A TMC-based organization supporting innovation pediatric medical devices has secured a $7.4 million grant. Photo via tmc.edu

The Southwest National Pediatric Device Innovation Consortium announced this month that it has received a $7.4 million grant from the Food and Drug Administration to continue developing innovative pediatric medical devices.

Led by Baylor College of Medicine and Texas Children’s Hospital, SWPDC supports the development and commercialization of devices relating to children's health, including synthetic pediatric heart valves, miniature injection devices and neonatal intensive care unit monitoring devices, according to a statement from Baylor.

According to Dr. Chester Koh, SWPDC executive director and principal investigator, who is also a professor of urology at Baylor and a pediatric urologist at Texas Children’s, physicians today often have to treat pediatric patients with devices that are designed for larger adult bodies.

"This grant allows us to continue to spur development of devices specifically designed for kids by providing funding, consulting, clinical expertise and other assistance, all of which is made possible by our co-existence in the healthcare innovation ecosystem of the Texas Medical Center,” he said in the statement.

The SWPDC received a similar five-year grant in 2018 from the FDA, and has since added 200 pediatric device projects in all stages of development to its portfolio, raising in total more than $200 million in follow-on funding for the technology. It's one of five consortia in the FDA’s Pediatric Device Consortia (PDC), with others in Pennsylvania, Washington D.C., the San Francisco Bay Area, and Los Angeles.

Regionally, the consortium members include engineers from Texas A&M University, Rice University, University of Houston and the University of Minnesota, as it looks to expand into the midwest. It also partners with Texas Medical Center Innovation, JLABS@TMC and Proxima CRO.

In addition to the $7.4 million grant, SWPDC also received funding for its real-world data/real-world evidence (RWD/RWE) demonstration projects that focus on postoperative cardiac care, according to BCM.

Earlier this summer, Houston-based medtech company CorInnova was one of five companies invited to invited to present pitches at the National Capital Consortium for Pediatric Device Innovation’s “Make Your Medical Device Pitch for Kids!” competition. The event takes place this month and the companies are competing for a share of $150,000 in grant funding from the FDA. CorInnova has developed a minimally invasive device for the treatment of congestive heart failure.

Texas Children's Hospital and Baylor College of Medicine are working on a new COVID-19 vaccine candidate. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

Houston health care organizations team up for the 'people's vaccine'

COVID Collaboration

Two major health care institutions in Houston — Texas Children's Hospital and the Baylor College of Medicine — are a step closer to rolling out what they dub the "people's vaccine" for COVID-19.

The two institutions, along with India-based vaccine and pharmaceutical company Biological E Ltd., have gained approval to move ahead this month with Phase III clinicals trials in India of a COVID-19 vaccine candidate called Corbevax. The Texas Children's Hospital Center for Vaccine Development developed the vaccine's protein antigen, which was licensed from the Baylor College of Medicine's BCM Ventures commercialization arm.

Unlike COVID-19 vaccines in the U.S., Corbevax contains the so-called "spike protein" from the surface of the novel coronavirus. Once that protein is injected via a vaccine, the body is supposed to begin building immunity against the protein and thereby prevent serious illness.

Experts envision Corbevax being a readily available weapon in the global fight against the COVID-19 pandemic, thanks to the simple vaccine platform (like the one used to prevent Hepatitis B) and the ability to store the vaccine in normal refrigerated settings. The targets of this vaccine are children and mothers.

"In the midst of India's public health crisis, it is our hope that our Texas Children's and Baylor COVID-19 vaccine can be released for emergency authorization in India and in all countries in need of essential COVID-19 vaccinations," Dr. Peter Hotez, co-director of the Texas Children's Hospital Center for Vaccine Development, says in a June 9 news release.

India has reported more than 29 million cases of COVID-19, causing 354,000 deaths. The country's COVID-19 surge reached its peak in May.

