Houston researcher advances promising early-stage cancer diagnosis method

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A University of Houston researcher has reported a 98.7-percent rate of accuracy for a method pioneered by his lab to identify cancers at their earliest stages. Photo via Getty Images

Could detecting cancer one day be as easy as taking a blood test? Wei-Chuan Shih, a University of Houston researcher and Cullen College of Engineering professor of electrical and computer engineering, has reported a 98.7-percent rate of accuracy for a method pioneered by his lab to identify cancers at their earliest stages.

The technology combines Shih’s own PANORAMA (PlAsmonic NanO-apeRture lAbel-free iMAging) with fluorescent imaging to view nanometer-sized membrane sacs, called extracellular vesicles or EVs. EVs carry different types of cargo, including proteins, nucleic acids and metabolites, throughout the bloodstream.

“We observed differences in small EV numbers and cargo in samples taken from healthy people versus people with cancer and are able to differentiate these two populations based on our analysis of the small EVs,” reports Shih, in Nature Communications Medicine. “The findings came from combining two imaging methods – our previously developed method PANORAMA and imaging of fluorescence emitted by small EVs—to visualize and count small EVs, determine their size and analyze their cargo.”

Shih introduced PANORAMA in 2020. The technology uses a glass side covered with gold nano discs that allows users to monitor changes in the transmission of light as well as determine the characteristics of nanoparticles as small as 25 nanometers in diameter. For the new publication, Shih and his team just had to count the number of small EVs in order to detect cancer.

“Using a cutoff of 70 normalized small EV counts, all cancer samples from 205 patients were above this threshold except for one sample, and for healthy samples, from 106 healthy individuals, all but three were above this cutoff, giving a cancer detection sensitivity of 99.5% and specificity of 97.3%,” says Shih.

The team was able to report 100-percent accuracy with further testing that analyzed two independent sets of samples from stage I-IV or recurrent leiomyosarcoma/gastrointestinal stromal tumors and early-and-late-stage cholangiocarcinoma combined with healthy samples.

Shih and collaborator Steven H. Lin have founded Seek Diagnostics with the goal of commercializing the technology that they’ve innovated. In 2022, the duo joined the Texas Medical Center Innovation's cancer-focused accelerator.


Wei-Chuan Shih is a professor of electrical and computer engineering at the University of Houston's Cullen College of Engineering. Photo via UH.edu

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Former Shopify exec joins Houston scale-up e-commerce software company

joining the team

Houston-based e-commerce software and services company Cart.com has hired a former Shopify executive as its chief people officer.

Before joining Cart.com, Lani Doyle was chief HR officer at Strategic Solutions Group, a provider of health care software. Previously, she was vice president of HR and people operations at 6 River Systems, a provider of software and robotics for warehouses. Prior to that, Doyle was head of talent development and operations at Shopify, an e-commerce platform for businesses that posted revenue of $7.1 billion in 2023.

“Cart.com is one of the fastest-growing companies in commerce today, and I’m excited to partner with our teams to help drive growth and scalability,” Doyle says in a news release. “I am eager to contribute to shaping our culture and developing programming that supports and elevates high-performing teams, ensuring we achieve our ambitious goals.”

Omair Tariq, founder and CEO of Cart.com, describes Doyle as a “strategic leader” who will help develop the startup’s continually growing team. The company, founded in 2020 in Houston, employs more than 1,600 people.

“Her deep expertise in HR strategy and talent development will be instrumental as we accelerate our growth trajectory and foster a dynamic workplace culture,” says Frank Parker, chief operating officer of Cart.com.

In February, Cart.com made another high-level executive move by promoting Joe Barth from senior vice president of fulfillment to chief logistics officer.

Cart.com has more than 6,000 customers. The company handles more than 75 million orders per year from 14 fulfillment centers in the U.S.

Earlier this year, Tariq joined the Houston Innovators Podcast to share a bit about his company's growth and its relocation from Austin back to Houston.

"I think Austin served its purpose. It certainly allowed us to be in the limelight in all the right ways, and I'm grateful for it," Tariq says on the show. "But once we got to a point, once we closed our series C round and became a unicorn ... I think we're now at a scale where the infrastructure that Houston provides is probably something that will be more attractive and useful for us in the long term."

Autonomous freight co. with Houston-Dallas pilot opens early access program

join the fleet

Texas has been a key testing area for autonomous freight technology for years, and one major player in the space has made its latest move to put the pedal to the metal on self-driving trucking.

