One of Houston's biggest medical office projects — the $1.3 billion, 400,000-square-foot O’Quinn Medical Tower — is expected to deliver this year. Photo courtesy of Baylor College of Medicine

Medical office and life sciences projects are making a big splash in Houston’s commercial real estate sector in 2023.

The 42Floors commercial real estate website ranks five Houston-area medical office buildings among the country’s 20 largest medical office projects set to open this year. Meanwhile, 42Floors identifies two Houston developments among the 20 biggest U.S. life sciences projects on tap to debut in 2023.

Leading the list of the largest U.S. medical office buildings scheduled to be completed this year is the $1.3 billion, 400,000-square-foot O’Quinn Medical Tower. Set to open April 14 at the McNair Campus of Baylor St. Luke’s Medical Center, the outpatient facility will adjoin the McNair Hospital Tower, which opened in 2019.

The O’Quinn tower will serve as the new clinical home of the Dan L Duncan Comprehensive Cancer Center. The center is a federally designated facility for cancer care and research.

Highlights of the 12-story O’Quinn tower, southeast of the Texas Medical Center, include:

  • Ambulatory surgery center with 12 operating rooms and 10 endoscopy suites
  • 80-bay setup for infusion therapy
  • More than 70 exam rooms
  • More than 850 parking spaces

In all, five medical office properties in the Houston area made the 42Floors list, representing the highest concentration of major projects in any U.S. metro area that are scheduled to open this year. The four medical office properties joining the O’Quinn tower on the list are:

  • Houston Methodist Sugar Land Medical Office Building 4, 159,252 square feet
  • Kelsey-Seybold Springwoods Village Campus, 157,983 square feet
  • Kelsey-Seybold Ambulatory Surgery Center in Clear Lake, 116,000 square feet
  • 1715 Project in Friendswood, 107,000 square feet

A separate 42Floors list ranks Dynamic One, part of Baylor College of Medicine’s TMC Helix Park, as the second largest life sciences project in the U.S. set to come online this year. Houston’s TMC3 Collaborative Building lands at No. 19.

The 12-story Dynamic One project will feature lab space, offices, restaurants, and stores. It represents the first of four buildings planned for the 37-acre, five-million-square-foot TMC Helix Park, which is projected to generate an economic impact of $5.4 billion.

The 42Floors list puts the square footage of Dynamic One’s north tower at 365,000. Organizations involved in the project cite the square footage as 355,000.

The Baylor College of Medicine has signed up as Dynamic One’s anchor tenant. It will occupy 114,000 square feet of lab and office space.

“Baylor College of Medicine is a major force in life sciences discovery and commercialization at TMC. Their move to TMC Helix Park will serve as a catalyst for enhanced collaboration with TMC’s other esteemed Institutions, as well as with industry leaders from around the world,” Bill McKeon, president and CEO of TMC, says in a news release.

Also located at TMC Helix Park, the four-story TMC3 Collaborative Building will span 250,000 square feet. It will contain research facilities for MD Anderson Cancer Center, the Texas A&M University Health Science Center, the University of Texas Health Science Center at Houston, and TMC.

In addition, the TMC3 Collaborative Building will house life sciences companies, the TMC Data Collaborative, the TMC Venture Fund, the Braidwell hedge fund, and venture capital and private equity firms.

The design and construction team has been announced for TMC3. Courtesy of Elkus Manfredi Architects

Texas Medical Center reveals new details and renderings for its TMC3 campus

Coming to hou in 2022

The Texas Medical Center just announced the dream team of architects and designers that are making TMC3 into a reality.

Elkus Manfredi Architects, Transwestern, and Vaughn Construction are the three companies that will serve as the architectural and development team for the 37-acre research campus. TMC3's founding institutions — TMC, Baylor College of Medicine, Texas A&M University Health Science Center, The University of Texas Health Science Center at Houston, and The University of Texas MD Anderson Cancer Center — decided on the three entities.

"Texas Medical Center is eager to move forward with a bold, imaginative and dynamic new design vision for the TMC3 Master Plan," says TMC CEO and president, Bill McKeon, in a press release. "With the combined talents of Elkus Manfredi Architects, Transwestern, and Vaughn Construction on-board, I couldn't be more confident that this dream team will flawlessly execute the totality of the project's vision and fulfill its mission to bring together leading researchers and top-tiered expertise from the private sector to create the number one biotechnology and bioscience innovation center in the entire world."

