Featured Innovator

This entrepreneur is changing the landscape of Houston's innovation ecosystem

Grace Rodriguez is the co-founder and executive director of Impact Hub Houston. Courtesy of Grace Rodriguez

It's been a winding road for Grace Rodriguez to get to where she is today, but she wouldn't have it any other way. Rodriguez's career has spanned from managing a collective of DJs called Kracker Nuttz and consulting to one of the co-founders of Station Houston — and now the co-founder and executive director of Impact Hub Houston.

Impact Hub is a worldwide collaborative of resources for entrepreneurs, thought provokers, and supporters, and Rodriguez has been working for a while now to get Houston's chapter off the ground. As of April 17, Impact Hub Houston has launched its first popup location at Sharespace (1120 Naylor) where the organization will be until May 17. The popup concept is so that the nonprofit can really get to know all corners of Houston's innovation ecosystem, Rodriguez says.

Additionally, Impact Hub Houston announced last month that it has launched its fundraising campaign called 321 Impact. The money donated will go to the programming, events, and development of the organization.

Rodriguez spoke with InnovationMap about her goals for the organization and her thoughts on the ecosystem as a whole.

InnovationMap: When you say you want to help "do gooders do greater," what does that mean for you?

Grace Rodriguez: For me, I want to help people at the idea stage — people who are beginning to build something. Talking to entrepreneurs, they say that's usually the hardest part. Once you get something going and you have some traction, it's easy to keep improving that. But, getting started is where people need the most help. With Impact Hub, we want to figure out how do we intentionally approach the problem of helping an entrepreneur go from 0 to 1, and 1 to 2, and then 2 to 10, and so on. And respond to their actual problems — versus what we think they need. There's a lot of personalization that needs to happen for early-stage entrepreneurs, and I'm hoping that this is the role in the Houston ecosystem that Impact Hub Houston can provide.

IM: What's Impact Hub's bigger picture goals?

GR: Our real vision is to help Houston become a role model for how the world solves the most pressing issues. We want to show the rest of the world that Houston has the talent, expertise, insight, and resources to solve issues around the world. Within that is the idea that Houston is an international city. A lot of times when people get together and talk about improving the perception of Houston, but honestly outside of the United States, Houston is seen as a major player on the world stage.

Another part of our mission is to move beyond discussing diversity toward actually creating equitable environments where people plug in and actively advocate for each other. A lot of people talk about how Houston is the most diverse city in the country and how it's a strength of Houston, but when you go to meetings with decision makers from the innovation ecosystem, you don't see that diversity represented. We want to make sure we are intentional about creating equitable environments and that diversity is included in the shaping of policy and institutions moving forward.

IM: How do the hubs work together?

GR: The interesting thing about Impact Hub is it isn't a franchise or like WeWork. It functions a lot like the United Nations. Each organization opts into the network, and you can form it anyway you want to — nonprofit or for-profit or a hybrid — and as large or as small you want to be. We are all connected by the common guideline of working alongside the United Nations to help advance the 17 sustainable development goals.

IM: What pain points do you see Houston entrepreneurs struggling with and how can the city address them?

GR: Over and over again, access to funding is a big issue — and access to someone who has the answers they need is another issue too. I feel like a lot of the conversation within the Houston innovation echo chamber has been around venture capital funding, but there's so many more types of capital that entrepreneurs can have access to. There's bootstrapping, angel investment, lending groups, and crowdfunding.

I've met a lot of Houston entrepreneurs who had to go to Austin for MassChallenge or Capital Factory and who didn't find that support or money here in Houston. And because they found it in Austin, they're considering moving there. This is how we lose our best and brightest. It's been happening and it keeps happening because we haven't focused on our city. Instead of being Austin, we need to figure out how to be Houston better. Until we start some really rough self reflection, then I don't think we'll ever be a better Houston. We'll continue trying to be "Silicon Bayou" versus being whatever Houston needs to be.

IM: I know with Impact Hub, you're trying to be transparent. But overall, do you feel like Houston's innovation ecosystem has a hard time being transparent?

GR: The challenge in Houston is trying to be shiny and polished. And, to me, shiny and polished is Dallas. No one in Houston wants to be Dallas. Let's accept the fact that we are an R&D city. We are a city that researches and develops and experiments new things. Let's lean hard into that and not say we're going to be perfect, and if we do that, then the need to try to appear perfect can go away. Being transparent on the things we are trying makes us become a role model for other cities. I feel like the feeling that we have to be polished and perfect for the rest of the world to be interested in us is the biggest hindrance to our progress. I already know the rest of the world is interested in us.

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Portions of this interview have been edited.

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Building Houston

 
 

Tvardi Therapeutics Inc. has fresh funds to support its drug's advancement in clinical trials. Photo via Getty Images

A Houston-based clinical-stage biopharmaceutical company has raised millions in its latest round.

Tvardi Therapeutics Inc. closed its $74 million series B funding round led by new investors New York-based Slate Path Capital, Florida-based Palkon Capital, Denver-based ArrowMark Partners, and New York-based 683 Capital, with continued support and participation by existing investors, including Houston-based Sporos Bioventures.

"We are thrilled to move out of stealth mode and partner with this lineup of long-term institutional investors," says Imran Alibhai, CEO at Tvardi. "With this financing we are positioned to advance the clinical development of our small molecule inhibitors of STAT3 into mid-stage trials as well as grow our team."

Through Slate Path Capital's investment, Jamie McNab, partner at the firm, will join Tvardi's board of directors.

"Tvardi is the leader in the field of STAT3 biology and has compelling proof of concept clinical data," McNab says in the release. "I look forward to partnering with the management team to advance Tvardi's mission to develop a new class of breakthrough medicines for cancer, chronic inflammation, and fibrosis."

Tvardi's latest fundraise will go toward supporting the company's products in their mid-stage trials for cancer and fibrosis. According to the release, Tvardi's lead product, TTI-101, is being studied in a Phase 1 trial of patients with advanced solid tumors who have failed all lines of therapy. So far, the drug has been well-received and shown multiple durable radiographic objective responses in the cancer patients treated.

Dr. Keith Flaherty, who is a member of Tvardi's scientific advisory board and professor of medicine at Harvard Medical School, offered his support of the company.

"STAT3 is a compelling and validated target. Beyond its clinical activity, Tvardi's lead molecule, TTI-101, has demonstrated direct downregulation of STAT3 in patients," he says in the release. "As a physician, I am eager to see the potential of Tvardi's molecules in diseases of high unmet medical need where STAT3 is a key driver."

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