The international prize winners include University of Texas alum and associate professor Bess Frost, Ph.D. UT Health San Antonio/Facebook

It’s a bittersweet moment, commending competitive research achievements in Alzheimer’s disease. On June 8, the University of Texas at San Antonio acknowledged some of the top contributions internationally to our collective understanding of how the degenerative disease starts. The Oskar Fischer Prize awards a total of $4 million, divided into gold, silver, and bronze categories.

“Over the past two years, UTSA has worked closely with a broad group of advisers from the scientific, business and public policy realms to evaluate a large number of visionary ideas,” said UTSA College of Sciences Dean David Silva in a press release. “This partnership demonstrates our leadership to further society’s understanding of the causes of Alzheimer’s disease.”

The gold prize ($500,000) goes to four finalists, two of which are in the United States, including one in San Antonio. Italy’s Carlo Abbate, Ph.D., theorizes that Alzheimer’s starts in neural stem cells while new neurons are formed, and Spain’s Estela Area-Gomez, Ph.D., theorizes that it’s a lipid disorder relating to the regulation of cholesterol metabolism. Ralph A. Nixon, Ph.D., M.D., represents Nathan S. Kline Institute for Psychiatric Research, and posits that an error in cleaning out waste in the brain leads to a toxic accumulation. Finally, and closest to home representing UTSA, Bess Frost, Ph.D. believes the issue is with DNA restructuring, which causes issues in cell identity and eventually cell death.

Frost’s personal statement through UTSA Health anchors her work to new research in tau, a protein and “a key pathological player in Alzheimer’s disease and other tauopathies.” Her laboratory makes discoveries in fruit flies, and compares those findings to post-mortem human specimens. Now an associate professor, she initially received her bachelor’s degree in Biochemistry and Molecular Biology at the University of Texas at Austin.

The silver prize ($400,000) goes to Germany’s Bernd Moosmann, Ph.D. and Canada’s Donald Weaver, M.D. Bronze prize recipients ($300,000) are Sweden’s Gunnar K. Gouras, M.D. and three working in America: Annelise E. Barron, Ph.D. at Stanford University, Varghese John, Ph.D. at University of California, Los Angeles, and Russell Swerdlow, M.D. at the University of Kansas Medical Center.

“Despite a century and tens of billions of dollars spent on Alzheimer’s Disease research, no definitive explanation for a cause has been found,” said Texas businessman James Truchard, whose philanthropic contribution established this prize, in the release. “The Prize’s goal is to bring forth ideas which can create a foundation for future research. While no single entry covered all the major aspects of Alzheimer’s, I believe a combination of these ideas creates a launchpad for future research.”

June is Alzheimer's & Brain Awareness Month through the Alzheimer's Association, which is organizing a worldwide fundraising day on June 21, “The Longest Day.” It estimates that Alzheimer’s or another dementia is the cause of death in one in three seniors, and more than 11 million people in America are providing care for patients with dementia.

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This article originally ran on CultureMap.

UTHealth School of Public Health launched its Own Every Piece campaign to promote women's health access and education. Photo courtesy of Own Every Piece

This Houston organization is rethinking access to and education on women's health

women's health

If you browse through the required school curriculum in Texas, you might be surprised to find that sex ed doesn't quite make the cut. Sex education is optional in the Lone Star State and state law requires schools to stress abstinence when choosing to teach the subject, which can make understanding birth control even more confusing for both teens and adult women.

UTHealth School of Public Health launched its Own Every Piece campaign as a way to empower women with information on birth control and ensure access to contraceptive care regardless of age, race, relationship status or socioeconomic status. One click to the Own Every Piece website and you'll be greeted by the smiles of diverse women, along with videos of their birth control journey and educational information on various birth control options.

"You feel like the campaign is talking to you as a friend, not talking down to you as an authority or in any type of shaming way," says Kimberly A. Baker, assistant professor at UTHealth School of Public Health. One of her favorite areas of the website is the "Find a Clinic" page, connecting teens and adult women to nearby clinics, because "one of the biggest complaints from women is that they didn't know where to go," says Baker.

