iBiochips was awarded a $1.5 million grant in September to help develop a new technology that delivers data about the cell's genetic makeup and reports abnormalities. Getty Images

Innovative Biochips, a Houston-based biotechnology company, is one step closer to commercializing technology that the company hopes will provide an opportunity for researchers to detect diseases earlier.

The company was founded three years ago by Dr. Lidong Qin, a professor at the Houston Methodist Research Institute's department of nanomedicine. He launched iBiochips as an independent faculty startup that licensed technology from Houston Methodist. Qin says he wanted to engineer and manufacture devices that focus on revolutionizing single-cell isolation and genetic analysis.

Qin says it can be difficult to launch a biotech startup in Houston, since the industry requires hefty initial funds to open a facility, get patents and hire a team of researchers.

"In the Houston area, even though it looks like it's a lot of state money (grants) around, it's very limited, and that's been a challenge of ours," Qin says.

But with the help of a $1.5 million investment from a private investor, Qin was able to launch iBiochips in 2015, and shortly after opened his own lab on Kirby Drive.

Recently, iBiochips was awarded a $1.5 million grant in September from the National Institutes of Health's Small Business Technology Transfer program. The grant will further support the company's research and development of an automated yeast dissection chip, which is designed to perform a raw analysis of single cells and deliver data about the cell's genetic makeup and report abnormalities.

Prior to the phase two grant, iBiochips was also awarded NIH's phase one grant of $225,000 in September 2017 to develop a prototype for the company's flagship cell isolation product, the Smart Aliquotor.

The Smart Aliquotor is a single-cell isolation dissection platform that allows scientists to analyze larger amounts of cells at a much faster rate than traditional isolation methods, Qin says. He says the system is also more convenient for researchers to operate because traditional cell isolation techniques require a lot of human effort.

To isolate the cells with a Smart Aliquotor, a scientist would take a patient's blood sample and inject it into a single point in the device. The blood sample would then travel through microfluidic channels into the device's 60 to 100 isolated holes, Qin says.

"In three days, we can handle about one million cells," Qin says. "In a traditional approach, people can handle only one or two cells in three days. So that is how we came to the [idea of the] chip can help a scientist do 20 years of work in three days."

The Smart Aliquotor can then be examined with iBiochips' newly funded automated dissection chip, which Qin says has the potential to detect cancer or infectious diseases earlier than before.

"If you isolate a cell by itself — even in the very beginning stage when the aggressive cells are not as dominating yet — you can still see that [abnormality in the sample]," Qin says.

iBiochips' products are currently only being manufactured for research use at clinical labs, universities and pharmacies. However, with the recent grant award, Qin says the company's research team plans to spend the next three to five years preparing the products for worldwide commercialization.


Dr. Lidong Qin is a professor at the Houston Methodist Research Institute's department of nanomedicine. He launched iBiochips as an independent faculty startup that licensed technology from Houston Methodist.Courtesy of Lidong Qin

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3 Houston innovators to know this week

who's who

Editor's note: In the week's roundup of Houston innovators to know, I'm introducing you to three female innovators across industries recently making headlines — all three focusing on investing in innovation from B2B software to energy tech.

Samantha Lewis, principal at Mercury Fund

Samantha Lewis, principal at Mercury Fund, joins this week's episode of the Houston Innovators Podcast. Photo courtesy of Mercury Fund

When Samantha Lewis started her new principal role at Houston-based Mercury Fund, she hit the ground running. Top priority for Lewis is building out procedure for the venture capital firm as well as finding and investing in game-changing fintech.

"(I'm focused on) the democratization of financial services," Lewis says on this week's episode of the Houston Innovators Podcast. "Legacy financial institutions have ignored large groups of our population here in America and broader for a very long time. Technology is actually breaking down a lot of those barriers, so there are all these groups that have traditionally been ignored that now technology can reach to help them build wealth." Click here to read more and stream the episode.

Barbara Burger, president of Chevron Technology Ventures

Houston-based Chevron Technology Ventures, spearheaded by Barbara Burger, has announced their latest fund. Courtesy of CTV

Chevron Technology Ventures LLC's recently announced $300 million Future Energy Fund II builds on the success of the first Future Energy Fund, which kicked off in 2018 and invested in more than 10 companies specializing in niches like carbon capture, emerging mobility, and energy storage. The initial fund contained $100 million.

