Portal Innovations announced that Monique Knighten as an executive director in Houston. Photo via LinkedIn

After announcing its expansion into Houston last summer and opening its office in a new Texas Medical Center building, Portal Innovations has named its Houston leader.

Portal Innovations announced that Monique Knighten as an executive director in Houston in a LinkedIn post this week. She has over 15 years of experience in supporting research scientists and clinicians working to develop therapeutics in labs and clinics. According to her LinkedIn, she's served in the position since November.

Prior to her new role at Portal, Knighten worked as a manager level at Sartorius Stedim in Houston for five years. Before that role, she served as a technical sales consultant in Texas at Miltenyi Biotec, primarily in the immuno-oncology therapeutic market in the TMC.

Portal first announced its expansion into Houston in June of last year.

“Houston is one of the fastest-growing cities in the U.S., and home to one of the world’s leading cancer research institutions, The University of Texas MD Anderson Cancer Center,” Portal’s Founder and CEO John Flavin said at the time. “It’s critical for us to open in Texas and leverage nearby pipelines from Rice University, UTHealth Houston, Texas A&M, University of Houston, Baylor College of Medicine, and others across Houston’s innovative life sciences ecosystem. We’re thrilled to work with TMC to help grow tomorrow’s biotech and medtech leaders.”

Portal's local office is in the Helix Park complex's Collaborative Building, which opened in October. Helix Park is a 37-acre mixed-use campus currently under construction. The institutional agnostic, 250,000-square-foot building will anchor Helix Park and house research initiatives from the four founding partners: Texas Medical Center, The University of Texas MD Anderson Cancer Center, Texas A&M University Health Science Center, and The University of Texas Health Science Center at Houston.

Mayor Sylvester Turner, TMC CEO Bill McKeon, Governor Greg Abbott, and others gave their remarks at the TMC3 Collaborative Building opening. Photo by Natalie Harms

Texas Medical Center opens first building in massive Helix Park project

tmc3

For nearly a decade, the Texas Medical Center and its partners have been working on the plans for Helix Park, a 37-acre campus expansion of TMC. As of this week, the first building has opened its doors to the public.

The TMC3 Collaborative Building officially opened today to a crowd of media, public officials, and health care executives. The institutional agnostic, 250,000-square-foot building will anchor Helix Park and house research initiatives from the four founding partners: Texas Medical Center, The University of Texas MD Anderson Cancer Center, Texas A&M University Health Science Center, and The University of Texas Health Science Center at Houston.

“Today, we lay the cornerstone of a new campus fully dedicated to streamlining the commercialization of life-changing innovations in medicine and technologies,” William McKeon, president and CEO of TMC, says at the event. “We are incredibly excited to both welcome our founding institutions and industry partners to the Collaborative Building and to invite the community to experience the Helix Park campus and its beautiful parks with a series of special events in the months ahead."

Established to be a place for academic institution collaboration, the building — designed by Boston-based Elkus Manfredi Architects — will have wet laboratories, office space, and event facilities. Two venture groups — Portal Innovations and the TMC Venture Fund — will also move into the building.

Each institution will bring in select programs and initiatives. MD Anderson will house two institutions within the new building, including the James P. Allison Institute focused on immunotherapy and the Institute for Data Science in Oncology.

"The future of life sciences in Houston is brighter than ever before as we come together to officially open the TMC3 Collaborative Building,” Dr. Peter WT Pisters, president of MD Anderson, says. “Our clinicians and scientists work daily to advance innovations in cancer research and care – all of which will be amplified in this new environment within Helix Park that further cultivates collaboration, connectivity, and creativity.”

UTHealth will move its Texas Therapeutics Institute into the facility.

“With a shared commitment to improving the health and well-being of individuals and communities, we are bringing together academics and industry to accelerate discovery and medical breakthroughs,” Dr. Giuseppe N. Colasurdo, president and Alkek-Williams Distinguished Chair at UTHealth Houston, says. “Through the Texas Therapeutics Institute — already a signature collaborative enterprise at UTHealth Houston — our world-renowned leaders in therapeutic antibody development will have the opportunity to work closely with other leading researchers in the Texas Medical Center, greatly enhancing our collective ability to translate discoveries and ideas into effective treatments.”