"The vaccines currently available cannot be manufactured quick enough to meet supply shortages in low-income countries," Hotez says. "Our vaccine is truly 'the people's vaccine,' created to serve the most marginalized and underserved populations that are hardest hit by this pandemic. This is the vaccine that could be used to vaccinate the world."

In the Phase III trial, the two-dose Corbevax vaccine will be administered to about 1,200 people age 18 to 80 at 15 sites in India. A larger global study of Corbevax is in the works.

According to India.com, Corbevax could be the most affordable COVID-19 vaccine available in the nation of nearly 1.37 billion people, costing close to $7 for a two-dose regimen. The Indian government already has preordered 300 million doses of Corbevax, which has shown promise in Phase I and Phase II trials. The Phase II trial ended in April.

If the Phase III trial goes as planned, doses could be widely administered as soon as August. Biological E initially plans to produce 75 million to 80 million doses per month, according to media reports. The Indian company foresees manufacturing at least 1 billion doses by the end of 2022.

Texas Children's Hospital is opening a new 365,000-square-foot location in Austin. Rendering courtesy of TCH and Page

Houston hospital reveals renderings of Austin outpost ahead of groundbreaking

ATX by way of HOU

Texas Children's Hospital is working on its first freestanding location in Austin — and the hospital system just released a first look at what the state-of-the-art building will look like.

The new Texas Children's Austin campus — to be located at 9835 North Lake Creek Parkway — will be open in the first quarter of 2024, according to a news release. The $485 million project is expected to break ground this spring.

The 365,000-square-foot, 52-bed hospital will serve women and children and include neonatal and pediatric intensive care units, operating rooms, epilepsy monitoring, sleep center, emergency center, fetal center for advanced fetal interventions and fetal surgery, diagnostic imaging, acute care, and an on-site Texas Children's Urgent Care location, per the release.

The location will have an adjacent 170,000-square-foot outpatient building — for subspecialties such as cardiology, oncology, neurology, pulmonology, fetal care, and more — and over 1,200 free parking spaces.

The new hospital is expected in 2024. Rendering courtesy of TCH and Page

The project was originally announced in May of 2020. The announced general contractor is St. Louis, Missouri-based McCarthy Building Companies, which has an office in Houston and Austin, and the architecture and engineering firm is Houston-based Page.

"At Texas Children's, our breadth and depth of expertise allows us to provide the full-spectrum of health care services which we believe helps improve the overall health and well-being of Austin children, women and families," says Michelle Riley-Brown, executive vice president at Texas Children's, in the original announcement. "Our promise to Austin remains strong – to deliver specialized care closer to you through our multiple locations across the city so children and women can access the right care, in the right place, at the right time."

Houston-based Texas Children's first entered the Austin market in March of 2018 with the opening of Texas Children's Urgent Care Westgate at 4477 South Lamar Blvd. Later that year, TCH opened Texas Children's Specialty Care Austin at 8611 North MoPac, Suite 300.Texas Children's Pediatrics currently has 10 locations in Austin.

"Texas Children's came from humble beginnings, opening in 1954 with a 106-bed pediatric hospital. From there, we grew into the preeminent hospital we are today, delivering the highest quality care possible by serving the needs of the children of Texas and beyond," says TCH's president and CEO, Mark A. Wallace, in the original release. "Texas Children's, like Austinites, dwell in possibilities. Every facet of our new hospital will be designed, engineered and tailored with your family's needs and desired experience."

The 365,000-square-foot hospital will have 52 beds. Rendering courtesy of TCH and Page

Here's what to attend at virtual SXSW this year. Photo via SXSW.com

7 can't-miss events at virtual SXSW featuring Houston speakers

south by the bayou

Many Houstonians were hoping to be able head out to Austin next week for SXSW 2021, but now they don't have to venture out from behind their computer screens.

SXSW has pivoted to virtual this year, but the online schedule still features all the thought leadership as previous years. If you're looking to hop into innovation and tech conversations featuring Houstonians, check out these events across space, health care, energy, and more.