"The new fund will focus on innovation likely to play a critical role in the future energy system in industrial decarbonization, emerging mobility, energy decentralization, and the growing circular carbon economy," Houston-based Chevron Technology Ventures says in a February 25 release.

Future Energy Fund II is the eighth venture fund created by Chevron Technology Ventures since its establishment in 1999. Click here to read more.

Lauren Bahorich, CEO and founder of Cloudbreak Enterprises

Cloudbreak Enterprises, founded by Lauren Bahorich is getting in on the ground level with software startups — quickly helping them take an idea to market. Photo courtesy of Cloudbreak

Lauren Bahorich wanted to stand up a venture studio that really focused on growing and scaling B-to-B SaaS-focused, early-stage technology. She founded Cloudbreak Enterprises last year and already has three growing portfolio companies.

"We truly see ourselves as co-founders, so our deals are structured with co-founder equity," Bahorich says, explaining that Cloudbreak is closer to a zero-stage venture capital fund than to any incubator. "We are equally as incentivized as our co-founders to de-risk this riskiest stage of startups because we are so heavily invested and involved with our companies."

This year, Bahorich is focused on onboarding a few new disruptive Houston startups. Click here to read more.

Sustainable plastics manufacturing company expands in Houston and beyond

Growing green

An under-the-radar company in Houston has ramped up its manufacturing capacity as it seeks to seize upon rising interest in sustainable plastics.

Houston-based Inhance Technologies, a sustainable manufacturer that transforms conventional plastics into high-performance materials, has a new site in St. Louis that comprises 75,000 square feet — more than double the size of the company's old facility there. As a result of the expansion, Inhance Technologies' headcount in St. Louis will rise to about 40. The size of the company's entire workforce wasn't available.

"The expansion in St. Louis is a great moment for the company and a sign of the organization's ambition in sustainable solutions for plastics," Patricia van Ee, chief commercial officer at Inhance Technologies, says in a release. "We know consumers are favoring more recyclable plastics, especially in packaging … ."

In January, the company promoted van Ee to her current role. She joined Inhance Technologies in 2019 as senior vice president of sales and marketing.

Patricia van Ee was recently named chief commercial officer at Inhance Technologies. Photo via inhancetechnologies.com

The announcement of van Ee's elevation to chief commercial officer came on the heels of Inhance Technologies occupying its new global headquarters at 22008 N. Berwick Dr. in northwest Houston. The company was founded in 1983, and about 75 people work at the Houston headquarters, which includes a science and technology center. That location is adjacent to one of its Texas manufacturing plants.

Among other products, the new plant in St. Louis makes Enkase, which transforms conventional plastics into fully recyclable packaging, and DuraBloc, which prevents fuel from seeping through plastic tanks on gas-powered equipment like motorcycles and personal watercraft. Customers include original equipment manufacturers, molders, and retailers in sectors such as consumer packaged goods, health care, and transportation.

"With a large expansion of warehouse space, a doubling of our manufacturing capacity, and new rapid-response lead times, our expanded St. Louis operation is equipped to meet new levels of demand as product brands, retailers, and consumers make a conscious choice to [purchase] more sustainable plastics," Michael Koma, chief operating officer at Inhance Technologies, says in a release.

ResearchAndMarkets.com predicts the global market for sustainable plastic packaging will jump from $89 billion in 2020 to $117.3 billion by 2025.

"The sustainable plastic packaging industry has been growing as a result of stringent laws and regulations levied by governments and governing bodies, as well as a shift in consumer preference toward recyclable and eco-friendly packaging materials," the research firm says.

Inhance Technologies' global presence should put it in a good position to capitalize on that market. The Houston and St. Louis sites are among more than 20 Inhance Technologies locations around the world, including offices in Australia, Brazil, Germany, and Mexico.

Los Angeles-based private equity firm Aurora Capital Partners bought Inhance Technologies from New York City-based private equity firm Arsenal Capital Partners in 2018 for an undisclosed amount. Arsenal bought Inhance Technologies from founders Monty Ballard and Bill Brown in 2012.

"Inhance fits seamlessly into our strategy of partnering with a market leader to support their vision and accelerate both organic and acquisition-driven growth," Michael Marino, a partner at Aurora Capital Partners, said in 2018.

A year after its acquisition by Aurora, Inhance Technologies bought Germany's Fluor Technik System for an undisclosed amount.

"Over the course of its history, Inhance has continually sought to expand both its breadth of technical capabilities and its geographical reach," said Andy Thompson, the company's president and CEO.