Houston-based CNSide Diagnostic's CSF assay tests cerebrospinal fluid for cancers that have metastasized to the spine or brain. Photo via Getty Images.

A Houston-based company is beginning a push on its proven test for central nervous system (CNS) cancers.

“We're going to start rolling out just in Texas and doing patient testing in the state of Texas, first with a few accounts where we've established a relationship, and then we'll continue our rollout through the United States in the next year or so,” says Russell Bradley, president and general manager of CNSide Diagnostics.

Bradley had retired from multinational diagnostics company Abbott Laboratories when he met Marc Hendrick, the CEO of Austin’s Plus Therapeutics, last year. When Hendrick told him about the recent acquisition of CNSide, a company formerly based in San Diego, Bradley says he felt compelled to join in its mission.

CNSide’s CSF assay tests cerebrospinal fluid for cancers that have metastasized to the spine or brain, primarily carcinomas and melanomas.

“Typically, they do an MRI, and that won't always show anything. If it's early stage, they do cytology, which is not very sensitive at finding cancer cells in the cerebrospinal fluid. By the time they're diagnosed, it can be very late-stage, and oftentimes, in fact, the studies show that half of these patients don't get treated,” Bradley says.

CNSide, then, is a ray of hope for patients who are often consigned to palliative care. By diagnosing their metastasis sooner, physicians have more treatment options to stop the CNS cancer before it’s wreaked havoc. Bradley also points out that once a treatment regimen is underway, doctors can continue to measure the cancer’s progress or lack thereof. He claims that, of the roughly 300 neuro-oncologists in the United States, about 200 have already used the test.

Moving from California to Houston briefly slowed progress for CNSide, but now, matters are moving ahead at a steady clip.

“It takes a little bit of time to establish the test in a new location, move the apparatus and establish the processes,” Bradley says. “You have to get the lab accredited, which we just did. So we're now accredited to run patient samples, and we've really just been doing our research samples as part of the clinical studies.”

Texas institutions, such as the University of Texas - Southwestern, MD Anderson Cancer Center, Mays Cancer Center, Baylor Scott & White Health and Texas Oncology, are beginning to use the technology.

Bradley, who lives in Austin but spends much of his time in Houston, says that the city has been nothing less than an ideal fit for the needs of his growing company and a lab that’s currently hiring. He praises the logistics potential of being close to a major hub, which will eventually be a key factor for getting lumbar puncture samples from around the country to the lab for quick testing.

“I think the business environment in Texas, generally, and in Houston, specifically, for us and the access to talent with a lot of institutions here around the Houston area that graduate the type of people that we want to employ is remarkable. And I'd say the cherry on top is really just access to world-class institutions like MD Anderson. I think from a holistic and comprehensive point of view, Houston has a lot to offer a company like us,” Bradley says.

And ultimately, what brought Bradley and CNSide to Texas is the quest to prolong the lives of people living with cancer. As he puts it, “It's a true privilege—and I know I speak on behalf of the team at CNSide and Plus—to be able to impact these patients and have the tools at this time in the history of cancer diagnostics to be able to really make a difference.”

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Houston edtech company closes oversubscribed $3M seed round

fresh funding

Houston-based edtech company TrueLeap Inc. closed an oversubscribed seed round last month.

The $3.3 million round was led by Joe Swinbank Family Limited Partnership, a venture capital firm based in Houston. Gamper Ventures, another Houston firm, also participated with additional strategic partners.

TrueLeap reports that the funding will support the large-scale rollout of its "edge AI, integrated learning systems and last-mile broadband across underserved communities."

“The last mile is where most digital transformation efforts break down,” Sandip Bordoloi, CEO and president of TrueLeap, said in a news release. “TrueLeap was built to operate where bandwidth is limited, power is unreliable, and institutions need real systems—not pilots. This round allows us to scale infrastructure that actually works on the ground.”

True Leap works to address the digital divide in education through its AI-powered education, workforce systems and digital services that are designed for underserved and low-connectivity communities.

The company has created infrastructure in Africa, India and rural America. Just this week, it announced an agreement with the City of Kinshasa in the Democratic Republic of Congo to deploy a digital twin platform for its public education system that will allow provincial leaders to manage enrollment, staffing, infrastructure and performance with live data.