The website and social media platforms preach of body-positivity, empowerment, and knowledge. Prompts from a "true or false"-style quiz debunk myths from birth control weight gain to proper condom use on the home page. In the name of inclusivity, women can even upload their own birth control story to share with Own Every Piece's audience.

Baker and her team got their start in school districts developing programs for middle and high schoolers while also training teachers on how to discuss birth control openly. After working in over 20 school districts with the goal of preventing teen pregnancy through education, Baker identified a new problem: the significant lack of access to health care within the Houston community.

"We wanted to figure out what the major gaps were," Baker says. "What we found, of course, was how expensive birth control was — especially with some of the most effective methods."

Kimberly A. Baker is assistant professor at UTHealth School of Public Health. Photo courtesy of Own Every Piece

Let's crunch some numbers. When interpreting the price of contraceptives, the type of birth control and access to health care can impact how much women pay out-of-pocket. According to Baker, the standard pill can cost anywhere from $10 to $30 a month while implanting long-acting reversible contraceptives like the IUD can cost upwards of $600 to $700. These calculations don't factor in the cost of a doctor's appointment, the removal of a device like the IUD, or even the average $4,500 it costs to give birth if you choose to have a child in the U.S.

After noticing gaps in who could pay for service, Baker and her team realized that some community centers didn't have the funds to have long-acting contraceptive on hand.

"We knew if we partnered with health clinics and health centers to help train them to better serve folks that they weren't serving well, and to give them more funds to buy methods that women couldn't probably afford...we would be filling that gap," she says.

Creating comfort and trust among women looking for contraceptives was another key intention in the campaign's launch.

"When [women] enter a community health clinic, they should feel confident to ask questions and to know that they're receiving all the accurate information they should be getting so they can make the best decision for them," says Baker.

Baker likes to think of the Own Every Piece project as a "more celebratory campaign around birth control that we hadn't seen before," she says. "There are so many stereotypes around sexuality and reproduction that are very shame-based," says Baker, particularly for "Latinx and Black women."

She acknowledges how epithetical birth control messaging that suggests women shouldn't "have more kids" or implies "pregnancy is a bad thing" frames reproductive health in a negative way. "We wanted a campaign that let women know that they own their body. They make decisions about their body, and birth control is a piece of that," she says.

The purpose of providing access took on a new meaning when the coronavirus hit. Since Own Every Piece began as a digital campaign targeted to Houston women ages 18 to 30, the initiative had a head start in the race to move online.

"We saw an opportunity to figure out how we can tell our community health centers to get into the telecontraception space because we've already established trust virtually through our campaign," explains Baker.

Prior to the COVID-19 pandemic, Texas held the title of the state with the most uninsured residents in the U.S. In a state with 2.9 million unemployment claims since March, access to affordable birth control has never been more essential for women.

"From women who lost their insurance due to losing their job because of COVID-19, this has been a godsend," says Baker.

Telemedicine has also added convenience for women who didn't have the time to check out a clinic in-person before the pandemic.

While COVID-19's strains on American health care continue to dominate headlines, birth control has also managed to make national news. On July 8, the Supreme Court ruled that employers can opt-out of birth control coverage—a decision that could result in an estimated 126,000 women losing contraceptive coverage from their employers, according to the New York Times.

The 7-to-2 Supreme Court decision is the latest in a seven-year-long litigation over religious objections to birth control. Outside of pregnancy prevention, birth control helps women cope with premenstrual dysmorphic disorder, polycystic ovarian syndrome, endometriosis, acne, and a number of other issues.

"We have to work harder to have inclusive messaging around [birth control usage], because birth control isn't just about pregnancy prevention," explains Baker. "People use birth control for a number of needs. When you message it just around pregnancy prevention, people start to feel like something is wrong with being pregnant, and that's not what we set out to do."

