that defines our students and faculty," Rice Chief Innovation Officer Paul Cherukuri says. "We are proud to support these groundbreaking projects on their journey from lab to market."

Former University of St. Thomas business school dean, Beena George, is taking on a new role at the university: Chief innovation officer. Courtesy of UST

Houston educator plans to lead her university into the future with her new role

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High school graduation numbers are decreasing, and, by 2025, far fewer college freshmen will be starting school. Some project as high as a 15 percent drop, says Beena George, inaugural chief innovation officer of Houston's St. Thomas University.

UST is looking forward to and anticipating changes and challenges within higher education like this, and one of the steps the university has been to create George's position.

"My role is to ferment that culture of innovation," George says. "Not just sit here and think of ideas."

As the school gets ready to welcome students back onto its Montrose campus, the former business dean gets ready to serve in her new role for the first semester. She spoke with InnovationMap about her career, goals, and the role UST plays within the Houston innovation ecosystem.

InnovationMap: What have you learned throughout your career that has prepared you for the role?

Beena George: I've always been interested in solving problems. If I saw something that was an opportunity, and we didn't take advantage of it, I'll keep thinking about it. I've been thinking about what makes me enjoy this role and stage in my career, and I think it's because most roles tend to be mostly operational, but this is thinking of new things and doing things differently and checking your own assumptions. That is what really engages me in my role. My career has given me different opportunities to use this, but not so much as now. When teaching, you have that opportunity every day — engaging students differently. Then as dean, it was about looking at new opportunities and programs for the business school, like our Master of Clinical Translation Management program.

IM: How did this clinical translation program come about?

BG: The idea of clinical translation is essentially to move a discovery from the lab to the patient's bedside — it's the commercialization of life sciences. The program trains students to shepherd a discovery from the lab to the commercial setting so that it's available to patients.It's a combination of business, life sciences, regulatory affairs. It's a one-year online program with some residency periods. It's the only of its kind in Houston and is one of less than 10 in the United States and, to my knowledge, the only of its kind in a business school.

IM: What does innovation mean to the University of St. Thomas and this inaugural position?

BG: I think innovation isn't entirely new on college campuses, but now is a time when higher education is in flux. There has been a lot of changes in the industry and in society in general that's requiring higher education institutions to react in a different way. Some of the things that we've always been doing — creating new programs, moving online, new campuses — now it's even more important to bring that to prominence and figure out how it fits with your university. Things have changed, so the rate at which you're innovating has to increase.

IM: What’s on your to-do list for this first year and within five years?

BG: Since this is a new role, my first goal for the next two to three months is the process of discovery — internally and externally. One of the cool things that's happening in Houston is all these partnerships and collaborations. That's what I'm trying to do — learn about the groups here and outside and make these connections. The other part of it is bringing information in from the outside. There are so many different ways of doing things. For instance, in higher education, it's been historically tied to credit hours. We know now there are many different ways to look at education. That's the kind of conversation I look to get started.

IM: You mention collaboration, and I think that’s key when it comes to higher education institutions within the innovation ecosystem, but how do you see that teamwork affecting the city as a whole?

BG: So I have been so glad to see that, because I've always believed that there has to be some competition — it ensures that everyone performs at their best. But there are some industries where you have to go beyond competition to the next level and manage competition and collaboration at the same time. We have two networks — Texas Medical Center and the academic partnership created by The Ion — and talk about what's happening on your campuses and how we can work together in Houston. There's also the 60x30 Texas, which has different advisory councils that offers that same conversation of collaboration to work together to meet our goals. Those types of conversations are important and having those types of venues to do that can have only a positive effect on Houston.

IM: How is UST finding new ways to prepare its students for the workforce?

BG: One thing that has gained a lot of attention here on campus is providing students with more experiential learning opportunities — more internships and apprenticeships and bringing the industry into the classroom. Carlos Monroy, a professor at UST, and his student worked on a project for the city. This is something that allows us to remain connected to the industry and it gives our faculty the idea of what the Industry needs and they can focus on that in the classroom.

IM: UST recently announced a major “renewal” plan. How is this going to affect innovation efforts on campus?

BG: I think the whole process is about innovation. What we have is an opportunity to recreate ourselves for the next millennium and create a sustainable operating model that will continue to provide for our students. I think it will affect everything.


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Portions of this interview have been edited.

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Axiom Space-tested cancer drug advances to clinical trials

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A cancer-fighting drug tested aboard several Axiom Space missions is moving forward to clinical trials.

Rebecsinib, which targets a cancer cloning and immune evasion gene, ADAR1, has received FDA approval to enter clinical trials under active Investigational New Drug (IND) status, according to a news release. The drug was tested aboard Axiom Mission 2 (Ax-2) and Axiom Mission 3 (Ax-3). It was developed by Aspera Biomedicine, led by Dr. Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute (SSCI).

The San Diego-based Aspera team and Houston-based Axiom partnered to allow Rebecsinib to be tested in microgravity. Tumors have been shown to grow more rapidly in microgravity and even mimic how aggressive cancers can develop in patients.

“In terms of tumor growth, we see a doubling in growth of these little mini-tumors in just 10 days,” Jamieson explained in the release.

Rebecsinib took part in the patient-derived tumor organoid testing aboard the International Space Station. Similar testing is planned to continue on Axiom Station, the company's commercial space station that's currently under development.

Additionally, the drug will be tested aboard Ax-4 under its active IND status, which was targeted to launch June 25.

“We anticipate that this monumental mission will inform the expanded development of the first ADAR1 inhibitory cancer stem cell targeting drug for a broad array of cancers," Jamieson added.

According to Axiom, the milestone represents the potential for commercial space collaborations.

“We’re proud to work with Aspera Biomedicines and the UC San Diego Sanford Stem Cell Institute, as together we have achieved a historic milestone, and we’re even more excited for what’s to come,” Tejpaul Bhatia, the new CEO of Axiom Space, said in the release. “This is how we crack the code of the space economy – uniting public and private partners to turn microgravity into a launchpad for breakthroughs.”

Chevron enters the lithium market with major Texas land acquisition

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Chevron U.S.A., a subsidiary of Houston-based energy company Chevron, has taken its first big step toward establishing a commercial-scale lithium business.

Chevron acquired leaseholds totaling about 125,000 acres in Northeast Texas and southwest Arkansas from TerraVolta Resources and East Texas Natural Resources. The acreage contains a high amount of lithium, which Chevron plans to extract from brines produced from the subsurface.

Lithium-ion batteries are used in an array of technologies, such as smartwatches, e-bikes, pacemakers, and batteries for electric vehicles, according to Chevron. The International Energy Agency estimates lithium demand could grow more than 400 percent by 2040.

“This acquisition represents a strategic investment to support energy manufacturing and expand U.S.-based critical mineral supplies,” Jeff Gustavson, president of Chevron New Energies, said in a news release. “Establishing domestic and resilient lithium supply chains is essential not only to maintaining U.S. energy leadership but also to meeting the growing demand from customers.”

Rania Yacoub, corporate business development manager at Chevron New Energies, said that amid heightening demand, lithium is “one of the world’s most sought-after natural resources.”

“Chevron is looking to help meet that demand and drive U.S. energy competitiveness by sourcing lithium domestically,” Yacoub said.

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This article originally appeared on EnergyCapital.