Houston small biz organization expands strategic partnerships

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The Houston SBA has joined forces with various organizations across a 32-county footprint to align with SBA’s goal of supporting small businesses. Photo via Unsplash

In alliance with their mission of supporting Houston small businesses the Small Business Administration Houston District Office has expanded its partnerships.

The Houston SBA has joined forces with various organizations across a 32-county footprint.

“Small businesses represent an important and valuable resource in our community and our robust SBE program shows just how much small businesses can contribute when given the chance, and what it can mean in terms of overall economic benefits to the economy," Sabeeta Bidasie-Singh, director of business equity for Port Houston, says in a news release. “Collaborating with partners like the SBA is a key part of our success in supporting the small business ecosystem.”

Organizations signed a Strategic Alliance Memoranda to collaborate to further the interests of small businesses. In 2023, strategic partnerships included Greater Houston Partnership, Indo-American Chamber of Commerce, Houston Hispanic Chamber of Commerce, Fort Bend County Economic Opportunity & Development, Port Houston, Harris County Department of Economic Equity and Opportunity, Harris County Department of Education, Ion, Impact HUB, and Vision Galveston.

“Every small business deserves the chance to prosper,” Tim Jeffcoat, district director for Houston SBA, says in a news release. “SBA Houston strategically chose to partner with these important organizations so that small businesses of all kinds, everywhere in the 32-county Houston district, will benefit.”

SBA works with small business owners to assist with resources and support business growth and development. SBA also assists with businesses that need recovery from a declared disaster. SBA field offices and partnerships with public and private organizations like Ion help the city’s entrepreneurs.

“As a premiere destination for entrepreneurs to make their ideas a reality, we’re delighted to collaborate with the Small Business Administration to help Houstonians start, maintain and grow businesses,” Deanea LeFlore, senior director of Strategic Alliances at Ion, says in a news release. “We're excited to expand our relationships with the SBA to empower Houston’s small business community to scale their businesses, contributing to greater economic growth in the city.”

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An expert from the U.S. Small Business Administration shares in an op-ed how critical women-owned businesses are to small business exports in Texas. Photo via Getty Images

Expert: The major impact women of Texas have on the state's small biz exports

guest column

Everything is bigger in Texas, including its small business ecosystem. There are over three million small businesses in the state, which represent 99.8 percent of all Texas businesses. However, according to the latest official U.S. Census Bureau data on small business exporters (2020), only 35,124 Texas-based companies exported goods abroad.

During my time in the Administration, I have had the opportunity to visit Texas on several occasions, including trips to Houston, San Antonio, and El Paso. Like most everything in Texas, the entrepreneurial ecosystem is sizable and a rich source of opportunity and ideas. But with over a thousand miles of shared border with Mexico, and considerable trade infrastructure like the Port of Houston, you can’t tell me that just 1 percent of Texas small businesses are exporting their products or services. This data, which mirrors the published trend for small business exporters nationwide, seemed severely undercounted. So, we endeavored to dig into what was going on.

As a result, the Office of International Trade (OIT) commissioned a study to determine the total addressable market (TAM) of small business exporters. The research dug deep into available public data and private surveys, which better accounted for smaller shipment values and growth in service exports. Among the key findings from the study is new data that places the actual number of exporting small businesses at 1.3 million – an almost fivefold increase over the estimates previously published by the Federal Government. Interestingly, minority, women-owned firms were found to over-index in selling abroad. The research also revealed a high concentration of certain tradeable sectors ranging from consumer, industrial, and other manufactured goods to services businesses in software, architectural, and engineering sectors. Ultimately, the study estimated the potential market size, or total addressable market, at over 2.6 million small businesses.

With the proliferation of digital commerce tools and with over 95 percent of the world’s consumers living outside the United States, international sales represent a rich growth opportunity for small businesses. Indeed, businesses that export are more resilient, expand faster, and create higher paying jobs for Americans.