Tuesday — Leading the Global Energy Transition

The Greater Houston Partnership is hosting a series of thought-leadership discussions focused on the global energy transition. Join Houston House for interviews with some of the brightest minds in energy who are leading the global energy transition through corporate innovation, energy technology, ESG, and the future of workforce.

Editor's note: InnovationMap was the facilitator for some of the interviews.

Catch the event Tuesday, March 16, from 10 am to 1 pm.

Tuesday — The Climate Crisis & American Cities

Cities are succumbing the ravages of a rapidly changing climate more and more often. Once in a lifetime flooding events are more frequent, wildfires are raging with greater intensity, droughts are being prolonged, and the rising seas levels are imperiling coastal communities. Aside from the ecological and economic impact of climate change, the effects of climate change are being disproportionately felt by low-income communities of color.

Hear from mayors of America's largest cities — including Houston Mayor Sylvester Turner — on how they are approaching this crisis and what you can do to help fight climate change in your community.

Catch the event Tuesday, March 16, from 10:15 am to 11:10 am.

Tuesday — The Health Trust Gap and How to Fix It

While the term "Infodemic" has circulated widely during the pandemic, the spread of health related misinformation is not a new phenomenon rather one that has been exacerbated. Now more than ever before we are seeing a divide in behaviors and in humanity. So how do we begin to build trust in this breakdown of communication? What steps can and should individuals, governments, media and businesses play?

Moderator Dr. Natalia Peart of Houston-based Catalyst Innovation Group will explore these questions and more with her panel of experts.

Catch the event Tuesday, March 16, from 10:15 am to 11:10 am.

Wednesday — Building a Thriving and Diverse Innovation Ecosystem

The Greater Houston Partnership is hosting a series of thought-leadership discussions focused on the global energy transition. Join Houston House for interviews with leaders from across the region's startup ecosystem discuss how Houston has become a thriving hub for digital technology while fostering a culture of inclusive innovation.

Editor's note: InnovationMap was the facilitator for some of the interviews.

Catch the event Wednesday, March 17, from 10 am to 1 pm.

Wednesday: Digital Access: A New Social Determinant of Health

Children's hospitals and T-Mobile are partnering to discuss the growing digital divide and the emergence of a new social determinant of health; digital access. Technology and digital access can now play a significant role in a patient's ability to have equitable access to healthcare, education and many other areas of their life.

Jackie Ward, chief nursing officer at Texas Children's Hospital joins this discussion.

Catch the event Wednesday, March 17, from 3:30 to 3:55 pm.

Thursday — Who on Earth should Govern Space?

Who will make the rules once out of the Earth's orbit? Can any commercial space company attempt to colonize Mars? These are just the start-off questions for those with insatiable curiosity. Texas A&M University's president, the director of space flight policy at SpaceX and an expert on who owns artifacts discovered in space confer with an award-winning science journalist.

Catch the event Thursday, March 18, from 9 to 9:55 pm.

Friday — Pushing our Bodies and Minds Beyond the Limits

In 2020 people across the globe experienced extreme isolation and mental health challenges. A source of empathy and education was found beyond the globe, in the small group that have spent time in space. An astronaut and sports psychologist discuss similarities and challenges of keeping mental and physical health in top shape while in isolation.

Houston-based former astronaut Bonnie Dunbar will be in on the discussion.

Catch the event Friday, March 19, from from 3:30 to 3:55 pm or at the encore Saturday, March 20, at 10 to 10:55 am.

Front-line and health care workers will get the vaccine first. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

7 Houston-area hospitals receive first doses of COVID-19 vaccine

CORONAVIRUS NEWS

Four sites in Texas received the COVID-19 vaccine on December 14, part of a rollout of doses being shipped out across the U.S.

Texas received 19,500 doses, with another 250,000 doses being distributed to 109 facilities in Texas this week.

