Health care companies dominated Fortune's America’s Most Innovative Companies report for 2025, with Houston’s top-rated company on the list falling into that sector. Photo via Getty Images

Eight Houston companies have been named to Fortune’s third annual list of America’s Most Innovative Companies, joining another 16 from the state of Texas.

The group of 300 companies nationwide was rated based on production innovation, process innovation, and innovation culture, according to Fortune. In partnership with Statista, the magazine considered IP portfolios, employee, expert and customer opinions; and many other factors.

While many of the top-rated companies fell into the tech sector, Fortune reports that health care companies made up the largest portion of the 2025 list. Sixty-three honorees fell into the health care category, including Houston’s top-rated company, Houston Methodist.

Here’s which Houston companies made the list and where they ranked:

  • No. 35 — Houston Methodist
  • No. 54. — ExxonMobil
  • No. 137 — NRG Energy
  • No. 158 — Hewlett-Packard Enterprise
  • No. 169 — BMC Software
  • No. 175 — Texas Children’s Hospital
  • No. 227 — Sysco
  • No. 268 — Chevron

“This award is a true credit to the culture we have created around innovation and the incredible work of Roberta Schwartz, our Chief Innovation Officer, and her team at the Center for Innovation,” Marc Boom, CEO of Houston Methodist, said in a LinkedIn post. “They have really set the tone for how we can use innovation and technology to continue to deliver the highest quality care for our patients.”

Dallas-Fort Worth claimed the largest number of Texas companies on the list, with 11 headquartered in the metroplex. Houston was home to the second-most with eight hailing from the Bayou City. Austin is home to only four of the companies on the list, however, companies from the Capital City ranked higher on average, with Oracle, Tesla and Dell Technologies claiming the top three spots for the state. Beloved Texas grocer H-E-B was the one company to represent San Antonio.

Here's how the other Texas companies fared:

  • No. 6 — Oracle
  • No. 11 — Tesla
  • No. 14 — Dell Technologies
  • No. 37 — AT&T
  • No. 59 — Texas Instruments
  • No. 89 — Charles Schwab
  • No. 91 — McKesson
  • No. 113 — Jacobs Solutions
  • No. 125 — Baylor, Scott & White Health
  • No. 165 — Frontier Communications
  • No. 201— H-E-B
  • No. 210 — CBRE Group
  • No. 219 — TTEC Holdings
  • No. 223 — GameStop
  • No. 251 — American Airlines Group
  • No. 271 — Caterpillar

California-based tech conglomerate Alphabet Inc. topped the list for the third year in a row, and California companies again represented the majority of companies on the list, according to Fortune. Alphabet, Microsoft, Apple, IBM and Salesforce made up the top five, of which three are headquartered in California.

The 2025 group had a median revenue of $22 billion over the last 12 months, according to Fortune. See the full report here.

Sarah Lee, CEO and co-founder of Relavo, won first place at the 2024 Ignite Health Fire Pitch Competition. Photo via Ignite/LinkedIn

Houston female-focused health tech accelerator names top companies at annual event

you go girls

A Houston organization that accelerates and supports female founders leading innovative health tech startups has concluded its 2024 program with the announcement of this year's top companies.

Ignite Health, an accelerator founded in 2017 by longtime Houston health care professional Ayse McCracken, named its 2024 winners at its annual Fire Pitch Competition in Houston last month. The companies pitched health tech solutions across lung health, renal therapy, breastfeeding tech, and more.

"This year’s competition was a culmination of passion, innovation, and hard work from the top startups in our 2024 Accelerator Program," reads a LinkedIn post from Ignite. "These trailblazing founders earned their spot on the stage by demonstrating exceptional leadership and the potential to revolutionize the healthcare industry with their solutions and devices."

First place winner was Sarah Lee, CEO and co-founder of Relavo, a New York-based company that's making home dialysis more effective, safer, and more affordable. Lee accepted awards from Johnson & Johnson and Wilson Sonsini Goodrich & Rosati.

Therese Canares, CEO and founder of CurieDx, took second place and won its awards from SWPDC - Southwest National Pediatric Device Innovation Consortium and Wilson Sonsini. CurieDx, based in Baltimore, Maryland, is creating remote diagnostic tools using smartphone technology.