Texas A&M, which has worked with Houston Methodist to develop its engineering medical program, will operate its Texas A&M Health’s Institute of Biosciences and Technology in the new space.

“As we open this state-of-the-art facility, we’re opening the door to a new era of collaboration. This building signifies the dismantling of silos to deliver game-changing therapies for the toughest diseases impacting Texans and citizens worldwide,” said John Sharp, Chancellor of The Texas A&M University System. “Texas A&M Health’s Institute of Biosciences and Technology has long been a trailblazer in drug discovery, and now, in the heart of this resource-rich ecosystem of the Texas Medical Center, we’re taking it up a notch. By positioning our scientists near their peers and esteemed clinicians, we’re igniting a spark that will fuel innovation and forge dynamic research programs.”

The next aspect of Helix Park to deliver will be the Dynamic One, a 700,000-square-foot industry research facility. Several other buildings, including a hotel, residential tower, and mixed-use building, are expected to deliver over the next few years. The "spine" of the project is six linked green spaces, designed by landscape architect Mikyoung Kim, that form an 18.7-acre campus, which is shaped like a DNA helix, hence the project's name.

At the opening event, leaders discussed the annual impact of over $5.4 billion expected after the campus is completed, and the 23,000 permanent new jobs and 19,000 construction jobs anticipated from Helix Park.

"Texas truly is the home of innovation. Our energy innovations are legendary, as are our innovations in space," says Texas Governor Greg Abbott, naming several of the state's innovative accomplishments. "Long before all of this innovation we're seeing now, Texas was the home of the Texas Medical Center."

Mayor Sylvester Turner spoke to the importance of collaboration.

"Individually, you can do things very well. Collectively, you can be transformational," he says. "One thing about this city, collaboration is the key. When we play well together, and when we build an integrated, robust ecosystem, everyone wins. That's Houston, and that's the way we operate."

The Dynamic One building in TMC Helix Park is expected to deliver later this year. Rendering via TMC.edu

Rising TMC development names Houston health care institution as anchor tenant

coming soon

TMC Helix Park, formerly known as TMC3, has announced its first anchor tenant.

The Texas Medical Center and Beacon Capital Partners announced that Baylor College of Medicine will be the anchor tenant of the Dynamic One building at TMC Helix Park. The facility is will be the first to deliver of the four TMC Helix Park industry buildings. The Topped off in December, the Dynamic One building is being developed by Beacon in collaboration with Zoë Life Science and is scheduled to open before the end of the year.

“Beacon is excited that Dynamic One will be our first entry into the fast-growing Houston Life Science market,” says Fred Seigel, president and CEO of Beacon, in a news release. “This state-of-the-art environment is designed to enable and encourage collaboration and will greatly accelerate the innovative lifesaving discoveries that emerge when industry and academic research work side-by-side.”

Baylor College of Medicine will lease 114,000 square-feet of lab and office space in the 355,000-square-foot building. BCM's goal is to house lab space for novel diagnostics and therapeutics — and provide space to house startups.

The organization is expanding its presence in Houston after decades of residing in the region.

“Baylor College of Medicine moved to Houston in 1943 and was the first institution built in the Texas Medical Center," says Dr. Paul Klotman, president and CEO and executive dean of Baylor, in the release. "Our researchers and scientists will have the opportunity to access the uniquely concentrated research environment being developed at TMC Helix Park, facilitating the continuing advancement of innovation and compassionate care."

TMC Helix Park, which includes more than 5 million-square-feet of space across 37-acres, also expects to deliver its research facility, the TMC3 Collaborative Building, later this year.

“Baylor College of Medicine is a major force in life sciences discovery and commercialization at TMC," says Bill McKeon, president and CEO of TMC, in the release. "Their move to TMC Helix Park will serve as a catalyst for enhanced collaboration with TMC’s other esteemed Institutions, as well as with industry leaders from around the world."

