5 most popular innovation stories in Houston this week

What's trending

WeWork opening its newest office was among this week's top stories. Courtesy of WeWork

This week was the beginning of the end for 2019. InnovationMap published its last curated list of business and innovation events for the year, WeWork opened its newest location in town, and a Houston startup founder shared her rollercoaster story of failure and next chapter.

Scroll through to see what Houston innovation stories trended this week.

3 Houston innovators to know this week

Get to know this week's Houston innovators to know — and the companies they've founded. Courtesy photos

This week's innovators to know are all Houston startup founders who have identified a need in their industries and created companies to provide solutions.

From blockchain and data to real estate and smart materials, these Houston entrepreneurs are making an impact across industries as well as the Houston innovation ecosystem. Continue reading.

Photos: WeWork opens 4th Houston location in Hines downtown trophy tower and plans expansion in the Galleria

WeWork opened the doors to its fourth Houston location. Courtesy of WeWork

WeWork has officially doubled down on its downtown presence in Houston. The coworking company has officially opened the doors of its space within Hines' trophy tower.

The coworking space makes up 50,000 square feet on two floors of 609 Main St. The 48-story building, which is owned and developed by Houston-based Hines, premiered on the downtown Houston skyline in 2017. Continue reading.

10+ can't-miss Houston business and innovation events for December

From startup competitions to thought-provoking panels, here's where you need to be in December. Getty Images

Before everyone checks out of 2019, Houston has a couple more weeks filled with exciting entrepreneurial networking opportunities. Scroll through the curated list of innovation events you can't miss. Continue reading.

Exclusive: Promising Houston-born DNA dating startup shuts down; founder shares story

Brittany Barreto founded the first nationwide DNA-based dating app, and she shares her story of its unexpected, and unavoidable, downfall. Photo courtesy of Pheramor

When Brittany Baretto was 18 years old and sitting in an undergraduate genetics seminar, she raised her hand. She asked, to her professor's point, if particular DNA trait differences between two people can result in attraction, could she, based on that logic, make a DNA-based dating tool. With that question, she set in motion a series of events.

These events included teaming up with Bin Huang to start a dating app, called Pheramor, that factored in user DNA; raising millions for the company; hiring a team from across the country; and signing up users in all 50 states. Though, Pheramor's hockey stick growth came to a sudden stop this year when Apple pulled the app from its store, and there was nothing the founders or their investors could do about it. Continue reading.

TMC Innovation Institute leader breaks down how much the program has grown in Houston

From robots and accelerator programs to her favorite health tech startups, Emily Reiser of the TMC Innovation Institute joins the Houston Innovators Podcast. Photo courtesy of Emily Reiser

The Texas Medical Center's Innovation Institute has just celebrated five years of advancing new technologies within health care, and over the past year, the institute has evolved to set up the TMC for its next years of innovation.

"In 2019, we had a lot of big changes around our team and our leadership," says Emily Reiser, senior manager of innovation community engagement at TMC. "That enabled us to take a bigger breath and a bigger pause to say, 'How are we really doing? And how could we be doing better?'" Continue reading and listen to the episode.

WeWork opened the doors to its fourth Houston location. Courtesy of WeWork

Photos: WeWork opens 4th Houston location in Hines downtown trophy tower and plans expansion in the Galleria

Coworking it out

WeWork has officially doubled down on its downtown presence in Houston. The coworking company has officially opened the doors of its space within Hines' trophy tower.

"The new WeWork space at 609 Main Street is a great complement to our state-of-the-art office building in downtown Houston," says Philip Croker, senior managing director at Hines, in a news release. "It's been a pleasure to work with this team and we are eager to see their space filled with Houston's cutting-edge businesses. We know WeWork in Houston is strong and look forward to our partnership growing in the years to come."

Meanwhile in the Galleria area, WeWork is opening two additional floors of its space in Galleria Tower I this month. More details on the expansion are still to come.

The new 609 Main location, which was originally announced this summer, joins the Galleria location and a Woodlands location in Hughes Landing, which also just announced its new location recently, as well as another downtown location in the Jones Building — just across the street at 708 Main St.

The new location is modern and high-end, per the release, which juxtaposes its historic sister location in downtown. The 609 Main location has a more executive feel than the homey environment of the Jones Building. For that, the new location charges a bit of a premium. Private offices at 609 Main begin at $780 a month, compared to the rates of $550 at the Jones Building and $580 at Galleria Tower I. Unassigned desk memberships are around $300 monthly for the two older locations, compared to closer to $400 for 609 Main.