According to the Texas Department of State Health Services, the first four sites to get it were:

  • MD Anderson Cancer Center in Houston
  • Methodist Dallas Medical Center
  • Wellness 360 at UT Health San Antonio
  • UT Health Austin's Dell Medical School

Another 75,000 doses will be delivered on December 15 to 19 sites in Texas:

  • Houston, Texas Children's Hospital Main
  • Houston, LBJ Hospital
  • Houston, CHI St. Luke's Health
  • Houston, Memorial Hermann Texas Medical Center
  • Houston, Houston Methodist Hospital
  • Houston, Ben Taub General Hospital
  • Galveston, University of Texas Medical Branch Hospital
  • Amarillo, Texas Tech Univ. Health Science Center Amarillo
  • Corpus Christi, Christus Spohn Health System Shoreline
  • Dallas, Parkland Hospital
  • Dallas, UT Southwestern
  • Edinburg, Doctors Hospital at Renaissance
  • Edinburg, UT Health RGV Edinburg
  • El Paso, University Medical Center El Paso
  • Fort Worth, Texas Health Resources Medical Support
  • Lubbock, Covenant Medical Center
  • San Angelo, Shannon Pharmacy
  • Temple, Baylor Scott and White Medical Center

Health care and front-line workers will receive the vaccine first. Officials are still working out the timeline but the general public is not expected to get the vaccine until spring 2021 at the earliest.

Dr. Paul Klotman, president of the Baylor College of Medicine in Houston, said in a press conference that getting vaccinated is helpful to both individuals and their communities.

"The thing about everyone pitching in, do it for yourself because it will help protect you, but when you get the herd immunity it will help protect people who are unable medically to get the vaccine," Klotman said.

------

This article originally ran on CultureMap.

Houston Methodist stood out yet again on an annual best hospitals report, but several other Houston institutions were recognized as well. Courtesy of Methodist Hospital/Facebook

New report recognizes best hospitals in Houston

better than all the rest

Hospitals across Houston were ranked by their patient care, patient safety, outcomes, nursing, advanced technology and reputation in an annual report that identifies the top medical facilities in the country.

U.S. News & World Report released its 31st annual best hospital rankings this week, which included both adult and children's hospital tracks across several categories. The report released both overall and local rankings after evaluating over 4,500 medical centers nationwide in 16 specialties, and 134 hospitals were ranked in at least one specialty.

For the ninth year in a row, the top hospital in Houston and Texas, according to the report, is Houston Methodist, which ranked at No. 20 nationally and made the report's Honor Roll.

"Our U.S. News rankings are especially meaningful right now as this has been an exceptionally difficult time for our health care workers," says Marc Boom, M.D., president and CEO of Houston Methodist, in a news release. "We have always served our community by providing exceptional care — during the COVID-19 pandemic and before. It's a true testament to our commitment to being unparalleled."

Houston Methodist Sugar Land Hospital tied for No. 4 in Houston and No. 6 (three-way tie) in Texas. Additionally, the hospital was recognized on the top lists for 11 specialties:

  • No. 12 for cardiology/heart surgery
  • No. 13 for orthopedics
  • No. 14 for gastroenterology/GI surgery
  • No. 17 for cancer
  • No. 19 (tie) for nephrology
  • No. 20 for pulmonology and lung surgery
  • No. 23 for neurology/neurosurgery
  • No. 26 for geriatrics
  • No. 26 (tie) for gynecology
  • No. 28 for diabetes and endocrinology
  • No. 49 for ear, nose and throat

The second-best hospital in Houston on this year's ranking was Baylor St. Luke's Medical Center, which was also named the No. 3 hospital in the state.

"At Baylor St. Luke's, we are transforming the way we deliver care for our patients through groundbreaking technologies and a multidisciplinary approach that allows us to give the best possible care to patients and their families," says Doug Lawson, CEO of St. Luke's Health, in a news release. "I praise our dedicated staff and physicians for helping us achieve this recognition."

