Featured Innovator

This entrepreneur is changing the landscape of Houston's innovation ecosystem

Grace Rodriguez is the co-founder and executive director of Impact Hub Houston. Courtesy of Grace Rodriguez

It's been a winding road for Grace Rodriguez to get to where she is today, but she wouldn't have it any other way. Rodriguez's career has spanned from managing a collective of DJs called Kracker Nuttz and consulting to one of the co-founders of Station Houston — and now the co-founder and executive director of Impact Hub Houston.

Impact Hub is a worldwide collaborative of resources for entrepreneurs, thought provokers, and supporters, and Rodriguez has been working for a while now to get Houston's chapter off the ground. As of April 17, Impact Hub Houston has launched its first popup location at Sharespace (1120 Naylor) where the organization will be until May 17. The popup concept is so that the nonprofit can really get to know all corners of Houston's innovation ecosystem, Rodriguez says.

Additionally, Impact Hub Houston announced last month that it has launched its fundraising campaign called 321 Impact. The money donated will go to the programming, events, and development of the organization.

Rodriguez spoke with InnovationMap about her goals for the organization and her thoughts on the ecosystem as a whole.

InnovationMap: When you say you want to help "do gooders do greater," what does that mean for you?

Grace Rodriguez: For me, I want to help people at the idea stage — people who are beginning to build something. Talking to entrepreneurs, they say that's usually the hardest part. Once you get something going and you have some traction, it's easy to keep improving that. But, getting started is where people need the most help. With Impact Hub, we want to figure out how do we intentionally approach the problem of helping an entrepreneur go from 0 to 1, and 1 to 2, and then 2 to 10, and so on. And respond to their actual problems — versus what we think they need. There's a lot of personalization that needs to happen for early-stage entrepreneurs, and I'm hoping that this is the role in the Houston ecosystem that Impact Hub Houston can provide.

IM: What's Impact Hub's bigger picture goals?

GR: Our real vision is to help Houston become a role model for how the world solves the most pressing issues. We want to show the rest of the world that Houston has the talent, expertise, insight, and resources to solve issues around the world. Within that is the idea that Houston is an international city. A lot of times when people get together and talk about improving the perception of Houston, but honestly outside of the United States, Houston is seen as a major player on the world stage.

Another part of our mission is to move beyond discussing diversity toward actually creating equitable environments where people plug in and actively advocate for each other. A lot of people talk about how Houston is the most diverse city in the country and how it's a strength of Houston, but when you go to meetings with decision makers from the innovation ecosystem, you don't see that diversity represented. We want to make sure we are intentional about creating equitable environments and that diversity is included in the shaping of policy and institutions moving forward.

IM: How do the hubs work together?

GR: The interesting thing about Impact Hub is it isn't a franchise or like WeWork. It functions a lot like the United Nations. Each organization opts into the network, and you can form it anyway you want to — nonprofit or for-profit or a hybrid — and as large or as small you want to be. We are all connected by the common guideline of working alongside the United Nations to help advance the 17 sustainable development goals.

IM: What pain points do you see Houston entrepreneurs struggling with and how can the city address them?

GR: Over and over again, access to funding is a big issue — and access to someone who has the answers they need is another issue too. I feel like a lot of the conversation within the Houston innovation echo chamber has been around venture capital funding, but there's so many more types of capital that entrepreneurs can have access to. There's bootstrapping, angel investment, lending groups, and crowdfunding.

I've met a lot of Houston entrepreneurs who had to go to Austin for MassChallenge or Capital Factory and who didn't find that support or money here in Houston. And because they found it in Austin, they're considering moving there. This is how we lose our best and brightest. It's been happening and it keeps happening because we haven't focused on our city. Instead of being Austin, we need to figure out how to be Houston better. Until we start some really rough self reflection, then I don't think we'll ever be a better Houston. We'll continue trying to be "Silicon Bayou" versus being whatever Houston needs to be.

IM: I know with Impact Hub, you're trying to be transparent. But overall, do you feel like Houston's innovation ecosystem has a hard time being transparent?

GR: The challenge in Houston is trying to be shiny and polished. And, to me, shiny and polished is Dallas. No one in Houston wants to be Dallas. Let's accept the fact that we are an R&D city. We are a city that researches and develops and experiments new things. Let's lean hard into that and not say we're going to be perfect, and if we do that, then the need to try to appear perfect can go away. Being transparent on the things we are trying makes us become a role model for other cities. I feel like the feeling that we have to be polished and perfect for the rest of the world to be interested in us is the biggest hindrance to our progress. I already know the rest of the world is interested in us.

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Portions of this interview have been edited.

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A research team housed out of the newly launched Rice Biotech Launch Pad received funding to scale tech that could slash cancer deaths in half. Photo via Rice University

A research funding agency has deployed capital into a team at Rice University that's working to develop a technology that could cut cancer-related deaths in half.

Rice researchers received $45 million from the National Institutes of Health's Advanced Research Projects Agency for Health, or ARPA-H, to scale up development of a sense-and-respond implant technology. Rice bioengineer Omid Veiseh leads the team developing the technology as principal investigator.

“Instead of tethering patients to hospital beds, IV bags and external monitors, we’ll use a minimally invasive procedure to implant a small device that continuously monitors their cancer and adjusts their immunotherapy dose in real time,” he says in a news release. “This kind of ‘closed-loop therapy’ has been used for managing diabetes, where you have a glucose monitor that continuously talks to an insulin pump. But for cancer immunotherapy, it’s revolutionary.”

Joining Veiseh on the 19-person research project named THOR, which stands for “targeted hybrid oncotherapeutic regulation,” is Amir Jazaeri, co-PI and professor of gynecologic oncology at the University of Texas MD Anderson Cancer Center. The device they are developing is called HAMMR, or hybrid advanced molecular manufacturing regulator.

“Cancer cells are continually evolving and adapting to therapy. However, currently available diagnostic tools, including radiologic tests, blood assays and biopsies, provide very infrequent and limited snapshots of this dynamic process," Jazaeri adds. "As a result, today’s therapies treat cancer as if it were a static disease. We believe THOR could transform the status quo by providing real-time data from the tumor environment that can in turn guide more effective and tumor-informed novel therapies.”

With a national team of engineers, physicians, and experts across synthetic biology, materials science, immunology, oncology, and more, the team will receive its funding through the Rice Biotech Launch Pad, a newly launched initiative led by Veiseh that exists to help life-saving medical innovation scale quickly.

"Rice is proud to be the recipient of the second major funding award from the ARPA-H, a new funding agency established last year to support research that catalyzes health breakthroughs," Rice President Reginald DesRoches says. "The research Rice bioengineer Omid Veiseh is doing in leading this team is truly groundbreaking and could potentially save hundreds of thousands of lives each year. This is the type of research that makes a significant impact on the world.”

The initial focus of the technology will be on ovarian cancer, and this funding agreement includes a first-phase clinical trial of HAMMR for the treatment of recurrent ovarian cancer that's expected to take place in the fourth year of THOR’s multi-year project.

“The technology is broadly applicable for peritoneal cancers that affect the pancreas, liver, lungs and other organs,” Veiseh says. “The first clinical trial will focus on refractory recurrent ovarian cancer, and the benefit of that is that we have an ongoing trial for ovarian cancer with our encapsulated cytokine ‘drug factory’ technology. We'll be able to build on that experience. We have already demonstrated a unique model to go from concept to clinical trial within five years, and HAMMR is the next iteration of that approach.”

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