3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes former city council member Amanda Edwards, Gaurav Khandelwal of Velostics, and Anshumali Shrivastava of ThirdAI. Courtesy photos

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from logistics tech to computer science — recently making headlines in Houston innovation.

Amanda Edwards, former Houston City Council Member

Amanda Edwards worked with local female leaders to launch BEAMW. Photo via LinkedIn

A couple years ago, Houston City Council Member Amanda K. Edwards, along with entrepreneurs Carolyn Rodz and Courtney Johnson Rose, formed a task force to provide Mayor Sylvester Turner with recommendations about increasing increase access to capital for minority- and women-owned business enterprises and assisting these business owners in scaling up their businesses. The task force created the Houston Small Business Community Report, which shed light on the disparities in access to resources for women and BIPOC-founders.

In response to this report, Edwards and a cohort of female leaders have launched the Business Ecosystem Alliance for Minorities and Women, or BEAMW, to address these disparities these businesses face when seeking capital and attempting to scale their businesses.

"It is not enough to state that Houston is the most diverse city in the country; we must be the city where the challenges that diverse communities face are solved," Edwards says in a release. Click here to read more.

Gaurav Khandelwal, CEO and founder of ChaiOne and Velostics

Serial entrepreneur says he sees logistics innovation as a "massive opportunity" for Houston. Photo courtesy

Gaurav Khandelwal has been an advocate for growing Houston's innovation ecosystem since he started his company ChaiOne — an industrial software provider — in 2008. Now, with his new company, Velostics, he is passionate about making Houston a hub for logistics innovation too.

"I think that there are some trends in Houston that I'm seeing as a founder, and one of them is logistics," Khandewal says on this week's episode of the Houston Innovators Podcast.

"If you look at Chicago — it's had some crazy amount of logistics unicorns that have popped up over the past few years, and they aren't slowing down," Khandewal says on the show. "Houston, I would argue, is better positioned, because we have this massive port. I think logistics is a massive opportunity for Houston." Click here to read more and listen to the episode.

Anshumali Shrivastava, CEO and co-founder of ThirdAI

Anshumali Shrivastava is also an associate professor of computer science at Rice University. Photo via rice.edu

A seed-stage company is changing the game for data science and artificial intelligence, and the technology was developed right on the Rice University campus.

ThirdAI, founded by Anshumali Shrivastava in April, raised $6 million in a seed funding round from three California-based VCs — Neotribe Ventures and Cervin Ventures, which co-led the round with support from Firebolt Ventures.

"We are democratizing artificial intelligence through software innovations," says Shrivastava in a news release from Rice. "Our innovation would not only benefit current AI training by shifting to lower-cost CPUs, but it should also allow the 'unlocking' of AI training workloads on GPUs that were not previously feasible." Click here to read more.

A group of entrepreneurs, small business support groups, and more teamed up to create the Business Ecosystem Alliance for Minorities and Women, or BEAMW. Photo via beamw.org

Collaborative organization launches to support minority and female founders

BEAMW me up

A group of organizations — consisting of entrepreneurs, investors, chambers of commerce, business support organizations, and small business advocates — have teamed up to bridge the gap in resources for women- and minority-owned businesses.

The Business Ecosystem Alliance for Minorities and Women, or BEAMW, celebrated its launch on August 26 at a virtual event, and announced its anchor partner, Texas Capital Bank.

"At Texas Capital Bank, we truly believe small businesses are the heartbeat of the economy and we are thrilled BEAMW has formed to serve as a collaborative network, committed to serving entrepreneurs across our region today and inspiring those of tomorrow," says Jenny Guzman of Texas Capital Bank, in the news release. "Small business owners are the lifeblood of every community and we're proud to serve alongside BEAMW as partners in providing technical assistance, mentors and support as this collaborative grows and positively impacts the fabric of economy and business ecosystem."

The mission of BEAMW is to address the disparities these businesses face when seeking capital and attempting to scale their businesses. BEAMW was first ideated by the group being the Houston Small Business Community Report, which was created by the City of Houston's Women and Minority-Owned Business Task Force. Led by former Houston City Council Member, Amanda K. Edwards, and co-chaired by entrepreneurs Carolyn Rodz and Courtney Johnson Rose, the task force provided Mayor Sylvester Turner with recommendations about increasing increase access to capital for minority- and women-owned business enterprises and assisting these business owners in scaling up their businesses.

Minority-owned businesses have been denied loans at three times the rate of non-minority-owned firms, according to the report, and only 24 percent of small businesses are owned by Houston women.

"It is not enough to state that Houston is the most diverse city in the country; we must be the city where the challenges that diverse communities face are solved," Former City Council Member Amanda Edwards says in the release.

BEAMW and Texas Capital Bank's Community Impact together will create programming for the rest of the year, specifically focused on:

  • One on One Financial Preparedness Small Business Counseling
  • Business Networking Forums
  • Texas Capital Bank Bankers' Roundtables

More information about BEAMW — including how to get involved — may be found at beamw.org.

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Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

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