Houston professor awarded $2.6M grant for retina, neurological research

seeing green

UH professor John O’Brien has landed new funding from the National Eye Institute. Photo courtesy UH.

University of Houston College of Optometry Professor John O’Brien has received a $2.6 million grant from the National Eye Institute to continue his research on the retina and neurological functions.

O’Brien is considered a leading expert in retinal neuroscience with more than 20 years of research in the field. The new funding will allow O’Brien and his team to continue to study the dense assembly of proteins associated with electrical synapses, or gap junctions, in the retina.

Gap junctions transfer electrical signals between neurons. And the plasticity of gap junctions changes the strength of a synapse, in turn changing how visual information is processed. Previous research has shown that reduced functions of electrical synapses could be linked to autism, while their hyperfunction may lead to seizures.

“The research we propose will significantly advance our understanding of the molecular complexes that control the function of electrical synapses,” O’Brien said in a news release.

The team at UH will work to identify the proteins and examine how they impact electrical synapses. It is particularly interested in the Connexin 36, or Cx36, protein. According to O’Brien, phosphorylation of Cx36, a short-term chemical modification of the protein, serves as a key driver of plasticity. And the protein has been linked to refractive error development, which is one of the largest vision problems in the world today.

Additionally, OBrien’s research has shown that plasticity is essential for all-day vision, allowing the retina to adjust sensitivity and sharpen images. He has also built a catalog of the core set of proteins surrounding electrical synapses that are conserved across species. His research has been funded by the NEI since 2000.

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Houston-based Incuentro provides online education with individuals with Autism, ADD, Asperger's, social anxiety, or learning differences — as well as parents or employers. Getty Images

Houston organization is providing access to special education resources 'anywhere there is Wi-Fi'

Autism Awareness Month

A Houston-based online platform is hoping to provide easy access to special education resources to support individuals with special needs, as well as their employers, teachers, and caregivers — or anyone with internet access.

The online program, Incuentro, launched April 1, coinciding with the start of Autism Awareness Month. The first 15 classes are slated to go live in June. These virtual classes are intended to be a resource for people from first grade all the way through adulthood who are coping with Autism, ADD, Asperger's, social anxiety, or learning differences.

"Over 30 students participated in the pilot program over the past 9 months," says Wendy Dawson, founder of Incuentro. "I've seen students relate to the lessons, make connections with the topics, engage in peer conversation, and find support and learning in a safe environment."

Students learn and practice skills applicable to school, employment, and social situations in the virtual company of a qualified teacher and peers from the comfort of their own home. The teaching style is as interactive as possible and requires participants to engage in discussion.

Life education
Dawson says that students will get the most out of this experience if they are verbal, able to sustain attention, and participate in a video conference forum. Hour-long classes focus on friendship, behavior, social interactions in the primary and elementary years, while tweens focus on making peer connections.

"We want to provide help upfront to reduce the anxiety and depression that we commonly see later in life," Dawson says.

Teen classes set up students with skills for future employment and transitions post-high school. Adult learners benefit from job skills and workplace behavior norms.

Students who are employed or looking for employment learn about topics like conversing with coworkers and supervisors, appropriate social interactions, and understanding the rules of the workplace. Equally important, teachers discuss with participants ways that they can be their own advocate as they maneuver through society.

A focus on inclusion
Incuentro offers employer training as well, to help foster a climate of inclusion in the workplace, to discourage a lowering of expectations when accommodating employees with Autistic traits. Classes give supervisors understanding and practicalities that will foster a positive environment for employees who are also enrolled in the course.

"Employers are coached on topics such as: understanding a literal mind, being factual, making simple accommodations like visual schedules, delivering information in a low-stress manner, and understanding learning styles," Dawson says.

Incuentro helps to bridge the gap between the service and people in need through technology.

"There is a huge disconnect between the people who need services, and the actual resources. Many times they don't know where to go, or are too far away to access them."

All you need is internet access
Accessing the classes remotely removes the barrier of accessibility for people in rural areas, as well as people who would rather not drive to a class after a long day at work or school. Oftentimes, students will feel more comfortable participating in a one-hour, online discussion with 5-7 peers, rather than enduring the social pressures of a classroom setting.

"Our desire is to bring access to special education expertise to anywhere there is Wi-Fi," says Dawson.