Baylor St. Luke's also made an appearance across five specialties:

  • No. 17 for cardiology/heart surgery
  • No. 21 for gastroenterology/GI surgery
  • No. 21 for neurology/neurosurgery
  • No. 27 for cancer
  • No. 47 for geriatrics

"This is a great report that confirms the efforts of our partnership at Baylor St. Luke's and our affiliated hospitals to provide unsurpassed care to patients, conduct research that will change lives and train the next generation of physicians", says Dr. Paul Klotman, president, CEO, and executive dean at Baylor College of Medicine. "Baylor St. Luke's high ranking in Texas is in parallel with Baylor College of Medicine being the highest ranked medical school in Texas. Together, we are an outstanding academic medical center and learning health system."

Memorial Hermann - Texas Medical Center came in No. 3 in Houston and No. 5 in Texas. The hospital ranked in one adult specialty and two children's specialties.

  • No. 43 for ear, nose and throat (adult)
  • No. 22 for cardiology/heart surgery (pediatric)
  • No. 31 for neurology/neurosurgery (pediatric)

On the children's hospital track, Houston's Texas Children's Hospital ranked as No. 4 nationally and was recognized in all 10 pediatric specialties, which included:

  • No. 1 for pediatric cardiology/heart surgery
  • No. 2 for pediatric nephrology
  • No. 2 for pediatric neurology/neurosurgery
  • No. 3 for pediatric pulmonology and lung surgery
  • No. 4 for pediatric cancer
  • No. 5 for pediatric diabetes and endocrinology
  • No. 5 for pediatric gastroenterology/GI surgery
  • No. 6 for pediatric urology
  • No. 10 for neonatology
  • No. 15 for pediatric orthopedics

Zooming in on the specific specialties, several other Houston hospitals in addition to these top tier hospitals, secured spots in the top 10 rankings.

University of Texas MD Anderson Cancer Center was ranked No. 1 nationally for adult cancer treatment. Additionally, the hospital made an appearance in six other adult specialties and one pediatric specialty.

  • No. 4 for ear, nose and throat
  • No. 6 for urology
  • No. 14 for gynecology
  • No. 27 for diabetes and endocrinology
  • No. 41 for geriatrics
  • No. 46 for gastroenterology/GI surgery
  • No. 38 for cancer (pediatric)
TIRR Memorial Hermann in Houston ranked No. 3 nationally for rehabilitation.
For all 31 years, The Menninger Clinic has been recognized as a top hospital in the psychiatric speciality. This year, the clinic ranked at No. 9 nationally.

"Our clinical teams provide personalized care with the right blend of art and science. We have pioneered measuring the effectiveness of this treatment, and the results consistently demonstrate that patients sustain their well-being for at least a year after they leave Menninger," says Armando Colombo, president and CEO, in a news release. "Going forward, we will improve access to make it easier for more Texans to access these life-changing results."

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Houston organizations launch collaborative center to boost cancer outcomes

new to HOU

Rice University's new Synthesis X Center officially launched last month to bring together experts in cancer care and chemistry.

The center was born out of what started about seven years ago as informal meetings between Rice chemist Han Xiao's research group and others from the Baylor College of Medicine’s Dan L Duncan Comprehensive Cancer Center at the Baylor College of Medicine. The level of collaboration between the two teams has grown significantly over the years, and monthly meetings now draw about 100 participants from across disciplines, fields and Houston-based organizations, according to a statement from Rice.

Researchers at the new SynthX Center will aim to turn fundamental research into clinical applications and make precision adjustments to drug properties and molecules. It will focus on improving cancer outcomes by looking at an array of factors, including prevention and detection, immunotherapies, the use of artificial intelligence to speed drug discovery and development, and several other topics.

