Now is the time to analyze and manage costs and investments, which will be crucial to capitalize on as we head into an upswing in business. Photo by Hero Images

Although the world may be going back to normal and it feels like we can see the light at the end of the tunnel, business owners across the country are seeing lasting negative effects of the COVID-19 pandemic on their companies. Especially in the restaurant industry, local business owners are having to rely on government aid to make sure employees and rent are paid, keeping stress levels very high.

Our company, Cerboni, is a financial firm that works with clients to relieve the burden business owners face by taking things like back-office work, inventory management and more off their plate to give them the freedom to focus on their trade. To help alleviate some of this stress, we are taking an in-depth look at some of the options available to business owners working to navigate government aid applications, along with opportunities for future prosperity.

Don’t let financial opportunities fall through the cracks

While business owners are often pulled in many directions, it's important to make sure you are taking advantage of any help that is available to you. Currently, the Restaurant Revitalization Fund, Employee Retention Credit and the Paycheck Protection Program are available to qualifying business owners. Taking the time to figure out which opportunities you should apply for and which ones are the best fit, will greatly benefit your company in the long run.

What to know about the Restaurant Revitalization Fund

The Restaurant Revitalization Fund provides funding equal to pandemic-related revenue loss up to $10 million per business and no more than $5 million per physical location for eligible restaurants, bars and other qualifying businesses where onsite sales to the public make-up at least 33 percent of gross sales receipts. Recipients have two years to use these funds, and the money can be used for business expenses such as payroll, mortgage obligations, rent payments, maintenance expenses, construction of outdoor seating and more.

The most important thing to know about this fund is how to calculate the funding amount. For those operating prior to or on January 1, 2019, applicants will calculate the 2019 gross receipts minus 2020 gross receipts minus PPP loan amounts. Applicants that began operations partially through 2019 should average the 2019 monthly gross receipts and multiply by 12, subtract 2020 gross receipts and then subtract PPP loan amounts. Businesses that began operations between January 1, 2020 and March 10, 2021, or those who have not yet opened but have incurred eligible expenses as of March 11, 2021, should calculate the amount spent on eligible expenses between February 15, 2020 and March 11, 2021, subtract 2020 gross receipts, then subtract 2021 gross receipts (through March 11, 2021) and, lastly, subtract PPP loan amounts.

Utilizing Employee Retention Credit

The Employee Retention Credit is a fully refundable tax credit for "qualified wages" paid to employers that were ordered to suspend operations fully or partially during 2020 or experienced a significant decline (below 50%) in gross receipts during the calendar quarter. The purpose of the Employee Retention Credit is to encourage employers to keep employees on payroll during the pandemic. Recipients can receive up to $5,000 for each full-time employee retained between March 13, 2020 and December 31, 2020 and up to $14,000 for each employee retained between January 1, 2021 and June 30, 2021. Qualified wages depend on the size of the operation. If the employer averaged more than 100 employees in 2019, the wages are only paid for the time the employee is not providing services. If the employer has less than 100 employees, the wages are paid to any employee during any period of hardship due to the pandemic. Recipients of PPP are not eligible for Employee Retention Credit.

Future prosperity

The restaurant industry was greatly impacted by the pandemic, but if you survived, you now have a great opportunity ahead of you. People are starting to return to a sense of normalcy and want to get back to enjoying things like events, shopping, eating out with friends and family and more.

Now is the time to analyze and manage costs and investments, which will be crucial to capitalize on as we head into an upswing in business. Understanding all of these financial nuances can seem daunting, so Cerboni can assist with knowing how to make the right investments in order to increase sales and profitability – this could be through marketing and advertising, changing up the menu to minimize cost of goods sold or managing operating costs.

For those who want to grow their footprint, the market is hot, and it's the perfect time to expand your market presence through negotiation of better lease terms and lower interest rates. Use this time to strategize on how to not only cut costs, but how to increase sales, and how to ultimately grow.

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Maria Degaine and Joshua Santana are co-founders of Houston-based Cerboni.

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CultureMap Emails are Awesome

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”