brainy research

Texas university awards $4 million for groundbreaking Alzheimer’s research

The international prize winners include University of Texas alum and associate professor Bess Frost, Ph.D. UT Health San Antonio/Facebook

It’s a bittersweet moment, commending competitive research achievements in Alzheimer’s disease. On June 8, the University of Texas at San Antonio acknowledged some of the top contributions internationally to our collective understanding of how the degenerative disease starts. The Oskar Fischer Prize awards a total of $4 million, divided into gold, silver, and bronze categories.

“Over the past two years, UTSA has worked closely with a broad group of advisers from the scientific, business and public policy realms to evaluate a large number of visionary ideas,” said UTSA College of Sciences Dean David Silva in a press release. “This partnership demonstrates our leadership to further society’s understanding of the causes of Alzheimer’s disease.”

The gold prize ($500,000) goes to four finalists, two of which are in the United States, including one in San Antonio. Italy’s Carlo Abbate, Ph.D., theorizes that Alzheimer’s starts in neural stem cells while new neurons are formed, and Spain’s Estela Area-Gomez, Ph.D., theorizes that it’s a lipid disorder relating to the regulation of cholesterol metabolism. Ralph A. Nixon, Ph.D., M.D., represents Nathan S. Kline Institute for Psychiatric Research, and posits that an error in cleaning out waste in the brain leads to a toxic accumulation. Finally, and closest to home representing UTSA, Bess Frost, Ph.D. believes the issue is with DNA restructuring, which causes issues in cell identity and eventually cell death.

Frost’s personal statement through UTSA Health anchors her work to new research in tau, a protein and “a key pathological player in Alzheimer’s disease and other tauopathies.” Her laboratory makes discoveries in fruit flies, and compares those findings to post-mortem human specimens. Now an associate professor, she initially received her bachelor’s degree in Biochemistry and Molecular Biology at the University of Texas at Austin.

The silver prize ($400,000) goes to Germany’s Bernd Moosmann, Ph.D. and Canada’s Donald Weaver, M.D. Bronze prize recipients ($300,000) are Sweden’s Gunnar K. Gouras, M.D. and three working in America: Annelise E. Barron, Ph.D. at Stanford University, Varghese John, Ph.D. at University of California, Los Angeles, and Russell Swerdlow, M.D. at the University of Kansas Medical Center.

“Despite a century and tens of billions of dollars spent on Alzheimer’s Disease research, no definitive explanation for a cause has been found,” said Texas businessman James Truchard, whose philanthropic contribution established this prize, in the release. “The Prize’s goal is to bring forth ideas which can create a foundation for future research. While no single entry covered all the major aspects of Alzheimer’s, I believe a combination of these ideas creates a launchpad for future research.”

June is Alzheimer's & Brain Awareness Month through the Alzheimer's Association, which is organizing a worldwide fundraising day on June 21, “The Longest Day.” It estimates that Alzheimer’s or another dementia is the cause of death in one in three seniors, and more than 11 million people in America are providing care for patients with dementia.

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This article originally ran on CultureMap.

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Building Houston

 
 

HOUSTON INNOVATORS PODCAST EPISODE 179

Houston founder on creating an app for sports connections and having fun

At the end of the day, Lydia Davies created her app to inspire new connections and fun activities. Photo courtesy of TEAMATES

Lydia Davies had the idea for an app that would forge friendship and fun — right at the beginning of the world's most isolating time.

She shouted her idea — an app that would allow golfers to connect when traveling or on nice weekends when other friends might not be free — to her husband over the heads of their rambunctious children.

"I started building the app right then and there in this tornado of noise and chaos, and it kind of just became my sanity in that early COVID time because I had something to work on and build," Davies says on this week's episode of the Houston Innovators Podcast.

The idea turned into TeeMates, which launched in 2021 and focused on golf exclusively, and evolved into the TEAMATES App, the current platform that now has a growing selection of sports and activities for users to sync up with others on.

As of this week, users have new features in the app that includes rewards and incentives for users to give feedback to each other on the app. Davies has even hosted events to bring people together in the name of socialization and activity.

"There is so much tension and fear after COVID in just communicating and connecting, and people just seem to feel a bit insecure. I didn't want people to feel that way," she says. "I wanted to create a community where people could just show up and be a part of a group because they are joining in an activity together."

Ultimately, the app — and its evolving features — is all about having fun and creating real human connections, Davies says.

"Activity and fun — adults have to have fun, and not just out at bars drinking," she says. "Sports and activities are fun — competition and learning something new is fun."

Davies shares her journey of entrepreneurship — which has included a pop music career and a real estate business — on the podcast. Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


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