Chevron has doubled down on its commitment to The Cannon in West Houston, a new study finds Houston a top city for STEM, a Houston startup takes home a win from a digital pitch competition, and more. Photo courtesy of The Cannon

Houston's innovation ecosystem has been booming with news, and it's likely some might have fallen through the cracks.

For this roundup of short stories within Houston innovation, a startup snags a win at a pitch competition, Chevron announces a new makerspace, a software company makes an acquisition, and more.

Houston named a best city for STEM

Image via SmartAsset

For the fifth year, personal finance website, SmartAsset, analyzed data for the 35 cities in the county with the largest STEM workforces. The study looked at the racial diversity index as well as the gender diversity index. The data for both metrics comes from the Census Bureau's 2019 1-year American Community Survey.

Houston ranked No. 7 on the list, and according to the report, the total number of STEM workers in Houston, Texas exceeds 79,500. Around 70 percent of the total STEM workers there are men, and more than 30 percent are women. Additionally, Houston has the third-best race/ethnicity index score in the study with more than 19 percent of STEM workers are Hispanic or Latino, almost 20 percent are Asian, and more than 8 percent are Black.

Texas makes up about a third of the top 10 list with Dallas and Fort Worth coming in at No. 9 and No.10, respectively.

Chevron announces digital makerspace in The Cannon

Photo courtesy of The Cannon

The Cannon and its surrounding Founders District in West Houston has announced the addition of Chevron's digital makerspace, which will be dedicated to startup partnerships and community organizations.

"Chevron's support for The Founders District and The Cannon expands our commitment to Houston's growing innovation ecosystem," says Barbara Burger, Chevron vice president, Innovation and president of Chevron Technology Ventures, in a news release. "We look forward to utilizing this new space to collaborate with other Chevron organizations, such as our Wells group, as we work to deliver more reliable, affordable, ever-cleaner energy."

While Chevron has been a key partner for The Cannon since 2018 and even had branded office space within the hub, this new space represents a new lease agreement for a significantly larger footprint.

"We are thrilled to partner with Chevron Technology Ventures in developing this exciting makerspace at The Founders District," says Mark Toon, CEO of Puma Development, the company developing The Founders District and founder of Work America Capital, a venture capital firm dedicated to investing in Houston-based businesses. "CTV is the paradigm for meaningful innovation in Houston. By investing in emerging technologies in energy, they are paving the way for innovation to remain at the heart of Houston's most prominent industry."

Lazarus 3D wins The Ion's pitch competition

Photo via Laz3d.com

After months of pitching events, The Ion's Startup Demo Day for 2020 concluded on November 18 with four final pitches from Lazarus 3D, Skylark Wireless, HelloWoofy, and Swoovy.

After each of the four founders presented at the virtual event, which was powered by Dell Technologies, Lazarus 3D, a startup that produces 3D-printed organs and tissues for surgical practice, took home the win and the cash prize.

"I'm so grateful to Ion Houston — I've met so many people and made so many connections," says Smriti Zaneveld, co-founder and president. "All of the companies that present at these events are doing something so meaningful."

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Houston tech co. acquires New Zealand business

Photo via Onit.com

Houston-based Onit Inc., a legal software provider, announced that the company has acquired McCarthyFinch and its artificial intelligence platform.

"Our vision is to build AI into our workflow platform and every product across the Onit and SimpleLegal product portfolios," says Eric M. Elfman, Onit CEO and co-founder, in a news release. "AI will have an active role in everything from enterprise legal management to legal spend management and contract lifecycle management, resulting in continuous efficiencies and cost savings for corporate legal departments.

"Historically, legal departments have been thought of as black boxes where requests go in and information, decisions or contracts come out with no real transparency," Elfman continues. "AI has the potential to enhance transparency and contribute to stronger enterprise-wide business collaboration in a way that conserves a lawyer's valuable time."

The newly acquired software has the capacity to accelerate contract processing by up to 70 percent and increase productivity by over 50 percent. With the acquisition, Onit is enhancing its new artificial intelligence platform Precedent and the company's first release on the platform will be ReviewAI.

New sustainability-focused app launches at Climathon

Photo courtesy of Footprint

Houston-based Footprint App Inc. launched its latest carbon footprint education and action software during the Houston Climathon that was hosted earlier this month by Impact Hub Houston.

By tracking the user's sustainable habits, the student-focused tool allows users to compete to reduce their environmental impact. Footprint has launched in over 50 classrooms across the nation and is also being used by several corporations.

"With the state of Texas recently receiving an 'F' in climate education from the National Science Foundation, we see Footprint as the perfect tool for K-12 and beyond to help Texas students engage with climate science in a fun, competitive way," says Dakota Stormer, Footprint App, Inc. CEO and co-founder, in a news release.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.