BCM is the first anchor tenant announced for TMC Helix Park. Rendering via TMC.edu

A TMC construction update, a Q&A with UH's med school donor, and other top health tech stories of 2022. Image courtesy of Elkus Manfredi Architects

Here are Houston's top health tech innovation stories of the year

2022 in review

Editor's note: As 2022 comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. In Houston, home to the world's largest medical center, health tech and innovation news is abound — from startups being named among the most promising by investors to new details on the Texas Medical Center's expansion. Here are five Houston health tech-focused articles that stood out to readers this year — be sure to click through to read the full story.


Houston organizations announce 10 most promising life science startups

Houston's medical innovation community congregated to discuss breakthrough innovations in health care. Photo via Getty Images

What startups are creating the future of health care? A Houston conference this week gathered to discuss.

The 10th annual Texas Life Science Forum hosted by BioHouston and the Rice Alliance for Technology and Entrepreneurship engaged thought leadership within the life science community with panels, discussions, and more. Additionally, 49 companies pitched their solutions across medical device, therapeutics, pharmaceuticals, and more to the crowd.

The event also named the 10 most promising life science companies selected by investors and presented by the Greater Houston Partnership. Read more.

Houston hospital system to open new innovative location

Houston Methodist broke ground on a 400-bed hospital in Cypress. Rendering courtesy of Houston Methodist

Houston Methodist will soon break ground on a “smart” hospital in Cypress that is poised to be the smartest of its nine hospitals.

The $650 million Cypress hospital will be modeled after Houston Methodist West and Houston Methodist The Woodlands hospitals. However, the Cypress location is on track to outdo them in terms of smart technology.

“Our commitment to innovation is one more way we set ourselves apart from other hospital systems, and we are committed to making this new hospital the most technologically advanced and innovative hospital ever,” Dr. Marc Boom, president and CEO of Houston Methodist, says in a note to employees. Read more.

Following $50M gift,Tilman Fertitta reveals goals for eponymous medical school at University of Houston

Fertitta and his family have gifted $50 million to UH's medical school. Photo courtesy

As Houston’s most high-profile billionaire and owner of the posh 5-star Post Oak Hotel and Houston Rockets, Tilman J. Fertitta has become synonymous with over-the-top opulence and big-time entertainment.

But the CEO of the massive Feritta Entertainment empire’s latest move has nothing to do with penthouses or point guards, but rather a legacy, game-changing appropriation meant to aid his home state’s health.

The longtime UH board member and former chairman and his family have just pledged $50 million to the University of Houston College of Medicine. In turn, the new medical school has been christened the Tilman J. Fertitta Family College of Medicine. Read more.

TMC unveils details of new bioport, Helix Park at annual Greater Houston Partnership event

TMC gave an update on TMC3 — now called TMC Helix Park — and introduced a new bioport project. Courtesy of Elkus Manfredi Architects

Within the next five to 10 years, the Texas Medical Center you know today will be double the size. That's what Bill McKeon, president and CEO of the TMC, said at yesterday's State of the Texas Medical Center event hosted by the Greater Houston Partnership.

The biggest project contributing to the TMC's growth is TMC3, a campus expansion that will bring 37 acres and 5 million square feet of space to the TMC, is now known as Helix Park. The name is a nod to the shape of the park and walkway design at the center of the campus. The TMC3 Collaborative Building — the first multi-institutional research facility in TMC’s history — will be the first of the project to deliver and is currently under construction and slated for completion in 2023.

However, the big news of the event was the TMC BioPort, the organization's upcoming biomanufacturing and medical supplies distribution engine. This new campus will span several hundred acres just down the road from TMC and will drive the much-needed repatriation of critical medical supplies and new cell and gene therapies, per a news release. Read more.

Overheard: Houston experts discuss women in med tech, insight from investors, and more

Health care innovators joined Houston Methodist and Texas A&M University's ENMED program to discuss women in health care innovation and venture capital investment. Photo courtesy of Houston Methodist

Houston's health innovation community is making strides every day toward greater quality of care and technology adoption — but what challenges is the industry facing these days?