In third place is Andrea Ippolito, CEO and founder of SimpliFed, a company focused on democratizing access to baby feeding and breastfeeding services through virtual care that's covered by insurance. The startup won awards from Texas Children's Hospital and Wilson Sonsini Goodrich & Rosati.

Three other finalists won other awards, including:

  • Kadambari Beelwar, CEO and co-founder, Henderson, Nevada-based Truss Health, which created an AI-powered sensor fusion platform that's designed to detect early signs of infection, won an award presented by Memorial Hermann Health System and Golden Seeds
  • Mimi Gendreau Kigawa, CEO and co-founder of New York-based Zeph Technologies, an AI-lung care company with technology for clinicians to deliver pulmonary care to patients with chronic respiratory disease, won an award presented by CU Innovations and Houston Methodist
  • Ashley Yesayan, CEO and co-founder, New York-based OneVillage, a software platform meant to support patients and family members through trying health events, won an award presented by CU Innovations

The companies were evaluated by the 2024 judges, which included: Allison Rhines, head of JLABS Houston; Andrew Truscott, global health technology lead at Accenture; Angela Shippy, senior physician executive at Amazon Web Services; Kimberly Muller, executive director of CU Innovations at University of Colorado Anschutz Medical Campus; Myra Davis, chief innovation and information officer at Texas Children's Hospital; and Winjie Tang Miao, senior executive vice president and COO of Texas Health Resources.

Texas Children's Hospital has been busy. Photo via tmc.edu

Houston hospital system scores $4.8M gift, opens new Austin clinic, and more

news roundup

Texas Children’s Hospital has lots of exciting news this month. Chief among its big announcements is a $4.8 million gift that will help to fund the hospital’s new behavioral health Intensive Outpatient Program (IOP) in The Woodlands.

The donation comes from Ovintiv, a natural gas exploration and production company headquartered in Denver, Colorado.

The pledge makes Ovintiv the first company sponsor to join the Council of Hope, Texas Children’s new corporate giving society. The council’s fundraising priorities include supporting Texas Children’s behavioral health initiatives. Texas Children’s formed a Behavioral Health Task Force last year in order to expand and upgrade services for patients who need specialized help, hopefully preventing the necessity of in-patient care.

The IOP is expected to open early next year. It will treat patients for four or five hours a day, using individual, group and family therapy, art and music therapy programs, and yoga and recreational therapy to improve outcomes in behavioral health.

“This IOP is desperately needed in the Woodlands, and we are committed to creating it because we believe that the behavioral and developmental health of children, adolescents and teens is just as important as their physical well-being. Ovintiv’s transformational gift will make a life-changing difference for so many patients and their families,” says Dr. Kirti Saxena, chief of psychiatry at Texas Children’s Hospital and associate professor of psychiatry and behavioral sciences at Baylor College of Medicine, in a press release.

The Woodlands, however, isn’t the only city seeing the debut of a new facility from Texas Children’s. Last week, Texas Children’s Pavilion for Women announced the grand opening of its obstetrics and gynecology clinic in North Austin. The location welcomes women for fertility management, prenatal and preventative care, and a full spectrum of gynecological services.

That’s just the beginning for Texas Children’s and its reach in central Texas. In addition to the new OB/GYN clinic, Texas Children’s Hospital North Austin will open its doors in early February. It will provide care for women and children, especially in the areas of maternal-fetal medicine, and fetal intervention and neonatology.

Additionally, the Houston hospital has been named a Center of Excellence in antimicrobial stewardship (AMS) by bioMerieux, a world leader in in vitro diagnostics. Texas Children’s is one of three in the United States to net the honor, and the only one that specializes in pediatrics.

It’s no secret that antimicrobial resistance (AMR) is a bête noire of hospitals around the world. Common infectious diseases are becoming increasingly difficult to treat. By ensuring that patients get the right drug, at the right dose, at the right time, antimicrobial stewardship is extremely important to fighting resistance and to continuing antibiotic efficacy for future generations.

Texas Children’s and bioMérieux will collaborate to further activate antimicrobial resistance measures that will improve patient care. They’ll share expertise to develop and scale innovative best practices based on the application of diagnostic technology. And through all of its innovations, Texas Children’s will continue to be a global leader in pediatric care.

