Texas bioscience company makes colossal move to resurrect the extinct woolly mammoth

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Ben Lamm and George Church are pioneering colossal de-extinction technology. Courtesy of Colossal

In a move that may conjure up fanciful thoughts of a particular Steven Spielberg film, a newly launched bioscience and genetics company with ties to Austin and Dallas is pioneering a plan to ensure the long extinct woolly mammoth will once again trudge through the Arctic tundra.

(No need to panic, movie fans, as the furry beast is an herbivore and has no taste for human flesh, lest we forget the lessons learned from Jurassic Park.)

The appropriately named Colossal, which is based across Austin, Dallas, and Boston, has secured $15 million in funding from a variety of sources (including Austin-based Capital Factory and famed self-help guru Tony Robbins) to bring the woolly mammoth back from its roughly 10,000-year extinction.

Colossal, the brainchild of Baylor University grad and tech and software entrepreneur Ben Lamm and George Church, a professor of genetics at Harvard Medical School who has innovated new approaches to gene editing. Their goal is to pioneer animal de-extinction technology to restore lost ecosystems for a healthier planet. And they're starting by resurrecting the woolly mammoth back to its cold-resistant, curled-tusk, fur-covered glory.

Specifically, Colossal will work to bring to life a cold-resistant elephant-mammoth hybrid with the core biological traits of the woolly mammoth, meaning it will walk, look, and sound like the giant creature, and will be able to inhabit the same ecosystem left abandoned by the woolly mammoth's extinction.

The company uses breakthrough advances in CRISPR genetic engineering to make such scientific dreams a reality. It's all in an effort to "rewild lost habitats and help combat the effects of climate change and the loss of biodiversity." And Colossal notes that its gene-editing process also has the potential to help advance biotechnology products and genomics while also treating diseases. Such technological advancements will also be used to help recover species on the brink of extinction.

"Never before has humanity been able to harness the power of this technology to rebuild ecosystems, heal our Earth, and preserve its future through the repopulation of extinct animals," Lamm says in a release. "In addition to bringing back ancient extinct species like the woolly mammoth, we will be able to leverage our technologies to help preserve critically endangered species that are on the verge of extinction and restore animals where humankind had a hand in their demise."

Indeed, Colossal points to a 2019 United Nations report that warned that more than 1 million animal, plant, and fungi species are now threatened with extinction. That situation could domino, leading to the collapse of ecosystems and negatively impacting human health and livelihood.

By resurrecting certain extinct species, Colossal hopes to rewild habitats and revitalize lost ecosystems, thereby creating a healthier planet. To wit, restoring the woolly mammoth can potentially revitalize the Arctic grasslands, which could combat the dire effects of climate change through a variety of properties, including carbon sequestering, methane suppression, and light reflection.

"Technologies discovered in pursuit of this grand vision — a living, walking proxy of a woolly mammoth — could create very significant opportunities in conservation and beyond, not least of which include inspiring public interest in STEM, prompting timely discussions in bioethics, and raising awareness of the vital importance of biodiversity," Church says.

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This article originally ran on CultureMap.

Life Time Work opening its first Houston location is among this roundup of Houston innovation news. Courtesy of Life Time Work

Hypergiant receives funding from Japan, UH honored for entrepreneur program, coworking space opens, and more Houston innovation news

Short stories

In the Houston innovation news cycle, it's hard to keep up. Three higher education institutions are celebrating big wins within innovation and entrepreneurialism, a new coworking space joins the scene, and a health tech competition launches out of the Texas Medical Center.

Here are all the short stories within Houston innovation that you may have missed.

Texas AI company makes international partnership

Photo via hypergiant.com

Hypergiant Industries, a Texas industrial AI company with a presence in Houston, announced that it has received funding from and has entered into a partnership with Japan-based Sumitomo Corporation of Americas. The relationship will allow the company to enable and accelerate Hypergiant's AI-driven innovation initiatives across over 900 Sumitomo subsidiaries and associated companies.

"We're proud to be backed by a global leader like SCOA," says Ben Lamm, CEO and co-founder of Hypergiant, in a release. "SCOA is a company that has advanced so many industries with critical technological breakthroughs decade after decade. This relationship will ensure that both SCOA and Hypergiant remain ahead of the competition in AI for years to come."

The funding amount wasn't disclosed.

Bauer College of Business gets top marks

Photo via bauerticker.uh.edu

The Deshpande Foundation has selected The University of Houston for its 2019 Entrepreneurial University Award, recognizing the Cyvia and Melvyn Wolff Center for Entrepreneurship at the C.T. Bauer College of Business.

"Over the past decade, the Wolff Center's reputation as one of the nation's leading entrepreneurship programs has grown tremendously, and this award from the Deshpande Foundation reinforces that Bauer College is empowering students to innovate through a world-class program that emphasizes experiential learning and personalized attention by dedicated mentors," says Paul A. Pavlou, incoming dean of the Bauer College, in a release.

The award was announced by the Massachusetts-based organization at the Deshpande Symposium for Innovation and Entrepreneurship in Higher Education at the University of Massachusetts Lowell on June 11.

