How this UH pharmacologist tapped into humanities to improve health outcomes in her study. Graphic by Miguel Tovar/University of Houston

The humanities, encompassing language, literature, arts, and history, are often seen as separate from scientific research in universities.

However, they hold the potential to contribute to improved health outcomes by fostering empathy, understanding of cultural context, and enhancing human connections. Meghana Trivedi, an associate professor of Pharmacy Practice and Translational Research at the University of Houston, has embarked on a research project to explore this transformative potential.

Using media to improve medicine adherence

Trivedi, a pharmacologist focusing on developing new drugs for breast cancer treatment, noticed a common issue among breast cancer patients — non-adherence to medication instructions, particularly among minority patients with low socioeconomic status. This non-adherence increases the risk of recurrence and poses a significant national problem.

Trivedi sought to understand the reasons behind this non-adherence and discovered that traditional educational pamphlets were ineffective in improving medication adherence. Instead, she decided to explore a theater-based approach.

Trivedi’s research involves developing a culturally sensitive educational video for breast cancer patients, written by a local African American playwright in collaboration with the clinical team and input from African American survivors. Additionally, her team is testing the effectiveness of motivational interviewing, where pharmacy students personally engage with patients to address barriers to adherence and suggest solutions. Trivedi believes that these approaches, rooted in the humanities, will demonstrate their impact on health outcomes.

The role of humanities in team science

Recognizing the value of interdisciplinary collaboration, Trivedi incorporated the arts and humanities into her research by partnering with professors from the School of Theatre and Dance and the Valenti School of Communication at UH. This collaboration has highlighted the importance of incorporating arts into STEM fields, leading Trivedi to advocate for STEAM (Science, Technology, Engineering, Arts, and Mathematics).

Trivedi emphasizes that effective team science requires shared interest in the project, transparency, and honesty among team members. “We are a very efficient team working to achieve a common and important goal – to improve treatment outcomes and survival in patients.”

The Big Idea

Trivedi’s research underscores the role of social and cultural factors in medication adherence among specific patient groups. By posing her research question outside of her discipline, Trivedi engaged new collaborators who became invested in — and contributed directly to — positive health outcomes. This interdisciplinary approach, combining the insights of the humanities and the collaborative nature of team science, facilitated the development of novel solutions to enhance medication adherence.

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This article originally appeared on the University of Houston's The Big Idea. Cory Thaxton, the author of this piece, is the communications coordinator for The Division of Research.

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Houston healthtech startup raises $30M to scale surgical healing gel

fresh funding

Houston-based healthtech startup TYBR Health has raised a $30 million Series A round to scale its B3 GEL System, which helps protect tendons from scarring after surgery.

The round was led by Minneapolis-based Vensana Capital and Cleveland-based Mutual Capital Partners, with participation from Denver-based Neovate Capital Partners and existing investors, according to a news release from the company.

TYBR Health said it plans to use the funding to broaden the B3 GEL System's clinical applications, expand commercialization and conduct studies to evaluate its ability to protect tissue and improve healing outcomes.

"Surgeons are exceptionally good at the structural repair, but the biology that follows is what determines how it heals. That part of the equation has gone largely unaddressed ... There's a shift underway across surgical specialties, from focusing almost entirely on the mechanical repair to also weighing the biological conditions that repair needs to succeed," Tim Keane, co-founder and CEO of TYBR Health, said in the news release. "This financing lets us reach more surgeons and generate the clinical evidence to move that shift forward."

As part of the financing round, Greg Banker of Vensana Capital and Liz Todia Zambory of Mutual Capital Partners will join the TYBR board, alongside independent director Aaron Smith.

"TYBR Health is addressing a gap surgeons have lived with for a long time, with a product that fits the way they already work," Zambory, principal at Mutual Capital Partners, added in the release. "We're excited to co-lead this round and support the company's growth."

TYBR was founded in 2020 and originated from the TMCi’s Biodesign fellowship and participated in the TMC's Accelerator for HealthTech. Its B3 GEL System is a flowable extracellular matrix hydrogel designed to protect tendons, ligaments, muscles, and the surrounding soft tissue while they heal from orthopedic surgery. It received FDA 510(k) clearance last June and launched an Australian clinical trial in the fall.

The B3 GEL System has been used in hand, wrist, shoulder, foot and ankle, and sports medicine procedures since it launched, according to the company, and was first used in the clinical setting earlier this year by Dr. Tammam Hanna with Texas Tech University Health Sciences Center.

Houston space companies win NASA funding to build Mars exploration robots

mission to mars

Two Houston-area spacetech companies have landed a portion of a $17 million award from NASA to develop robots for exploring the surface of Mars, the agency announced this month.

Houston-based Inuitive Machines and Webster, Texas-based MEI Technologies, which does business as Aegis Aerospace, were among the seven companies selected to receive the funding from NASA's Science Transport and Robotic Innovation for Deployment and Exploration (STRIDE) initiative.

According to the release from NASA, the companies are tasked with creating "innovative mobility systems" that would allow future Mars missions to access more challenging terrain and difficult-to-reach regions of the planet, and to travel farther distances. NASA estimated that the work will begin this fall.

NASA solicited proposals for participants in the STRIDE initiative in January. The seven named companies are the first selected to participate in the program.

The additional five companies to receive STRIDE funding include:

"STRIDE demonstrates NASA’s commitment to strong public-private partnerships, allowing the agency to explore new approaches for Mars surface exploration while identifying key capability gaps and development needs for commercial systems that could operate and traverse realistic Martian environments," NASA shared in the announcement.

Last month, Intuitive Machines was awarded $148.3 million to deliver its Nova-C lander to the moon. The funding was part of $600 million the space agency awarded to three companies as part of its Moon Base Program and was Intuitive Machines' sixth task order under NASA's Commercial Lunar Payload Services (CLPS) program. Astrobotic was also one of the companies to land funding for the Moon Base program, as well as Austin-based Firefly Aerospace.

Around the same time, Firefly Aerospace was awarded a $13 million subcontract from NASA’s Jet Propulsion Laboratory to develop technology for NASA’s SkyFall mission to Mars. The mission aims to deploy three Mars helicopters to "perform science and demonstrate airborne subsurface mapping and resource prospecting on the planet." Read more here.