These Houston hospitals are the best in Texas and beyond. Photo via tmc.edu

Houston hospitals soar on annual list ranking best in Texas

top health care

Houston Methodist Hospital now shares its status as the state’s best hospital with Dallas’ UT Southwestern Medical Center.

In U.S. News & World Report’s latest ranking of Texas hospitals, Houston Methodist and UT Southwestern share the No. 1 spot. Last year, Houston Methodist was the lone holder of first-place honors in Texas.

The Houston Methodist system comprises a primary care facility within the Texas Medical Center and six community hospitals across the region. In all, Houston Methodist operates more than 2,600 patient beds and employs more than 29,700 people.

Overall, Houston hospitals fared well in this year’s Texas rankings:

  • Houston Methodist, No. 1
  • Baylor St. Luke’s Medical Center, No. 3
  • Memorial Hermann Hospital-Texas Medical Center, No. 4
  • Memorial Hermann Greater Heights Hospital, No. 6
  • Houston Medical Sugar Land Hospital, No. 9
  • Memorial Hermann Memorial Medical Center, No. 10

Specialty institutions in Houston also garnered accolades.

For instance, the University of Texas MD Anderson Cancer Center ranked first in the country for cancer care. Since the inception of the U.S. News & World Report survey in 1990, MD Anderson has been among the country’s top two institutions for cancer care.

“At MD Anderson, we remain singularly focused on eliminating cancer,” Dr. Peter WT Pisters, president of MD Anderson, says in a news release. “We are pleased to see this commitment recognized, but there is work still to be done.”

For its part, Houston Methodist nabbed national rankings in 10 specialties, including No. 4 for diabetes and endocrinology and No. 5 for gastroenterology and GI surgery.

Elsewhere in the Houston area:

  • Texas Children’s Hospital nailed down the No. 1 ranking among children’s hospitals in the state.
  • TIRR Memorial Hermann was again ranked as the Best Rehabilitation Hospital in Texas.
  • The Texas Heart Institute at Baylor St. Luke’s Medical Center claimed the No. 2 ranking among cardiovascular, heart, and vascular surgery facilities in the state.
  • The Menninger Clinic again makes the top 10 psychiatric hospitals. It ranked No. 7 in that specialty.

“A recent survey of U.S. News users revealed more than four in five (84 percent) consider a hospital’s quality metrics to be important factors when deciding where to seek treatment for a serious medical issue,” Ben Harder, chief of health analysis and managing editor at U.S. News, says in a news release. “Consumers want useful resources to help them assess which hospital can best meet their specific care needs.”

Harder adds that his publication’s hospital rankings “offer patients and the physicians with whom they consult a data-driven source for comparing performance in outcomes, patient satisfaction, and other metrics that matter to them.”

Texas Children's Hospital has expanded. Photo courtesy of TCH

Houston hospital opens next phase in $245M expansion

now open

Texas Children's Hospital has announced the opening of its newest medical tower in the Texas Medical Center.

Pavilion for Women Tower II is now open to patients, the Texas Children's Hospital revealed this week. It's the second phase of a $245 million expansion within the TMC. The new tower houses women’s services outpatient clinics and connects to the Pavilion for Women via a new sky bridge,

“I’ve always said that outgrowing a space is a good problem to have because it means that we’re doing something right and our patients and their families trust us to provide the safe and high-quality care they deserve,” says Mark A. Wallace, president and CEO of Texas Children’s, in a news release. “I am so proud of everything we’ve done together and I’m beyond grateful and excited for the continuous growth of Texas Children’s Pavilion for Women.”

The Pavilion for Women continues to grow its medical services, according to the release, including "pelvic medicine and reconstructive surgery, menopause treatment, maternal fetal medicine care, the Texas Children’s Fetal Center, reproductive psychiatry, reproductive endocrinology and infertility, and minimally invasive gynecology surgery."

“This latest milestone is one more indication of the dedication of Texas Children's Hospital to women's health,” Dr. Michael Belfort, OB/GYN-in-chief at Texas Children’s Pavilion for Women and professor and chair of the Department of Obstetrics and Gynecology at Baylor College of Medicine, says in the release. “That's very, very important to me. For the first time in this country, a children's hospital has embraced women throughout the spectrum of their health care from birth to menopause.”

