Houston investors, mentors name 9 most promising energy startups at Rice Alliance event

best of the rest

Here are the most promising energy tech startups in the market today. Natalie Harms/InnovationMap

This week, 39 energy startup companies from all over the world pitched in Houston — and nine were recognized as being the most promising of the batch.

The Rice Alliance for Technology and Entrepreneurship returned its Offshore Technology Conference pitch event to its in-person capacity and host the annual event at the Ion Houston for the first time. The event featured three-minute pitches from the companies, and a select group of corporate and venture investors decided on the top nine to honor.

"We asked investors and corporates to look at the companies here today and help us determine the companies most promising — based on those that have an innovative technology that is solving a large problem, has customers willing to pay for it, and has the right team to build and grow their company," Brad Burke, managing director of the Rice Alliance says to the crowd at the event on May 3.

Here's which energy tech companies stood out to investors.

EarthEn

EarthEn, a Chandler, Arizona-based company, is a grid-scale energy storage solution. The technology can provide short-term — 6 to 8 hours — and long-term — over 100 hours — storage. The EarthEn pods provide a cheaper alternative and are built using 3D printing.

Echogen Power Systems

Based in Akron, Ohio, Echogen Power Systems has created a technology that captures heat that would otherwise be lost and converts it to a useable power source. The solution allows for any customer that operates at significant levels of heat to have a cost-effective energy option.

FuelX Innovation

Based in Aiken, South Carolina, FuelX Innovation is manufacturing solid-state hydrogen products and power systems, impacting mobile hydrogen fuel cell-powered applications. The company is focused on producing the lowest cost Alane, or aluminum hydride, for the fuel cell.

Lillianah Technologies

Lillianah Technologies, based in the Houston area in Spring, uses algae to remove carbon dioxide from the atmosphere. The company sells carbon offsets to corporations.

oPRO.ai

​oPRO.ai — which is based in Los Altos, California — is providing its customers with deep learning optimization software for process and responsible operations for oil and gas, petrochemical, chemicals, and metal industries.

Proteum Energy

Phoenix, Arizona-based Proteum Energy provides its customers low-cost, clean hydrogen by reforming renewable ethanol into renewable hydrogen.

Sync Power Solutions

Embracing a clean sheet approach, Sync Power Solutions, based in Abilene, Texas, created a solution involving a redesign of electric motors and generators to increase energy efficiency, save on costs, and more.

Utility Global

Houston-based Utility Global is using high temperature electrolysis without the use of electricity to produce hydrogen from waste gases.

ZL Innovations

Based in Portland, Oregon, ZL Innovations is focused on eliminating greenhouse gas emissions from failed industrial valves. The company's solution is a magnetic actuation assembly that can be better sealed to prevent emissions.

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Play it back: Houston home tech startup begins 2025 with fresh funding

HOUSTON INNOVATORS PODCAST EPISODE 272

One of the dozen or so Houston startups kicking of the new year with fresh funding is SmartAC.com, a company that's designed a platform that enables contractors in the HVAC and plumbing industries to monitor, manage, and optimize their maintenance memberships through advanced sensors, AI-driven diagnostics, and proactive alerts.

Last month, the SmartAC.com raised a follow-on round with support from local investor Mercury to continue growth and expansion of the product, which has evolved on many ways since the company launched in 2020, emerging from stealth with $10 million raised in a series A. In a May 2023 interview for the Houston Innovators Podcast, Founder and CEO Josh Teekell explained how he embraced the power of a pivot.

The company's sensors can monitor all aspects of air conditioning units and report back any issues, meaning homeowners have quicker and less costly repairs. While SmartAC.com started with providing the service and tech to homeowners directly, Teekell says he's had a greater interest in working with plumbers and HVAC companies who then deploy the technology to their customers.

"It became quite evident that homeowners don't care about air conditioning really at all until their system breaks," Teekell says on the show. "The technology is really built around giving those contractors as another way to gain a customer relationship and keep it."

Revisit the podcast episode below where Teekell talks about SmartAC.com's last raise.

SmartAC.com's previous round in 2023 — a $22 million series B — was used grow its team that goes out to deploy the technology and train the contractors on the platform.

"We've been very fortunate to get some of the biggest names in Houston on our cap table," Teekell says in the May 2023 conversation. "Since we're raising a bunch of money locally, everyone understands what a pain air conditioning can be."

