The Ion Smart Cities Accelerator program's inaugural cohort is moving into its next phase, and some participating startups earned some cash along the way. Courtesy of Station Houston

The Ion Smart Cities Accelerator wrapped up the first phase of its inaugural program with a demo day this week as the startups move onto the pilot phase.

Over the past three months, the 10 selected startups have been working with mentors and the Station Houston resources to hone their companies within the program's new dedicated space, which includes a prototyping lab. At the demo day, which represents the conclusion of the first part of the Intel- and Microsoft-backed program, the startups presented their companies, what they've accomplished, and where they are headed.

Two companies received $5,000 checks from sponsors. GoKid, a carpooling optimization tool, received a prize from Brex, a credit card for startups. The other big winner was Aatonomy, a self-driving communities technology, which was awarded by Gulf States Toyota.

Ion Accelerator Demo Day F. Carter Smith

The second leg of the journey begins in January with pilot programs for the next six months. According to Christine Galib, director of Ion Smart Cities Accelerator, the companies have 15 pilots in the Houston area that hope to positively affect the lives of Houstonians.

"Our startups' technology focuses on connecting people. And this is what makes Houston truly the smartest city in America," says Galib. "To truly be the smartest city in America, we must continue to focus on how we connect people, and why we connect people, as well as to provide the processes and partnerships for these connections — not only to occur by chance, but also to be sustainable."

Gabriella Rowe, executive director of The Ion, echoed the importance people had on the smart cities equation.

"The great success that this accelerator has experienced over the last three months has really been because of people," she says.

Among those people who received a special shoutout from Rowe were the program's inaugural set of mentors. Several of these mentors introduced each of the startups as they presented.

"All of you opened your calendars, your time, and your wisdom to help these startups, but also to help our city," Rowe says to the crowd, which included the program mentors. "And to express a universal desire to make Houston the best possible city it can be, accessible to all Houstonians in every way as we grow to be that innovation economy and city of the future."

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German biotech co. to relocate to Houston thanks to $4.75M CPRIT grant

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Armed with a $4.75 million grant from the Cancer Prevention and Research Institute of Texas, a German biotech company will relocate to Houston to work on developing a cancer medicine that fights solid tumors.

Eisbach Bio is conducting a clinical trial of its EIS-12656 therapy at Houston’s MD Anderson Cancer Center. In September, the company announced its first patient had undergone EIS-12656 treatment. EIS-12656 works by suppressing cancer-related genome reorganization generated by DNA.

The funding from the cancer institute will support the second phase of the EIS-12656 trial, focusing on homologous recombination deficiency (HRD) tumors.

“HRD occurs when a cell loses its ability to repair double-strand DNA breaks, leading to genomic alterations and instability that can contribute to cancerous tumor growth,” says the institute.

HRD is a biomarker found in most advanced stages of ovarian cancer, according to Medical News Today. DNA constantly undergoes damage and repairs. One of the repair routes is the

homologous recombination repair (HRR) system.

Genetic mutations, specifically those in the BCRA1 and BCRA1 genes, cause an estimated 10 percent of cases of ovarian cancer, says Medical News Today.

The Cancer Prevention and Research Institute of Texas (CPRIT) says the Eisbach Bio funding will bolster the company’s “transformative approach to HRD tumor therapy, positioning Texas as a hub for innovative cancer treatments while expanding clinical options for HRD patients.”

The cancer institute also handed out grants to recruit several researchers to Houston:

  • $2 million to recruit Norihiro Goto from the Massachusetts Institute of Technology to MD Anderson.
  • $2 million to recruit Xufeng Chen from New York University to MD Anderson.
  • $2 million to recruit Xiangdong Lv from MD Anderson to the University of Texas Health Science Center at Houston.

In addition, the institute awarded:

  • $9,513,569 to Houston-based Marker Therapeutics for a first-phase study to develop T cell-based immunotherapy for treatment of metastatic pancreatic cancer.
  • $2,499,990 to Lewis Foxhall of MD Anderson for a colorectal cancer screening program.
  • $1,499,997 to Abigail Zamorano of the University of Texas Health Science Center at Houston for a cervical cancer screening program.
  • $1,497,342 to Jennifer Minnix of MD Anderson for a lung cancer screening program in Northeast Texas.
  • $449,929 to Roger Zoorob of the Baylor College of Medicine for early prevention of lung cancer.

On November 20, the Cancer Prevention and Research Institute granted funding of $89 million to an array of people and organizations involved in cancer prevention and research.

West Coast innovation organization unveils new location in Houston suburb to boost Texas tech ecosystem

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Leading innovation platform Plug and Play announced the opening of its new flagship Houston-area location in Sugar Land, which is its fourth location in Texas.

Plug and Play has accelerated over 2,700 startups globally last year with corporate partners that include Dell Technologies, Daikin, Microsoft, LG Chem, Shell, and Mercedes. The company’s portfolio includes PayPal, Dropbox, LendingClub, and Course Hero, with 8 percent of the portfolio valued at over $100 million.

The deal, which facilitated by the Sugar Land Office of Economic Development and Tourism, will bring a new office for the organization to Sugar Land Town Square with leasing and hiring between December and January. The official launch is slated for the first quarter of 2025, and will feature 15 startups announced on Selection Day.

"By expanding to Sugar Land, we’re creating a space where startups can access resources, build partnerships, and scale rapidly,” VP Growth Strategy at Plug and Play Sherif Saadawi says in a news release. “This location will help fuel Texas' innovation ecosystem, providing entrepreneurs with the tools and networks they need to drive real-world impact and contribute to the state’s technological and economic growth."

Plug and Play plans to hire four full-time equivalent employees and accelerate two startup batches per year. The focus will be on “smart cities,” which include energy, health, transportation, and mobility sectors. One Sugar Land City representative will serve as a board member.

“We are excited to welcome Plug and Play to Sugar Land,” Mayor of Sugar Land Joe Zimmerma adds. “This investment will help us connect with corporate contacts and experts in startups and businesses that would take us many years to reach on our own. It allows us to create a presence, attract investments and jobs to the city, and hopefully become a base of operations for some of these high-growth companies.”

The organization originally entered the Houston market in 2019 and now has locations in Bryan/College Station, Frisco, and Cedar Park in Texas.