"WeWork is eager to continue its expansion in the Houston area with the opening of our fourth location in Houston and second downtown," says Nathan Lenahan, general manager for Texas at WeWork, in the release. "The space at 609 Main Street is a perfect location for those businesses and entrepreneurs downtown looking to expand and have a flexible, creative office environment that promotes community."

Last month, the New York Times announced job cuts companywide for WeWork, however there has not been any regional reports for the coworking company or any information on how the cuts will affect Houston locations.

Executive feel

Courtesy of WeWork

Compared to WeWork's other Houston locations, the 609 Main space has more of an executive feel — and monthly membership reflects that. Rates are a full $200 more a month for a private office compared to WeWork's other downtown location.

WeWork will have a fourth Houston location. Photo courtesy of WeWork

WeWork doubles down on downtown with its 4th Houston coworking space announced

Coworkers unite

WeWork has decided to open yet another coworking location in Houston — this time, the new office is just down the street from an existing location.

The New York City-based coworking company has opened three locations across Houston — one in downtown's The Jones Building, one in the Galleria Office Tower I, and one in Hughes Landing in The Woodlands, which was recently announced in May.

The new location will occupy 56,000 square feet of the 25th and 26th floors of 609 Main, Houston-based Hines' 48-story trophy tower that joined the Houston skyline in early 2017. The building now has tenants to the tune of United Airlines, Kirkland & Ellis LLP, Orrick, and Hogan Lovells, to name a few.

"The modern office is evolving and providing a coworking component is essential to a building's long-term viability," says Philip Croker, Hines senior managing director, in a release. "Adding a tenant of WeWork's caliber further reinforces the strength of 609 Main and will deliver an outstanding amenity for the building and its future occupants."

In addition to the usual WeWork perks — like 24/7 building access, coffee, community events, and business resources — members will also have access to a 7,000-square-foot high-performance fitness center in the building and the lobby coffee shop.

Michael Anderson and Damon Thames with Colvill Office Properties represented Hines in the transaction and Mark O'Donnell with Savills Commercial Real Estate negotiated on behalf of WeWork.

"Houston is a thriving business hub and innovative city," says Nathan Lenahan, general manager of WeWork, in a release. "We are excited to expand our footprint with a second location downtown and continue to strengthen the WeWork network with the opening of 609 Main Street."

In May, WeWork announced that it would be opening 1,000 desks in its new Woodlands location, but the company also disclosed that 775 desks will be added to the Galleria location in 2019 too. In the same release, an additional 1,000 desks were noted to be in the works, pending new leases. This figure could have been referring to the then-unannounced downtown location.

"In 2018, WeWork grew its footprint in a very big way in Houston. Now, in 2019, we're growing even more, but in a way that's as much about desks as it is impact," says Roniel Bencosme, WeWork Houston's community director, in the news release. "In this next year, WeWork will build a constellation of opportunity through new spaces spread across Houston, and opening in the Woodlands is key to that effort."

Regionally, WeWork has a presence in five cities in Texas — Dallas, Fort Worth, Houston, Austin, and Plano — but will launch in its sixth Texas city, San Antonio, in early 2020.

Last month, WeWork announced that Houston's Jones Building location would be one of three WeWork locations selected for a 3D printing pilot program. Additionally, earlier this year the company announced its early-stage incubator program, WeWork Labs, also in the Jones Building location.

Ad Placement 300x100

Ad Placement 300x600

CultureMap Emails are Awesome

Property Showcase

Johnson Space Center and UT partner to expand research, workforce development

onward and upward

NASA’s Johnson Space Center in Houston has forged a partnership with the University of Texas System to expand collaboration on research, workforce development and education that supports space exploration and national security.

“It’s an exciting time for the UT System and NASA to come together in new ways because Texas is at the epicenter of America’s space future. It’s an area where America is dominant, and we are committed as a university system to maintaining and growing that dominance,” Dr. John Zerwas, chancellor of the UT System, said in a news release.

Vanessa Wyche, director of Johnson Space Center, added that the partnership with the UT System “will enable us to meet our nation’s exploration goals and advance the future of space exploration.”

The news release noted that UT Health Houston and the UT Medical Branch in Galveston already collaborate with NASA. The UT Medical Branch’s aerospace medicine residency program and UT Health Houston’s space medicine program train NASA astronauts.

“We’re living through a unique moment where aerospace innovation, national security, economic transformation, and scientific discovery are converging like never before in Texas," Zerwas said. “UT institutions are uniquely positioned to partner with NASA in building a stronger and safer Texas.”

