Houston-based CNSide Diagnostic's CSF assay tests cerebrospinal fluid for cancers that have metastasized to the spine or brain. Photo via Getty Images.

A Houston-based company is beginning a push on its proven test for central nervous system (CNS) cancers.

“We're going to start rolling out just in Texas and doing patient testing in the state of Texas, first with a few accounts where we've established a relationship, and then we'll continue our rollout through the United States in the next year or so,” says Russell Bradley, president and general manager of CNSide Diagnostics.

Bradley had retired from multinational diagnostics company Abbott Laboratories when he met Marc Hendrick, the CEO of Austin’s Plus Therapeutics, last year. When Hendrick told him about the recent acquisition of CNSide, a company formerly based in San Diego, Bradley says he felt compelled to join in its mission.

CNSide’s CSF assay tests cerebrospinal fluid for cancers that have metastasized to the spine or brain, primarily carcinomas and melanomas.

“Typically, they do an MRI, and that won't always show anything. If it's early stage, they do cytology, which is not very sensitive at finding cancer cells in the cerebrospinal fluid. By the time they're diagnosed, it can be very late-stage, and oftentimes, in fact, the studies show that half of these patients don't get treated,” Bradley says.

CNSide, then, is a ray of hope for patients who are often consigned to palliative care. By diagnosing their metastasis sooner, physicians have more treatment options to stop the CNS cancer before it’s wreaked havoc. Bradley also points out that once a treatment regimen is underway, doctors can continue to measure the cancer’s progress or lack thereof. He claims that, of the roughly 300 neuro-oncologists in the United States, about 200 have already used the test.

Moving from California to Houston briefly slowed progress for CNSide, but now, matters are moving ahead at a steady clip.

“It takes a little bit of time to establish the test in a new location, move the apparatus and establish the processes,” Bradley says. “You have to get the lab accredited, which we just did. So we're now accredited to run patient samples, and we've really just been doing our research samples as part of the clinical studies.”

Texas institutions, such as the University of Texas - Southwestern, MD Anderson Cancer Center, Mays Cancer Center, Baylor Scott & White Health and Texas Oncology, are beginning to use the technology.

Bradley, who lives in Austin but spends much of his time in Houston, says that the city has been nothing less than an ideal fit for the needs of his growing company and a lab that’s currently hiring. He praises the logistics potential of being close to a major hub, which will eventually be a key factor for getting lumbar puncture samples from around the country to the lab for quick testing.

“I think the business environment in Texas, generally, and in Houston, specifically, for us and the access to talent with a lot of institutions here around the Houston area that graduate the type of people that we want to employ is remarkable. And I'd say the cherry on top is really just access to world-class institutions like MD Anderson. I think from a holistic and comprehensive point of view, Houston has a lot to offer a company like us,” Bradley says.

And ultimately, what brought Bradley and CNSide to Texas is the quest to prolong the lives of people living with cancer. As he puts it, “It's a true privilege—and I know I speak on behalf of the team at CNSide and Plus—to be able to impact these patients and have the tools at this time in the history of cancer diagnostics to be able to really make a difference.”

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New UH survey reveals concerns over AI data center growth in Houston

data findings

A new report out of the University of Houston shows that area residents remain wary of the long-term effects of operating data centers.

The recent survey from the University of Houston’s latest SPACE City Panel, conducted by the Center for Public Policy at the Hobby School of Public Affairs, shows that while 85 percent of Houston-area residents use AI, nearly 63 percent oppose the construction of AI data centers within 1 mile of their homes.

Respondents’ concerns centered around data centers’ high energy demand and the area’s power grid reliability. According to the survey, 32 percent of residents who oppose local data center projects would be more likely to support the centers if they relied on renewable energy over fossil fuels.

“Respondents understand that AI can bring economic and educational benefits, but they are also concerned about the physical infrastructure needed to fuel AI, especially data centers,” Soran Mohtadi, post-doctoral fellow at the Hobby School and a researcher on the report, said in a news release. “This physical infrastructure demands more electricity and water, leading to environmental impacts.”

Experts estimate that 6.5 gigawatts of data center capacity will be added to the Texas grid by 2030. And Houston’s data center capacity is predicted to more than double by 2028.

The Electric Reliability Council of Texas also projects electricity demand could reach 218 gigawatts by 2031, which would be more than double the record peak set in August 2023. Data centers are expected to account for 86 gigawatts of that new demand.

Survey respondents also said they are concerned about the state's future water supply, given the large amounts of water that data centers need to stay cool.

In terms of who’s responsible for that issue, 57.6 percent of respondents said they put the onus on Texas lawmakers, while 31.5 percent say tech companies should be responsible.