Incuentro curriculum is created by Education Visionary Specialist Brandi Timmons, a Board Certified Behavior Analyst (BCBA) and a Licensed Behavior Analyst (LBA). Classes are taught by expert teachers who specialize in special needs education.

Family business
Dawson's passion behind Incuentro was inspired by her step-son, Cameron Dawson, who was diagnosed with Autism at the age of two.

"There were no services to fit his needs available in the market," Dawson says, "so we've spent 10 years advocating and learning, and figuring out how to best bring services to people who need them."

Cameron participated in the Incuentro pilot program while attending Texas Tech, and in May he will be graduating with his degree in Communication Studies. Upon returning home to Houston, he will be seeking a job in one of many local churches, where Dawson says he has experienced love and support throughout his life.

As a mother of a child with Autism and advocate for people with special needs, Dawson has seen the challenges faced by parents. Parents not only must navigate the ups and downs of school life and home life with their child each step of the way, but also plan next steps past high school graduation, and long-term care, if necessary. Incuentro helps to facilitate the discussion and provide resources for caregivers wanting to learn what options are available.

With April designated as Autism Awareness Month, Incuentro seeks to partner with organizations serving special needs populations, such as school districts, health clinics, or Autism support networks, and reach the people who need it most. Incuentro has pledged to donate a portion of its profits to a Houston non-profit that offers in-person classes for people with special needs, Social Motion. At its heart, Incuentro intends to be an answer to the question: how do we set individuals with special needs up for success, and help give them the tools to live an independent and fulfilling life?

Brandi Timmons (left) and Wendi Dawson, Incuentro founderCourtesy of Incuentro

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Houston researchers develop dissolvable implant for targeted cancer drug delivery

cancer research

Researchers at Houston Methodist have developed a biodegradable implant that can be used to safely and consistently deliver drug treatments to tumors and then dissolve without the need for further surgery.

The implant is only the size of a grain of rice, but its potential is staggering. The biodegradable nanofibrous drug-eluting seed (b-NDES) works as a reservoir parked inside a soft tumor, where it can slowly release immune-stimulating drugs over time. This overcomes a consistent problem with drugs such as immune checkpoint inhibitors. Normal systemic administration sees comparatively little of the drug making its way to the tumor, with most of it circulating throughout the body. The b-NDES is like deploying a small guerrilla fighting force embedded in enemy territory, doing maximum damage to the entrenched tumor.

"To improve cancer treatment, we're trying to start a fire inside the tumor itself," Corrine Chua, associate professor in the Center for BioNanoengineering at Houston Methodist Research Institute, said in a news release. "By activating immune cells directly within the tumor microenvironment, those cells can then travel throughout the body and seek out cancer wherever it exists. The b-NDES platform was developed to help keep therapeutic drugs concentrated inside tumors while minimizing exposure to healthy tissues.”

Chua co-led the study with Alessandro Grattoni, chair and director of the Center for BioNanoengineering at Houston Methodist Research Institute.

The study included support from the Nancy Owens Breast Cancer Foundation and the National Institutes of Health/National Cancer Institute.

Chau and Grattoni used preclinical models of triple-negative breast cancer, an aggressive form of cancer that is estrogen receptor-negative, progesterone receptor-negative and HER2-negative. Because of the receptor negativity, some popular treatments like tamoxifen and trastuzumab are ineffective. Chemotherapy has been shown to be the best course of action.

The b-NDES implant is deployed alongside radiation drugs. It keeps the drugs focused on the tumor, reducing the amount of harmful side effects typically seen when drugs are circulated more widely in the body. In 60 percent of the models, tumors were eliminated and did not cause side effects beyond the tumor site. Once the drugs have been deployed, the implant breaks down naturally.

While promising, more research will have to be done to expand use to other tumor types.

"Although the study focused on triple-negative breast cancer models, the approach could have broader applications for solid tumors," Grattoni added in the release. "It could potentially be used in cancers where there is a tumor lesion accessible for placement, including pancreatic or lung cancers."

New Houston platform Same Day Reels launches for on-demand content creation

In The Moment

If an event doesn't happen on Instagram, did it even really happen? In today's social media-driven age of branding and audience engagement, the answer increasingly is no.

Houston entrepreneur Karen De Amat is looking to fill the online content creation needs of companies with her new venture, Same Day Reels, which launched in early August. It will serve as a platform to connect companies and brands with talent that can help turn an event into a viral moment as it is happening.