Houston biotech company tests hard-to-fight cancer therapeutics

fighting cancer

A Houston-based, female-founded biotech company has developed a treatment that could prove to be an effective therapy for a rare blood cancer.

Cellenkos Therapeutics has completed promising Phase 1b testing of its Treg cell therapy, CK0804, in the fight against myelofibrosis. According to a news release from the Cellenkos team, the use of its cord-blood-derived therapeutics could signal a paradigm shift for the treatment of this hard-to-fight cancer.

Cellenkos was founded by MD Anderson Cancer Center physician and professor Simrit Parmar. Her research at the hospital displayed the ability of a unique subset of T cells’ capability to home in on a patient’s bone marrow, restoring immune balance, and potentially halting disease progression.

Myelofibrosis has long been treated primarily with JAK (Janus Kinase) inhibitors, medications that help to block inflammatory enzymes. They work by suppressing the immune response to the blood cancer, but don’t slow the progression of the malady. And they’re not effective for every patient.

“There is a significant need for new therapeutic options for patients living with myelofibrosis who have suboptimal responses to approved JAK inhibitors,” Parmar says. “We are greatly encouraged by the safety profile and early signs of efficacy observed in this patient cohort and look forward to continuing our evaluation of the clinical potential of CK0804 in our planned expansion cohort.”

The expansion cohort is currently enrolling patients with myelofibrosis. What exactly are sufferers dealing with? Myelofibrosis is a chronic disease that causes bone marrow to form scar tissue. This makes it difficult for the body to produce normal blood cells, leaving patients with fatigue, spleen enlargement and night sweats.

Myelofibrosis is rare, with just 16,000 to 18,500 people affected in the United States. But for patients who don’t respond well to JAKs, the prognosis could mean a shorter span than the six-year median survival rate outlined for the disease by Cleveland Clinic.

Helping myelofibrosis patients to thrive isn’t the only goal for Cellenkos right now.

The company seeks to aid people with rare conditions, particularly inflammatory and autoimmune disorders, with the use of CK0804, but also other candidates including one known as CK0801. The latter drug has shown promising efficacy in aplastic anemia, including transfusion independence in treated patients.

The company closed its $15 million series A round led by BVCF Management, based in Shanghai, in 2021. Read more here.

Pioneering Houston biotech startup expands to Brazil for next phase

On the Move

Houston biotech company Cemvita has expanded into Brazil. The company officially established a new subsidiary in the country under the same name.

According to an announcement made earlier this month, the expansion aims to capitalize on Brazil’s progressive regulatory framework, including Brazil’s Fuel of the Future Law, which was enacted in 2024. The company said the expansion also aims to coincide with the 2025 COP30, the UN’s climate change conference, which will be hosted in Brazil in November.

Cemvita utilizes synthetic biology to transform carbon emissions into valuable bio-based chemicals.

“For decades Brazil has pioneered the bioeconomy, and now the time has come to create the future of the circular bioeconomy,” Moji Karimi, CEO of Cemvita, said in a news release. “Our vision is to combine the innovation Cemvita is known for with Brazil’s expertise and resources to create an ecosystem where waste becomes opportunity and sustainability drives growth. By joining forces with Brazilian partners, Cemvita aims to build on Brazil’s storied history in the bioeconomy while laying the groundwork for a circular and sustainable future.”

The Fuel of the Future Law mandates an increase in the biodiesel content of diesel fuel, starting from 15 percent in March and increasing to 20 percent by 2030. It also requires the adoption of Sustainable Aviation Fuel (SAF) and for domestic flights to reduce greenhouse gas emissions by 1 percent starting in 2027, growing to 10 percent reduction by 2037.

Cemvita agreed to a 20-year contract that specified it would supply up to 50 million gallons of SAF annually to United Airlines in 2023.

"This is all made possible by our innovative technology, which transforms carbon waste into value,” Marcio Da Silva, VP of Innovation, said in a news release. “Unlike traditional methods, it requires neither a large land footprint nor clean freshwater, ensuring minimal environmental impact. At the same time, it produces high-value green chemicals—such as sustainable oils and biofuels—without competing with the critical resources needed for food production."

In 2024, Cemvita became capable of generating 500 barrels per day of sustainable oil from carbon waste at its first commercial plant. As a result, Cemvita quadrupled output at its Houston plant. The company had originally planned to reach this milestone in 2029.

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This story originally appeared on our sister site, EnergyCapitalHTX.

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