The Baylor Obstetrics and Gynecology will relocate to the new tower by the end of the year. In 2024, TCH will add more adult inpatient and neonatal intensive care beds.

“This investment in our Pavilion for Women will allow us to increase delivery volumes significantly, but additionally the added space will also allow us to continue to grow those specialized clinics that cater to women at every stage of their life,” says Michele Birsinger, assistant vice president of Women's Services at Texas Children’s Pavilion for Women.

The Texas Medical Center is also undergoing a major renovation to create Helix Park, a complex with a few new multidisciplinary buildings for research, innovation, and health care. The first of the buildings, the TMC3 Collaborative Building, is expected to deliver this year.

This week's roundup of Houston innovators includes Sarah Essama of Teach for America Houston, Scott Schneider of HTX Labs, and Drs. Maria Elena Bottazzi and Peter Hotez. Photos courtesy

4 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to four local innovators across industries — from health tech to software — recently making headlines in Houston innovation.

Sarah Essama, director of social innovation at Teach For America Houston

Sarah Essama of Teach For America Houston shares how she innovated a new way for students themselves to learn how to innovate. Photo courtesy of Sarah Essama

As director of social innovation at Teach For America Houston, it's Sarah Essama's job to come up with new ways for the organization to support both students and teachers. But, as she explains on the Houston Innovators Podcast this week, Essama realized a huge lesson modern students needed was to learn this innovation process themselves.

This line of thinking turned into Essama founding The Dream Lab, powered by Teach for America Houston.

"The Dream Lab is a set of immersive design spaces where young people leverage their imagination and creativity to innovate and solve problems within their community," she explains.

Last month, the new concept rolled out to high school students in partnership with DivInc Houston, a nonprofit focused on social and economic equity in entrepreneurship, and 21 ninth graders spent the day at the Ion for a mini-innovation accelerator and design showcase. Click here to read more.

Scott Schneider, CEO and founder of HTX Labs

Scott Schneider of HTX Labs has something to celebrate. Photo via htxlabs.com

A Houston-based virtual reality training provider has closed its first round of funding. HTX Labs announced last month that it has received a $3.2 million investment from Cypress Growth Capital.

“We have been looking to secure outside capital to accelerate the growth of our EMPACT platform and customer base but we hadn’t found the right partner who provided an investment vehicle that matched our needs,“ says HTX Labs CEO Scott Schneider in the release. “We found everything we were looking for in Cypress Growth Capital. They have a non-dilutive funding model that aligns with our capital expectations and have the level of experience that really makes this smart money.

The fresh funding will go toward growing and scaling the company's operations — both within the current Department of Defense and expansion opportunities into key commercial markets, like heavy industry, manufacturing, and higher education. Additionally, the funding will support increased customer adoption. Click here to read more.

​Drs. Maria Elena Bottazzi and Peter Hotez 

Two Houston health care innovators got the green light to distribute their low-cost COVID-19 vaccine in Indonesia. Photo courtesy of TMC

After months of development and testing, the Houston-born COVID-19 vaccine has gotten the go-ahead to be produced and distributed in Indonesia.

IndoVac was created by the Texas Children’s Hospital Center for Vaccine Development and Baylor College of Medicine. Drs. Peter Hotez and Maria Elena Bottazzi lead the vaccine project. Bio Farma is licensing IndoVac from BCM Ventures, the commercial group at the Baylor College of Medicine.

“Access to vaccines in the developing world is critical to the eradication of this virus,” Hotez, co-director of the Texas Children’s Hospital Center for Vaccine Development and dean of the National School of Tropical Medicine at Baylor College of Medicine, says in a news release. Click here to read more.

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Texas cybersecurity co. expands unique train-to-hire model to Houston

job search

It’s increasingly more difficult to ensure the confidentiality, integrity, and availability of proprietary data and information in the ever-changing, ever-evolving digital world.

Cyberattacks, including malware, phishing, and ransomware, are becoming increasingly common and sophisticated, posing a consistent threat to a company’s sustainability and bottom line.