Life Time Work opens its doors

Courtesy of Life Time Work

Life Time Work's first Houston-area location has opened its doors in City Centre Five at 825 Town & Country Lane. The next location has already been announced to open in downtown Houston next year.

"Life Time Work is a natural extension of the lifestyle brand we have built in our athletic resorts over the past 27 years," says Life Time Work president, James O'Reilly, in a release. "With Houston's continued growth and diversified business and entrepreneurial community, City Centre is the perfect location for us to unveil this concept. We look forward to helping our members in their pursuit of a fulfilling and healthy work life."

The 25,000-square-foot space features 79 desks, 48 offices, lounge spaces, eight phone booths, two phone rooms, five conference rooms, and more features.

JLABS @ TMC opens contest for health care startups

Photo via jlabs.jnjinnovation.com

Johnson & Johnson Innovation, the Texas Medical Center, and AngelMD have teamed up to launch the Breakthrough Medical Technologies QuickFire Challenge, which is looking for game-changing medical device ideas from all over the world for a chance to win prizes.

The winner — or winners — will "receive up to $250,000 in convertible notes funding from TMC, entry to the TMCx accelerator program, one year of residency at JLABS @ TMC in Houston, Texas, and access to the Johnson & Johnson, Innovation - JLABS global ecosystem," according to the website. Also on the line — an additional convertible note investment up to $100,000 from AngelMD's Catalyst Fund.

The competition is looking for innovations within a wide range of health technologies, from oncology to 3D printing.

Houston hospital ranks No. 1 in the state for being one of America's Best Employers

Courtesy of Methodist Hospital/Facebook

Forbes partnered with market research company Statista to identify the best employers in each state. In Texas, Houston was represented at the top. Houston Methodist ranked as the number one company on the Texas list.

Royal Dutch Shell, which ranks at No. 11, is the next Houston-headquartered company on the list, followed by The University of Texas Health Science Center at Houston (No. 19), Katy Independent School District (No. 22), and Texas Children's Hospital (No. 23.)

HCC recognized for innovation of the year

Photo courtesy of HCC

Houston Community College received the Innovation of the Year Award from the League for Innovation in the Community College. HCC won for its Zero Textbook Degree initiative, which launched in 2017 and has grown from 28 to 98 sections across five HCC campuses.

"The Z-Degree program is managed by an entire group of hardworking and forward-thinking HCC faculty who are all deserving of the accolades currently bestowed on them," says Chancellor Cesar Maldonado in a news release.

Textbook prices have increased 88 percent since 2006, according to the Bureau of Labor Statistics, and, according to the release, textbooks could end up costing some HCC students more than their tuition.

Rice University hosts inaugural program for future entrepreneurs

Photo courtesy of Lilie



Rice's Liu Idea Lab for Innovation and Entrepreneurship got a jump on molding its young minds. Lilie hosted 44 incoming freshmen as a part of its inaugural Lilie Change Maker Summit. For four days, the to-be students had the opportunity to get get a taste of the program and entrepreneurialism through workshops, guest speakers, and more.

The summit was led by Jamie Jones, executive director of Lilie, and Hesam Panahi, lecturer in entrepreneurship at Rice's Jones Graduate School of Business and a faculty member at Lilie.

"We truly believe this will be a game changer in the Rice entrepreneurial ecosystem," says Caitlin Bolanos, associate director at Lilie, in an email to InnovationMap. "We were able to connect with these students and build loyalty before they even officially started in the fall, and the students are so pumped to have found each other and to continue working on their ideas while at Rice."

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Greentown Labs names Lawson Gow as its new Houston leader

head of hou

Greentown Labs has named Lawson Gow as its Head of Houston.

Gow is the founder of The Cannon, a coworking space with seven locations in the Houston area, with additional partner spaces. He also recently served as managing partner at Houston-based investment and advisory firm Helium Capital. Gow is the son of David Gow, founder of Energy Capital's parent company, Gow Media.

According to Greentown, Gow will "enhance the founder experience, cultivate strategic partnerships, and accelerate climatetech solutions" in his new role.

“I couldn’t be more excited to join Greentown at this critical moment for the energy transition,” Gow said in a news release. “Greentown has a fantastic track record of supporting entrepreneurs in Houston, Boston, and beyond, and I am eager to keep advancing our mission in the energy transition capital of the world.”

Gow has also held analyst, strategy and advising roles since graduating from Rice University.

“We are thrilled to welcome Lawson to our leadership team,” Georgina Campbell Flatter, CEO of Greentown Labs, added in the release. “Lawson has spent his career building community and championing entrepreneurs, and we look forward to him deepening Greentown’s support of climate and energy startups as our Head of Houston.”

Gow is the latest addition to a series of new hires at Greentown Labs following a leadership shakeup.

Flatter was named as the organization's new CEO in February, replacing Kevin Dutt, Greentown’s interim CEO, who replaced Kevin Knobloch after he announced that he would step down in July 2024 after less than a year in the role.

Greentown also named Naheed Malik its new CFO in January.

Timmeko Moore Love was named the first Houston general manager and senior vice president of Greentown Labs. According to LinkedIn, she left the role in January.

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This article originally appeared on our sister site, EnergyCapitalHTX.com.

Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

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