UH professor John O’Brien has landed new funding from the National Eye Institute. Photo courtesy UH.

University of Houston College of Optometry Professor John O’Brien has received a $2.6 million grant from the National Eye Institute to continue his research on the retina and neurological functions.

O’Brien is considered a leading expert in retinal neuroscience with more than 20 years of research in the field. The new funding will allow O’Brien and his team to continue to study the dense assembly of proteins associated with electrical synapses, or gap junctions, in the retina.

Gap junctions transfer electrical signals between neurons. And the plasticity of gap junctions changes the strength of a synapse, in turn changing how visual information is processed. Previous research has shown that reduced functions of electrical synapses could be linked to autism, while their hyperfunction may lead to seizures.

“The research we propose will significantly advance our understanding of the molecular complexes that control the function of electrical synapses,” O’Brien said in a news release.

The team at UH will work to identify the proteins and examine how they impact electrical synapses. It is particularly interested in the Connexin 36, or Cx36, protein. According to O’Brien, phosphorylation of Cx36, a short-term chemical modification of the protein, serves as a key driver of plasticity. And the protein has been linked to refractive error development, which is one of the largest vision problems in the world today.

Additionally, OBrien’s research has shown that plasticity is essential for all-day vision, allowing the retina to adjust sensitivity and sharpen images. He has also built a catalog of the core set of proteins surrounding electrical synapses that are conserved across species. His research has been funded by the NEI since 2000.

Houston-based Incuentro provides online education with individuals with Autism, ADD, Asperger's, social anxiety, or learning differences — as well as parents or employers. Getty Images

Houston organization is providing access to special education resources 'anywhere there is Wi-Fi'

Autism Awareness Month

A Houston-based online platform is hoping to provide easy access to special education resources to support individuals with special needs, as well as their employers, teachers, and caregivers — or anyone with internet access.

The online program, Incuentro, launched April 1, coinciding with the start of Autism Awareness Month. The first 15 classes are slated to go live in June. These virtual classes are intended to be a resource for people from first grade all the way through adulthood who are coping with Autism, ADD, Asperger's, social anxiety, or learning differences.

"Over 30 students participated in the pilot program over the past 9 months," says Wendy Dawson, founder of Incuentro. "I've seen students relate to the lessons, make connections with the topics, engage in peer conversation, and find support and learning in a safe environment."

Students learn and practice skills applicable to school, employment, and social situations in the virtual company of a qualified teacher and peers from the comfort of their own home. The teaching style is as interactive as possible and requires participants to engage in discussion.

Life education
Dawson says that students will get the most out of this experience if they are verbal, able to sustain attention, and participate in a video conference forum. Hour-long classes focus on friendship, behavior, social interactions in the primary and elementary years, while tweens focus on making peer connections.

"We want to provide help upfront to reduce the anxiety and depression that we commonly see later in life," Dawson says.

Teen classes set up students with skills for future employment and transitions post-high school. Adult learners benefit from job skills and workplace behavior norms.

Students who are employed or looking for employment learn about topics like conversing with coworkers and supervisors, appropriate social interactions, and understanding the rules of the workplace. Equally important, teachers discuss with participants ways that they can be their own advocate as they maneuver through society.

A focus on inclusion
Incuentro offers employer training as well, to help foster a climate of inclusion in the workplace, to discourage a lowering of expectations when accommodating employees with Autistic traits. Classes give supervisors understanding and practicalities that will foster a positive environment for employees who are also enrolled in the course.

"Employers are coached on topics such as: understanding a literal mind, being factual, making simple accommodations like visual schedules, delivering information in a low-stress manner, and understanding learning styles," Dawson says.

Incuentro helps to bridge the gap between the service and people in need through technology.

"There is a huge disconnect between the people who need services, and the actual resources. Many times they don't know where to go, or are too far away to access them."

All you need is internet access
Accessing the classes remotely removes the barrier of accessibility for people in rural areas, as well as people who would rather not drive to a class after a long day at work or school. Oftentimes, students will feel more comfortable participating in a one-hour, online discussion with 5-7 peers, rather than enduring the social pressures of a classroom setting.

"Our desire is to bring access to special education expertise to anywhere there is Wi-Fi," says Dawson.

Incuentro curriculum is created by Education Visionary Specialist Brandi Timmons, a Board Certified Behavior Analyst (BCBA) and a Licensed Behavior Analyst (LBA). Classes are taught by expert teachers who specialize in special needs education.

Family business
Dawson's passion behind Incuentro was inspired by her step-son, Cameron Dawson, who was diagnosed with Autism at the age of two.

"There were no services to fit his needs available in the market," Dawson says, "so we've spent 10 years advocating and learning, and figuring out how to best bring services to people who need them."

Cameron participated in the Incuentro pilot program while attending Texas Tech, and in May he will be graduating with his degree in Communication Studies. Upon returning home to Houston, he will be seeking a job in one of many local churches, where Dawson says he has experienced love and support throughout his life.

As a mother of a child with Autism and advocate for people with special needs, Dawson has seen the challenges faced by parents. Parents not only must navigate the ups and downs of school life and home life with their child each step of the way, but also plan next steps past high school graduation, and long-term care, if necessary. Incuentro helps to facilitate the discussion and provide resources for caregivers wanting to learn what options are available.