To combat that trend, Nukudo, a San Antonio-based cybersecurity workforce development company, is expanding its initiative to bridge the global cybersecurity talent gap through immersive training and job placement to Houston.

“We saw that there was a need in the market because there's a shortage of skilled manpower within the cybersecurity industry and other digital domains,” says Dean Gefen, CEO of NukuDo. “So, our initial goal was to take a large pool of people and then make them to be fully operational in cybersecurity in the shortest amount of time.”

The company refers to the plan as the “training-to-employment model,” which focuses on providing structured training to select individuals who then acquire the skills and knowledge necessary to secure and maintain fruitful careers.

The company identifies potential associates through its proprietary aptitude test, which recognizes individuals who possess the innate technical acumen and potential for success in various cybersecurity roles, regardless of their level of education.

“We take in people from all walks of life, meaning the program is purely based on the associate’s potential,” Gefen says. “We have people who were previously aircraft engineers, teachers, graphic designers, lawyers, insurance agents and so forth.”

Once selected, associates are trained by cybersecurity experts while gaining hands-on experience through scenario-based learning, enabling them to be deployed immediately as fully operational cybersecurity professionals.

The program training lasts just six months—all paid—followed by three years of guaranteed employment with NukuDo.

While in training, associates are paid $ 4,000 per month; then, they’re compensated by nearly double that amount over the next three years, ultimately pushing their salaries to well into the six figures after completing the entire commitment.

In addition to fostering a diverse talent pipeline in the cybersecurity field, NukuDo is creating a comprehensive solution to address the growing shortage of technical talent in the global workforce.

And arming people with new marketable skills has a litany of benefits, both professional and personal, Gefen says.

“Sometimes, we have associates who go on to make five times their previous salary,” says Gefen. “Add to that fact that we had someone that had a very difficult life beforehand and we were able to put him on a different path. That really hits home for us that we are making a difference.

Nulkudo currently has partnerships with companies such as Accenture Singapore and Singapore Airlines. Gefen says he and his team plans to have a new class of associates begin training every month by next year and take the model to the Texas Triangle (Houston, Austin and Dallas)—then possibly nationwide.

“The great thing about our program is that we train people above the level of possible threat of replacement by artificial intelligence,” Gefen says. “But what we are also doing, and this is due to requirements that we have received from clients that are already hiring our cyber professionals, is that we are now starting to deliver AI engineers and data scientists in other domains.”

“That means that we have added more programs to our cybersecurity program. So, we're also training people in data science and machine learning,” he continues.

All interested candidates for the program should be aware that a college degree is not required. NukuDo is genuinely interested in talented individuals, regardless of their background.

“The minimum that we are asking for is high school graduates,” Gefen says. “They don't need to have a college degree; they just need to have aptitude. And, of course, they need to be hungry to make this change.”

2 Houston universities declared among world’s best in 2026 rankings

Declaring the Best

Two Houston universities are in a class of their own, earning top spots on a new global ranking of the world's best universities.

Rice University and University of Houston are among the top 1,200 schools included in the QS World University Rankings 2026. Ten more schools across Texas make the list.

QS (Quacquarelli Symonds), a London-based provider of higher education data and analytics, compiles the prestigious list each year; the 2026 edition includes more than 1,500 universities from around the world. Factors used to rank the schools include academic reputation; employer reputation; faculty-student ratio; faculty research; and international research, students, and faculty.

In Texas, University of Texas at Austin lands at No. 1 in the state, No. 20 in the U.S., and No. 68 globally.

Houston's Rice University is close behind as Texas' No. 2 school. It ranks 29th in the U.S. and No. 119 in the world. Unlike UT, which fell two spots globally this year (from No. 66 to 68), Rice climbed up the charts, moving from 141st last year to No. 119.

University of Houston impresses as Texas' 4th highest-ranked school. It lands at No. 80 in the U.S. and No. 556 globally, also climbing about 100 spots up the chart.

Rice and UH are on a roll in regional, national, and international rankings this year.

Rice earned top-15 national rankings by both Niche.com and Forbes last fall. Rice claimed No. 1 and UH ranked No. 8 in Texas in U.S. News & World Report's 2025 rankings. Rice also topped WalletHub's 2025 list of the best colleges and universities in Texas for 2025.

