If Houston wants to maintain its title as Space City, it needs to channel the innovation of its history as space exploration moves forward. Pexels

Space has captured the imagination of mankind since we first looked up at the night sky. We've reached out to touch the stars, and now endeavor to inhabit them.

Earlier this month, a prominent collection of experts on space health attended the first Space Health Innovation Conference co-hosted by the University of California, San Francisco, and Houston-based Translational Research Institute for Space Health.

As NASA eyes a return to the moon with the Artemis Program, attendees of the Space Health Innovation Conference advanced a national discussion of human space exploration by seeking to manage the many health risks associated with humans during space flight. The event included NASA leadership, innovative companies, commercial space vendors, as well as leaders from the space health and life sciences communities.

The conference's goal is to inform, inspire and invite participation in the exciting challenge of optimizing health and medical management in space environments.

With its headquarters in Houston, TRISH partnered with the Human Research Program at Johnson Space Center to source and seed the best emerging health technologies to support NASA's space exploration. TRISH is based out of the Center for Space Medicine at Baylor College of Medicine and is a consortium that includes the rich space pedigree of the Massachusetts Institute of Technology and the California Institute of Technology. The Space Health Innovation Conference is the result of a grant by TRISH to UCSF. TRISH has also hosted Space Health focused events at the MIT Media lab and at Caltech.

TRISH's main charge is finding disruptive health technologies and new scientists to fuel the US Space Program. TRISH explores emerging areas of science that support health and human performance in the harsh environment of microgravity and high radiation. TRISH funds novel research in artificial intelligence, omics, human computer interfaces, behavioral health and beyond. Projects all share one goal: predicting and protecting future Mars explorers. And NASA leadership encourages TRISH to take the risks that could mean huge leaps forward.

Innovation and risk tolerance are hallmarks of Houston and its rich history. From the city's humble origins, to Jesse Jones's national financial leadership, to the building of the Houston Ship Channel, and to the explosion of the energy industry, Houston has always dared to leap forward. President John F. Kennedy's iconic speech entitled "Address at Rice University on the Nation's Space Effort" declared the US ambition to embrace the new frontier of space and conquer the moon. Humble Oil donated the 1,620 acres for JSC to Rice University, who then sold the land to NASA for $20. (Humble Oil would later become Exxon Mobil.)

JSC housed flight control, space flight training, and the NASA Astronaut Corps. JSC gave Houston the nickname "Space City", which led to the naming of the local NBA team to be the Rockets and the local MLB team to be the Astros. JSC's support for the astronaut corps began with the Lunar Receiving Laboratory, which evaluated the Apollo astronauts upon return to Earth. And the Christopher C Kraft Mission Control facility has directed all crewed space flights since the early Gemini program. An American flag flies atop Mission Control at JSC every day that an American is in space. That flag has flown continuously since November 2, 2000.

Nearly two decades since Bill Shepherd first boarded the International Space Station, the conversation around supporting human health and performance in space continues. And Houston will continue to lead the way for all our sakes, in space and on terra firma.

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James Hury is the deputy director and chief innovation officer at Houston-based Translational Research Institute for Space Health.

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Rice University lands $18M to revolutionize lymphatic disease detection

fresh funding

An arm of the U.S. Department of Health and Human Services has awarded $18 million to scientists at Rice University for research that has the potential to revolutionize how lymphatic diseases are detected and help increase survivability.

The lymphatic system is the network of vessels all over the body that help eliminate waste, absorb fat and maintain fluid balance. Diseases in this system are often difficult to detect early due to the small size of the vessels and the invasiveness of biopsy testing. Though survival rates of lymph disease have skyrocketed in the United States over the last five years, it still claims around 200,000 people in the country annually.

Early detection of complex lymphatic anomalies (CLAs) and lymphedema is essential in increasing successful treatment rates. That’s where Rice University’s SynthX Center, directed by Han Xiao and Lei Li, an assistant professor of electrical and computer engineering, comes in.

Aided by researchers from Texas Children’s Hospital, Baylor College of Medicine, the University of Texas at Dallas and the University of Texas Southwestern Medical Center, the center is pioneering two technologies: the Visual Imaging System for Tracing and Analyzing Lymphatics with Photoacoustics (VISTA-LYMPH) and Digital Plasmonic Nanobubble Detection for Protein (DIAMOND-P).

Simply put, VISTA-LYMPH uses photoacoustic tomography (PAT), a combination of light and sound, to more accurately map the tiny vessels of the lymphatic system. The process is more effective than diagnostic tools that use only light or sound, independent of one another. The research award is through the Advanced Research Projects Agency for Health (ARPA-H) Lymphatic Imaging, Genomics and pHenotyping Technologies (LIGHT) program, part of the U.S. HHS, which saw the potential of VISTA-LYMPH in animal tests that produced finely detailed diagnostic maps.

“Thanks to ARPA-H’s award, we will build the most advanced PAT system to image the body’s lymphatic network with unprecedented resolution and speed, enabling earlier and more accurate diagnosis,” Li said in a news release.

Meanwhile, DIAMOND-P could replace the older, less exact immunoassay. It uses laser-heated vapors of plasmonic nanoparticles to detect viruses without having to separate or amplify, and at room temperature, greatly simplifying the process. This is an important part of greater diagnosis because even with VISTA-LYMPH’s greater imaging accuracy, many lymphatic diseases still do not appear. Detecting biological markers is still necessary.

According to Rice, the efforts will help address lymphatic disorders, including Gorham-Stout disease, kaposiform lymphangiomatosis and generalized lymphatic anomaly. They also could help manage conditions associated with lymphatic dysfunction, including cancer metastasis, cardiovascular disease and neurodegeneration.

“By validating VISTA-LYMPH and DIAMOND-P in both preclinical and clinical settings, the team aims to establish a comprehensive diagnostic pipeline for lymphatic diseases and potentially beyond,” Xiao added in the release.

The ARPA-H award funds the project for up to five years.

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.