Words are hard. Here's how to pick the best ones to use to better communicate your science-based startup's mission. Miguel Tovar/University of Houston

So you're a researcher. Communicating science to a non-scientific audience scares the chemistry out of you.

You've spent your entire career studying fungiform papillae density. The mere thought of fungiform papillae density gives you a rush that even love cannot provide. You know everything about fungiform papillae density. One day you have an interview with a reporter. You're preparing to present at a conference for shareholders. You're writing a grant application. Or you're just at the family cookout and your crazy Uncle Joe with the glass eye wants to know what you do for work.

It's time.

This is the moment where you have to reach deep within yourself to scrape every bit of communications skill in your body. It's time to do what has challenged even the most brilliant scientific minds for ages: explain your work simply.

Yes, there is difficulty in simplicity. The irony is as rich as it is tragic.

Thankfully, there is hope. There are plenty of things you can do to ensure your message is communicated effectively to your non-scientific audience.

Communicating science with better word choices

The old '80s band Missing Persons once sang, "What are words for, when no one listens anymore?"

If what you're saying is not engaging, direct, or simple to understand, your listener will stop listening. The same thing is true for writing.

The words you use matter. They determine whether or not your audience will lock on to what you're trying to convey. Use language that is clear and simple and registers your message.

Personal pronouns like I, you, we help connect readers with the writer and his or her message. Such pronouns present your writing as more of a conversation. People tend to invest more in a conversation than a research paper. Conversations are natural and everyone understands them because everyone is experienced with them. The same cannot be said for research papers about, say, the role of lactic acid production by probiotic Lactobacillus species.

Let's look at the pronouns in action. In the first sentence, you'll see an unnecessarily long, bombastic, impersonal message. In the second, you'll find a more personable, inviting message:

Investigators with supplemental queries or interest in funding opportunities should contact the program.

Contact us if you are interested in funding opportunities.

Words are choice

Your word choices are vital in helping your readers digest your material. Choosing the appropriate words in communicating science stories can not only capture your readers' attention, but keep it.

Use positive words over negative ones. Negative words like don't or not can confuse readers.

Consider this sentence: "The machine doesn't run if you don't follow these instructions exactly as they are written."

It's confusing, isn't it?

Let's rework it with positive words: "The machine will run better if you follow these instructions exactly."

Now there's a sentence that inspires hope.

Inclusive language also helps everyone feel engaged. Stay away from male only pronouns like he and his. Unless you're writing a research paper specifically about men, it's always better to use inclusive language so that non-male readers can follow along and become invested in what you're communicating.

Simple sentences

Using direct, efficiently constructed sentences well get your point across most effectively. According to the search engine optimization platform Yoast, you should keep your sentences under 20 words. Keeping it short with no more than two punctuation points in the body of the sentence will help the reader understand your message. It lets them breathe. It's not overwhelming when it's short.

Make sure to keep your sentences simple, too. Make sure you only cover one idea in every sentence. Keep each paragraph centered on one theme only. Introducing more than one idea or theme will dilute the focus a reader has, because he or she has to divide their attention to give to more things.

Cut the fat. You don't need intensifiers like very, really, actually, or carefully in communicating science stories. They don't really have a purpose. If something is hot and you want to emphasize that point, don't describe it as "really hot." Instead, say that it's "dangerously hot." Say that people have been hospitalized from touching this hot thing. Now you're really saying something.

Verbs with a vengence

Summon the absolute power of verbs.

"Frankie broke the guitar" is a much more vivid portrayal of what happened than "The guitar was broken by Frankie."

Passive voice is often used in a not-so-creative way to hide wrongdoing.

"The money was taken."

Who took the money? The reader might conclude that the writer is hiding something.

"The store manager took the money."

Now you're telling us something we can use. Arrest the store manager.

What you just witnessed is the difference between passive voice (the former) and the active voice (the latter).

It's undeniable that the choices you make with your words and sentences can either connect or kill your audience's interest. They can make the process of communicating science easier or put the brakes on.

Making your technical paper a casual conversation without compromising the integrity of your research helps the lay audience follow along. Using active voice over passive voice helps your readers maintain interest because you're showing a sense of action where someone is doing something. Using universal pronouns expands your reach because everyone can feel they can invest in your writing. Hope is not lost. You can communicate even the most arcane material to the least scientific audiences.

"It is easy for us to forget the power of words. We use them the way an engineer uses a slide rule or a surgeon uses a scalpel." – Jonathan Capehart, Pulitzer Prize winner, The Washington Post.

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This article originally appeared on the University of Houston's The Big Idea.

Rene Cantu is the writer and editor at UH Division of Research.

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Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”