"At Rice, we are strong on the fundamental side of research in organic chemistry, chemical biology, bioengineering and nanomaterials,” Xiao says in the statement. “Starting at the laboratory bench, we can synthesize therapeutic molecules and proteins with atom-level precision, offering immense potential for real-world applications at the bedside ... But the clinicians and fundamental researchers don’t have a lot of time to talk and to exchange ideas, so SynthX wants to serve as the bridge and help make these connections.”

SynthX plans to issue its first merit-based seed grants to teams with representatives from Baylor and Rice this month.

With this recognition from Rice, the teams from Xiao's lab and the TMC will also be able to expand and formalize their programs. They will build upon annual retreats, in which investigators can share unpublished findings, and also plan to host a national conference, the first slated for this fall titled "Synthetic Innovations Towards a Cure for Cancer.”

“I am confident that the SynthX Center will be a great resource for both students and faculty who seek to translate discoveries from fundamental chemical research into medical applications that improve people’s lives,” Thomas Killian, dean of the Wiess School of Natural Sciences, says in the release.

Rice announced that it had invested in four other research centers along with SynthX last month. The other centers include the Center for Coastal Futures and Adaptive Resilience, the Center for Environmental Studies, the Center for Latin American and Latinx Studies and the Rice Center for Nanoscale Imaging Sciences.

Earlier this year, Rice also announced its first-ever recipients of its One Small Step Grant program, funded by its Office of Innovation. The program will provide funding to faculty working on "promising projects with commercial potential," according to the website.

Houston physicist scores $15.5M grant for high-energy nuclear physics research

FUTURE OF PHYSICS

A team of Rice University physicists has been awarded a prestigious grant from the Department of Energy's Office of Nuclear Physics for their work in high-energy nuclear physics and research into a new state of matter.

The five-year $15.5 million grant will go towards Rice physics and astronomy professor Wei Li's discoveries focused on the Compact Muon Solenoid (CMS), a large, general-purpose particle physics detector built on the Large Hadron Collider (LHC) at CERN, a European organization for nuclear research in France and Switzerland. The work is "poised to revolutionize our understanding of fundamental physics," according to a statement from Rice.

Li's team will work to develop an ultra-fast silicon timing detector, known as the endcap timing layer (ETL), that will provide upgrades to the CMS detector. The ETl is expected to have a time resolution of 30 picoseconds per particle, which will allow for more precise time-of-flight particle identification.

The Rice team is collaborating with others from MIT, Oak Ridge National Lab, the University of Illinois Chicago and University of Kansas. Photo via Rice.edu

This will also help boost the performance of the High-Luminosity Large Hadron Collider (HL-LHC), which is scheduled to launch at CERN in 2029, allowing it to operate at about 10 times the luminosity than originally planned. The ETL also has applications for other colliders apart from the LHC, including the DOE’s electron-ion collider at the Brookhaven National Laboratory in Long Island, New York.

“The ETL will enable breakthrough science in the area of heavy ion collisions, allowing us to delve into the properties of a remarkable new state of matter called the quark-gluon plasma,” Li explained in a statement. “This, in turn, offers invaluable insights into the strong nuclear force that binds particles at the core of matter.”

The ETL is also expected to aid in other areas of physics, including the search for the Higgs particle and understanding the makeup of dark matter.

Li is joined on this work by co-principal investigator Frank Geurts and researchers Nicole Lewis and Mike Matveev from Rice. The team is collaborating with others from MIT, Oak Ridge National Lab, the University of Illinois Chicago and University of Kansas.

Last year, fellow Rice physicist Qimiao Si, a theoretical quantum physicist, earned the prestigious Vannevar Bush Faculty Fellowship grant. The five-year fellowship, with up to $3 million in funding, will go towards his work to establish an unconventional approach to create and control topological states of matter, which plays an important role in materials research and quantum computing.

Meanwhile, the DOE recently tapped three Houston universities to compete in its annual startup competition focused on "high-potential energy technologies,” including one team from Rice.

------

This article originally ran on EnergyCapital.