With April designated as Autism Awareness Month, Incuentro seeks to partner with organizations serving special needs populations, such as school districts, health clinics, or Autism support networks, and reach the people who need it most. Incuentro has pledged to donate a portion of its profits to a Houston non-profit that offers in-person classes for people with special needs, Social Motion. At its heart, Incuentro intends to be an answer to the question: how do we set individuals with special needs up for success, and help give them the tools to live an independent and fulfilling life?

Brandi Timmons (left) and Wendi Dawson, Incuentro founderCourtesy of Incuentro

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

5+ must-know application deadlines for Houston innovators

apply now

Editor's note: As 2026 ramps up, the Houston innovation scene is looking for the latest groups of innovative startups that'll make an impact. A number of accelerators and competitions have opened applications. Read below to see which might be a good fit for you or your venture. And take careful note of the deadlines. Please note: this article may be updated to include additional information and programs.

Did we miss an accelerator or competition accepting applications? Email innoeditor@innovationmap.com for editorial consideration.

2026 HCC Business Plan Competition

Deadline: Jan. 26

Details: HCC’s annual Business Plan Competition (BPC) is an opportunity for proposed, startup and existing entrepreneurs to develop focused plans to start or grow their businesses. Accepted teams will be announced and training will begin in late February and run through early June, with six free, three-hour training sessions. Advising will be provided to each accepted team. Applicants can apply as a team of up to five persons. Finalists will present to to gudges on May 27, 2026. Last year, $26,000 was awarded in seed money to the top five teams. In-kind prizes were also awarded to all graduating teams including free products, services and memberships, with an estimated in-kind value totaling $147,000. Find more information here.

University of Houston Technology Bridge Innov8 Hub (Spring 2026)

Deadline: Jan . 30

Details: UHTB Innov8 Hub’s immersive, 12-week startup acceleration program designed to help early-stage founders launch and scale their technology startups. Selected participants will gain access to expert mentors and advisors, collaborate with a cohort of peers, and compete for cash prizes during our final pitch event. The cohort begins Feb. 16, 2026. The program culminates in Pitch Day, where participants present their ventures to an audience of investors and partners from across the UH innovation ecosystem. Find more information here.

Rice Business Plan Competition 2026

Deadline: Jan. 31

Details: The Rice Business Plan Competition, hosted by the Rice Alliance for Technology and Entrepreneurship, gives collegiate entrepreneurs real-world experience to pitch their startups, enhance their business strategy and learn what it takes to launch a successful company. Forty-two teams will compete for more than $1 million in cash, investments and prizes on April 9-11, 2026. Find more information here.

Rice Veterans Business Battle 2026

Deadline: Jan. 31

Details: The Rice Veterans Business Battle is one of the nation’s largest pitch competitions for veteran-led startups, providing founders with mentorship, exposure to investors and the opportunity to compete for non-dilutive cash prizes. The event has led to more than $10 million of investments since it began in 2015. Teams will compete April 8-9, 2026. Find more information here.

TEX-E Fellows Application 2026-2027

Deadline: Feb. 10

Details: The TEX‑E Fellowship is a hands-on program designed for students interested in energy, climate, and entrepreneurship across Texas. It connects participants with industry mentors, startup founders, investors and academic leaders while providing practical, "real-world" experience in customer discovery, business modeling, and energy-transition innovation. Fellows gain access to workshops, real-world projects, and a statewide network shaping the future of energy and climate solutions. Participants must be a student at PVAMU, UH, UT Austin, Rice University, MIT or Texas A&M. Find more information here.

2026 Energy Venture Day & Pitch Competition

Deadline: Feb. 13

Details: The Rice Alliance, the Houston Energy Transition Initiative (HETI) and TEX-E will present the annual Energy Venture Day and Pitch Competition during CERAWeek on March 24-25, 2026. Energy Venture Day features two days of presentations by energy tech ventures driving efficiency and advancements toward the energy transition. On March 24, the Pitch Preview at the Ion will feature over 50 companies presenting in front of Rice Alliance's robust network of investors and industry partners. On March 25, the Energy Venture Day and Pitch Competition during CERAWeek will showcase 36 ventures at the George R Brown Convention Center. The pitch competition is divided up into the TEX-E university track, in which Texas student-led energy startups compete for $50,000 in cash prizes, and the industry ventures track. The industry track is subdivided into three additional tracks, spanning materials to clean energy. The top three companies from each industry track will be named. The winner of the CERAWeek competition will also have the chance to advance and compete for the $1 million investment prize at the Startup World Cup. Find more information here.

Greentown Go Make 2026

Deadline: March 10

Details: Greentown Go Make 2026 is an open-innovation program with Shell and Technip Energies. The six-month program is advancing industrial decarbonization by accelerating catalytic innovations. Selected startups will gain access to a structured platform to engage leadership from Shell and Technip Energies and explore potential partnership outcomes, including pilots and demonstrations. They’ll also receive networking opportunities, partnership-focused programming, and marketing visibility throughout the program. The cohort will be selected in May. Find more information here.