Through a partnership between Houston Methodist and Texas A&M University's ENMED program at Houston Tech Rodeo, health innovators weighed in on topics surrounding the industry, including biases and investment opportunities.

Missed the conversation? Here are seven key moments from the panels that took place at A&M's new ENMED building in the Texas Medical Center on Thursday, March 3. Read more.

TMC3's Collaborative Building has topped out. Image courtesy of Texas Medical Center

First TMC3 Collaborative Building tops out, plans to open next year

medical milestone

Construction of Houston’s 250,000-square-foot TMC3 Collaborative Building has reached a milestone.

Founders of the research facility recently celebrated completion of the uppermost part of the building, known as “topping out.” Construction started in January 2021.

The building is part of the first phase of the TMC3 campus, a 37-acre life science property designed to capitalize on the intersection of medicine and commercialization. Founders of the campus are Texas Medical Center, the University of Texas MD Anderson Cancer Center, Texas A&M University Health Science Center, and the University of Texas Health Science Center at Houston.

The TMC3 Collaborative Building, set to open in 2023, will promote innovation and collaboration among the founding institutions, as well as with academic, healthcare, and industry partners. A key feature is a 43,000-square-foot research lab that’ll be shared by MD Anderson, Texas A&M Health, and UT Health Houston.

“The topping out of the TMC3 Collaborative Building marks an integral milestone in the future of life science research and innovation and reflects an unprecedented commitment to collaboration among the four founding institutions,” William McKeon, president and CEO of Texas Medical Center, says in a news release. “The lifesaving research and technologies that will come out of this building will truly revolutionize healthcare.”

In addition to the research lab, the building will include:

  • 85,000 square feet of lab and office space for industry partners.
  • 14,200 square feet for Texas Medical Center’s strategic initiatives, the Braidwell investment firm, the TMC Venture Fund, and national venture and equity fund partners.
  • A 7,000-square-foot atrium for lectures, programs, and informal events.

“Houston already has a place on the world stage as a leader in clinical care and life sciences. With the launch of the TMC3 Collaborative Building and larger TMC3 campus, we showcase why our city leads in the areas of innovation and technology,” Houston Mayor Sylvester Turner says. “In the process, we will create opportunities to bring new partners and industry to our city and generate new jobs for the residents of the Greater Houston community.”

The Texas Medical Center announced the groundbreaking of the TMC3 Collaborative Building. Image courtesy of Elkus Manfredi Architects

TMC breaks ground on collaborative Houston research center

in the works

A fall 2023 opening is set for a research center under construction at the Texas Medical Center's new TMC3 life science campus.

The 250,000-square-foot TMC3 Collaborative Building will house research initiatives organized by the Texas Medical Center, University of Texas MD Anderson Cancer Center, Texas A&M University Health Science Center, and University of Texas Health Science Center at Houston. Construction began in January.

"The founding institutions behind [this building] are among the world's leading innovators in health and science. Their work at both the bench and bedside saves lives. The entire spirit behind this building reflects a joint investment — both financially and strategically — in lifesaving research, data collaborations, and technologies," William McKeon, president and CEO of Texas Medical Center, says in a September 20 news release.

Located at the heart of the 37-acre TMC3 campus and facing the site's Helix Gardens, the $185.8 million, four-story building is designed to foster collaboration among academic healthcare institutions and industry partners. Within the building, the three academic healthcare partners will create a 43,000-square-foot joint research lab. Furthermore, a 7,000-square-foot, 500-seat atrium will be available for lectures and other activities.

Beyond space shared by TMC3's four founders, 85,000 square feet of lab and office space will be developed for industry partners, and MD Anderson will create a 14,000-square-foot space for strategic initiatives. The building also includes 14,200 square feet that will host TMC's strategic initiatives; Braidwell, a life science-focused investment firm; the TMC Venture fund; and national venture and equity and partners.

"This project represents a once-in-a-generation opportunity for Houston's academic medical community to collaborate together and with industry to advance our missions and accelerate knowledge and cures," says Dr. Peter WT Pisters, president of MD Anderson.