Additionally, more than 75 percent of respondents believed that data center developers and technology companies—not residents—should bear the cost of infrastructure upgrades to support data centers.

“Every decision legislators make has implications on residents’ everyday lives and local infrastructure now and in the future,” Maria P. Perez Arguelles, lead researcher on the report and research assistant professor at the Hobby School, added in the news release. “This issue is going to become more important in years to come, so this is just the beginning.”

Read the full report here.

Houston-born Cemvita makes breakthrough in sustainable fuel production

clean fuels

Houston-based biotech company Cemvita announced that it recently reached a critical milestone in the development of its FermOil product, which can be used to create Sustainable Aviation Fuel (SAF) and other renewable fuels at industrial scale.

The company shared in a news release that it completed a 75,000-liter industrial fermentation run at Belgium's Bio Base Europe Pilot Plant.

The campaign achieved target technical metrics for the production of FermOil, Cemvita’s renewable natural oil (RNO). FermOil is produced from industrial crude glycerin, an industrial byproduct, as opposed to traditional sugar-based feedstocks used in many bio-oil fermentation processes. It's designed to be a drop-in feedstock for creating SAFs.

Cemvita had previously advanced its FermOil production process through multiple scale-up stages before successfully reaching the 75,000-liter demonstration campaign, according to the company.

“This is not just a fermentation milestone,” Moji Karimi, CEO at Cemvita, said in the release. “It is a blueprint for how existing industrial infrastructure can evolve into circular bioeconomy infrastructure. Every biodiesel plant generating crude glycerin is a potential platform for renewable natural oil production.”

The milestone also supports the deployment of Cemvita’s industrial biomanufacturing platform, FermWorks, which integrates with existing energy and industrial infrastructure to turn waste carbon streams into SAFs and other materials. According to the release, Cemvita plans to move forward with commercial deployment discussions with partners in Brazil, Europe and in the UK. Cemvita already has a partnership with the Brazilian sustainable research institution REMA.

“We are proud to support innovative companies like Cemvita in scaling breakthrough industrial biotechnology solutions,” Hendrik Waegeman, head of business operations at Bio Base Europe Pilot Plant, added in the release. “Successfully operating at the 75,000-liter scale using a feedstock such as crude glycerin highlights both the maturity of the technology and the quality of the scale-up execution achieved by the Cemvita team.”

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This article originally appeared on our sister site, EnergyCapitalHTX.com.

Eli Lilly scoops up Houston biotech startup in $300 million deal

big pharma deal

Pharmaceutical giant Eli Lilly has acquired Houston biotech startup CrossBridge Bio, which develops antibody-drug conjugates for cancer, in a deal worth up to $300 million. The deal was celebrated by TMC Venture Fund and the University of Texas Health Science Center at Houston last week.

CrossBridge, founded in 2023, is developing ADCs based on research by Kyoji Tsuchikama and Zhiqiang An, both of UT Health Houston. Tsuchikama is an associate professor of medicinal chemistry and a globally recognized ADC pioneer, and An is a professor of molecular science and vice president of drug discovery.

Antibody-drug conjugates (ADCs) are a potent combination of targeted therapy and chemotherapy that kills cancer cells while saving healthy tissue.

Clinical trials for CrossBridge’s primary ADC candidate, CBB-120, are expected to start this year, pending approval from the U.S. Food and Drug Administration (FDA).

“I’m proud of how well our team has executed and advanced our platform in such a short time since the company’s founding,” Michael Torres, co-founder and CEO of CrossBridge, said in a news release. “By becoming a part of Lilly, a leader in patient-focused therapeutic development, we are well-positioned to further accelerate the clinical potential of this approach.”

Under the Lilly deal, CrossBridge shareholders were expected to receive an upfront payment along with a follow-up payment based on the achievement of certain milestones.

In 2024, CrossBridge closed a $10 million seed round. Among the investors in CrossBridge are the Texas Medical Center Venture Fund, CE-Ventures, Alexandria Venture Investments, Portal Innovations, Linden Lake Labs, and the Cancer Prevention and Research Institute of Texas (CPRIT). It was formed in TMC Innovation’s Accelerator for Cancer Therapeutics program."Built within the TMC ecosystem, CrossBridge Bio grew with the support, funding, and resources that helped shape its trajectory. TMC led the company's early financing and watched it evolve from its earliest days to its acquisition by Eli Lilly," William McKeon, president and CEO of the Texas Medical Center, shared in a LinkedIn post. "[This is a] strong reminder that breakthrough science and the right early backing can change what’s possible."