My colleague, District Director Tim Jeffcoat agrees. With his finger on the local pulse of the Houston-area economic market, he knows that exporting can be both an enormous growth opportunity, but at the same time filled with a daunting set of challenges to navigate. In his

Houston area network alone, they have over 200 advisors, mentors, and counselors that can guide you to develop a robust exporting plan, connect you with capital to fund your overseas expansion, and can even help you pursue a competitive grant to kick-start international sales.

This is exactly the case for Pat Hartmann, founder of Hartmann’s Inc., an Abilene, TX-based woman-owned small business. As a manufacturer of high-quality parts from state-of-the-art metal fabrication and welding departments, Hartmann has leveraged international sales to grow her company over three generations. In her words: “exporting has allowed us to become competitive in multiple markets throughout the entire world. It has diversified our knowledge base allowing us to work in manufacturing situations that span multiple types of standards including European and Japanese. Exporting now makes up 20 percent of our sales.”

As a result, Regional Administrator Ted James and I are among the many Administration officials who are pleased to recognize Pat Hartmann of Hartmann’s Inc. as the 2023 South Central Regional Exporter of the Year. She has established herself as a personal and professional role model due to their expansion and contributions to the community. We are confident that small businesses like these, as well as those identified in our Total Addressable Market study, can start and continue to leverage SBA resources to scale their business and access international opportunities, just as Hartmann did.

Pat Hartmann is one of the more than 11 million female founders the SBA is recognizing during Women’s History Month this March. While the post-pandemic recovery has complicated the economic landscape, we continue to better understand the important role women-owned small businesses play in our entrepreneurial ecosystem. They continue to contribute substantially to the national economy, showcasing innovative solutions and trailblazing techniques to lead the way forward.

If you are a current or future entrepreneur looking for assistance in how to get started or grow internationally, contact the SBA’s Office of International Trade or our network of 68 district offices which offer access to counseling, access to contracts, and access to capital.

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Gabriel Esparza is the associate administrator for the Office of International Trade at the U.S. Small Business Administration.

Houston-based PolyVascular has invented a polymer-based heart valve for children with congenital heart disease. Photo courtesy of TMC Innovation

Houston startup with life-saving innovation receives $2M grant

for the children

A $2 million federal grant will enable Houston-based PolyVascular to launch human trials of what it hails as the first polymer-based heart valve for children.

In conjunction with the grant, Dr. Will Clifton has joined the medical device company as chief operating officer. He will oversee the grant as principal investigator, and will manage the company's operations and R&D. Clifton is president and co-founder of Houston-based Enventure, a medical innovation incubator and education hub. He previously was senior director of medical affairs at Houston-based Procyrion, a clinical-stage medical device company.

PolyVascular's Phase II grant came from the Small Business Innovation Research (SBIR) program, which promotes technological projects.

The PolyVascular heart valve will help treat congenital heart disease affecting more than 1 million around the world. PolyVascular plans to launch clinical trials of the valve in children 5 and over within two years.

"Congenital heart disease remains the most common category of birth defect and a leading cause of childhood death in the developed world," reads a March 30 news release from PolyVascular, founded in 2014.

PolyVascular says the valve can be implanted without surgery, and can avoid the use of valve replacements from humans or animals. Those valve replacements are difficult to find and often don't last too long, leading to frequent follow-up surgeries.

"Our aim at PolyVascular is to transform the care of children with congenital heart disease by developing an entirely new generation of valves made of medical-grade polymer devoid of any biological tissue," Dr. Henri Justino, chief medical officer at PolyVascular, says in a release. "The valves in use so far for children have been made of biological tissue. Unfortunately, our immune systems target and destroy this biological tissue, sometimes rapidly, rendering the valve ineffective."

The SBIR grant isn't the only win for PolyVascular in recent years.