Zerwas became chancellor of the UT System in 2025. He joined the system in 2019 as executive vice chancellor for health affairs. Zerwas represented northwestern Ford Bend County in the Texas House from 2007 to 2019.

In 1996, he co-founded a Houston-area medical practice that became part of US Anesthesia Partners in 2012. He remained active in the practice until joining the UT System. Zerwas was chief medical officer of the Memorial Hermann Hospital System from 2003 to 2008 and was its chief physician integration officer until 2009.

Zerwas, a 1973 graduate of the Houston area’s Bellaire High School, is an alumnus of the University of Houston and Baylor College of Medicine.

3 Houston innovators who are making headlines right now

Featured Innovators

Editor's note: Houston innovators have kicked off the new year with big developments, from an immune-boosting nanodrug to NSF research funding and more. Below, meet three local innovators who have recently been in the headlines.

Kirsten Adam, Rice University

Kirsten Adam. Courtesy photo.

Rice University psychologist Kirsten Adam has received a $600,000 National Science Foundation CAREER Award to research how visual distractions like phone notifications, flashing alerts, crowded screens and busy workspaces can negatively impact focus—and how the brain works to try to regain it. Adam’s work will aim to clarify how the brain refocuses in the age of screens, instant gratification and other lingering distractions. The funding will also be used to train graduate students in advanced cognitive neuroscience methods, expand access to electroencephalography (EEG) and for public data sharing. Read more.

Houston lab-test startup seeks $1M for nationwide expansion

Jim Gebhart, founder and CEO of TheLabCafe.com. Courtesy photo.

Driven by the desire to knock down lab-test barriers, health care industry veteran Jim Gebhart founded Houston-based TheLabCafe.com in 2024. The platform provides access to low-cost medical tests without requiring patients to carry health insurance. It currently serves patients in six states and is poised for major U.S. expansion early this year. Read more.

Wei Gao, University of Houston College of Pharmacy

Wei Gao (center). Photo courtesy UH.

Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to regulatory B cells (Bregs) which block the body's natural immunity and are found in pancreatic and lung cancers. Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight these cancers. Read more.

Texas booms as No. 3 best state to start a business right now

Innovation Starts Here

High employment growth and advantageous entrepreneurship rates have led Texas into a triumphant No. 3 spot in WalletHub's ranking of "Best and Worst States to Start a Business" for 2026.

Texas bounced back into the No. 3 spot nationally for the first time since 2023. After dropping into 8th place in 2024, the state hustled into No. 4 last year.

Ever year, WalletHub compares all 50 states based on their business environment, costs, and access to financial resources to determine the best places for starting a business. The study analyzes 25 relevant metrics to determine the rankings, such as labor costs, office space affordability, financial accessibility, the number of startups per capita, and more.

When about half of all new businesses don't last more than five years, finding the right environment for a startup is vital for long-term success, the report says.

Here's how Texas ranked across the three main categories in the study:

No. 1 – Business environment
No. 11 – Access to resources
No. 34 – Business costs

The state boasts the 10th highest entrepreneurship rates nationwide, and it has the 11th-highest share of fast-growing firms. WalletHub also noted that more than half (53 percent) of all Texas businesses are located in "strong clusters," which suggests they are more likely to be successful long-term.

"Clusters are interconnected businesses that specialize in the same field, and 'strong clusters' are ones that are in the top 25 percent of all regions for their particular specialization," the report said. "If businesses fit into one of these clusters, they will have an easier time getting the materials they need, and can tap into an existing customer base. To some degree, it might mean more competition, though."

Texas business owners should also keep their eye on Houston, which was recently ranked the 7th best U.S. city for starting a new business, and it was dubbed one of the top-10 tech hubs in North America. Workers in Texas are the "third-most engaged" in the country, the study added, a promising attribute for employers searching for the right place to begin their next business venture.

"Business owners in Texas benefit from favorable conditions, as the state has the third-highest growth in working-age population and the third-highest employment growth in the country, too," the report said.

The top 10 best states for starting a business in 2026 are:

No. 1 – Florida
No. 2 – Utah
No. 3 – Texas
No. 4 – Oklahoma
No. 5 – Idaho
No. 6 – Mississippi
No. 7 – Georgia
No. 8 – Indiana
No. 9 – Nevada
No. 10 – California

---

This article originally appeared on CultureMap.com.

View All Listings

INNOVATIONMAP EMAILS ARE AWESOME