TMC3 was first announced just over a year ago and is planned to open in 2022. The campus will incorporate research facilities, retail space, residential plans, a hotel and conference center, and green space. Parking will be underground to optimize surface area.

Design in mind

The 37-acre research campus will be interconnected by a DNA helix outdoor promenade.

Courtesy of Elkus Manfredi Architects

From a design perspective, the key element will be a DNA helix-shape that looks like a necklace chain that connects the campus.

"Our idea was to expand on the DNA design concept and create a series of spaces that would elongate the strand all the way north to the historic core of the Texas Medical Center and south to the new development by UTHealth and MD Anderson in order to create more opportunity for connections and collisions," says Elkus Manfredi Architects CEO and founding principal, David Manfredi, in the release. "We're implementing the connective tissue between all these places and establishing opportunities for unplanned interactions. Science, technology, medicine, discovery and innovation are all about making connections, and we are building a space for institutions, industry and startups to interact."

Manfredi's firm is responsible for a few other iconic medical facilities, such as the original Broad Institute of MIT and Harvard and The Stanley Building at the Broad Institute in Cambridge, Massachusetts, and the New York Genome Center.

"We want to create spaces that attract talent," Manfredi says in the release. "You can attract talent with great colleagues, research and facilities, but if you don't have a great social environment for people to live, learn, and play, people move on. We are creating a place where people will want to be because they're constantly stimulated – whether it's breakfast at the local coffee shop, or a volleyball league in the afternoon, or working in a central lab and the person next to them is doing something intersects with their own research."

Growing partner institutions

TMC3 Collaborative will be a centrally located building on the campus that is designed to host gatherings and share space with industry leaders.

Courtesy of Elkus Manfredi Architects

While a big portion of the attraction in the new campus is this multi-purposeful and connective space, the project opens doors for the five partner institutions. For Baylor College of Medicine, TMC3 means an expansion of its facilities and an increased footprint for Baylor St. Luke's Medical Center's McNair Campus. The second tower of the hospital will be right at TMC3's eastern edge.

"The selection of a development team is an important milestone for the TMC3 project," says Paul Klotman, president, CEO and executive dean of Baylor College of Medicine, in the release. "The project itself is a huge step in developing the biotech industry in Houston. At Baylor, we look forward to working closely with TMC leaders, as well as those of the other anchor institutions, in making this project a reality."

Additionally, the Texas A&M Health Science Center research building — led by Carrie L. Byington, M.D — on the north end adjacent to BCM's building and the hotel and conference center. On the south side of the campus, MD Anderson and UTHealth will each develop new research facilities that will connect to the existing University of Texas Research Park that is directly to the south of the campus. UT Research Park will be connected to TMC3 via a new skybridge.

The release also describes a central building dubbed TMC3 Collaborative that will create collaborative research space for industry partners. The first level of the building will be an open atrium for gatherings and have food and beverage concepts.

"When TMC3 opens in 2022, Texas Medical Center will officially plant a tangible flag that signals its arrival as the Third Coast for life sciences for the foreseeable future," McKeon says in the release.

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Booming Houston suburb, other Texas towns among the fastest-growing U.S. cities in 2023

by the numbers

One Houston suburb experienced one of the most rapid growth spurts in the country last year: Fulshear, whose population grew by 25.6 percent, more than 51 times that of the nation’s growth rate of 0.5 percent. The city's population was 42,616 as of July 1, 2023.

According to U.S. Census Bureau's Vintage 2023 Population Estimates, released Thursday, May 16, Fulshear — which lies west of Katy in northwest Fort Bend County - ranked No. 2 on the list of fastest-growing cities with a population of 20,000 or more. It's no wonder iconic Houston restaurants like Molina's Cantina see opportunities there.

The South still dominates the nation's growth, even as America’s Northeast and Midwest cities are rebounding slightly from years of population drops. The census estimates showed 13 of the 15 fastest-growing cities in the U.S. were in the South — eight in Texas alone.