Aurora Innovation (NASDAQ: AUR) announced a new program with Uber Freight. Premier Autonomy, which will provide "early access to over 1 billion of Aurora’s driverless miles to Uber Freight carriers through 2030," is launching to deploy autonomous freight vehicles on the Uber Freight network.

Uber Freight, an end-to-end logistics company managing over $18 billion of freight, is also reportedly going to be among Aurora's first customers for its Dallas-to-Houston freight route that anticipates driverless hauls beginning at the end of 2024.

“Uber Freight and Aurora see a tremendous opportunity to democratize autonomous trucks for carriers of all sizes, enabling them to drive more revenue, scale their fleets, and strengthen their bottom lines,” Lior Ron, founder and CEO of Uber Freight, says in a news release. “Autonomous trucks will make moving goods more efficient, and this industry-first program will help facilitate and accelerate the adoption of autonomous trucks with our carriers. We’re proud to work alongside the amazing team at Aurora to bring this technology into the hands of carriers and ultimately usher in a new era of logistics.”

The new program, a first for the industry, allows customers to purchase and begin implementing Aurora Driver, a self-driving system that can work with multiple vehicle types, including freight trucks and passenger vehicles. Aurora provides driver-as-a-service products for trucking and ride-hailing industries and has a slew of partners in addition to Uber and Uber Freight, including FedEx, Toyota, Volvo Trucks, Volvo Autonomous Solutions, and more.

“With Uber Freight, we can provide hundreds of carriers priority access to autonomous truck capacity that they wouldn’t otherwise have. Working with carriers of all sizes is one of the many ways we will transform the industry and see thousands of driverless trucks on the road,” Ossa Fisher, president of Aurora, says in the release. “It’s exciting and validating that companies like Uber Freight are reserving our long-term capacity for their customers. We all see collective value in this offering.”

With enrollment into the new Premier Autonomy Program, customers receive a subscription to the Aurora Driver for autonomous freight hauling, the opportunity to access over 1 billion driverless miles through 2030, and access to autonomous trucks via a planned, seamless integration of the Aurora Driver into the Uber Freight platform, according to the news release.

Since 2020, Uber Freight and Aurora have hauled millions of pounds of cargo through their pilot program that operated on the Dallas-Houston route.

Houston startup designs new platform for better navigating health care

patient portal

Taking control of your health can be a difficult path to walk on your own. A new startup, created by eight female Rice University students, is aimed at wading through the health care system.

The Healthcare Navigator is a platform that helps users to learn about not just treatment options, but also the financial bearings thereof.

“About 88 percent of Americans aren’t health literate,” founder and president Kayla Grimes says in a news release. “It’s very hard for them to navigate health care in the way to get the best benefit for it, so what our platform will do is essentially give them the tools and resources to confidently navigate the health care system. We also help with price transparency specifically.”

The multidisciplinary team includes women majoring in pre-med, computer science, medical humanities, art and business. According to Grimes (a rising senior business major), the seed for the idea’s success was planted two years ago when she was volunteering for the National Patient Advocacy Foundation.

“They told me, ‘If you do this right, this could actually change everything in health care,’” she remembers.

Now she and her team have an app, as well as an accessible website, composed of several features all meant to make it easier to save money — and users’ health. The features are:

  • Cost Compass, which compares procedure costs across local hospitals, enabling users to shop around and save money.
  • Care Genius AI, an AI chatbot that helps users to negotiate medical bills and answers health care system questions.
  • Patient Power Modules, which are interactive educational videos that make understanding the health care system easy and engaging.
  • Pocket Doc, which helps consumers find the best providers for them based on location, ratings and quality metrics.
  • Pulse Check Alert keeps users informed on important health care news and patient insights.
  • Care Manager streamlines users’ health care needs and goals in one convenient place.

Grimes says that she hopes that users will skip Google reviews and go straight to their Pocket Doc, which includes information on hospitals, clinics, urgent care centers and freestanding emergency rooms.

“We have that in the system, so that you can actually see useful metrics instead of just going on Google reviews and reading their readmission rate — we’re going to explain what’s a good readmission rate and what’s a bad readmission rate,” she says. “That’s the whole point: We’re not just going to give you these metrics, we’re also going to give you some benchmarks, so you can make the decision for yourself.”

When dealing with your health, knowledge is certainly power, and Healthcare Navigator is bestowing a new kind of power on its users.

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