Three Houston companies are going into the semifinals of Cleantech.org's competition. Photo via Getty Images

Three Houston energy startups are in the running for the $100,000 cash prize in Cleantech.org's GS Beyond Energy Innovation Challenge.

Amperon Holdings, Cemvita Factory, and Veloce Energy are among the competition's 24 semifinalists, which were announced June 17. Five semifinalists will be chosen to pitch their concepts during a virtual event July 21, and then the winner of the $100,000 prize will be named.

"This is not like the cleantech sector was 10 years ago. Getting down to 24 [semifinalists] was hard. Getting down to five finalists will be extremely challenging," Neal Dikeman, chairman and founder of Cleantech.org and a partner at one of the prize sponsors, Houston-based Energy Transition Ventures, says in a news release.

Amperon, with an office in Houston and headquarters in New York City, is a semifinalist in the "digitization of energy" category. The company, founded in 2017, builds real-time electricity demand tools for utilities, energy retailers, grid operators, and institutional traders. So far, Amperon has raised $4.3 million in funding, according to Crunchbase.

Houston-based Cemvita, founded in 2017 by siblings Tara and Moji Karimi, is a semifinalist in the "new fuels" category. Its biotechnology transforms carbon dioxide emissions into sustainable chemicals and polymers. In a recent interview for the Houston Innovators Podcast, Moji Karimi explained how unprecedented his work is — and how ready for collaboration his team is.

"There weren't biotech companies working with oil and gas companies for this use case that we have now," Karimi says. "We're defining this new category for application of synthetic biology in heavy industries for decarbonization."

Veloce, with an office in Houston and headquarters in Los Angeles, is a semifinalist in the "e-mobility in cities" category. The company, founded in 2020, aims to make installation of electric vehicle charging stations cheaper and faster. Veloce is an inaugural member of Greentown Houston, an incubator for climate technology startups.

Greentown Labs has announced its inaugural batch of members for its new Houston location. Photo via greentownlabs.com

New-to-Houston cleantech incubator names inaugural members

to the lab

A Somerville, Massachusetts-based cleantech accelerator has announced the 16 startups that will be a part of its new Houston incubator program.

Greentown Labs named the companies in the cohort this week just a few weeks after announcing the location of its new lab and workspace. The 40,000-square-foot space is being renovated from a former grocery store and is expected to open next spring.

"These early-access members are innovating across the key greenhouse gas-emitting sectors—including electricity, manufacturing, buildings, and more—and their solutions are helping create a sustainable future for all," reads a blog post on the company's website.

Here are Greentown Houston's inaugural members:

  • Austin-based Applied Bioplastics is creating affordable plastic alternatives with plant matter to help reduce consumers' carbon footprint.
  • Black Mountain Metals, based in Fort Worth, is focused on nickel and copper mining for lithium-ion battery cathodes.
  • Carbon Free Technologies created a home battery system that can store electricity when rates are low.
  • ClearValue uses pure hydrogen and oxygen as a sustainable power system.
  • e^2: equitable energy is described as a "multi-brand cause-marketing platform" that connects consumers to sustainable energy solutions through promotion and incentivization.
  • Eclipse Solar Projects builds, owns, and operates solar projects across the country through new technology and battery storage operations.
  • Houston-based Ennuity Holdings allows users to have access to solar energy subscription service — even though they don't have access to installing panels themselves.
  • Excipicio Energy , based in Houston, is taking renewable energy offshore by integrating wind, wave, and more into a single floating platform.
  • Houston-based Quantum New Energy platform, EnerWisely, helps people and companies make smart energy choices "to maximize their monetary savings and reduce their environmental impacts."
  • Spring, Texas-based Renu Energy is creating sustainable change through waste recycling and community engagement, according to its website.
  • REVOLUTION Turbine Technologies, based in North Carolina, is working on a power generator that can be used in the offshore setting.
  • Houston-based Revterra is developing a long-duration energy storage solution.
  • Skylark, based in Houston, created a "broadband last-mile radio systems for internet service providers, with a focus on 40 million unserved Americans in rural markets."
  • Austin-based swytchX is working on a cloud-based SaaS solution that uses blockchain technology to optimize renewable energy delivery.
  • Houston-based Varea Energy, a software company, uses data to build business models focusing on eliminating barriers to green initiatives.
  • California-based Veloce Energy develops faster electric vehicle charging infrastructure.
Companies interested in joining the incubator should reach out to Greentown Labs online.

The 16 startups will move into the Greentown space when it opens in the spring. Image via greentownlabs.com

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.