WeWork opened the doors to its fourth Houston location. Courtesy of WeWork

Photos: WeWork opens 4th Houston location in Hines downtown trophy tower and plans expansion in the Galleria

Coworking it out

WeWork has officially doubled down on its downtown presence in Houston. The coworking company has officially opened the doors of its space within Hines' trophy tower.

The coworking space makes up 50,000 square feet on two floors of 609 Main St. The 48-story building, which is owned and developed by Houston-based Hines, premiered on the downtown Houston skyline in 2017.

"The new WeWork space at 609 Main Street is a great complement to our state-of-the-art office building in downtown Houston," says Philip Croker, senior managing director at Hines, in a news release. "It's been a pleasure to work with this team and we are eager to see their space filled with Houston's cutting-edge businesses. We know WeWork in Houston is strong and look forward to our partnership growing in the years to come."

Meanwhile in the Galleria area, WeWork is opening two additional floors of its space in Galleria Tower I this month. More details on the expansion are still to come.

The new 609 Main location, which was originally announced this summer, joins the Galleria location and a Woodlands location in Hughes Landing, which also just announced its new location recently, as well as another downtown location in the Jones Building — just across the street at 708 Main St.

The new location is modern and high-end, per the release, which juxtaposes its historic sister location in downtown. The 609 Main location has a more executive feel than the homey environment of the Jones Building. For that, the new location charges a bit of a premium. Private offices at 609 Main begin at $780 a month, compared to the rates of $550 at the Jones Building and $580 at Galleria Tower I. Unassigned desk memberships are around $300 monthly for the two older locations, compared to closer to $400 for 609 Main.

"WeWork is eager to continue its expansion in the Houston area with the opening of our fourth location in Houston and second downtown," says Nathan Lenahan, general manager for Texas at WeWork, in the release. "The space at 609 Main Street is a perfect location for those businesses and entrepreneurs downtown looking to expand and have a flexible, creative office environment that promotes community."

Last month, the New York Times announced job cuts companywide for WeWork, however there has not been any regional reports for the coworking company or any information on how the cuts will affect Houston locations.

Executive feel

Courtesy of WeWork

Compared to WeWork's other Houston locations, the 609 Main space has more of an executive feel — and monthly membership reflects that. Rates are a full $200 more a month for a private office compared to WeWork's other downtown location.

WeWork will have a fourth Houston location. Photo courtesy of WeWork

WeWork doubles down on downtown with its 4th Houston coworking space announced

Coworkers unite

WeWork has decided to open yet another coworking location in Houston — this time, the new office is just down the street from an existing location.

The New York City-based coworking company has opened three locations across Houston — one in downtown's The Jones Building, one in the Galleria Office Tower I, and one in Hughes Landing in The Woodlands, which was recently announced in May.

The new location will occupy 56,000 square feet of the 25th and 26th floors of 609 Main, Houston-based Hines' 48-story trophy tower that joined the Houston skyline in early 2017. The building now has tenants to the tune of United Airlines, Kirkland & Ellis LLP, Orrick, and Hogan Lovells, to name a few.

"The modern office is evolving and providing a coworking component is essential to a building's long-term viability," says Philip Croker, Hines senior managing director, in a release. "Adding a tenant of WeWork's caliber further reinforces the strength of 609 Main and will deliver an outstanding amenity for the building and its future occupants."

In addition to the usual WeWork perks — like 24/7 building access, coffee, community events, and business resources — members will also have access to a 7,000-square-foot high-performance fitness center in the building and the lobby coffee shop.

Michael Anderson and Damon Thames with Colvill Office Properties represented Hines in the transaction and Mark O'Donnell with Savills Commercial Real Estate negotiated on behalf of WeWork.

"Houston is a thriving business hub and innovative city," says Nathan Lenahan, general manager of WeWork, in a release. "We are excited to expand our footprint with a second location downtown and continue to strengthen the WeWork network with the opening of 609 Main Street."

In May, WeWork announced that it would be opening 1,000 desks in its new Woodlands location, but the company also disclosed that 775 desks will be added to the Galleria location in 2019 too. In the same release, an additional 1,000 desks were noted to be in the works, pending new leases. This figure could have been referring to the then-unannounced downtown location.

"In 2018, WeWork grew its footprint in a very big way in Houston. Now, in 2019, we're growing even more, but in a way that's as much about desks as it is impact," says Roniel Bencosme, WeWork Houston's community director, in the news release. "In this next year, WeWork will build a constellation of opportunity through new spaces spread across Houston, and opening in the Woodlands is key to that effort."

Regionally, WeWork has a presence in five cities in Texas — Dallas, Fort Worth, Houston, Austin, and Plano — but will launch in its sixth Texas city, San Antonio, in early 2020.

Last month, WeWork announced that Houston's Jones Building location would be one of three WeWork locations selected for a 3D printing pilot program. Additionally, earlier this year the company announced its early-stage incubator program, WeWork Labs, also in the Jones Building location.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.