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New Houston venture studio emerges to target early-stage hardtech, energy transition startups

funding the future

The way Doug Lee looks at it, there are two areas within the energy transition attracting capital. With his new venture studio, he hopes to target an often overlooked area that's critical for driving forward net-zero goals.

Lee describes investment activity taking place in the digital and software world — early stage technology that's looking to make the industry smarter. But, on the other end of the spectrum, investment activity can be found on massive infrastructure projects.

While both areas need funding, Lee has started his new venture studio, Flathead Forge, to target early-stage hardtech technologies.

“We are really getting at the early stage companies that are trying to develop technologies at the intersection of legacy industries that we believe can become more sustainable and the energy transition — where we are going. It’s not an ‘if’ or ‘or’ — we believe these things intersect,” he tells EnergyCapital.

Specifically, Lee's expertise is within the water and industrial gas space. For around 15 years, he's made investments in this area, which he describes as crucial to the energy transition.

“Almost every energy transition technology that you can point to has some critical dependency on water or gas,” he says. “We believe that if we don’t solve for those things, the other projects won’t survive.”

Lee, and his brother, Dave, are evolving their family office to adopt a venture studio model. They also sold off Azoto Energy, a Canadian oilfield nitrogen cryogenic services business, in December.

“We ourselves are going through a transition like our energy is going through a transition,” he says. “We are transitioning into a single family office into a venture studio. By doing so, we want to focus all of our access and resources into this focus.”

At this point, Flathead Forge has seven portfolio companies and around 15 corporations they are working with to identify their needs and potential opportunities. Lee says he's gearing up to secure a $100 million fund.

Flathead also has 40 advisers and mentors, which Lee calls sherpas — a nod to the Flathead Valley region in Montana, which inspired the firm's name.

“We’re going to help you carry up, we’re going to tie ourselves to the same rope as you, and if you fall off the mountain, we’re falling off with you,” Lee says of his hands-on approach, which he says sets Flathead apart from other studios.

Another thing that's differentiating Flathead Forge from its competition — it's dedication to giving back.

“We’ve set aside a quarter of our carried interest for scholarships and grants,” Lee says.

The funds will go to scholarships for future engineers interested in the energy transition, as well as grants for researchers studying high-potential technologies.

“We’re putting our own money where our mouth is,” Lee says of his thesis for Flathead Forge.

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This article originally ran on EnergyCapital.

Houston-based lunar mission's rocky landing and what it means for America's return to the moon

houston, we have a problem

A private U.S. lunar lander tipped over at touchdown and ended up on its side near the moon’s south pole, hampering communications, company officials said Friday.

Intuitive Machines initially believed its six-footed lander, Odysseus, was upright after Thursday's touchdown. But CEO Steve Altemus said Friday the craft “caught a foot in the surface," falling onto its side and, quite possibly, leaning against a rock. He said it was coming in too fast and may have snapped a leg.

“So far, we have quite a bit of operational capability even though we’re tipped over," he told reporters.

But some antennas were pointed toward the surface, limiting flight controllers' ability to get data down, Altemus said. The antennas were stationed high on the 14-foot (4.3-meter) lander to facilitate communications at the hilly, cratered and shadowed south polar region.

Odysseus — the first U.S. lander in more than 50 years — is thought to be within a few miles (kilometers) of its intended landing site near the Malapert A crater, less than 200 miles (300 kilometers) from the south pole. NASA, the main customer, wanted to get as close as possible to the pole to scout out the area before astronauts show up later this decade.

NASA's Lunar Reconnaissance Orbiter will attempt to pinpoint the lander's location, as it flies overhead this weekend.

With Thursday’s touchdown, Intuitive Machines became the first private business to pull off a moon landing, a feat previously achieved by only five countries. Japan was the latest country to score a landing, but its lander also ended up on its side last month.

Odysseus' mission was sponsored in large part by NASA, whose experiments were on board. NASA paid $118 million for the delivery under a program meant to jump-start the lunar economy.