In 2019, the startup came away with several honors in the 2019 Texas A&M New Ventures Competition. It won the pitch competition (complete with a $5,000 cash award), and received the Biotex Investment Prize, Amerra Visualization Services Prize, and GOOSE Society Investment Prize.

Also in 2019, PolyVascular, a member of TMCx's 2017 medical device cohort, won in the medical device and health disparities and equity categories at the fifth annual Impact Pediatric Health pitch competition. Additionally, the Southwest National Pediatric Device Consortium granted the company up to $25,000.

Last year, MedTech Innovator, a nonprofit accelerator in the medical technology sector, announced PolyVascular was one of 50 companies chosen to participate in the organization's flagship four-month accelerator program.

"During these uncertain and challenging times, the need for health innovations — specifically those that promise to deliver long-term value to the health care system and patients — is more critical than ever," said Paul Grand, CEO of MedTech Innovator.

Another Houston startup, Vivante Health, also was picked for the MedTech Innovator program. Vivante is a digital health company that helps people address digestive health and wellness.

Following Winter Storm Uri, the United States Small Business Association has launched recovery resources for Texas small businesses. Photo via Getty Images

SBA launches Virtual Business Recovery Center to assist Texas loan applicants after winter storm

funds for small biz

Texas small businesses impacted by Winter Storm Uri are now eligible for up to $2 million in low-interest loans from the U.S. Small Business Administration as a result of President Joe Biden's major disaster declaration last week.

"Getting our businesses and communities up and running after a disaster is our highest priority at SBA," says SBA's acting Administrator Tami Perriello.

According to a release from the SBA, businesses in 77 counties are covered under the declaration for damages incurred during the storm, starting February 11. Loans can be used to repair or replace damaged or destroyed real estate, machinery and equipment, inventory and other business assets. The funds can also be used to make improvements that will protect, prevent, or minimize damage from any future freezes.

Interest rates for businesses start at 3 percent. Loans to private nonprofit organizations will start at 2 percent and homeowners and renters will incur interest at 1.25. All loans are set with 30 years terms.

Loan amounts and terms are determined by the SBA based on each applicant's financial condition.

The SBA will also launch a Virtual Business Recovery Center on February 23 — similar to the Women Business Centers it launched across the country in 2020, but all virtual due to COVID-related health concerns.

Applicants can call or email the virtual center to receive personalized assistance in their online loan applications at 800-659-2955 or FOCWAssistance@sba.gov, from 8 a.m. to 8 p.m.

Assistance will also be provided to help homeowners and renters through a similar Virtual Disaster Loan Outreach Center, which applicants can reach through the same number and email address.

Homeowners are eligible for up to $200,000 to repair or replace damaged or destroyed real estate.Renters and homeowners are also eligible for up to $40,000 for destroyed personal property.

To get started, applicants must contact FEMA at disasterassistance.gov. To download an application visit disasterloanassistance.sba.gov. Individuals who are deaf or hard‑of‑hearing can call 800-877-8339.

Re:3D is one of two Houston companies to be recognized by the SBA's technology awards. Photo courtesy of re:3D

2 Houston startups win national technology award from SBA

winner, winner

A couple of Houston startups have something to celebrate. The United States Small Business Administration announced the winners of its Tibbetts Award, which honors small businesses that are at the forefront of technology, and two Houston startups have made the list.

Re:3D, a sustainable 3D printer company, and Raptamer Discovery Group, a biotech company that's focused on therapeutic solutions, were Houston's two representatives in the Tibbetts Award, named after Roland Tibbetts, the founder of the SBIR Program.

"I am incredibly proud that Houston's technology ecosystem cultivates innovative businesses such as re:3D and Raptamer. It is with great honor and privilege that we recognize their accomplishments, and continue to support their efforts," says Tim Jeffcoat, district director of the SBA Houston District Office, in a press release.