"By breaking down silos and bringing clinicians and scientists together in this resource-rich location to speed new therapies to market from regenerative medicine and advanced imaging to drug discovery and data sciences, we will have the ability to translate discoveries into preventions and treatments for patients in need," adds Jon Mogford, chief operating officer and senior vice president of Texas A&M Health.

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Rice University's edtech company receives $90M to lead NSF research hub

major collaboration

An educational technology company based out of Rice University has received $90 million to create and lead a research and development hub for inclusive learning and education research. It's the largest research award in the history of the university.

OpenStax received the grant funding from the U.S. National Science Foundation for a five-year project create the R&D hub called SafeInsights, which "will enable extensive, long-term research on the predictors of effective learning while protecting student privacy," reads a news release from Rice. It's the NSF's largest single investment commitment to national sale education R&D infrastructure.

“We are thrilled to announce an investment of $90 million in SafeInsights, marking a significant step forward in our commitment to advancing scientific research in STEM education,” NSF Director Sethuraman Panchanathan says in the release. “There is an urgent need for research-informed strategies capable of transforming educational systems, empowering our nation’s workforce and propelling discoveries in the science of learning.

"By investing in cutting-edge infrastructure and fostering collaboration among researchers and educators, we are paving the way for transformative discoveries and equitable opportunities for learners across the nation.”

SafeInsights is funded through NSF’s Mid-scale Research Infrastructure-2 (Mid-scale RI-2) program and will act as a central hub for 80 partners and collaborating institutions.

“SafeInsights represents a pivotal moment for Rice University and a testament to our nation’s commitment to educational research,” Rice President Reginald DesRoches adds. “It will accelerate student learning through studies that result in more innovative, evidence-based tools and practices.”

Richard Baraniuk, who founded OpenStax and is a Rice professor, will lead SafeInsights. He says he hopes the initiative will allow progress to be made for students learning in various contexts.

“Learning is complex," Baraniuk says in the release. "Research can tackle this complexity and help get the right tools into the hands of educators and students, but to do so, we need reliable information on how students learn. Just as progress in health care research sparked stunning advances in personalized medicine, we need similar precision in education to support all students, particularly those from underrepresented and low-income backgrounds.”

2 Houston startups selected by US military for geothermal projects

hot new recruits

Two clean energy companies in Houston have been recruited for geothermal projects at U.S. military installations.

Fervo Energy is exploring the potential for a geothermal energy system at Naval Air Station Fallon in Nevada.

Meanwhile, Sage Geosystems is working on an exploratory geothermal project for the Army’s Fort Bliss post in Texas. The Bliss project is the third U.S. Department of Defense geothermal initiative in the Lone Star State.

“Energy resilience for the U.S. military is essential in an increasingly digital and electric world, and we are pleased to help the U.S. Army and [the Defense Innovation Unit] to support energy resilience at Fort Bliss,” Cindy Taff, CEO of Sage, says in a news release.

A spokeswoman for Fervo declined to comment.

Andy Sabin, director of the Navy’s Geothermal Program Office, says in a military news release that previous geothermal exploration efforts indicate the Fallon facility “is ideally suited for enhanced geothermal systems to be deployed onsite.”

As for the Fort Bliss project, Michael Jones, a project director in the Army Office of Energy Initiatives, says it’ll combine geothermal technology with innovations from the oil and gas sector.

“This initiative adds to the momentum of Texas as a leader in the ‘geothermal anywhere’ revolution, leveraging the robust oil and gas industry profile in the state,” says Ken Wisian, associate director of the Environmental Division at the U.S. Bureau of Economic Geology.

The Department of Defense kicked off its geothermal initiative in September 2023. Specifically, the Army, Navy, and Defense Innovation Unit launched four exploratory geothermal projects at three U.S. military installations.

One of the three installations is the Air Force’s Joint Base San Antonio. Canada-based geothermal company Eavor is leading the San Antonio project.

Another geothermal company, Atlanta-based Teverra, was tapped for an exploratory geothermal project at the Army’s Fort Wainwright in Alaska. Teverra maintains an office in Houston.

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This article originally ran on EnergyCapital.