“What sets TrueLeap apart is their infrastructure mindset,” Joe Swinbank, General Partner at Joe Swinbank Family Limited Partnership, added in the news release. “They are building the physical and digital rails that allow entire ecosystems to function. The convergence of edge compute, connectivity, and services makes this a compelling global infrastructure opportunity.”

TrueLeap was founded by Bordoloi and Sunny Zhang and developed out of Born Global Ventures, a Houston venture studio focused on advancing immigrant-founded technology. It closed an oversubscribed pre-seed in 2024.

Texas space co. takes giant step toward lunar excavator deployment

Out of this world

Lunar exploration and development are currently hampered by the fact that the moon is largely devoid of necessary infrastructure, like spaceports. Such amenities need to be constructed remotely by autonomous vehicles, and making effective devices that can survive the harsh lunar surface long enough to complete construction projects is daunting.

Enter San Antonio-based Astroport Space Technologies. Founded in San Antonio in 2020, the company has become a major part of building plans beyond Earth, via its prototype excavator, and in early February, it completed an important field test of its new lunar excavator.

The new excavator is designed to function with California-based Astrolab's Flexible Logistics and Exploration (FLEX) rover, a highly modular vehicle that will perform a variety of functions on the surface of the moon.

In a recent demo, the Astroport prototype excavator successfully integrated with FLEX and proceeded to dig in a simulated lunar surface. The excavator collected an average of 207 lbs (94kg) of regolith (lunar surface dust) in just 3.5 minutes. It will need that speed to move the estimated 3,723 tons (3,378 tonnes) of regolith needed for a lunar spaceport.

After the successful test, both Astroport and Astrolab expressed confidence that the excavator was ready for deployment. "Leading with this successful excavator demo proves that our technology is no longer theoretical—it is operational," said Sam Ximenes, CEO of Astroport.

"This is the first of many implements in development that will turn Astrolab's FLEX rover into the 'Swiss Army Knife' of lunar construction. To meet the infrastructure needs of the emerging lunar economy, we must build the 'Port' before the 'Ship' arrives. By leveraging the FLEX platform, we are providing the Space Force, NASA, and commercial partners with a 'Shovel-Ready' construction capability to secure the lunar high ground."

"We are excited to provide the mobility backbone for Astroport's groundbreaking construction technology," said Jaret Matthews, CEO of Astrolab, in a release. "Astrolab is dedicated to establishing a viable lunar ecosystem. By combining our FLEX rover's versatility with Astroport's civil engineering expertise, we are delivering the essential capabilities required for a sustainable lunar economy."

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This article originally appeared on CultureMap.com.

Houston biotech co. raises $11M to advance ALS drug development

drug money

Houston-based clinical-stage biotechnology company Coya Therapeutics (NASDAQ: COYA) has raised $11.1 million in a private investment round.

India-based pharmaceuticals company Dr. Reddy’s Laboratories Inc. led the round with a $10 million investment, according to a news release. New York-based investment firm Greenlight Capital, Coya’s largest institutional shareholder, contributed $1.1 million.

The funding was raised through a definitive securities purchase agreement for the purchase and sale of more than 2.5 million shares of Coya's common stock in a private placement at $4.40 per share.

Coya reports that it plans to use the proceeds to scale up manufacturing of low-dose interleukin-2 (IL-2), which is a component of its COYA 302 and will support the commercial readiness of the drug. COYA 302 enhances anti-inflammatory T cell function and suppresses harmful immune activity for treatment of Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Parkinson’s disease and Alzheimer’s disease.

The company received FDA acceptance for its investigational new drug application for COYA 302 for treating ALS and FTD this summer. Its ALSTARS Phase 2 clinical trial for ALS treatment launched this fall in the U.S. and Canada and has begun enrolling and dosing patients. Coya CEO Arun Swaminathan said in a letter to investors that the company also plans to advance its clinical programs for the drug for FTD therapy in 2026.

Coya was founded in 2021. The company merged with Nicoya Health Inc. in 2020 and raised $10 million in its series A the same year. It closed its IPO in January 2023 for more than $15 million. Its therapeutics uses innovative work from Houston Methodist's Dr. Stanley H. Appel.