The Texas cities joining Fulshear on the fastest-growing-cities list are:

  • Celina (No. 1) with 26.6 percent growth (42,616 total population)
  • Princeton (No. 3) with 22.3 percent growth (28,027 total population)
  • Anna (No. 4) with 16.9 percent growth (27,501 total population)
  • Georgetown (No. 8) with 10.6 percent growth (96,312 total population)
  • Prosper (No. 9) with 10.5 percent growth (41,660 total population)
  • Forney (No. 10) with 10.4 percent growth (35,470 total population)
  • Kyle (No. 11) with 9 percent growth (62,548 total population)

Texas trends
San Antonio saw the biggest growth spurt in the United States last year, numbers-wise. The Alamo City added about 22,000 residents. San Antonio now has nearly 1.5 million people, making it the the seventh largest city in the U.S. and second largest in Texas.

Its population boom was followed by those of other Southern cities, including Fort Worth; Charlotte, North Carolina; Jacksonville, Florida; and Port St. Lucie, Florida.

Fast-growing Fort Worth (978,000) surpassed San Jose, California (970,000) to become the 12th most populous city in the country.

Meanwhile, population slowed in the Austin area. Jacksonville, Florida (986,000), outpaced Austin (980,000), pushing the Texas capital to 11th largest city in the U.S. (barely ahead of Fort Worth).

Population growth in Georgetown, outside Austin, slowed by more than one-fourth its population growth in 2022, the report says, from 14.4 percent to 10.6 percent. It's the same story in the Central Texas city of Kyle, whose population growth decreased by nearly 2 percent to 9 percent in 2023.

Most populated cities
New York City with nearly 8.3 million people remained the nation's largest city in population as of July 1, 2023. Los Angeles was second at close to 4 million residents, while Chicago was third at 2.7 million and Houston was fourth at 2.3 million residents.

The 15 populous U.S. cities in 2023 were:

  1. New York, New York (8.3 million)
  2. Los Angeles, California (4 million)
  3. Chicago, Illinois (2.7 million)
  4. Houston, Texas (2.3 million)
  5. Phoenix, Arizona (1.7 million)
  6. Philadelphia, Pennsylvania (1.6 million)
  7. San Antonio (1.5 million)
  8. San Diego, California (1.4 million)
  9. Dallas (1.3 million)
  10. Jacksonville, Florida (986,000)
  11. Austin (980,000)
  12. Fort Worth (978,000)
  13. San Jose (970,000)
  14. Columbus, Ohio (913,000)
  15. Charlotte, North Carolina (911,000)

Modest reversals of population declines were seen last year in large cities in the nation's Northeast and Midwest. Detroit, for example, which grew for the first time in decades, had seen an exodus of people since the 1950s. Yet the estimates released Thursday show the population of Michigan’s largest city rose by just 1,852 people from 631,366 in 2022 to 633,218 last year.

It's a milestone for Detroit, which had 1.8 million residents in the 1950s only to see its population dwindle and then plummet through suburban white flight, a 1967 race riot, the migration to the suburbs by many of the Black middle class and the national economic downturn that foreshadowed the city's 2013 bankruptcy filing.

Three of the largest cities in the U.S. that had been bleeding residents this decade staunched those departures somewhat. New York City, which has lost almost 550,000 residents this decade so far, saw a drop of only 77,000 residents last year, about three-fifths the numbers from the previous year.

Los Angeles lost only 1,800 people last year, following a decline in the 2020s of almost 78,000 residents. Chicago, which has lost almost 82,000 people this decade, only had a population drop of 8,200 residents last year.

And San Francisco, which has lost a greater share of residents this decade than any other big city — almost 7.5 percent — actually grew by more than 1,200 residents last year.

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This article originally ran on CultureMap.

How this Houston clean energy entrepreneur is navigating geothermal's hype to 100x business growth

houston innovators podcast Episode 237

Geothermal energy has been growing in recognition as a major player in the clean energy mix, and while many might think of it as a new climatetech solution, Tim Latimer, co-founder and CEO of Fervo Energy, knows better.

