First thing's first: Don't tell everyone. Jonathan Kitchen/Getty Images

If you have a successful tech startup, you may be working towards an exit plan where your vision and innovation is turned into liquidity. When a unique, innovative idea hits the big time, investors and other tech companies take notice, and some founders of startups discover themselves with sudden wealth.

Whether you take your company public or are eventually acquired by a much larger organization, you may find yourself looking at millions or billions of dollars one day. If this happens to you, there are crucial steps you should consider to help ensure you stay financially healthy for the long-term.

Keep your head down and do your homework.

First, be as quiet as possible about your new windfall. While selling your company may be public knowledge, keep conversations about your finances and situation minimal and confidential until you have a plan. The more hushed you keep your new financial situation, the less pressure you may have from others asking for favors and handouts.

Additionally, do your research before making any decisions. While you are coming to terms with your new wealth, search for the right team, including a financial adviser, attorney, and accountant, to help you set your goals, both long and short term. This may include tax efficiency and structure, such as trusts and family limited partnerships.

Research a potential advisers' philosophy, fees, and expertise. Have a background check run on anyone you hire, including their financial situation. Review your engagement letter and understand the small print. Be patient as you search for the right team — they are extremely important to your future.

Find an adviser you trust.

Part of your team should include a financial adviser who can be an invaluable resource during this time and into the future for many reasons.

First, he or she can help you identify potential present and future financial goals, plan for the next generation, and structure an income stream, which will ultimately help guide your money to survive you. You might find yourself in the unique position to make donations you have only dreamed of, and that, too, requires guidance.

A financial adviser can also help when friends and organizations are looking for financial contributions from you. Sudden wealth often leads to many changes which are hard to anticipate. Do not let your guard down. Family and friends can come out of the woodwork. Also, be aware of frivolous lawsuits and threats. Keep you and your family safe.

Don't go crazy.

Be disciplined in your spending. Some pro-athletes and lottery winners have filed for bankruptcy after blowing all of their wealth. Do not fall into this trap.

With the help of your financial adviser, you may decide to put your money where you cannot access it easily, such as a house or a 529 savings plan for your children's college. Or, you may decide to have your financial adviser help establish a salary for you each month so you can control your cash better.

After working hard to build a product or platform and the success of selling it for top dollar, ensure you are just as wise with your proceeds. Follow trusted advice from a well-vetted financial adviser and take your time to make major decisions. Trust your gut and enjoy the ride!

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Gail Stalarow is vice president and financial adviser with The Clarity Group in the Wealth Management Division of Morgan Stanley in Houston.

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Rice University lands $18M to revolutionize lymphatic disease detection

fresh funding

An arm of the U.S. Department of Health and Human Services has awarded $18 million to scientists at Rice University for research that has the potential to revolutionize how lymphatic diseases are detected and help increase survivability.

The lymphatic system is the network of vessels all over the body that help eliminate waste, absorb fat and maintain fluid balance. Diseases in this system are often difficult to detect early due to the small size of the vessels and the invasiveness of biopsy testing. Though survival rates of lymph disease have skyrocketed in the United States over the last five years, it still claims around 200,000 people in the country annually.

Early detection of complex lymphatic anomalies (CLAs) and lymphedema is essential in increasing successful treatment rates. That’s where Rice University’s SynthX Center, directed by Han Xiao and Lei Li, an assistant professor of electrical and computer engineering, comes in.

Aided by researchers from Texas Children’s Hospital, Baylor College of Medicine, the University of Texas at Dallas and the University of Texas Southwestern Medical Center, the center is pioneering two technologies: the Visual Imaging System for Tracing and Analyzing Lymphatics with Photoacoustics (VISTA-LYMPH) and Digital Plasmonic Nanobubble Detection for Protein (DIAMOND-P).

Simply put, VISTA-LYMPH uses photoacoustic tomography (PAT), a combination of light and sound, to more accurately map the tiny vessels of the lymphatic system. The process is more effective than diagnostic tools that use only light or sound, independent of one another. The research award is through the Advanced Research Projects Agency for Health (ARPA-H) Lymphatic Imaging, Genomics and pHenotyping Technologies (LIGHT) program, part of the U.S. HHS, which saw the potential of VISTA-LYMPH in animal tests that produced finely detailed diagnostic maps.

“Thanks to ARPA-H’s award, we will build the most advanced PAT system to image the body’s lymphatic network with unprecedented resolution and speed, enabling earlier and more accurate diagnosis,” Li said in a news release.

Meanwhile, DIAMOND-P could replace the older, less exact immunoassay. It uses laser-heated vapors of plasmonic nanoparticles to detect viruses without having to separate or amplify, and at room temperature, greatly simplifying the process. This is an important part of greater diagnosis because even with VISTA-LYMPH’s greater imaging accuracy, many lymphatic diseases still do not appear. Detecting biological markers is still necessary.

According to Rice, the efforts will help address lymphatic disorders, including Gorham-Stout disease, kaposiform lymphangiomatosis and generalized lymphatic anomaly. They also could help manage conditions associated with lymphatic dysfunction, including cancer metastasis, cardiovascular disease and neurodegeneration.

“By validating VISTA-LYMPH and DIAMOND-P in both preclinical and clinical settings, the team aims to establish a comprehensive diagnostic pipeline for lymphatic diseases and potentially beyond,” Xiao added in the release.

The ARPA-H award funds the project for up to five years.

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.