One of the NASA experiments was pressed into service when the lander's navigation system did not kick in. Intuitive Machines caught the problem in advance when it tried to use its lasers to improve the lander's orbit. Otherwise, flight controllers would not have discovered the failure until it was too late, just five minutes before touchdown.

“Serendipity is absolutely the right word,” mission director Tim Crain said.

It turns out that a switch was not flipped before flight, preventing the system's activation in space.

Launched last week from Florida, Odysseus took an extra lap around the moon Thursday to allow time for the last-minute switch to NASA's laser system, which saved the day, officials noted.

Another experiment, a cube with four cameras, was supposed to pop off 30 seconds before touchdown to capture pictures of Odysseus’ landing. But Embry-Riddle Aeronautical University’s EagleCam was deliberately powered off during the final descent because of the navigation switch and stayed attached to the lander.

Embry-Riddle's Troy Henderson said his team will try to release EagleCam in the coming days, so it can photograph the lander from roughly 26 feet (8 meters) away.

"Getting that final picture of the lander on the surface is still an incredibly important task for us,” Henderson told The Associated Press.

Intuitive Machines anticipates just another week of operations on the moon for the solar-powered lander — nine or 10 days at most — before lunar nightfall hits.

The company was the second business to aim for the moon under NASA's commercial lunar services program. Last month, Pittsburgh's Astrobotic Technology gave it a shot, but a fuel leak on the lander cut the mission short and the craft ended up crashing back to Earth.

Until Thursday, the U.S. had not landed on the moon since Apollo 17's Gene Cernan and Harrison Schmitt closed out NASA's famed moon-landing program in December 1972. NASA's new effort to return astronauts to the moon is named Artemis after Apollo's mythological twin sister. The first Artemis crew landing is planned for 2026 at the earliest.

3 female Houston innovators to know this week

who's who

Editor's note: Welcome to another Monday edition of Innovators to Know. Today I'm introducing you to three Houstonians to read up about — three individuals behind recent innovation and startup news stories in Houston as reported by InnovationMap. Learn more about them and their recent news below by clicking on each article.

Emma Konet, co-founder and CTO of Tierra Climate

Emma Konet, co-founder and CTO of Tierra Climate, joins the Houston Innovators Podcast. Photo via LinkedIn

If the energy transition is going to be successful, the energy storage space needs to be equipped to support both the increased volume of energy needed and new energies. And Emma Konet and her software company, Tierra Climate, are targeting one part of the equation: the market.

"To me, it's very clear that we need to build a lot of energy storage in order to transition the grid," Konet says on the Houston Innovators Podcast. "The problems that I saw were really on the market side of things." Read more.

Cindy Taff, CEO of Sage Geosystems

Houston-based Sage Geosystems announced the first close of $17 million round led by Chesapeake Energy Corp. Photo courtesy of Sage

A Houston geothermal startup has announced the close of its series A round of funding.

Houston-based Sage Geosystems announced the first close of $17 million round led by Chesapeake Energy Corp. The proceeds aim to fund its first commercial geopressured geothermal system facility, which will be built in Texas in Q4 of 2024. According to the company, the facility will be the first of its kind.

“The first close of our Series A funding and our commercial facility are significant milestones in our mission to make geopressured geothermal system technologies a reality,” Cindy Taff, CEO of Sage Geosystems, says. Read more.

Clemmie Martin, chief of staff at The Cannon

With seven locations across the Houston area, The Cannon's digital technology allows its members a streamlined connection. Photo courtesy of The Cannon

After collaborating over the years, The Cannon has acquired a Houston startup's digital platform technology to become a "physical-digital hybrid" community.

Village Insights, a Houston startup, worked with The Cannon to create and launch its digital community platform Cannon Connect. Now, The Cannon has officially acquired the business. The terms of the deal were not disclosed.

“The integration of a world-class onsite member experience and Cannon Connect’s superior virtual resource network creates a seamless, streamlined environment for member organizations,” Clemmie Martin, The Cannon’s newly appointed chief of staff, says in the release. “Cannon Connect and this acquisition have paved new pathways to access and success for all.” Read more.