"Every overnight success is a decade in the making, and I think Fervo, fortunately — and geothermal as a whole — has become much more high profile recently as people realize that it can be a tremendous solution to the challenges that our energy sector and climate are facing," he says on the Houston Innovators Podcast.

In fact, Latimer has been bullish on geothermal as a clean energy source since he quit his job as a drilling engineer in oil and gas to pursue a dual degree program — MBA and master's in earth sciences — at Stanford University. He had decided that, with the reluctance of incumbent energy companies to try new technologies, he was going to figure out how to start his own company. Through the Stanford program and Activate, a nonprofit hardtech program that funded two years of Fervo's research and development, Latimer did just that.

And the bet has more than paid off. Since officially launching in 2017, Fervo Energy has raised over $430 million — most recently collecting a $244 million series D round. Even more impressive to Latimer — his idea for drilling horizontal wells works. The company celebrated a successful pilot program last summer by achieving continuous carbon-free geothermal energy production with Project Red, a northern Nevada site made possible through a 2021 partnership with Google.

Next up for Fervo is growing and scaling at around a 100x pace. While Project Red included three wells, Project Cape, a Southwest Utah site, will include around 100 wells with significantly reduced drilling cost and an estimated 2026 delivery. Latimer says there are a dozen other projects like Project Cape that are in the works.

"It's a huge ramp up in our drilling, construction, and powerplant programs from our pilot project, but we've already had tremendous success there," Latimer says of Project Cape. "We think our technology has a really bright future."

While Latimer looks ahead to the rapid growth of Fervo Energy, he says it's all due to the foundation he put in place for the company, which has a culture built on the motto, "Build things that last."

“You’re not going to get somewhere that really changes the world by cutting corners and taking short steps. And, if you want to move the needle on something as complicated as the global energy system that has been built up over hundreds of years with trillions of dollars of capital invested in it – you’re not going to do it overnight," he says on the show. "We’re all in this for the long haul together."

Houston researchers create AI model to tap into how brain activity relates to illness

brainiac

Houston researchers are part of a team that has created an AI model intended to understand how brain activity relates to behavior and illness.

Scientists from Baylor College of Medicine worked with peers from Yale University, University of Southern California and Idaho State University to make Brain Language Model, or BrainLM. Their research was published as a conference paper at ICLR 2024, a meeting of some of deep learning’s greatest minds.

“For a long time we’ve known that brain activity is related to a person’s behavior and to a lot of illnesses like seizures or Parkinson’s,” Dr. Chadi Abdallah, associate professor in the Menninger Department of Psychiatry and Behavioral Sciences at Baylor and co-corresponding author of the paper, says in a press release. “Functional brain imaging or functional MRIs allow us to look at brain activity throughout the brain, but we previously couldn’t fully capture the dynamic of these activities in time and space using traditional data analytical tools.

"More recently, people started using machine learning to capture the brain complexity and how it relates it to specific illnesses, but that turned out to require enrolling and fully examining thousands of patients with a particular behavior or illness, a very expensive process,” Abdallah continues.

Using 80,000 brain scans, the team was able to train their model to figure out how brain activities related to one another. Over time, this created the BrainLM brain activity foundational model. BrainLM is now well-trained enough to use to fine-tune a specific task and to ask questions in other studies.

Abdallah said that using BrainLM will cut costs significantly for scientists developing treatments for brain disorders. In clinical trials, it can cost “hundreds of millions of dollars,” he said, to enroll numerous patients and treat them over a significant time period. By using BrainLM, researchers can enroll half the subjects because the AI can select the individuals most likely to benefit.

The team found that BrainLM performed successfully in many different samples. That included predicting depression, anxiety and PTSD severity better than other machine learning tools that do not use generative AI.

“We found that BrainLM is performing very well. It is predicting brain activity in a new sample that was hidden from it during the training as well as doing well with data from new scanners and new population,” Abdallah says. “These impressive results were achieved with scans from 40,000 subjects. We are now working on considerably increasing the training dataset. The stronger the model we can build, the more we can do to assist with patient care, such as developing new treatment for mental illnesses or guiding neurosurgery for seizures or DBS.”

For those suffering from neurological and mental health disorders, BrainLM could be a key to unlocking treatments that will make a life-changing difference.