More recently, in April, both UH and Rice made U.S. News' 2025 list of top grad schools.

In all, 192 U.S. universities made the 2026 QS World University Rankings — the most of any country. Topping the global list is the Massachusetts Institute of Technology (MIT).

“The results show that while U.S. higher education remains the global leader, its dominance is increasingly challenged by fast-rising emerging systems,” says the QS World University Rankings report. “A decade ago, 32 American universities [were] featured in the world’s top 100; today, that number has dropped to 26, and only 11 of these institutions have improved their position this year."

The 12 Texas universities that appear in the QS World University Rankings 2026 list are:

  • University of Texas at Austin, No. 20 in the U.S. and No. 68 in the world (down from No. 66 last year).
  • Rice University, No. 29 in the U.S. and No. 119 in the world (up from No. 141 last year).
  • Texas A&M University, No. 32 in the U.S. and No. 144 in the world (up from No. 154 last year).
  • University of Houston, No. 80 in the U.S. and No. 556 in the world (up from 651-660 last year).
  • University of Texas at Dallas, No. 85 in the U.S. and No. 597 in the world (down from 596 last year).
  • Texas Tech University, No. 104 in the U.S. and No. 731-740 in the world (unchanged from last year).
  • University of North Texas, No. 123 in the U.S. and No. 901-950 in the world (up from 1,001-1,200 last year)
  • Baylor University, tied for No. 136 in the U.S. and at No. 1,001-1,200 in the world (unchanged from last year).
  • Southern Methodist University, tied for No. 136 in the U.S. and at 1,001-1,200 in the world (unchanged from last year).
  • University of Texas Arlington, tied for No. 136 in the U.S. and at 1,001-1,200 in the world (unchanged from last year).
  • University of Texas at San Antonio, tied for No. 136 in the U.S. and at 1,001-1,200 in the world (unchanged from last year).
  • University of Texas at El Paso, No. 172 in the U.S. and at 1,201-1,400 in the world (down from 1,001-1,200 last year).
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This article originally appeared on CultureMap.com.

Houston students develop new device to prepare astronauts for outer space

space race

Rice University students from the George R. Brown School of Engineering and Computing designed a space exercise harness that is comfortable, responsive, and adaptable and has the potential to assist with complex and demanding spacewalks.

A group of students—Emily Yao, Nikhil Ashri, Jose Noriega, Ben Bridges and graduate student Jack Kalicak—mentored by assistant professor of mechanical engineering Vanessa Sanchez, modernized harnesses that astronauts use to perform rigorous exercises. The harnesses are particularly important in preparing astronauts for a reduced-gravity space environment, where human muscles and bones atrophy faster than they do on Earth. However, traditional versions of the harnesses had many limitations that included chafing and bruising.

The new harnesses include sensors for astronauts to customize their workouts by using real-time data and feedback. An additional two sensors measure astronauts’ comfort and exercise performance based on temperature and humidity changes during exercise and load distribution at common pressure points.

“Our student-led team addressed this issue by adding pneumatic padding that offers a customized fit, distributes pressure over a large surface area to reduce discomfort or injuries and also seamlessly adapts to load shifts — all of which together improved astronauts’ performance,” Sanchez said in a news release. “It was very fulfilling to watch these young engineers work together to find innovative and tangible solutions to real-world problems … This innovative adjustable exercise harness transforms how astronauts exercise in space and will significantly improve their health and safety during spaceflights.”

The project was developed in response to a challenge posted by the HumanWorks Lab and Life Science Labs at NASA and NASA Johnson Space Center for the 2025 Technology Collaboration Center’s (TCC) Wearables Workshop and University Challenge, where teams worked to solve problems for industry leaders.

Rice’s adaptive harness won the Best Challenge Response Award. It was funded by the National Science Foundation and Rice’s Office of Undergraduate Research and Inquiry.

“This challenge gave us the freedom to innovate and explore possibilities beyond the current harness technology,” Yao added in the release. “I’m especially proud of how our team worked together to build a working prototype that not only has real-world impact but also provides a foundation that NASA and space companies can build and iterate upon.”