"Events move quickly, and social media moves even faster,” said De Amat. “Same Day Reels was built to help brands capture the moment while it still matters. We are creating a more efficient way for businesses and creators to work together. Brands need content faster, and creators need more opportunities to turn their talent into real work. Same Day Reels brings those needs together.”

The company is focused on adding livestreams and concurrent short video content to "activations, launches, fundraisers, grand openings, conferences, hospitality experiences, and private celebrations." Such content can significantly increase the visibility of a product or brand according to digital marketing brands like Wyzowl, whose data found 63 percent of people in 2026 prefer to learn about new products via short video.

Packages offered by Same Day Reels will include filming, editing, and publishing content within hours of the targeted event.

De Amat says that her content creation platform will be a way to preserve the excitement of events and launches by enshrining them with immediate social media-driven memories.

“Event content is no longer just something you post after the fact,” De Amat said. “It is part of how people experience, remember and share the moment.”

Previously, De Amat is also the founder and CEO of Social Behavior, an influencer marketing company she launched from her home in 2014. It quickly garnered an array of clients and thrust De Amat into the spotlight, including numerous appearances on Fox 26's The Isiah Factor. Influencer Marketing Hub named her one of the top CEOs of influencer marketing companies in Houston in 2025.

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This article originally appeared on CultureMap.com.

Bristol Myers Squibb to build $2.3B Houston pharma manufacturing campus

coming soon

New Jersey-based pharmaceutical giant Bristol Myers Squibb Co. has officially named Houston as the home of its new state-of-the-art manufacturing site.

The 60,000-square-foot facility represents a $2.3 billion investment, according to a news release. It is expected to create 500 skilled jobs and will be located in Houston's Generation Park.

BMS first announced that it was considering Houston among 16 other cities for the facility in May. The new hub will manufacture small molecule, biologic and antibody-drug conjugates and is part of a $40 billion commitment to invest in the United States over five years. Construction is slated to begin next year, with the facility coming online in 2030.

"We're building the domestic manufacturing capabilities needed to deliver the next generation of medicines and support future scientific breakthroughs. Houston and the state of Texas offer the talent, infrastructure, and partnership needed to help bring that vision to life," Christopher Boerner, CEO and board chair of BMS, said in the release.

The new facility will feature a modular, multi-modal design, which will allow the company to reconfigure and add to its manufacturing capabilities over time. BMS says it expects the facility to "(grow) in scale and capability well beyond its opening configuration."

"Our decision to build this state-of-the-art manufacturing campus in Houston, Texas, reflects our confidence in the region’s ability to support a world-class, digitally advanced supply operation,” Karin Shanahan, EVP and chief supply chain and operations officer of BMS, added in the release. “This facility is designed to deliver the speed, quality, and reliability that patients depend on, combining flexible, modular manufacturing with advanced digital capabilities to ensure consistent supply across multiple modalities. It strengthens our ability to operate with resilience and positions us to reliably deliver medicines to patients today while adapting future demands.”

Texas Gov. Greg Abbott shared that the state has granted BMS a $4.89 million Texas Enterprise Fund (TEF) grant for the project. TEF grants, administered by the Texas Economic Development & Tourism Office, support business relocation or expansion projects that create "new, good-paying jobs in the community and attract significant new capital investment to the state." The development is also a qualified project under the Texas Jobs, Energy, Technology, and Innovation (JETI) program.

“Texas is a global hub for life sciences, where today’s innovations shape the future of healthcare,” Abbott said in a news release. “This $2.3 billion investment by Bristol Myers Squibb in the dynamic biotech ecosystem in Houston is a testament to the depth of our skilled workforce and the pipeline of talent coming through our nation-leading technical colleges and research universities. With lower operating costs and easy access to markets across the U.S. and the world, Texas drives affordability for consumers.”

"Bristol Myers Squibb’s announcement is a tremendous win for Texas and the Houston region, further reinforcing our position as a premier destination for life sciences and advanced manufacturing,” added Greater Houston Partnership President and CEO Steve Kean.

Last fall, Eli Lilly and Co. selected Generation Park, a 4,300-acre, master-planned commercial district near Lake Houston, for its $6.5 billion manufacturing plant. More than 300 locations in the U.S. competed for the factory. Read more here.

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