Re:3D, which was founded in 2013 by NASA contractors Samantha Snabes and Matthew Fiedler to tackle to challenge of larger scale 3D printing, is no stranger to awards. The company's printer, the GigaBot 3D, recently was recognized as the Company of the Year for 2020 by the Consumer Technology Association. Re:3D also recently completed The Ion Smart and Resilient Cities Accelerator this year, which has really set the 20-person team with offices in Clear Lake and Puerto Rico up for new opportunities in sustainability.

"We're keen to start to explore strategic pilots and partnerships with groups thinking about close-loop economies and sustainable manufacturing," Snabes recently told InnovationMap on the Houston Innovators Podcast.

Raptamer's unique technology is making moves in the biotech industry. The company has created a process that makes high-quality DNA Molecules, called Raptamers™, that can target small molecules, proteins, and whole cells to be used as therapeutic, diagnostic, or research agents. Raptamer is in the portfolio of Houston-based Fannin Innovation Studio, which also won a Tibbetts Award that Fannin Innovation Studio in 2016.

"We are excited by the research and clinical utility of the Raptamer technology, and its broad application across therapeutics and diagnostics including biomarker discovery in several diseases, for which we currently have an SBIR grant," says Dr. Atul Varadhachary, managing partner at Fannin Innovation Studio.

This year, 38 companies were honored online with Tibbetts Awards. Since its inception in 1982, the awards have recognized over 170,000 honorees, according to the release, with over $50 billion in funding to small businesses through the 11 participating federal agencies.

The SBA announced plans to open 20 new centers to serve female entrepreneurs — and one is coming to the Houston area. Photo via Getty Images

SBA grant to open new centers to support women in business — and one will serve the Houston area

coming soon

The Houston area is benefitting from national funding that will be dedicated to creating female-focused resource centers across the country.

The United States Small Business Administration announced grant funding to launch 20 new Women's Business Centers (WBC) across the country. The centers, which are slated to go into rural and underserved markets, will also be partnering with Historically Black Colleges and Universities.

With the funds from the grant and through a partnership with the Greater Houston Women's Chamber of Commerce, the new center will rise in Northeast Houston to serve the Montgomery, East Harris and Chambers' Counties.

"We are incredibly excited that an organization as prominent as the Greater Houston Women's Chamber of Commerce is joining the SBA team," says Tim Jeffcoat, director if the SBA in Houston. "We are looking forward to working with them to empower women-owned businesses in Houston to reach new heights of success."

These new efforts represent the largest expansion of the WBC program in its 30-year existence.

"We are thrilled to partner with the SBA in opening another Women's Business Center, providing resources and tools for our region's women-led organizations to launch and expand," says Suzan Deison, CEO, president and founder of the Greater Houston Women's Chamber of Commerce. "We are honored the SBA chose to partner with us to expand needed services in Montgomery, East Harris & Chambers' counties, especially during these challenging times."

The SBA has 136 centers open across the country, and each offers business counseling, training, networking, workshops, and more to area female entrepreneurs.

"Opening the doors to the new Women's Business Centers is crucial to the vitality of women-owned small business owners. This network expansion will provide female entrepreneurs with the resources they need to start, grow, and expand their businesses," says Associate Administrator for the Office of Entrepreneurial Development Allen Gutierrez. "We look forward to the continued success of the WBC program as it contributes to the overall health of our economy and creates jobs in their local communities."

According to the release, the timing of these new centers is especially important as entrepreneurs continue to be challenged amid the COVID-19 pandemic.

"Over the past several months, we have seen Women's Business Centers provide aid to our nation's innovative and determined entrepreneurs, allowing countless small business owners to pivot with confidence to stay afloat during the pandemic," says SBA Administrator Jovita Carranza. "Expanding the WBC program is part of this Administration's longstanding commitment to the success of female entrepreneurs and women-owned small businesses. Adding these new Women's Business Centers to the already existing network of centers across America will boost timely resources to our nation's female economic drivers, providing them with local training and counseling."

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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